KR102640198B1 - Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료 - Google Patents

Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료 Download PDF

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KR102640198B1
KR102640198B1 KR1020177035838A KR20177035838A KR102640198B1 KR 102640198 B1 KR102640198 B1 KR 102640198B1 KR 1020177035838 A KR1020177035838 A KR 1020177035838A KR 20177035838 A KR20177035838 A KR 20177035838A KR 102640198 B1 KR102640198 B1 KR 102640198B1
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certain embodiments
actriib
delete delete
signaling inhibitor
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KR20180006437A (ko
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케네스 엠. 아티에
아브데라만 라아뎀
라제쉬 쵸프라
제이 백스트롬
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셀진 코포레이션
악셀레론 파마 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020177035838A 2015-05-13 2016-05-12 Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료 Active KR102640198B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562161136P 2015-05-13 2015-05-13
US62/161,136 2015-05-13
US201562173836P 2015-06-10 2015-06-10
US62/173,836 2015-06-10
US201562243457P 2015-10-19 2015-10-19
US62/243,457 2015-10-19
PCT/US2016/031999 WO2016183280A1 (en) 2015-05-13 2016-05-12 Treatment of beta-thalassemia using actrii ligand traps

Publications (2)

Publication Number Publication Date
KR20180006437A KR20180006437A (ko) 2018-01-17
KR102640198B1 true KR102640198B1 (ko) 2024-02-23

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KR1020177035838A Active KR102640198B1 (ko) 2015-05-13 2016-05-12 Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료

Country Status (15)

Country Link
US (1) US20180125928A1 (https=)
EP (1) EP3294320A4 (https=)
JP (2) JP6976859B2 (https=)
KR (1) KR102640198B1 (https=)
CN (1) CN107847562A (https=)
AU (2) AU2016261913B2 (https=)
CA (1) CA2985777A1 (https=)
HK (1) HK1251157A1 (https=)
IL (2) IL284686B2 (https=)
JO (1) JOP20160092B1 (https=)
MY (1) MY189601A (https=)
PH (1) PH12017502079A1 (https=)
TN (1) TN2017000468A1 (https=)
TW (2) TWI814187B (https=)
WO (1) WO2016183280A1 (https=)

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JP7663502B2 (ja) * 2018-10-31 2025-04-16 セルジーン コーポレイション 環状鉄芽球が見られる対象における非常に低リスク、低リスクまたは中程度のリスクの骨髄異形成症候群による貧血の、アクチビン－ａｃｔｒｉｉリガンドトラップを用いた治療
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Publication number Publication date
IL255527A (en) 2018-01-31
TW201709927A (zh) 2017-03-16
CN107847562A (zh) 2018-03-27
EP3294320A4 (en) 2018-12-26
AU2021258087A1 (en) 2021-11-25
IL255527B (en) 2021-07-29
JP6976859B2 (ja) 2021-12-08
HK1251157A1 (zh) 2019-01-25
TN2017000468A1 (en) 2019-04-12
WO2016183280A1 (en) 2016-11-17
AU2016261913A1 (en) 2017-11-30
IL284686B2 (en) 2023-05-01
NZ737043A (en) 2025-02-28
JP2021191755A (ja) 2021-12-16
MY189601A (en) 2022-02-18
CA2985777A1 (en) 2016-11-17
AU2021258087B2 (en) 2023-04-27
TW202231294A (zh) 2022-08-16
IL284686B (en) 2023-01-01
TWI814187B (zh) 2023-09-01
TWI762444B (zh) 2022-05-01
US20180125928A1 (en) 2018-05-10
AU2016261913B2 (en) 2021-08-12
PH12017502079A1 (en) 2018-06-11
EP3294320A1 (en) 2018-03-21
KR20180006437A (ko) 2018-01-17
JOP20160092B1 (ar) 2023-03-28
IL284686A (en) 2021-08-31
JP2018520094A (ja) 2018-07-26

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