JP2018523675A5 - - Google Patents
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- Publication number
- JP2018523675A5 JP2018523675A5 JP2018507672A JP2018507672A JP2018523675A5 JP 2018523675 A5 JP2018523675 A5 JP 2018523675A5 JP 2018507672 A JP2018507672 A JP 2018507672A JP 2018507672 A JP2018507672 A JP 2018507672A JP 2018523675 A5 JP2018523675 A5 JP 2018523675A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound
- pharmaceutical formulation
- streptococcus
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 206010060945 Bacterial infection Diseases 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 229940055033 Proteus mirabilis Drugs 0.000 claims 3
- 241000588770 Proteus mirabilis Species 0.000 claims 3
- 229940076185 Staphylococcus aureus Drugs 0.000 claims 3
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 150000003840 hydrochlorides Chemical class 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000588626 Acinetobacter baumannii Species 0.000 claims 2
- 241000589513 Burkholderia cepacia Species 0.000 claims 2
- 229940092559 Enterobacter aerogenes Drugs 0.000 claims 2
- 229940032049 Enterococcus faecalis Drugs 0.000 claims 2
- 241000194032 Enterococcus faecalis Species 0.000 claims 2
- 241000194031 Enterococcus faecium Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 229940023064 Escherichia coli Drugs 0.000 claims 2
- 229940047650 Haemophilus influenzae Drugs 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000588915 Klebsiella aerogenes Species 0.000 claims 2
- 229940045505 Klebsiella pneumoniae Drugs 0.000 claims 2
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 2
- 229940115932 Legionella pneumophila Drugs 0.000 claims 2
- 241000589242 Legionella pneumophila Species 0.000 claims 2
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 2
- 241000588655 Moraxella catarrhalis Species 0.000 claims 2
- 229940055023 Pseudomonas aeruginosa Drugs 0.000 claims 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- 241000607715 Serratia marcescens Species 0.000 claims 2
- 229940098362 Serratia marcescens Drugs 0.000 claims 2
- 241000122973 Stenotrophomonas maltophilia Species 0.000 claims 2
- 229940030998 Streptococcus agalactiae Drugs 0.000 claims 2
- 241000193985 Streptococcus agalactiae Species 0.000 claims 2
- 229940031000 Streptococcus pneumoniae Drugs 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- 229940076156 Streptococcus pyogenes Drugs 0.000 claims 2
- 241000193996 Streptococcus pyogenes Species 0.000 claims 2
- 206010046577 Urinary tract infection Diseases 0.000 claims 2
- 201000005661 acute cystitis Diseases 0.000 claims 2
- 229960003085 meticillin Drugs 0.000 claims 2
- 241000217846 Bacteroides caccae Species 0.000 claims 1
- 241000606124 Bacteroides fragilis Species 0.000 claims 1
- 241001135228 Bacteroides ovatus Species 0.000 claims 1
- 241000315377 Bremia ovata Species 0.000 claims 1
- 102100014408 CYBC1 Human genes 0.000 claims 1
- 108060002022 CYBC1 Proteins 0.000 claims 1
- 241000588923 Citrobacter Species 0.000 claims 1
- 210000003555 Cloaca Anatomy 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 229940119563 Enterobacter cloacae Drugs 0.000 claims 1
- 241000588697 Enterobacter cloacae Species 0.000 claims 1
- 241001505295 Eros Species 0.000 claims 1
- 241000588768 Providencia Species 0.000 claims 1
