JP2018520094A5 - - Google Patents
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- JP2018520094A5 JP2018520094A5 JP2017559025A JP2017559025A JP2018520094A5 JP 2018520094 A5 JP2018520094 A5 JP 2018520094A5 JP 2017559025 A JP2017559025 A JP 2017559025A JP 2017559025 A JP2017559025 A JP 2017559025A JP 2018520094 A5 JP2018520094 A5 JP 2018520094A5
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- Japan
- Prior art keywords
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- signaling inhibitor
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021131870A JP2021191755A (ja) | 2015-05-13 | 2021-08-13 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562161136P | 2015-05-13 | 2015-05-13 | |
| US62/161,136 | 2015-05-13 | ||
| US201562173836P | 2015-06-10 | 2015-06-10 | |
| US62/173,836 | 2015-06-10 | ||
| US201562243457P | 2015-10-19 | 2015-10-19 | |
| US62/243,457 | 2015-10-19 | ||
| PCT/US2016/031999 WO2016183280A1 (en) | 2015-05-13 | 2016-05-12 | Treatment of beta-thalassemia using actrii ligand traps |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021131870A Division JP2021191755A (ja) | 2015-05-13 | 2021-08-13 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520094A JP2018520094A (ja) | 2018-07-26 |
| JP2018520094A5 true JP2018520094A5 (https=) | 2019-06-20 |
| JP6976859B2 JP6976859B2 (ja) | 2021-12-08 |
Family
ID=57248528
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559025A Expired - Fee Related JP6976859B2 (ja) | 2015-05-13 | 2016-05-12 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
| JP2021131870A Pending JP2021191755A (ja) | 2015-05-13 | 2021-08-13 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021131870A Pending JP2021191755A (ja) | 2015-05-13 | 2021-08-13 | ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20180125928A1 (https=) |
| EP (1) | EP3294320A4 (https=) |
| JP (2) | JP6976859B2 (https=) |
| KR (1) | KR102640198B1 (https=) |
| CN (1) | CN107847562A (https=) |
| AU (2) | AU2016261913B2 (https=) |
| CA (1) | CA2985777A1 (https=) |
| HK (1) | HK1251157A1 (https=) |
| IL (2) | IL284686B2 (https=) |
| JO (1) | JOP20160092B1 (https=) |
| MY (1) | MY189601A (https=) |
| PH (1) | PH12017502079A1 (https=) |
| TN (1) | TN2017000468A1 (https=) |
| TW (2) | TWI814187B (https=) |
| WO (1) | WO2016183280A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190006086A (ko) | 2005-11-23 | 2019-01-16 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| SMT202300222T1 (it) | 2008-08-14 | 2023-09-06 | Acceleron Pharma Inc | Trappole di gdf |
| BRPI1010587A2 (pt) | 2009-06-08 | 2019-04-09 | Acceleron Pharma Inc. | métodos para aumentar adipócitos termogênicos |
| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| JP6267425B2 (ja) | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ， インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するａｃｔｒｉｉｂタンパク質およびその改変体およびその使用 |
| US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| NZ707477A (en) | 2012-11-02 | 2019-09-27 | Celgene Corp | Activin-actrii antagonists and uses for treating bone and other disorders |
| WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
| JP2018501307A (ja) | 2014-12-03 | 2018-01-18 | セルジーン コーポレイション | アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用 |
| MA42160A (fr) | 2015-05-20 | 2018-03-28 | Maria Cappellini | Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii |
| US11123430B2 (en) | 2015-11-04 | 2021-09-21 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels and treating ineffective erythropoiesis |
| CA3005975A1 (en) | 2015-11-23 | 2017-06-01 | Acceleron Pharma Inc. | Methods for treating eye disorders |
| HRP20210694T1 (hr) | 2016-07-15 | 2021-09-17 | Acceleron Pharma, Inc. | Pripravci koji sadrže actriia polipeptide za uporabu za liječenje plućne hipertenzije |
| PL3490582T3 (pl) | 2016-07-27 | 2024-09-23 | Acceleron Pharma Inc. | Kompozycje do zastosowania w leczeniu mielofibrozy |
| CN110430890B (zh) | 2016-11-10 | 2024-09-10 | 科乐斯疗法公司 | 激活素受体iia型变体及其使用方法 |
| HRP20241477T1 (hr) * | 2017-06-14 | 2025-01-03 | Celgene Corporation | Postupci liječenja mijeloproliferativne neoplazme povezane s mijelofibrozom i anemijom |
| EP3706777B1 (en) | 2017-11-09 | 2024-05-22 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| IL320014A (en) | 2018-01-12 | 2025-06-01 | Keros Therapeutics Inc | Activin receptor type iib variants and methods of use thereof |
| US12263205B2 (en) | 2018-04-30 | 2025-04-01 | The Children's Hospital Of Philadelphia | Methods of improving anemias by combining agents |
| JP7405772B2 (ja) | 2018-05-09 | 2023-12-26 | ケロス セラピューティクス インコーポレイテッド | アクチビンｉｉａ型受容体変異体および同変異体を含む医薬組成物 |
