JP2018522592A5 - - Google Patents
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- JP2018522592A5 JP2018522592A5 JP2018524548A JP2018524548A JP2018522592A5 JP 2018522592 A5 JP2018522592 A5 JP 2018522592A5 JP 2018524548 A JP2018524548 A JP 2018524548A JP 2018524548 A JP2018524548 A JP 2018524548A JP 2018522592 A5 JP2018522592 A5 JP 2018522592A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021112019A JP2021178824A (ja) | 2015-07-29 | 2021-07-06 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
| JP2021112020A JP7359346B2 (ja) | 2015-07-29 | 2021-07-06 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15178899.9 | 2015-07-29 | ||
| EP15178899 | 2015-07-29 | ||
| GB1603655.0 | 2016-03-02 | ||
| GBGB1603655.0A GB201603655D0 (en) | 2016-03-02 | 2016-03-02 | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| GB201605457 | 2016-03-31 | ||
| GB1605457.9 | 2016-03-31 | ||
| GBGB1610164.4A GB201610164D0 (en) | 2016-06-10 | 2016-06-10 | Modified natural killer cells and natural killer cell lines having increased cytoxicity |
| GB1610164.4 | 2016-06-10 | ||
| PCT/EP2016/068001 WO2017017184A1 (en) | 2015-07-29 | 2016-07-28 | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021112019A Division JP2021178824A (ja) | 2015-07-29 | 2021-07-06 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
| JP2021112020A Division JP7359346B2 (ja) | 2015-07-29 | 2021-07-06 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522592A JP2018522592A (ja) | 2018-08-16 |
| JP2018522592A5 true JP2018522592A5 (https=) | 2019-12-19 |
| JP6974681B2 JP6974681B2 (ja) | 2021-12-01 |
Family
ID=56683913
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524548A Active JP6974681B2 (ja) | 2015-07-29 | 2016-07-28 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
| JP2021112020A Active JP7359346B2 (ja) | 2015-07-29 | 2021-07-06 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
| JP2021112019A Pending JP2021178824A (ja) | 2015-07-29 | 2021-07-06 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021112020A Active JP7359346B2 (ja) | 2015-07-29 | 2021-07-06 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
| JP2021112019A Pending JP2021178824A (ja) | 2015-07-29 | 2021-07-06 | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10034925B2 (https=) |
| EP (6) | EP3434762B1 (https=) |
| JP (3) | JP6974681B2 (https=) |
| KR (1) | KR20180028530A (https=) |
| CN (3) | CN108026512B (https=) |
| AU (2) | AU2016300128B2 (https=) |
| BR (1) | BR112018001660A2 (https=) |
| CA (2) | CA3156128A1 (https=) |
| DK (3) | DK3434762T3 (https=) |
| ES (5) | ES2970269T3 (https=) |
| HK (1) | HK1252582B (https=) |
| MX (2) | MX380813B (https=) |
| WO (1) | WO2017017184A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10066207B2 (en) | 2012-04-18 | 2018-09-04 | Board Of Trustees Of Michigan State University | Natural killer cells with enhanced immune response |
| US10906951B2 (en) * | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| ES2970269T3 (es) | 2015-07-29 | 2024-05-27 | Onk Therapeutics Ltd | Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada |
| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| EP3581190B1 (en) | 2016-12-09 | 2021-03-10 | ONK Therapeutics Limited | Engineered natural killer cells and uses thereof |
