JP2018524005A5 - - Google Patents
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- Publication number
- JP2018524005A5 JP2018524005A5 JP2018500911A JP2018500911A JP2018524005A5 JP 2018524005 A5 JP2018524005 A5 JP 2018524005A5 JP 2018500911 A JP2018500911 A JP 2018500911A JP 2018500911 A JP2018500911 A JP 2018500911A JP 2018524005 A5 JP2018524005 A5 JP 2018524005A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fragment
- amino acid
- residues
- homology
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims description 145
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 121
- 230000004927 fusion Effects 0.000 claims description 117
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 116
- 229920001184 polypeptide Polymers 0.000 claims description 112
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 112
- 102100035323 Fibroblast growth factor 18 Human genes 0.000 claims description 107
- 101000878128 Homo sapiens Fibroblast growth factor 18 Proteins 0.000 claims description 107
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 99
- 230000001747 exhibiting effect Effects 0.000 claims description 65
- 210000004027 cell Anatomy 0.000 claims description 14
- 108091008794 FGF receptors Proteins 0.000 claims description 13
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 claims description 13
- 125000000539 amino acid group Chemical group 0.000 claims description 10
- 210000001612 chondrocyte Anatomy 0.000 claims description 10
- 230000004048 modification Effects 0.000 claims description 9
- 238000012986 modification Methods 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 210000000845 cartilage Anatomy 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 230000035755 proliferation Effects 0.000 claims description 5
- 238000003786 synthesis reaction Methods 0.000 claims description 5
- 241000124008 Mammalia Species 0.000 claims description 4
- 230000010261 cell growth Effects 0.000 claims description 4
- 230000007547 defect Effects 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 claims description 2
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 claims description 2
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims description 2
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 102220313252 rs1386345719 Human genes 0.000 claims description 2
- 125000006850 spacer group Chemical group 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 102000001708 Protein Isoforms Human genes 0.000 description 4
- 108010029485 Protein Isoforms Proteins 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 2
- 206010007710 Cartilage injury Diseases 0.000 description 1
- 206010061246 Intervertebral disc degeneration Diseases 0.000 description 1
- 208000013201 Stress fracture Diseases 0.000 description 1
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N butyric aldehyde Natural products CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 1
- 208000018180 degenerative disc disease Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 description 1
- 229920001427 mPEG Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2015/084133 | 2015-07-15 | ||
| CNPCT/CN2015/084133 | 2015-07-15 | ||
| PCT/CN2016/090110 WO2017008758A1 (en) | 2015-07-15 | 2016-07-15 | Fusion polypeptides and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524005A JP2018524005A (ja) | 2018-08-30 |
| JP2018524005A5 true JP2018524005A5 (enExample) | 2019-08-15 |
| JP6951318B2 JP6951318B2 (ja) | 2021-10-20 |
Family
ID=57756671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500911A Active JP6951318B2 (ja) | 2015-07-15 | 2016-07-15 | 融合ポリペプチドおよび使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11020454B2 (enExample) |
| EP (2) | EP3957654A1 (enExample) |
| JP (1) | JP6951318B2 (enExample) |
| CN (1) | CN107849151B (enExample) |
| WO (1) | WO2017008758A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107849151B (zh) | 2015-07-15 | 2022-05-24 | 德益阳光生物技术（北京）有限责任公司 | 融合多肽及使用方法 |
| US20180065317A1 (en) | 2016-09-06 | 2018-03-08 | Cc3D Llc | Additive manufacturing system having in-situ fiber splicing |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| US5728546A (en) * | 1995-06-05 | 1998-03-17 | Human Genome Sciences, Inc. | Fibroblast growth factor 13 |
| ATE491029T1 (de) | 1996-10-16 | 2010-12-15 | Zymogenetics Inc | Fibroblasten-wachstumsfaktoren-homologe |
| WO1998052976A1 (en) | 1997-05-21 | 1998-11-26 | Biovation Limited | Method for the production of non-immunogenic proteins |
| GB9815157D0 (en) | 1998-07-13 | 1998-09-09 | Metron Designs Ltd | High resolution pulse width setting from relatively low frequency clocks |
| US7470665B2 (en) * | 1999-12-02 | 2008-12-30 | Zymogenetics, Inc. | Methods for targeting cells that express fibroblast growth receptor-3 or -2 |
| IL139380A0 (en) * | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| US7414019B2 (en) * | 2002-10-04 | 2008-08-19 | Auckland Uniservices Limited | FGF-8 methods of use |
| SI1828239T1 (sl) | 2004-12-10 | 2011-11-30 | Zymogenetics Inc | Proizvodnja fgf18 v prokariotskih gostiteljih |
| WO2007099953A1 (ja) | 2006-02-28 | 2007-09-07 | National University Corporation Tokyo Medical And Dental University | 歯根形成促進剤及び歯根形成促進方法 |
| KR101419961B1 (ko) * | 2006-08-25 | 2014-07-30 | 아레스 트레이딩 에스.에이. | Ｆｇｆ-18 로 연골 질환의 치료 |
| MY148277A (en) | 2006-08-25 | 2013-03-29 | Ares Trading Sa | Treatment of cartilage disorders with fgf-18 |
| EP2213296B1 (en) | 2007-10-12 | 2015-04-15 | National Institute of Advanced Industrial Science and Technology | Fgf1/fgf2 chimeric protein and uses thereof |
| CN102656266B (zh) * | 2009-10-15 | 2016-08-03 | 霍夫曼-拉罗奇有限公司 | 具有改变的受体特异性的嵌合成纤维细胞生长因子 |
| WO2012038953A2 (en) * | 2010-09-21 | 2012-03-29 | Hepacore Ltd. | Fgf-18 truncated variants having increased receptor specificity and uses thereof |
| WO2013006486A2 (en) | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
| US9421245B2 (en) * | 2012-06-25 | 2016-08-23 | The Brigham And Women's Hospital, Inc. | Targeted therapeutics |
| CN107849151B (zh) | 2015-07-15 | 2022-05-24 | 德益阳光生物技术（北京）有限责任公司 | 融合多肽及使用方法 |
-
2016
- 2016-07-15 CN CN201680041325.1A patent/CN107849151B/zh active Active
- 2016-07-15 EP EP21184080.6A patent/EP3957654A1/en not_active Withdrawn
- 2016-07-15 WO PCT/CN2016/090110 patent/WO2017008758A1/en not_active Ceased
- 2016-07-15 JP JP2018500911A patent/JP6951318B2/ja active Active
- 2016-07-15 US US15/744,712 patent/US11020454B2/en active Active
- 2016-07-15 EP EP16823905.1A patent/EP3322736B1/en active Active
-
2021
- 2021-04-26 US US17/240,218 patent/US20210322516A1/en not_active Abandoned
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