JP2018518655A - サンプル分析用デバイス及び方法 - Google Patents

サンプル分析用デバイス及び方法 Download PDF

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JP2018518655A
JP2018518655A JP2017551668A JP2017551668A JP2018518655A JP 2018518655 A JP2018518655 A JP 2018518655A JP 2017551668 A JP2017551668 A JP 2017551668A JP 2017551668 A JP2017551668 A JP 2017551668A JP 2018518655 A JP2018518655 A JP 2018518655A
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wells
array
substrate
droplet
mixture
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Japanese (ja)
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JP2018518655A5 (enExample
Inventor
ジェフリー ビー ハフ
ジェフリー ビー ハフ
マーク エイ ヘイデン
マーク エイ ヘイデン
ピーター ジェイ カラバツォス
ピーター ジェイ カラバツォス
アンドリュー ティー フィッシャー
アンドリュー ティー フィッシャー
ジョン エム ロビンソン
ジョン エム ロビンソン
シェリー アール ホレッツ−マコーマック
シェリー アール ホレッツ−マコーマック
ソフィー ローレンソン
ソフィー ローレンソン
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Abbott Laboratories
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Abbott Laboratories
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Publication of JP2018518655A publication Critical patent/JP2018518655A/ja
Publication of JP2018518655A5 publication Critical patent/JP2018518655A5/ja
Priority to JP2021168863A priority Critical patent/JP2022020665A/ja
Priority to JP2023184560A priority patent/JP2024020244A/ja
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
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    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/08—Geometry, shape and general structure
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

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  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Micromachines (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Optical Measuring Cells (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
JP2017551668A 2015-04-03 2016-04-02 サンプル分析用デバイス及び方法 Pending JP2018518655A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021168863A JP2022020665A (ja) 2015-04-03 2021-10-14 サンプル分析用デバイス及び方法
JP2023184560A JP2024020244A (ja) 2015-04-03 2023-10-27 サンプル分析用デバイス及び方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562142858P 2015-04-03 2015-04-03
US62/142,858 2015-04-03
PCT/US2016/025785 WO2016161400A1 (en) 2015-04-03 2016-04-02 Devices and methods for sample analysis

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JP2021168863A Division JP2022020665A (ja) 2015-04-03 2021-10-14 サンプル分析用デバイス及び方法

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JP2018518655A true JP2018518655A (ja) 2018-07-12
JP2018518655A5 JP2018518655A5 (enExample) 2020-09-10

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US (2) US11633738B2 (enExample)
EP (1) EP3277427A1 (enExample)
JP (3) JP2018518655A (enExample)
CN (2) CN107666962B (enExample)
AU (3) AU2016243034A1 (enExample)
BR (1) BR112017021256A2 (enExample)
CA (1) CA2981512A1 (enExample)
MX (1) MX2017012742A (enExample)
RU (2) RU2712610C2 (enExample)
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JP2020081937A (ja) * 2018-11-20 2020-06-04 国立研究開発法人産業技術総合研究所 液体操作装置
KR20200113070A (ko) * 2019-03-20 2020-10-06 주식회사 토바 롤투롤을 활용한 바이오칩 제작 시스템
WO2020261512A1 (ja) * 2019-06-27 2020-12-30 昭和電工マテリアルズ株式会社 被覆膜付き基体及びその製造方法、並びに、検査センサ
JP2022547801A (ja) * 2019-08-27 2022-11-16 ヴォルタ ラブズ，インク． 液滴操作のための方法およびシステム
JP2023507599A (ja) * 2019-12-18 2023-02-24 ローベルト ボツシユ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 流体を収容するための収容ユニット、収容ユニットを製造するための方法および装置、収容ユニットを操作するための方法および装置、ならびに収容装置
JP2024113082A (ja) * 2020-08-20 2024-08-21 大日本印刷株式会社 試薬担持基材、試薬入りマイクロ流路構造体、及び試薬入りマイクロ流路デバイス

