JP2018518161A5 - - Google Patents
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- JP2018518161A5 JP2018518161A5 JP2017557944A JP2017557944A JP2018518161A5 JP 2018518161 A5 JP2018518161 A5 JP 2018518161A5 JP 2017557944 A JP2017557944 A JP 2017557944A JP 2017557944 A JP2017557944 A JP 2017557944A JP 2018518161 A5 JP2018518161 A5 JP 2018518161A5
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- 238000000034 method Methods 0.000 claims description 27
- 239000000047 product Substances 0.000 claims description 21
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- 238000001914 filtration Methods 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 7
- 244000005700 microbiome Species 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
- 229960000074 biopharmaceutical Drugs 0.000 claims description 5
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- 239000012930 cell culture fluid Substances 0.000 claims description 5
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 3
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- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- -1 dimethyl bicarbonate Chemical compound 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
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- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
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- 108010041986 DNA Vaccines Proteins 0.000 description 1
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- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 description 1
- 108010053775 Nisin Proteins 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 229940022005 RNA vaccine Drugs 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000010350 erythorbic acid Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 229940026239 isoascorbic acid Drugs 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
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- 108700021021 mRNA Vaccine Proteins 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000004311 natamycin Substances 0.000 description 1
- 235000010298 natamycin Nutrition 0.000 description 1
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 description 1
- 229960003255 natamycin Drugs 0.000 description 1
- 239000004309 nisin Substances 0.000 description 1
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- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
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- 238000010979 pH adjustment Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229940023143 protein vaccine Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15166686.4 | 2015-05-07 | ||
| EP15166686.4A EP3015542A1 (de) | 2015-05-07 | 2015-05-07 | Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes |
| PCT/EP2016/059700 WO2016177650A1 (de) | 2015-05-07 | 2016-04-29 | Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518161A JP2018518161A (ja) | 2018-07-12 |
| JP2018518161A5 true JP2018518161A5 (https=) | 2019-06-06 |
| JP6794372B2 JP6794372B2 (ja) | 2020-12-02 |
Family
ID=53177140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557944A Expired - Fee Related JP6794372B2 (ja) | 2015-05-07 | 2016-04-29 | 殺菌状態で生成物を連続的に生産および／または調製するモジュラーシステムおよび方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10696940B2 (https=) |
| EP (2) | EP3015542A1 (https=) |
| JP (1) | JP6794372B2 (https=) |
| KR (1) | KR20180002783A (https=) |
| CN (1) | CN107995924B (https=) |
| AR (1) | AR104523A1 (https=) |
| AU (1) | AU2016257253B2 (https=) |
| BR (1) | BR112017023912A2 (https=) |
| CA (1) | CA2984981A1 (https=) |
| HK (1) | HK1254902A1 (https=) |
| IL (1) | IL255383B (https=) |
| MX (1) | MX383628B (https=) |
| RU (1) | RU2721535C2 (https=) |
| SA (1) | SA517390299B1 (https=) |
| SG (1) | SG11201709094WA (https=) |
| TW (1) | TWI696696B (https=) |
| WO (1) | WO2016177650A1 (https=) |
| ZA (1) | ZA201708284B (https=) |
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|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| WO2018075830A1 (en) | 2016-10-19 | 2018-04-26 | Flodesign Sonics, Inc. | Affinity cell extraction by acoustics |
| EP3141594A3 (en) * | 2016-11-11 | 2017-06-14 | Bayer Pharma Aktiengesellschaft | Method for sampling fluid streams for monitoring contaminants in a continuous flow |
| KR20190079662A (ko) * | 2016-11-11 | 2019-07-05 | 바이엘 악티엔게젤샤프트 | 연속적 유동 내의 오염물을 모니터링하기 위한 유체 스트림의 샘플링 방법 |
| CN106474466B (zh) * | 2016-12-07 | 2018-04-13 | 申联生物医药（上海）股份有限公司 | 一种口蹄疫疫苗的制备方法 |
| EP3363517A1 (en) | 2017-02-17 | 2018-08-22 | Bayer Healthcare LLC | Degassing in methods for continuous production of a healthcare product |
| SG11201906766TA (en) | 2017-02-17 | 2019-08-27 | Bayer Ag | Degassing in methods for continuous processing of a healthcare product |
| CN107286226A (zh) * | 2017-06-28 | 2017-10-24 | 浙江新银象生物工程有限公司 | 高清澈度和高效价乳酸链球菌素水溶液的制备方法 |