| KR102528384B1 (ko) * | 2017-01-06 | 2023-05-02 | 이뮤너티바이오, 인크. | 감소된 cd96/tigit 발현을 갖는 유전자 변형된 nk-92 세포 |
| CN110546265A (zh) * | 2017-02-09 | 2019-12-06 | 因达普塔治疗公司 | 工程化自然杀伤(nk)细胞及其组合物和方法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| DE102017002645A1 (de) * | 2017-03-17 | 2018-09-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Bestrahlung von Säugetierzellen mit Elektronenstrahlen und/oder Röntgenstrahlen |
| US11903968B2 (en) | 2017-07-21 | 2024-02-20 | Cellectis | Engineered immune cells resistant to tumor microenvironment |
| WO2019016360A1 (en) * | 2017-07-21 | 2019-01-24 | Cellectis | MODIFIED IMMUNE CELLS RESISTANT TO TUMOR MICRO-ENVIRONMENT |
| CN111788301A (zh) * | 2017-11-24 | 2020-10-16 | 昂克治疗有限公司 | 靶向肿瘤细胞的经修饰的自然杀伤细胞和自然杀伤细胞系 |
| IL278723B2 (en) * | 2018-05-16 | 2024-07-01 | Res Inst Nationwide Childrens Hospital | Generation of knock-out primary and expanded human nk cells using cas9 ribonucleoproteins |
| US20210230542A1 (en) * | 2018-06-06 | 2021-07-29 | Stemcell Technologies Canada Inc. | Kits, compositions and methods for cell enrichment |
| CN108743595B (zh) * | 2018-06-08 | 2020-11-27 | 厦门诺康得生物科技有限公司 | 一种nk细胞免疫检查点抑制剂及其制备方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US12410402B2 (en) | 2018-11-21 | 2025-09-09 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (NK) cell subset and related compositions and methods |
| WO2020113029A2 (en) * | 2018-11-28 | 2020-06-04 | Board Of Regents, The University Of Texas System | Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment |
| EP3924467A1 (en) * | 2019-02-15 | 2021-12-22 | Editas Medicine, Inc. | Modified natural killer (nk) cells for immunotherapy |
| CN109908155A (zh) * | 2019-03-11 | 2019-06-21 | 上海中医药大学 | 丹参酮ⅱa的药物用途 |
| KR102292657B1 (ko) | 2019-03-15 | 2021-08-24 | 한국과학기술연구원 | 암 상살 능력이 향상된 면역세포 |
| WO2020189942A1 (ko) * | 2019-03-15 | 2020-09-24 | 한국과학기술연구원 | 암 상살 능력이 향상된 면역세포 |
| AU2020242305A1 (en) | 2019-03-21 | 2021-09-30 | Onk Therapeutics Limited | Modified immune effector cells with increased resistance to cell death |
| EP3712257A1 (en) | 2019-03-21 | 2020-09-23 | ONK Therapeutics Limited | Modified natural killer cells with increased resistance to cell death |
| RU2731293C1 (ru) | 2019-04-12 | 2020-09-01 | Игорь Петрович Белецкий | Способ получения генно-модифицированных линий клеток натуральных киллеров с нокаутированным геном PD-1 и повышенной экспрессией белков семейства Фактора Некроза Опухолей для иммунотерапии онкологических заболеваний |
| CN109970869A (zh) * | 2019-04-12 | 2019-07-05 | 南京卡提医学科技有限公司 | 一种靶向人trail死亡受体的嵌合受体配体及其应用 |
| EP3789485A1 (en) * | 2019-09-06 | 2021-03-10 | ONK Therapeutics Limited | Cellular therapies for cancer |
| AU2020358863A1 (en) | 2019-10-03 | 2022-05-12 | Celyntra Therapeutics Sa | CRISPR systems with engineered dual guide nucleic acids |
| CN111849896B (zh) * | 2020-07-31 | 2022-07-01 | 广东昭泰体内生物医药科技有限公司 | 一种car-nk细胞培养基及其应用 |
| AU2021392032A1 (en) | 2020-12-03 | 2023-06-22 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| EP4298212A4 (en) | 2021-02-25 | 2026-04-15 | Celyntra Therapeutics Sa | Compositions and methods for targeting, editing, or modifying genes |
