JP2018518273A - バイオマテリアル組成物、移植片およびその作成方法 - Google Patents
バイオマテリアル組成物、移植片およびその作成方法 Download PDFInfo
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2002/30772—Apertures or holes, e.g. of circular cross section
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Abstract
Description
本出願は2015年6月10日出願の米国特許出願14/735,460号の一部継続出願であり、参照としてその全体が本明細書に組み込まれる。
Claims (20)
- 骨再生を助けるための埋込型バイオマテリアル作成方法であって、前記方法が、
粒子形態の脱灰骨を得ることと、
前記脱灰、粉砕骨を型に加えることと、
前記脱灰、粉砕骨を前記型内にて所定の形の成形バイオマテリアル組成物を形成するのに十分な時間および圧力で圧縮すること、さらに
前記成形バイオマテリアル組成物を凍結乾燥して前記埋込型バイオマテリアルを形成することとを含み、ここで
前記埋込型バイオマテリアルの形は前記型によって決定される、方法。 - 生理活性ガラス、リン酸三カルシウム、またはその組合せを前記脱灰、粉砕骨に加えることをさらに含む、請求項1の方法。
- 前記脱灰骨が脱灰皮質または海綿質繊維の形態である、請求項1の方法。
- 前記埋込型バイオマテリアルが多層である、請求項1の方法。
- 前記多層埋込型バイオマテリアルの隣接する層は互いに組成的に異なる、請求項4の方法。
- 前記埋込型バイオマテリアルが、共に組み立てられた複数の相補的な形を含む、請求項1の方法。
- 前記複数の相補的な形が、第1部分のほぞ穴に受けたほぞを有する第2部分と連結したほぞ穴を有する第1部分を含む、請求項6の方法。
- 前記複数の相補的な形が、相互に連結した複数の実質的同心環を含む、請求項6の方法。
- 前記埋込型バイオマテリアルが、1以上の骨移植材料を受けるような大きさとされ、かつ構成された1以上の開口部分を含む、請求項1の方法。
- 前記埋込型バイオマテリアルが、骨ファスナーの一部分を受けるよう構成された1以上のノッチを含む、請求項1の方法。
- 骨再生を助けるための埋込型バイオマテリアルの作成方法であり、前記方法が、
粒子形態の脱灰骨を得ることと、
脱灰、粉砕骨の第1層を型に加えることと、
脱灰、粉砕骨の第2層を型に加えることと、
脱灰粉砕骨層を前記型内にて、分離された別個の層を有する所定の形の成形バイオマテリアル組成物を形成するのに十分な時間と圧力で圧縮すること、さらに
前記成形バイオマテリアル組成物を凍結乾燥して埋込型バイオマテリアルを形成すること、とを含み、ここで
前記埋込型バイオマテリアルの形が前記型によって決定される、方法。 - 前記第1層と前記第2層は、組成的に異なる、請求項11の方法。
- 脱灰、粉砕骨の第3層を前記型に加えることをさらに含み、ここで前記第3層は前記第1層と組成的に同じである、請求項11の方法。
- 複数の追加の層を前記型に加えることをさらに含み、ここで前記得られる層状化埋込型バイオマテリアルが異なる材料の交互層を含む、請求項11の方法。
- 哺乳動物における骨または創傷治癒を促進する方法であって、前記方法が、
粒子形態の脱灰骨を含んで成る圧縮、多層埋込型バイオマテリアルを提供すること、また
前記埋込型バイオマテリアルを標的修復部位内に投与して前記標的修復部位での骨の修復または再生を促進すること、とを含む方法。 - 前記埋込型バイオマテリアルが、前記埋込型バイオマテリアルと異なる材料で形成されたフレーム内に位置し保持される、請求項15の方法。
- 前記埋込型バイオマテリアルおよび前記フレームが、隣接する椎骨に1以上の骨ファスナーで固定されるよう構成された独立型移植片を形成する、請求項16の方法。
- 前記埋込型バイオマテリアルが、1以上の骨移植材料を受けるような大きさとされ、構成された1以上の開口部分を含む、請求項15の方法。
- 前記埋込型バイオマテリアルが、骨ファスナーの一部分を受けるよう構成された1以上のノッチを含む、請求項15の方法。
- 前記標的修復部位が脊椎における傷害または欠損である、請求項15の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/735,460 US10016529B2 (en) | 2015-06-10 | 2015-06-10 | Biomaterial compositions, implants, and methods of making the same |
US14/735,460 | 2015-06-10 | ||
US14/810,858 US11426489B2 (en) | 2015-06-10 | 2015-07-28 | Biomaterial compositions, implants, and methods of making the same |
US14/810,858 | 2015-07-28 | ||
PCT/US2016/036824 WO2016201185A1 (en) | 2015-06-10 | 2016-06-10 | Biomaterial compositions, implants, and methods of making the same |
Publications (2)
Publication Number | Publication Date |
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JP2018518273A true JP2018518273A (ja) | 2018-07-12 |
JP6763888B2 JP6763888B2 (ja) | 2020-09-30 |
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JP2017563957A Active JP6763888B2 (ja) | 2015-06-10 | 2016-06-10 | バイオマテリアル組成物、移植片およびその作成方法 |
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US9572912B2 (en) | 2013-04-19 | 2017-02-21 | Theracell, Inc. | Demineralized bone fibers having controlled geometry and shapes and methods thereof |
US10780196B2 (en) | 2013-10-09 | 2020-09-22 | Lifenet Health | Compressed bone composition and methods of use thereof |
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