|
US2859239A
(en)
*
|
1956-08-17 |
1958-11-04 |
Dow Chemical Co |
Acrylic acid compounds
|
|
CH549339A
(de)
|
1971-05-12 |
1974-05-31 |
Ciba Geigy Ag |
Herbizides mittel.
|
|
US5763647A
(en)
*
|
1990-03-30 |
1998-06-09 |
Shionogi & Co., Ltd. |
Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives
|
|
EP0520419A3
(en)
*
|
1991-06-26 |
1993-06-16 |
Union Carbide Chemicals & Plastics Technology Corporation |
Production of unsaturated cycloaliphatic esters and derivatives thereof
|
|
AU1507199A
(en)
|
1997-12-15 |
1999-07-05 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel pyrimidine-5-carboxamide derivatives
|
|
ES2274634T3
(es)
|
1998-08-29 |
2007-05-16 |
Astrazeneca Ab |
Compuestos de pirimidina.
|
|
AU5107900A
(en)
|
1999-06-09 |
2000-12-28 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel heterocyclic carboxamide derivatives
|
|
WO2000076980A1
(en)
|
1999-06-10 |
2000-12-21 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
|
|
AU5636900A
(en)
|
1999-06-30 |
2001-01-31 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
|
MXPA02001565A
(es)
|
1999-08-13 |
2005-07-14 |
Vertex Pharma |
Inhibidores de cinasas c-jun n-terminal (jnk) y de otras cinasas proteicas.
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
JPWO2003082855A1
(ja)
|
2002-03-28 |
2005-08-04 |
協和醗酵工業株式会社 |
抗炎症剤
|
|
AU2003244098A1
(en)
|
2002-06-28 |
2004-01-19 |
Yamanouchi Pharmaceutical Co., Ltd. |
Diaminopyrimidinecarboxa mide derivative
|
|
ES2445208T3
(es)
|
2002-07-29 |
2014-02-28 |
Rigel Pharmaceuticals, Inc. |
Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias
|
|
JPWO2004054617A1
(ja)
|
2002-12-13 |
2006-04-20 |
協和醗酵工業株式会社 |
中枢疾患の予防および/または治療剤
|
|
US7358384B2
(en)
*
|
2003-01-16 |
2008-04-15 |
Toray Fine Chemicals Co., Ltd. |
Processes for the recovery of optically active diacyltartaric acids
|
|
EP1590341B1
(en)
|
2003-01-17 |
2009-06-17 |
Warner-Lambert Company LLC |
2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation
|
|
ATE440087T1
(de)
|
2003-01-30 |
2009-09-15 |
Boehringer Ingelheim Pharma |
2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
|
|
NZ585188A
(en)
|
2003-08-15 |
2011-09-30 |
Novartis Ag |
2,4-Pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
|
|
JP2007506746A
(ja)
|
2003-09-24 |
2007-03-22 |
ワイス・ホールディングズ・コーポレイション |
抗癌剤としての5−アリールピリミジン類
|
|
WO2005095382A1
(ja)
|
2004-03-30 |
2005-10-13 |
Kyowa Hakko Kogyo Co., Ltd. |
抗腫瘍剤
|
|
JP2008505910A
(ja)
|
2004-07-08 |
2008-02-28 |
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド |
Pkc−シータのインヒビターとして有用なピリミジン誘導体
|
|
EP1796679A1
(en)
|
2004-09-10 |
2007-06-20 |
Altana Pharma AG |
Ciclesonide and syk inhibitor combination and methods of use thereof
|
|
CA2579017A1
(en)
|
2004-09-10 |
2006-03-16 |
Altana Pharma Ag |
Roflumilast and syk inhibitor combination and methods of use thereof
|
|
JP2006124387A
(ja)
|
2004-09-30 |
2006-05-18 |
Taisho Pharmaceut Co Ltd |
新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
|
|
ATE542802T1
(de)
|
2004-09-30 |
2012-02-15 |
Tibotec Pharm Ltd |
Hiv-inhibierende 5-substituierte pyrimidine
|
|
WO2006091737A1
(en)
|
2005-02-24 |
2006-08-31 |
Kemia, Inc. |
Modulators of gsk-3 activity
|
|
KR20080004488A
(ko)
|
2005-03-10 |
2008-01-09 |
바이엘 파마슈티칼스 코포레이션 |
과다증식성 장애 치료용 피리미딘 유도체
|
|
WO2007032445A1
(ja)
|
2005-09-16 |
2007-03-22 |
Kyowa Hakko Kogyo Co., Ltd. |
タンパク質キナーゼ阻害剤
|
|
MX2009000769A
(es)
|
2006-07-21 |
2009-01-28 |
Novartis Ag |
Compuestos de 2,4-di(arilaminio)-pirimidin-5-carboxamida como inhibidores de cinasas jak.
