JP2018519831A5 - - Google Patents
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- JP2018519831A5 JP2018519831A5 JP2017568143A JP2017568143A JP2018519831A5 JP 2018519831 A5 JP2018519831 A5 JP 2018519831A5 JP 2017568143 A JP2017568143 A JP 2017568143A JP 2017568143 A JP2017568143 A JP 2017568143A JP 2018519831 A5 JP2018519831 A5 JP 2018519831A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077341A JP7459168B2 (ja) | 2015-07-02 | 2022-05-10 | ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法 |
Applications Claiming Priority (5)
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| WO2016115500A1 (en) * | 2015-01-16 | 2016-07-21 | City Of Hope | Cell penetrating antibodies |
| CN114525279A (zh) | 2015-04-22 | 2022-05-24 | 米纳治疗有限公司 | C/EBP α SARNA组合物和使用方法 |
| JP7073109B2 (ja) * | 2015-07-02 | 2022-05-23 | シティ・オブ・ホープ | ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法 |
| WO2018145086A1 (en) | 2017-02-06 | 2018-08-09 | Mpeg La, Llc | Multimeric oligonucleotides having decreased kidney clearance |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| US11554178B2 (en) | 2017-06-30 | 2023-01-17 | City Of Hope | Compositions and methods of modulating macrophage activity |
| EP3679139B1 (en) | 2017-09-08 | 2022-11-02 | MiNA Therapeutics Limited | Stabilized hnf4a sarna compositions and methods of use |
| CN113584027B (zh) * | 2018-04-10 | 2025-01-10 | 中美瑞康核酸技术(南通)研究院有限公司 | 一种激活p21基因表达的方法 |
| WO2019241766A1 (en) * | 2018-06-15 | 2019-12-19 | City Of Hope | Oligonucleotide-based proteolysis targeting chimera |
| CN109762042B (zh) * | 2018-09-21 | 2022-04-08 | 河北艾克美冀生物科技有限公司 | 一种治疗癌症的药物、其合成方法和应用 |
| CA3132505A1 (en) * | 2019-03-04 | 2020-09-10 | Mpeg La, L.L.C. | Multimeric oligonucleotides with enhanced bioactivity |
| EP4003423A4 (en) * | 2019-07-26 | 2024-03-06 | MiNA Therapeutics Limited | Compositions and methods of using c/ebp alpha sarna |
| KR102433981B1 (ko) * | 2020-12-15 | 2022-08-19 | 대구가톨릭대학교산학협력단 | HIF-1α 및 STAT5 전사인자를 억제하는 합성 디코이 올리고핵산 및 이를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물 |
| CN117377764A (zh) * | 2021-02-08 | 2024-01-09 | 中美瑞康核酸技术(南通)研究院有限公司 | 多价寡核苷酸试剂及其使用方法 |
| WO2023034853A2 (en) * | 2021-08-31 | 2023-03-09 | City Of Hope | Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof |
| CN114908094B (zh) * | 2022-05-31 | 2024-03-12 | 中山大学 | 一类反义寡核苷酸分子及其在制备治疗恶性肿瘤药物中的应用 |
| EP4599065A2 (en) * | 2022-10-07 | 2025-08-13 | City of Hope | Double-stranded oligonucleotides and methods of use |
| EP4627086A2 (en) * | 2022-11-29 | 2025-10-08 | Lonza Sales AG | Methods of using extracellular vesicle-aso targeting stat6 |
| CN118480552B (zh) * | 2024-01-18 | 2024-10-01 | 成都先衍生物技术有限公司 | 一种靶向CEBPA基因表达的saRNA及其用途 |
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| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6423493B1 (en) * | 1998-10-26 | 2002-07-23 | Board Of Regents The University Of Texas System | Combinatorial selection of oligonucleotide aptamers |
| US6159694A (en) | 1999-04-08 | 2000-12-12 | Isis Pharmaceuticals Inc. | Antisense modulation of stat3 expression |
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| AU2005248410B2 (en) * | 2004-05-27 | 2010-04-22 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Differential expression of molecules associated with acute stroke |
| CA2604532C (en) * | 2005-04-15 | 2017-03-07 | The Regents Of The University Of California | Small activating rna molecules and methods of use |
| US8748405B2 (en) * | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| WO2008094254A2 (en) | 2007-01-26 | 2008-08-07 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| WO2009018332A1 (en) * | 2007-08-01 | 2009-02-05 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand |
| CA2745811C (en) * | 2008-12-04 | 2021-07-13 | Joseph Collard | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
| WO2012128785A1 (en) | 2011-03-22 | 2012-09-27 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| PE20142463A1 (es) * | 2011-04-01 | 2015-01-22 | Isis Pharmaceuticals Inc | Modulacion de la expresion del transductor de senales y activador de la transcripcion 3 (stat3) |
| WO2014047649A1 (en) * | 2012-09-24 | 2014-03-27 | The Regents Of The University Of California | Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy |
| RS58576B1 (sr) * | 2012-10-31 | 2019-05-31 | Ionis Pharmaceuticals Inc | Tretman raka |
| AU2014236370C1 (en) * | 2013-03-14 | 2019-01-17 | City Of Hope | 5-bromo-indirubins |
| EP3071696B1 (en) | 2013-11-22 | 2019-08-07 | Mina Therapeutics Limited | C/ebp alpha short activating rna compositions and methods of use |
| WO2015077657A2 (en) | 2013-11-22 | 2015-05-28 | City Of Hope | Stat3 inhibitors and uses thereof |
| JP7073109B2 (ja) * | 2015-07-02 | 2022-05-23 | シティ・オブ・ホープ | ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法 |
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