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EP4234716A3 (en) 2013-06-25 2023-12-06 Prognosys Biosciences, Inc. Methods for determining spatial patterns of biological targets in a sample
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CN110383068A (zh) 2016-10-03 2019-10-25 雅培实验室 评估患者样品中uch-l1状态的改进方法
US11016053B2 (en) 2016-10-05 2021-05-25 Abbott Laboratories Devices and methods for sample analysis
US11198129B2 (en) 2016-10-05 2021-12-14 Abbott Laboratories Devices and methods for sample analysis
CN106769359B (zh) * 2016-12-30 2023-07-07 中国农业科学院草原研究所 一种植物根部观测仪以及检测植物根部的方法
ES2908883T3 (es) 2017-01-18 2022-05-04 Abbott Lab Métodos para el análisis de muestras
CA3052513A1 (en) 2017-03-23 2018-09-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
CN110476067A (zh) * 2017-03-29 2019-11-19 国立研究开发法人科学技术振兴机构 微小物质检测方法及微小物质检测用装置
JP7344797B2 (ja) 2017-04-15 2023-09-14 アボット・ラボラトリーズ 早期バイオマーカーを使用する、ヒト対象における外傷性脳損傷の、超急性の診断及び決定の一助となるための方法
WO2018200823A1 (en) 2017-04-28 2018-11-01 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
AU2018272054B2 (en) 2017-05-25 2024-10-31 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
AU2018275236B2 (en) 2017-05-30 2024-11-07 Abbott Laboratories Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin I
US10942110B2 (en) * 2017-06-15 2021-03-09 United Arab Emirates University System and method for detecting abnormalities in cells
CA3068041C (en) 2017-07-03 2024-06-25 Abbott Laboratories Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood
US10408788B2 (en) 2017-07-12 2019-09-10 Sharp Life Science (Eu) Limited Spacer for side loaded EWOD device
WO2019023646A2 (en) * 2017-07-27 2019-01-31 Maxim Integrated Products, Inc. ANALYTE SENSOR HOUSING AND METHOD FOR ANALYZING FLUID SAMPLES
WO2019046307A1 (en) * 2017-08-29 2019-03-07 Celsee Diagnostics, Inc. SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
US11016105B2 (en) 2017-12-09 2021-05-25 Abbott Laboratories Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of GFAP and UCH-L1
JP7344801B2 (ja) 2017-12-09 2023-09-14 アボット・ラボラトリーズ グリア原線維性酸性タンパク質（ｇｆａｐ）及び／又はユビキチンカルボキシ末端ヒドロラーゼｌ１（ｕｃｈ－ｌ１）を使用する、整形外科損傷を負っており、軽度外傷性脳損傷（ｔｂｉ）などの頭部への損傷を負ったか又は負った可能性がある対象についての診断及び査定の一助となるための方法
CN111699391A (zh) 2017-12-29 2020-09-22 雅培实验室 用于诊断和评估创伤性脑损伤的新型生物标志物和方法
EP3735315A4 (en) * 2018-01-05 2021-09-29 SiMPore Inc. SAMPLE PREPARATION AND FLOW SENSORS USING FUNCTIONALIZED SILICON MEMBRANES
EP3737503A2 (en) 2018-01-08 2020-11-18 Quantum-Si Incorporated System and methods for electrokinetic loading of sub-micron-scale reaction chambers
CN108169480B (zh) * 2018-02-07 2024-03-08 上海澜澈生物科技有限公司 一种生物标志物的分子数量的检测方法及系统、芯片
CN108254549A (zh) * 2018-02-07 2018-07-06 上海澜澈生物科技有限公司 一种待测标志物的分子数量的检测方法及系统、芯片
US10871430B2 (en) * 2018-03-03 2020-12-22 Labcyte Inc. System and method for extracting a target moiety from a sample using acoustic droplet ejection
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CN112384801A (zh) * 2018-05-04 2021-02-19 雅培制药有限公司 用于改进小体积样品的免疫测定灵敏度和动力学的依次采样方法
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