- 241000588777 Providencia rettgeri Species 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 claims 1
- 241000122971 Stenotrophomonas Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Claims (17)
- 下記式の化合物又は薬学的に許容されるその塩。
- 塩酸塩の形態で存在する、請求項１に記載の化合物又は薬学的に許容されるその塩。
- 請求項１に記載の化合物又は薬学的に許容されるその塩、及び薬学的に許容される担体を含む、医薬製剤。
- リポソーム製剤として存在する、請求項３に記載の医薬製剤。
- 細菌感染症を治療するための、請求項３又は４に記載の医薬製剤。
- 細菌感染症が尿路感染症である、請求項５に記載の医薬製剤。
- 細菌感染症が、インフルエンザ菌(Haemophilus influenzae)、モラクセラ・カタラーリス(Moraxella catarrhalis)、アシネトバクター・バウマニ(Acinetobacter baumannii)、大腸菌(Escherichia coli)、緑膿菌（Pseudomonas aeruginosa）、プロテウス・ミラビリス(Proteus mirabilis)、レジオネラ・ニューモフィラ(Legionella pneumophila)、エンテロバクター・クロアカ(Enterobacter cloacae)、エンテロバクター・アエロゲネス(Enterobacter aerogenes)、肺炎桿菌（Klebsiella pneumoniae）、ステノトロフォモナス・マルトフィリア(Stenotrophomonas maltophilla)、サイトロバクター属の種(Citrobacter spp)、バークホルデリア・セパシア(Burkholderia cepacia)、セラチア・マルセッセンス(Serratia marcescens)、プロビデンシア・レットゲリ(Providencia rettgeri)、黄色ブドウ球菌(Staphylococcus aureus)、肺炎レンサ球菌(Streptococcus pneumoniae)、化膿レンサ球菌(Streptococcus pyogenes)、エンテロコッカス・フェカリス(Enterococcus faecalis)、ストレプトコッカス・アガラクティアエ(Streptococcus agalactiae)、エンテロコッカス・フェシウム(Enterococcus faecium)、メチシリン耐性黄色ブドウ球菌(MRSA)、バクテロイデス・フラギリス(Bacteroides fragilis)、B.カカエ(B. caccae)、B.オバタス(B. ovatus)及びB.テタイオタミクロン(B. thetaiotamicron)からなる群から選択される１種以上の生物体により引き起こされるものである、請求項５に記載の医薬製剤。
- 下記式の化合物又は薬学的に許容されるその塩。
- 請求項８に記載の化合物又は薬学的に許容されるその塩、及び薬学的に許容される担体を含む、医薬製剤。
- リポソーム製剤として存在する、請求項９に記載の医薬製剤。
- 細菌感染症を治療するための、請求項９又は１０に記載の医薬製剤。
- 塩酸塩として存在する、下記式の化合物。
- 請求項１２に記載の化合物の塩酸塩、及び薬学的に許容される担体を含む、医薬製剤。
- リポソーム製剤として存在する、請求項１３に記載の医薬製剤。
- 細菌感染症を治療するための、請求項１３又は１４に記載の医薬製剤。
- 細菌感染症が尿路感染症である、請求項１５に記載の医薬製剤。
- 細菌感染症が、インフルエンザ菌、モラクセラ・カタラーリス、アシネトバクター・バウマニ、大腸菌、緑膿菌、プロテウス・ミラビリス、レジオネラ・ニューモフィラ、エンテロバクター・クロアカ、エンテロバクター・アエロゲネス、肺炎桿菌、ステノトロフォモナス・マルトフィリア、サイトロバクター属の種、バークホルデリア・セパシア、セラチア・マルセッセンス、プロビデンシア・レットゲリ、黄色ブドウ球菌、肺炎レンサ球菌、化膿レンサ球菌、エンテロコッカス・フェカリス、ストレプトコッカス・アガラクティアエ、エンテロコッカス・フェシウム、メチシリン耐性黄色ブドウ球菌(MRSA)、バクテロイデス・フラギリス、B.カカエ、B.オバタス及びB.テタイオタミクロンからなる群から選択される１種以上の生物体により引き起こされるものである、請求項１５に記載の医薬製剤。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562205732P | 2015-08-16 | 2015-08-16 | |
| US62/205,732 | 2015-08-16 | ||
| US201662308928P | 2016-03-16 | 2016-03-16 | |
| US62/308,928 | 2016-03-16 | ||
| PCT/IB2016/054890 WO2017029602A2 (en) | 2015-08-16 | 2016-08-15 | Compounds for use in antibacterial applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523675A JP2018523675A (ja) | 2018-08-23 |
| JP2018523675A5 true JP2018523675A5 (ja) | 2019-09-26 |
| JP6757402B2 JP6757402B2 (ja) | 2020-09-16 |
Family
ID=57218948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018507672A Expired - Fee Related JP6757402B2 (ja) | 2015-08-16 | 2016-08-15 | ピラジノ［２，３−ｂ］［１，４］オキサジン−３−オン又は関連する環系を含む抗菌剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10364254B2 (ja) |
| EP (1) | EP3334739A2 (ja) |
| JP (1) | JP6757402B2 (ja) |
| KR (1) | KR20180038046A (ja) |
| CN (1) | CN108137616B (ja) |
| AU (2) | AU2016307969C1 (ja) |
| CA (1) | CA2995715A1 (ja) |
| CL (1) | CL2018000403A1 (ja) |
| CO (1) | CO2018002204A2 (ja) |
| CR (1) | CR20180111A (ja) |
| DO (1) | DOP2018000049A (ja) |
| EA (1) | EA033314B1 (ja) |
| HK (1) | HK1248680A1 (ja) |
| IL (1) | IL257265B (ja) |
| MA (1) | MA42621A (ja) |
| MX (1) | MX2018002033A (ja) |
| PE (1) | PE20181143A1 (ja) |
| PH (1) | PH12018500358A1 (ja) |
| TW (1) | TW201722965A (ja) |
| UY (1) | UY36851A (ja) |