|
|
US8188113B2
(en)
|
2006-09-14 |
2012-05-29 |
Deciphera Pharmaceuticals, Inc. |
Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
US20080139531A1
(en)
|
2006-12-04 |
2008-06-12 |
Alcon Manufacturing Ltd. |
Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
|
|
CL2007003693A1
(es)
*
|
2006-12-22 |
2008-06-27 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
|
|
BRPI0810411B8
(pt)
|
2007-04-18 |
2021-05-25 |
Pfizer Prod Inc |
derivados de sulfonil amida para o tratamento de crescimento celular anormal, seu sos, bem como composição farmacêutica
|
|
WO2008132505A1
(en)
|
2007-04-27 |
2008-11-06 |
Astrazeneca Ab |
N' - (phenyl) -n- (morpholin-4-yl-pyridin-2-yl) -pyrimidine-2, 4-diamine derivatives as ephb4 kinase inhibitors for the treatment of proliferative conditions
|
|
EP2183242A2
(en)
|
2007-07-16 |
2010-05-12 |
AstraZeneca AB |
Pyrimidine derivatives 934
|
|
CA2693594A1
(en)
|
2007-07-17 |
2009-01-22 |
Rigel Pharmaceuticals, Inc. |
Cyclic amine substituted pyrimidinediamines as pkc inhibitors
|
|
JP5269444B2
(ja)
*
|
2008-03-11 |
2013-08-21 |
東ソー・ファインケム株式会社 |
固体ルイス酸触媒、それを用いたディールスアルダー付加物の製造方法
|
|
SG2014015085A
(en)
|
2008-04-16 |
2014-06-27 |
Portola Pharm Inc |
2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors
|
|
EA024109B1
(ru)
|
2008-04-16 |
2016-08-31 |
Портола Фармасьютиклз, Инк. |
Ингибиторы протеинкиназ
|
|
NZ588830A
(en)
|
2008-04-22 |
2012-11-30 |
Portola Pharm Inc |
Inhibitors of protein kinases
|
|
WO2009132980A1
(en)
|
2008-04-29 |
2009-11-05 |
F. Hoffmann-La Roche Ag |
Pyrimidinyl pyridone inhibitors of jnk.
|
|
PT2300013T
(pt)
|
2008-05-21 |
2017-10-31 |
Ariad Pharma Inc |
Derivados de fósforo como inibidores de cinases
|
|
UY31929A
(es)
|
2008-06-25 |
2010-01-05 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
TWI546290B
(zh)
|
2008-06-27 |
2016-08-21 |
賽基艾維洛米斯研究股份有限公司 |
雜芳基化合物及其用途
|
|
JP5644499B2
(ja)
|
2008-09-01 |
2014-12-24 |
アステラス製薬株式会社 |
2,4−ジアミノピリミジン化合物
|
|
EP2159220A1
(en)
*
|
2008-09-02 |
2010-03-03 |
Nabriva Therapeutics AG |
Organic compounds
|
|
TWI453207B
(zh)
*
|
2008-09-08 |
2014-09-21 |
Signal Pharm Llc |
胺基三唑并吡啶,其組合物及使用其之治療方法
|
|
MX2011002825A
(es)
|
2008-09-18 |
2011-04-05 |
Astellas Pharma Inc |
Compuestos heterociclicos de carboxamida.
