JP2018518540A5 - - Google Patents
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- JP2018518540A5 JP2018518540A5 JP2018519261A JP2018519261A JP2018518540A5 JP 2018518540 A5 JP2018518540 A5 JP 2018518540A5 JP 2018519261 A JP2018519261 A JP 2018519261A JP 2018519261 A JP2018519261 A JP 2018519261A JP 2018518540 A5 JP2018518540 A5 JP 2018518540A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- binding protein
- antigen
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021117516A JP2021177768A (ja) | 2015-06-23 | 2021-07-16 | 新規ｐｄ−１免疫調節剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562183297P | 2015-06-23 | 2015-06-23 | |
| US62/183,297 | 2015-06-23 | ||
| US201562266398P | 2015-12-11 | 2015-12-11 | |
| US62/266,398 | 2015-12-11 | ||
| PCT/US2016/039015 WO2016210129A1 (en) | 2015-06-23 | 2016-06-23 | Novel pd-1 immune modulating agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021117516A Division JP2021177768A (ja) | 2015-06-23 | 2021-07-16 | 新規ｐｄ−１免疫調節剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518540A JP2018518540A (ja) | 2018-07-12 |
| JP2018518540A5 true JP2018518540A5 (cg-RX-API-DMAC7.html) | 2019-08-08 |
| JP6974311B2 JP6974311B2 (ja) | 2021-12-01 |
Family
ID=56373127
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519261A Active JP6974311B2 (ja) | 2015-06-23 | 2016-06-23 | 新規ｐｄ−１免疫調節剤 |
| JP2021117516A Ceased JP2021177768A (ja) | 2015-06-23 | 2021-07-16 | 新規ｐｄ−１免疫調節剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021117516A Ceased JP2021177768A (ja) | 2015-06-23 | 2021-07-16 | 新規ｐｄ−１免疫調節剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11136392B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3313883B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6974311B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180019725A (cg-RX-API-DMAC7.html) |
| CN (2) | CN114133448A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016281641B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3006224A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1254803A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL256463A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI773647B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016210129A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| KR20180019725A (ko) * | 2015-06-23 | 2018-02-26 | 메모리얼 슬로안-케터링 캔서 센터 | 신규의 피디 1 면역 조절제 |
| WO2017011580A2 (en) | 2015-07-13 | 2017-01-19 | Cytomx Therapeutics, Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
| HK1257840A1 (zh) | 2015-09-01 | 2019-11-01 | Agenus Inc. | 抗-pd-1抗体及其使用方法 |
| CN108289953B (zh) | 2015-09-29 | 2022-03-11 | 细胞基因公司 | Pd-1结合蛋白及其使用方法 |
| IL257110B (en) | 2015-10-02 | 2022-09-01 | Hoffmann La Roche | Bispecific antibodies specific against pd1 and tim3 |
| MA43186B1 (fr) | 2015-11-03 | 2022-03-31 | Janssen Biotech Inc | Anticorps se liant spécifiquement à pd-1 et leurs utilisations |
| WO2017133175A1 (en) * | 2016-02-04 | 2017-08-10 | Nanjing Legend Biotech Co., Ltd. | Engineered mammalian cells for cancer therapy |
| WO2017165683A1 (en) * | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| BR112019004733A2 (pt) | 2016-09-19 | 2019-05-28 | Celgene Corp | métodos de tratamento de distúrbios imunes usando proteínas de ligação a pd-1 |
| US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| AU2017373945B2 (en) | 2016-12-07 | 2025-01-23 | Agenus Inc. | Antibodies and methods of use thereof |
| EP3557671A4 (en) * | 2016-12-19 | 2020-08-19 | Showa Denko K.K. | PROCEDURE FOR OPERATING A REDOX FLOW BATTERY |