| EP4419672A2 (en) | 2021-06-01 | 2024-08-28 | Artisan Development Labs, Inc. | Compositions and methods for targeting, editing, or modifying genes |
| JP2024522756A (ja) | 2021-06-18 | 2024-06-21 | オーエヌケイ セラピューティクス リミテッド | ダブルノックアウトナチュラルキラー細胞 |
| EP4370676A2 (en) | 2021-06-18 | 2024-05-22 | Artisan Development Labs, Inc. | Compositions and methods for targeting, editing or modifying human genes |
| CN113684180B (zh) * | 2021-08-31 | 2023-05-26 | 山东大学第二医院 | 一种提高骨髓瘤杀伤活性的nk细胞制备方法 |
| CN114544971B (zh) * | 2022-02-22 | 2024-08-30 | 广东省科学院动物研究所 | 一种功能蛋白活性的检测方法 |
| EP4486881A1 (en) | 2022-03-01 | 2025-01-08 | Celyntra Therapeutics SA | Composition and methods for transgene insertion |
| CN114796483B (zh) * | 2022-06-28 | 2022-11-08 | 北京大学 | 活化t细胞与阻断性抗体联合制备抗肿瘤药物的用途及抗肿瘤药物 |
| EP4353741A1 (en) | 2022-10-14 | 2024-04-17 | ONK Therapeutics Limited | Double knockout natural killer cells |
| CN120091827A (zh) | 2022-11-10 | 2025-06-03 | 昂克医疗有限公司 | 使用免疫调节药物的联合疗法 |
| CN116590237B (zh) * | 2023-05-29 | 2023-10-31 | 上海贝斯昂科生物科技有限公司 | 一种遗传修饰的自然杀伤细胞及其制备和用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1299522B1 (en) | 2000-06-30 | 2011-11-02 | University Of Louisville Research Foundation, Inc. | Alteration of cell membrane |
| CA2388441A1 (en) | 2002-06-10 | 2003-12-10 | Wei-Ping Min | Immunomodulation using rna interference |
| WO2006004518A1 (en) * | 2004-07-02 | 2006-01-12 | Avaris Ab | Method for the genetic activation of cells and uses of said cells |
| DE602005016683D1 (de) * | 2004-07-10 | 2009-10-29 | Fox Chase Cancer Ct | Genetisch modifizierte, menschliche, natürliche killerzellenlinien: |
| EP1621550A1 (en) * | 2004-07-29 | 2006-02-01 | Dompé S.P.A. | Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) |
| GB0724532D0 (en) * | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| WO2012011113A2 (en) | 2010-07-22 | 2012-01-26 | Shai Yarkoni | Regulatory immune cells with enhanced targeted cell death effect |
| CN102908612A (zh) * | 2011-08-02 | 2013-02-06 | 北京诺赛基因组研究中心有限公司 | TRAIL截短型变异体活化NF-κB和在炎症反应中的应用 |
| EP2906684B8 (en) * | 2012-10-10 | 2020-09-02 | Sangamo Therapeutics, Inc. | T cell modifying compounds and uses thereof |
| CN103073644B (zh) * | 2012-12-31 | 2014-03-12 | 中国科学技术大学 | 特异性抗小鼠tigit的单克隆抗体及其制备方法、鉴定及应用 |
| AU2014223344A1 (en) * | 2013-02-27 | 2015-10-01 | Massachusetts Institute Of Technology | T cell balance gene expression, compositions of matters and methods of use thereof |
| WO2015012145A1 (ja) | 2013-07-25 | 2015-01-29 | 株式会社ブリヂストン | 防振装置 |
| PL3036258T3 (pl) * | 2013-08-22 | 2023-12-11 | The Council Of The Queensland Institute Of Medical Research | Modulowanie receptora dla leczenia raka i infekcji wirusowych |
| EP3057991B8 (en) * | 2013-10-15 | 2019-09-04 | The Scripps Research Institute | Chimeric antigen receptor t cell switches and uses thereof |
| EP3593812A3 (en) * | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| AU2015244039B2 (en) | 2014-04-07 | 2021-10-21 | Novartis Ag | Treatment of cancer using anti-CD19 chimeric antigen receptor |
| CA2945335A1 (en) | 2014-04-18 | 2015-10-22 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| KR20250067191A (ko) * | 2014-09-17 | 2025-05-14 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| KR20260048600A (ko) | 2015-03-27 | 2026-04-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 변형된 t 세포 및 이의 제조 및 사용 방법 |