| WO (1) | WO2017029602A2 (ja) |
| ZA (1) | ZA201800722B (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY36851A (es) * | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| WO2019180634A1 (en) | 2018-03-23 | 2019-09-26 | Glaxosmithkline Intellectual Property Development Limited | Synthesis of oxazinone-containing bicyclic aromatic and heteroaromatic aldehydes |
| TW202116782A (zh) | 2019-07-16 | 2021-05-01 | 瑞士商愛杜西亞製藥有限公司 | 喹啉酮衍生物 |
| CN111269247B (zh) * | 2020-03-04 | 2020-11-24 | 河南科技大学第一附属医院 | 具有抑制大肠杆菌作用的噻嗪酮药物分子的制备方法 |
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| MX366510B (es) | 2008-12-05 | 2019-07-11 | Liquidia Tech Inc | Metodo para producir materiales modelados. |
| SI2376497T1 (sl) * | 2008-12-12 | 2014-01-31 | Actelion Pharmaceuticals Ltd. | Derivati 5-amino-2-(1-hidroksi-etil)-tetrahidropirana |
| US20120114554A1 (en) | 2009-07-13 | 2012-05-10 | Liquidia Technologies, Inc. | Engineered Aerosol Particles, And Associated Methods |
| JP5685589B2 (ja) * | 2010-05-25 | 2015-03-18 | 大正製薬株式会社 | 新規な複素環化合物又はその塩 |
| CA2840060A1 (en) * | 2011-06-27 | 2013-01-03 | Kyorin Pharmaceutical Co., Ltd. | Bridged bicyclic compounds for the treatment of bacterial infections |
| TW201326180A (zh) * | 2011-11-30 | 2013-07-01 | Actelion Pharmaceuticals Ltd | ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素 |
| EA029361B1 (ru) | 2013-04-16 | 2018-03-30 | Идорсиа Фармасьютиклз Лтд | Антибактериальные биароматические производные |
| UY36851A (es) * | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
-
2016
- 2016-08-12 UY UY0001036851A patent/UY36851A/es not_active Application Discontinuation
- 2016-08-12 TW TW105125824A patent/TW201722965A/zh unknown
- 2016-08-15 EA EA201890412A patent/EA033314B1/ru not_active IP Right Cessation
- 2016-08-15 JP JP2018507672A patent/JP6757402B2/ja not_active Expired - Fee Related
- 2016-08-15 PE PE2018000236A patent/PE20181143A1/es unknown
- 2016-08-15 WO PCT/IB2016/054890 patent/WO2017029602A2/en active Application Filing
- 2016-08-15 KR KR1020187007548A patent/KR20180038046A/ko unknown
- 2016-08-15 CA CA2995715A patent/CA2995715A1/en not_active Abandoned
- 2016-08-15 CN CN201680056596.4A patent/CN108137616B/zh not_active Expired - Fee Related
- 2016-08-15 MX MX2018002033A patent/MX2018002033A/es unknown
- 2016-08-15 CR CR20180111A patent/CR20180111A/es unknown
- 2016-08-15 US US15/752,639 patent/US10364254B2/en not_active Expired - Fee Related
- 2016-08-15 AU AU2016307969A patent/AU2016307969C1/en not_active Ceased
- 2016-08-15 EP EP16788799.1A patent/EP3334739A2/en not_active Withdrawn
- 2016-08-15 MA MA042621A patent/MA42621A/fr unknown
-
2018
- 2018-01-31 IL IL257265A patent/IL257265B/en active IP Right Grant
- 2018-02-02 ZA ZA2018/00722A patent/ZA201800722B/en unknown
- 2018-02-14 CL CL2018000403A patent/CL2018000403A1/es unknown
- 2018-02-15 PH PH12018500358A patent/PH12018500358A1/en unknown
- 2018-02-16 DO DO2018000049A patent/DOP2018000049A/es unknown
- 2018-02-27 CO CONC2018/0002204A patent/CO2018002204A2/es unknown
- 2018-06-25 HK HK18108126.0A patent/HK1248680A1/zh unknown
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2019
- 2019-01-14 AU AU2019200226A patent/AU2019200226B2/en not_active Ceased
- 2019-05-17 US US16/415,319 patent/US10683307B2/en active Active
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