|
|
TW201016676A
(en)
|
2008-10-03 |
2010-05-01 |
Astrazeneca Ab |
Heterocyclic derivatives and methods of use thereof
|
|
PL2346988T3
(pl)
|
2008-10-31 |
2017-10-31 |
Janssen Biotech Inc |
Różnicowanie ludzkich zarodkowych komórek macierzystych do linii endokrynnej trzustki
|
|
US8513242B2
(en)
|
2008-12-12 |
2013-08-20 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Pyrimidine compounds and methods of making and using same
|
|
WO2010080864A1
(en)
|
2009-01-12 |
2010-07-15 |
Array Biopharma Inc. |
Piperidine-containing compounds and use thereof
|
|
AU2010219097A1
(en)
|
2009-01-13 |
2011-08-04 |
Glaxo Group Limited |
Pyrimidinecarboxamide derivatives as inhibitors of SYK kinase
|
|
CA2749837C
(en)
|
2009-01-21 |
2017-07-11 |
Rigel Pharmaceuticals, Inc. |
Derivatives of n2-(3-pyridil or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases
|
|
AR076550A1
(es)
|
2009-05-06 |
2011-06-22 |
Portola Pharm Inc |
Inhibidores de la janus tirosina kinasa (jak)
|
|
SI2428508T1
(sl)
|
2009-05-08 |
2016-04-29 |
Astellas Pharma Inc. |
Diamino heterociklična karboksamidna spojina
|
|
JP2012148977A
(ja)
|
2009-05-20 |
2012-08-09 |
Astellas Pharma Inc |
アミノシクロヘキシルアルキル基を有する2,4−ジアミノピリミジン化合物
|
|
WO2010144468A1
(en)
|
2009-06-10 |
2010-12-16 |
Abbott Laboratories |
2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors
|
|
JP2012197231A
(ja)
|
2009-08-06 |
2012-10-18 |
Oncotherapy Science Ltd |
Ttk阻害作用を有するピリジンおよびピリミジン誘導体
|
|
WO2011065800A2
(ko)
|
2009-11-30 |
2011-06-03 |
주식회사 오스코텍 |
피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
|
|
US20110130415A1
(en)
|
2009-12-01 |
2011-06-02 |
Rajinder Singh |
Protein kinase c inhibitors and uses thereof
|
|
EP2582671A4
(en)
*
|
2010-06-17 |
2014-02-26 |
Reddys Lab Ltd Dr |
PROCESS FOR PREPARING A SINGLE ENANTIOMER FROM 3-AMINOPIPERIDIN DIHYDROCHLORIDE
|
|
EP2595982B1
(en)
|
2010-07-21 |
2018-06-13 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
US8580805B2
(en)
|
2010-08-31 |
2013-11-12 |
Hubert Maehr |
Pyrimidine carboxamide derivatives
|
|
WO2012044936A1
(en)
|
2010-09-30 |
2012-04-05 |
Portola Pharmaceuticals, Inc. |
Combination therapy with 4-(3-(2h-1,2,3-triazol-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide
|
|
WO2012045020A1
(en)
|
2010-09-30 |
2012-04-05 |
Portola Pharmaceuticals, Inc. |
Combinations of 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide and fludarabine
|
|
SMT202400031T1
(it)
*
|
2011-04-22 |
2024-03-13 |
Signal Pharm Llc |
Diamminocarbossammide e diamminocarbonitrile pirimidine sostituite, loro composizioni e metodi di trattamento con esse
|
|
WO2014019166A1
(zh)
*
|
2012-08-01 |
2014-02-06 |
上海威智医药科技有限公司 |
高活性硼烷类化合物的工业化生产方法
|
|
JP2014031327A
(ja)
*
|
2012-08-02 |
2014-02-20 |
Kaneka Corp |
光学活性シス−2−アミノ−シクロヘキサンカルボン酸誘導体およびその前駆体の製造法
|
|
EP3082819B1
(en)
|
2013-12-20 |
2020-06-17 |
Signal Pharmaceuticals, LLC |
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
TWI523838B
(zh)
*
|
2014-03-21 |
2016-03-01 |
Far Eastern New Century Corp |
Terephthalic acid and 4-methyl-3-cyclohexene-1-carboxylic acid Ester preparation method
|
|
MX388321B
(es)
|
2014-10-06 |
2025-03-19 |
Signal Pharm Llc |
Compuestos de aminopurina sustituida, composiciones del mismo, y metodos de tratamiento con los mismos.
|
|
EP3233808B1
(en)
|
2014-12-16 |
2021-07-14 |
Signal Pharmaceuticals, LLC |
Medical uses comprising methods for measurement of inhibition of c-jun n-terminal kinase in skin
|
|
BR112017012795A2
(pt)
|
2014-12-16 |
2018-01-02 |
Signal Pharmaceuticals, Llc |
Formulações de 2-(terc-butilamino)-4-((1r,3r,4r)-3- hidroxi-4-metilciclo-hexilamino)-pirimidina-5- carboxamida
|
|
WO2016123291A1
(en)
|
2015-01-29 |
2016-08-04 |
Signal Pharmaceuticals, Llc |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
CA3208587A1
(en)
*
|
2015-07-24 |
2017-02-02 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|