| EP4043556B1 (en) * | 2015-06-30 | 2024-02-07 | Cellectis | Methods for improving functionality in nk cell by gene inactivation using specific endonuclease |
| AU2016297014B2 (en) * | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| ES2970269T3 (es) * | 2015-07-29 | 2024-05-27 | Onk Therapeutics Ltd | Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada |
| US10906951B2 (en) * | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| CN111788301A (zh) * | 2017-11-24 | 2020-10-16 | 昂克治疗有限公司 | 靶向肿瘤细胞的经修饰的自然杀伤细胞和自然杀伤细胞系 |
| WO2021209625A1 (en) * | 2020-04-17 | 2021-10-21 | Onk Therapeutics Limited | High potency natural killer cells |
-
2016
- 2016-07-28 ES ES20213303T patent/ES2970269T3/es active Active
- 2016-07-28 CA CA3156128A patent/CA3156128A1/en active Pending
- 2016-07-28 DK DK18194107.1T patent/DK3434762T3/da active
- 2016-07-28 CA CA2993796A patent/CA2993796C/en active Active
- 2016-07-28 EP EP18194107.1A patent/EP3434762B1/en active Active
- 2016-07-28 ES ES18194107T patent/ES2876938T3/es active Active
- 2016-07-28 EP EP21152246.1A patent/EP3878951A1/en not_active Withdrawn
- 2016-07-28 KR KR1020187005673A patent/KR20180028530A/ko not_active Ceased
- 2016-07-28 ES ES18187137T patent/ES2890859T3/es active Active
- 2016-07-28 JP JP2018524548A patent/JP6974681B2/ja active Active
- 2016-07-28 CN CN201680049392.8A patent/CN108026512B/zh active Active
- 2016-07-28 ES ES21152473T patent/ES2939084T3/es active Active
- 2016-07-28 ES ES16750677T patent/ES2701338T3/es active Active
- 2016-07-28 CN CN202210987123.3A patent/CN116064400B/zh active Active
- 2016-07-28 AU AU2016300128A patent/AU2016300128B2/en not_active Ceased
- 2016-07-28 EP EP20213303.9A patent/EP3971284B1/en active Active
- 2016-07-28 CN CN202211000656.4A patent/CN116064401A/zh active Pending
- 2016-07-28 EP EP16750677.3A patent/EP3317401B1/en active Active
- 2016-07-28 DK DK18187137.7T patent/DK3421590T3/da active
- 2016-07-28 EP EP21152473.1A patent/EP3828266B1/en active Active
- 2016-07-28 MX MX2018001074A patent/MX380813B/es unknown
- 2016-07-28 DK DK16750677.3T patent/DK3317401T3/da active
- 2016-07-28 EP EP18187137.7A patent/EP3421590B1/en active Active
- 2016-07-28 BR BR112018001660-8A patent/BR112018001660A2/pt not_active Application Discontinuation
- 2016-07-28 HK HK18111896.2A patent/HK1252582B/en not_active IP Right Cessation
- 2016-07-28 WO PCT/EP2016/068001 patent/WO2017017184A1/en not_active Ceased
-
2017
- 2017-01-12 US US15/405,163 patent/US10034925B2/en active Active
-
2018
- 2018-01-24 MX MX2020010014A patent/MX2020010014A/es unknown
- 2018-07-11 US US16/032,626 patent/US10960064B2/en active Active
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2020
- 2020-11-30 US US17/107,696 patent/US20210138051A1/en not_active Abandoned
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2021
- 2021-07-06 JP JP2021112020A patent/JP7359346B2/ja active Active
- 2021-07-06 JP JP2021112019A patent/JP2021178824A/ja active Pending
-
2022
- 2022-05-18 AU AU2022203339A patent/AU2022203339A1/en not_active Abandoned
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