| EP3431168A1 (en) * | 2017-07-19 | 2019-01-23 | Bayer Aktiengesellschaft | Élimination de médicament non lié après couplage conjugué anticorps-médicament |
| DE102017127017A1 (de) * | 2017-11-16 | 2019-05-16 | Sartorius Stedim Biotech Gmbh | Automatisierte Einweg-Filtrationsvorrichtung und Verfahren zur Steuerung einer automatisierten Einweg-Filtrationsvorrichtung |
| DE102017127020A1 (de) * | 2017-11-16 | 2019-05-16 | Sartorius Stedim Biotech Gmbh | Verfahren zum Filtrieren eines großen Volumens eines Mediums mit einer vorsterilisierbaren, wenigstens teilautomatisierten Einweg-Filtrationsvorrichtung |
| KR102439221B1 (ko) | 2017-12-14 | 2022-09-01 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| US10792618B2 (en) * | 2018-06-19 | 2020-10-06 | Sartorius Stedim Biotech Gmbh | Particle separation and/or purification of a fluid |
| US11028359B2 (en) | 2018-09-11 | 2021-06-08 | Global Life Sciences Solutions Usa Llc | Separation devices, associated methods, and systems |
| CN113227349A (zh) * | 2018-10-19 | 2021-08-06 | 尤尼沃尔塞尔斯技术股份公司 | 净化生物分子生产系统的方法及适用于净化的系统 |
| US11433332B2 (en) * | 2018-11-05 | 2022-09-06 | Hollingsworth & Vose Company | Filter media with irregular structure |
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| EP3663623A1 (en) * | 2018-12-05 | 2020-06-10 | Bayer AG | Pressure stabilizer |
| CN109603201B (zh) * | 2018-12-28 | 2021-07-16 | 晨光生物科技集团股份有限公司 | 辣椒提取物中苯甲酸的去除方法 |
| JP7231419B2 (ja) * | 2019-01-22 | 2023-03-01 | 日東電工株式会社 | 分離膜モジュール及びそれを用いた液体処理システム |
| CN110776138B (zh) * | 2019-10-31 | 2021-12-24 | 南京工大膜应用技术研究所有限公司 | 一种钢铁酸洗废水膜法处理装置及方法 |
| DE102020103925A1 (de) * | 2020-02-14 | 2021-08-19 | Sartorius Stedim Biotech Gmbh | Einweg-Vorrichtung zur Separation oder Aufreinigung eines großen Volumens eines Stoffgemischs |
| WO2022196698A1 (ja) * | 2021-03-15 | 2022-09-22 | 旭化成株式会社 | 原料液減容方法及びシステム |
| WO2022215495A1 (ja) * | 2021-04-08 | 2022-10-13 | 株式会社カネカ | 環状リポペプチド化合物のバイオバーデンの低減方法 |
| TWI788850B (zh) * | 2021-05-17 | 2023-01-01 | 張勝致 | 生物力學測試系統及其反應器模組 |
| JPWO2023191008A1 (https=) * | 2022-03-30 | 2023-10-05 | ||
| EP4501335A4 (en) | 2022-03-30 | 2025-07-23 | Fujifilm Corp | METHOD FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, SYSTEM FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, AND ACTIVE INGREDIENT OF BIOLOGICAL DRUG |
| KR102853272B1 (ko) * | 2022-12-27 | 2025-09-01 | 삼성바이오로직스 주식회사 | 분리된 정제구획을 포함하는 생물학적 물질의 정제 시스템 |
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| CN116590137B (zh) * | 2023-05-19 | 2026-04-07 | 四川大学华西医院 | 一次性高致病性微生物或灭活疫苗的生产系统以及方法 |
| WO2025078462A1 (de) * | 2023-10-12 | 2025-04-17 | KyooBe Tech GmbH | Modul für die förderung eines fluids |
| JP7751674B2 (ja) * | 2024-02-06 | 2025-10-08 | オルガノ株式会社 | 水処理装置およびその運転方法 |
| WO2025217607A1 (en) * | 2024-04-12 | 2025-10-16 | Sartorius Bioanalytical Instruments, Inc. | Cell culture systems and methods |
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| RU2493872C1 (ru) * | 2012-08-08 | 2013-09-27 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации ( ФГУП "НПО "Микроген" Минздрава России) | Способ очистки вируса гриппа |
| AU2014226126B2 (en) | 2013-03-08 | 2019-02-14 | Genzyme Corporation | Continuous purification of therapeutic proteins |
| EP3301115B1 (en) * | 2013-05-06 | 2021-11-10 | Sanofi | Continuous multistep process for purifying antibodies |
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2015
- 2015-05-07 EP EP15166686.4A patent/EP3015542A1/de not_active Withdrawn
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2016
- 2016-04-29 CN CN201680039860.3A patent/CN107995924B/zh not_active Expired - Fee Related
- 2016-04-29 CA CA2984981A patent/CA2984981A1/en not_active Abandoned
- 2016-04-29 KR KR1020177034919A patent/KR20180002783A/ko not_active Ceased
- 2016-04-29 MX MX2017014278A patent/MX383628B/es unknown
- 2016-04-29 BR BR112017023912-4A patent/BR112017023912A2/pt not_active Application Discontinuation
- 2016-04-29 SG SG11201709094WA patent/SG11201709094WA/en unknown
- 2016-04-29 EP EP16722580.4A patent/EP3292195A1/de not_active Withdrawn
- 2016-04-29 RU RU2017142617A patent/RU2721535C2/ru active
- 2016-04-29 WO PCT/EP2016/059700 patent/WO2016177650A1/de not_active Ceased
- 2016-04-29 US US15/571,754 patent/US10696940B2/en not_active Expired - Fee Related
- 2016-04-29 JP JP2017557944A patent/JP6794372B2/ja not_active Expired - Fee Related
- 2016-04-29 AU AU2016257253A patent/AU2016257253B2/en not_active Ceased
- 2016-04-29 HK HK18114001.8A patent/HK1254902A1/zh unknown
- 2016-05-04 AR ARP160101271A patent/AR104523A1/es active IP Right Grant
- 2016-05-05 TW TW105113911A patent/TWI696696B/zh not_active IP Right Cessation
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2017
- 2017-11-01 IL IL255383A patent/IL255383B/en unknown
- 2017-11-07 SA SA517390299A patent/SA517390299B1/ar unknown
- 2017-12-06 ZA ZA2017/08284A patent/ZA201708284B/en unknown
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