| AU2018234810B2 (en) | 2017-03-15 | 2023-05-11 | Pandion Operations, Inc. | Targeted immunotolerance |
| KR102461885B1 (ko) | 2017-04-03 | 2022-11-03 | 에프. 호프만-라 로슈 아게 | 항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체 |
| IL268620B2 (en) * | 2017-04-05 | 2024-04-01 | Hoffmann La Roche | Antibodies against LAG3 pharmaceutical formulations containing them, and their uses for cancer treatment |
| EP4516809A3 (en) | 2017-04-05 | 2025-09-03 | F. Hoffmann-La Roche AG | Bispecific antibodies specifically binding to pd1 and lag3 |
| EP3612222A4 (en) * | 2017-04-19 | 2020-12-23 | University of Southern California | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER |
| JP7538601B2 (ja) | 2017-04-26 | 2024-08-22 | ユーリカ セラピューティックス， インコーポレイテッド | キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用 |
| CN110809582B (zh) * | 2017-05-01 | 2023-12-22 | 儿童医疗中心有限公司 | 涉及抗pd1抗体试剂的方法以及组合物 |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| KR20200037250A (ko) * | 2017-07-06 | 2020-04-08 | 메뤼스 엔.페. | 세포에 의해 발현되는 생물학적 활성을 조절하는 항체 |
| WO2019018727A1 (en) * | 2017-07-21 | 2019-01-24 | Washington University | METHODS AND COMPOSITIONS FOR T-CELL ACTIVATION |
| BR112020008638A2 (pt) | 2017-11-01 | 2020-10-20 | Juno Therapeutics Inc | receptores de antígenos quiméricos específicos para antígenos de maturação de células b (bcma) |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| KR20200128014A (ko) * | 2018-01-31 | 2020-11-11 | 셀진 코포레이션 | 입양 세포 요법 및 체크포인트 억제제를 이용한 병용 요법 |
| CN112041432A (zh) | 2018-02-15 | 2020-12-04 | 纪念斯隆-凯特林癌症中心 | Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法 |
| AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
| KR20210011919A (ko) | 2018-04-17 | 2021-02-02 | 셀덱스 쎄라퓨틱스, 인크. | 항-cd27 항체 및 항-pd-l1 항체 및 이중특이적 작제물 |
| EA202190181A1 (ru) * | 2018-07-04 | 2021-05-27 | Сайтоиммьюн Терапьютикс, Инк. | Композиции и способы для направленной иммунотерапии flt3, pd-1 и/или pd-l1 |
| EP3876958A1 (en) | 2018-11-08 | 2021-09-15 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| CN111320690B (zh) * | 2018-12-17 | 2022-04-05 | 程联胜 | 一种抗人Tim3单克隆抗体及其应用 |
| CN111748580B (zh) * | 2019-03-28 | 2022-09-13 | 百奥泰生物制药股份有限公司 | 一种检测免疫检查点抗体活性的方法 |
| CN111892655B (zh) * | 2019-05-06 | 2022-10-28 | 四川大学 | 抗pd-1纳米抗体的筛选及应用 |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| JP7680967B2 (ja) * | 2019-06-14 | 2025-05-21 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｐｄ－１に対する抗体およびその使用方法 |
| TWI809286B (zh) | 2019-07-05 | 2023-07-21 | 日商小野藥品工業股份有限公司 | 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療 |
| EP3996735A4 (en) | 2019-07-12 | 2023-07-19 | The Research Foundation for The State University of New York | COMPOSITIONS AND METHODS FOR BLOCKING AND BINDING CXCR4 TO MODULATE CELLULAR FUNCTION |
| US20220332825A1 (en) | 2019-08-08 | 2022-10-20 | Ono Pharmaceutical Co., Ltd. | Bispecific protein |
| CA3147837A1 (en) * | 2019-08-16 | 2021-02-25 | Marco Davila | Anti-cd83 chimeric antigen receptor expressing t regulatory cells |
| CN112852740A (zh) * | 2019-11-27 | 2021-05-28 | 深圳市菲鹏生物治疗股份有限公司 | Car-t细胞和检测方法 |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| MX2022014974A (es) | 2020-05-26 | 2023-01-11 | Boehringer Ingelheim Int | Anticuerpos anti-pd-1. |
| CN114437229B (zh) * | 2020-11-01 | 2024-03-12 | 复旦大学 | 携带pd-1単链抗体且靶向egfr抗原的car t免疫细胞的制备及其用途 |
| CN112812174A (zh) * | 2021-01-15 | 2021-05-18 | 新乡学院 | 猪pd-l14qn-af表位多肽及其应用 |