| US20210346464A1 (en) * | 2018-10-31 | 2021-11-11 | Celgene Corporation | TREATMENT OF ANEMIA DUE TO VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES IN SUBJECTS WITH RING SIDEROBLASTS USING ACTIVIN-ACTRll LIGAND TRAPS |
| EP3999059A1 (en) | 2019-07-19 | 2022-05-25 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of transfusion-dependent beta-thalassemia (tdt) |
| CN112924684B (zh) * | 2019-12-05 | 2022-07-29 | 中国科学院大连化学物理研究所 | 用于区分抑郁症和非抑郁症的生物标志物和包括其的诊断试剂盒 |
| IL296394A (en) | 2020-03-20 | 2022-11-01 | Keros Therapeutics Inc | Type ii activin receptor chimeras and methods of using them |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| WO2021211418A1 (en) * | 2020-04-13 | 2021-10-21 | Celgene Corporation | Methods for treating anemia using an actriib ligand trap and fedratinib |
| EP4142769A4 (en) | 2020-04-28 | 2024-05-15 | Acceleron Pharma Inc. | ACTRII PROTEINS AND USE IN THE TREATMENT OF POSTCAPILLARY PULMONARY HYPERTENSION |
| US12186370B1 (en) | 2020-11-05 | 2025-01-07 | Celgene Corporation | ACTRIIB ligand trap compositions and uses thereof |
| EP4240399A4 (en) * | 2020-11-06 | 2024-10-09 | Acceleron Pharma Inc. | FORMULATIONS WITH ACTRII POLYPEPTIDE VARIANTS |
| EP4274600A4 (en) * | 2021-01-08 | 2024-11-20 | Acceleron Pharma Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PULMONARY HYPERTENSION |
| US20250268878A1 (en) | 2021-01-20 | 2025-08-28 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of myelodysplastic syndromes (mds) |
| EP4731218A1 (en) | 2023-06-26 | 2026-04-29 | Vifor (International) AG | Ferroportin-inhibitors for the use in the treatment of hereditary haemochromatosis (hh) |
| WO2025122830A1 (en) * | 2023-12-08 | 2025-06-12 | Keros Therapeutics, Inc. | Methods of using activin receptor type ii signaling inhibitors |
| WO2026041650A1 (en) | 2024-08-20 | 2026-02-26 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of lupus nephritis |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247A (en) * | 1845-11-01 | Jordan l | ||
| US6231880B1 (en) * | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| DK2124999T3 (da) * | 2006-12-18 | 2013-01-14 | Acceleron Pharma Inc | Activin-actrii antagonister og anvendelser til behandling af anæmi |
| AU2009262970A1 (en) * | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| SMT202300222T1 (it) * | 2008-08-14 | 2023-09-06 | Acceleron Pharma Inc | Trappole di gdf |
| BR112012005225B8 (pt) * | 2009-09-09 | 2023-01-10 | Acceleron Pharma Inc | Uso de uma proteína de fusão actriib-fc para o tratamento de um transtorno relacionado ao osso ou associado à perda de músculo por crescimento muscular insuficiente |
| BR112014009528B1 (pt) * | 2011-10-17 | 2020-12-29 | Acceleron Pharma, Inc. | usos de polipeptídeos actriib para a fabricação de um medicamento para tratar eritropoiese ineficaz |
| EA201491578A1 (ru) * | 2012-03-30 | 2015-04-30 | Шир Хьюман Дженетик Терапис, Инк. | Подкожное введение идуронат-2-сульфатазы |
| AU2013334660B2 (en) * | 2012-10-24 | 2018-08-09 | Celgene Corporation | Methods for treating anemia |
| CN104968801B (zh) * | 2012-10-24 | 2021-06-15 | 细胞基因公司 | 用于治疗贫血症的生物标志物 |
| SG11201504038XA (en) * | 2012-11-27 | 2015-06-29 | Childrens Medical Center | Targeting bcl11a distal regulatory elements for fetal hemoglobin reinduction |
-
2016
- 2016-05-12 CN CN201680041002.2A patent/CN107847562A/zh active Pending
- 2016-05-12 JP JP2017559025A patent/JP6976859B2/ja not_active Expired - Fee Related
- 2016-05-12 EP EP16793499.1A patent/EP3294320A4/en active Pending
- 2016-05-12 TW TW110148304A patent/TWI814187B/zh active
- 2016-05-12 HK HK18110608.3A patent/HK1251157A1/zh unknown
- 2016-05-12 KR KR1020177035838A patent/KR102640198B1/ko active Active
- 2016-05-12 JO JOP/2016/0092A patent/JOP20160092B1/ar active
- 2016-05-12 WO PCT/US2016/031999 patent/WO2016183280A1/en not_active Ceased
- 2016-05-12 US US15/573,177 patent/US20180125928A1/en not_active Abandoned
- 2016-05-12 CA CA2985777A patent/CA2985777A1/en active Pending
- 2016-05-12 IL IL284686A patent/IL284686B2/en unknown
- 2016-05-12 TN TNP/2017/000468A patent/TN2017000468A1/en unknown
- 2016-05-12 TW TW105114763A patent/TWI762444B/zh active
- 2016-05-12 AU AU2016261913A patent/AU2016261913B2/en active Active
- 2016-05-12 MY MYPI2017704290A patent/MY189601A/en unknown
-
2017
- 2017-11-08 IL IL255527A patent/IL255527B/en unknown
- 2017-11-16 PH PH12017502079A patent/PH12017502079A1/en unknown
-
2021
- 2021-08-13 JP JP2021131870A patent/JP2021191755A/ja active Pending
- 2021-10-29 AU AU2021258087A patent/AU2021258087B2/en active Active
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