JP2006515883A5 - - Google Patents

Info

Publication number

JP2006515883A5

JP2006515883A5 JP2006500881A JP2006500881A JP2006515883A5 JP 2006515883 A5 JP2006515883 A5 JP 2006515883A5 JP 2006500881 A JP2006500881 A JP 2006500881A JP 2006500881 A JP2006500881 A JP 2006500881A JP 2006515883 A5 JP2006515883 A5 JP 2006515883A5

Authority

JP

Japan

Prior art keywords

composition

cancer

effective dose

administration

formulation

Prior art date

2004-01-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 42
• VRYALKFFQXWPIH-PBXRRBTRSA-N (3r,4s,5r)-3,4,5,6-tetrahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)CC=O VRYALKFFQXWPIH-PBXRRBTRSA-N 0.000 claims 22
• 206010028980 Neoplasm Diseases 0.000 claims 16
• 201000011510 cancer Diseases 0.000 claims 13
• 239000002246 antineoplastic agent Substances 0.000 claims 7
• 238000009472 formulation Methods 0.000 claims 7
• 230000037396 body weight Effects 0.000 claims 4
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 3
• PMMURAAUARKVCB-UHFFFAOYSA-N alpha-D-ara-dHexp Natural products OCC1OC(O)CC(O)C1O PMMURAAUARKVCB-UHFFFAOYSA-N 0.000 claims 3
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
• 229930012538 Paclitaxel Natural products 0.000 claims 2
• 239000002775 capsule Substances 0.000 claims 2
• 229960004562 carboplatin Drugs 0.000 claims 2
• 190000008236 carboplatin Chemical compound 0.000 claims 2
• 229960004316 cisplatin Drugs 0.000 claims 2
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
• 229960003668 docetaxel Drugs 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 229960001592 paclitaxel Drugs 0.000 claims 2
• 239000003826 tablet Substances 0.000 claims 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 235000013361 beverage Nutrition 0.000 claims 1
• 239000007894 caplet Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
• 239000006187 pill Substances 0.000 claims 1
• 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
• 238000005303 weighing Methods 0.000 claims 1