| CN115521378B (zh) * | 2021-07-23 | 2023-12-22 | 南京吉盛澳玛生物医药有限公司 | Pd-l1抗体及其用途 |
| WO2024182754A2 (en) * | 2023-03-02 | 2024-09-06 | Fred Hutchinson Cancer Center | Anti-pd-1 chimeric antigen receptor t cells and therapeutic uses thereof |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| WO2025085538A1 (en) * | 2023-10-17 | 2025-04-24 | Lanier Biotherapeutics, Inc. | Alarmin binding molecules and treatment of cancer |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4834976A (en) * | 1986-07-03 | 1989-05-30 | Genetic Systems Corporation | Monoclonal antibodies to pseudomonas aeruginosa flagella |
| ES2367430T3 (es) * | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| EP1896582A4 (en) * | 2005-05-09 | 2009-04-08 | Ono Pharmaceutical Co | HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS |
| PT2520590T (pt) * | 2007-04-03 | 2018-11-14 | Amgen Res Munich Gmbh | Domínio de ligação específico de espécies cruzadas |
| WO2008156712A1 (en) * | 2007-06-18 | 2008-12-24 | N. V. Organon | Antibodies to human programmed death receptor pd-1 |
| EA201490364A1 (ru) * | 2011-07-29 | 2014-08-29 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Костимулирующие рецепторы-переключатели |
| WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| CN103965363B (zh) * | 2013-02-06 | 2021-01-15 | 上海白泽生物科技有限公司 | 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途 |
| EP3811954A1 (en) * | 2013-02-26 | 2021-04-28 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
| CN103242448B (zh) * | 2013-05-27 | 2015-01-14 | 郑州大学 | 一种全人源化抗pd-1单克隆抗体及其制备方法和应用 |
| CN104558177B (zh) * | 2013-10-25 | 2020-02-18 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途 |
| MY192062A (en) * | 2014-12-05 | 2022-07-25 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof |
| CN104479020B (zh) * | 2014-12-26 | 2019-08-02 | 上海复宏汉霖生物技术股份有限公司 | 一种抗pd-1人源抗体 |
| WO2016191246A2 (en) * | 2015-05-22 | 2016-12-01 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for a prame peptide |
| KR20180019725A (ko) * | 2015-06-23 | 2018-02-26 | 메모리얼 슬로안-케터링 캔서 센터 | 신규의 피디 1 면역 조절제 |
| IL259747B (en) * | 2015-12-04 | 2022-09-01 | Memorial Sloan Kettering Cancer Center | Antibodies targeting fc receptor-like 5 and methods of use |
| JP7022067B2 (ja) * | 2016-01-14 | 2022-02-17 | メモリアル スローン ケタリング キャンサー センター | Ｆｏｘｐ３由来のペプチドに特異的なｔ細胞受容体様抗体 |
| SI3535298T1 (sl) * | 2016-11-02 | 2022-01-31 | Jounce Therapeutics, Inc. | Protitelesa proti pd-1 in njihove uporabe |
| AU2018339528A1 (en) * | 2017-09-26 | 2020-04-16 | Longwood University | PD1-specific chimeric antigen receptor as an immunotherapy |
-
2016
- 2016-06-23 KR KR1020187002014A patent/KR20180019725A/ko not_active Withdrawn
- 2016-06-23 HK HK18113888.8A patent/HK1254803A1/zh unknown
- 2016-06-23 TW TW105119709A patent/TWI773647B/zh not_active IP Right Cessation
- 2016-06-23 WO PCT/US2016/039015 patent/WO2016210129A1/en not_active Ceased
- 2016-06-23 AU AU2016281641A patent/AU2016281641B2/en active Active
- 2016-06-23 CN CN202111160281.3A patent/CN114133448A/zh active Pending
- 2016-06-23 EP EP16736667.3A patent/EP3313883B1/en active Active
- 2016-06-23 CN CN201680037151.1A patent/CN108337890B/zh active Active
- 2016-06-23 JP JP2018519261A patent/JP6974311B2/ja active Active
- 2016-06-23 CA CA3006224A patent/CA3006224A1/en not_active Abandoned
-
2017
- 2017-12-20 US US15/849,107 patent/US11136392B2/en active Active
- 2017-12-20 IL IL256463A patent/IL256463A/en unknown
-
2021
- 2021-07-16 JP JP2021117516A patent/JP2021177768A/ja not_active Ceased