JP2018516966A5 - - Google Patents
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- JP2018516966A5 JP2018516966A5 JP2017564349A JP2017564349A JP2018516966A5 JP 2018516966 A5 JP2018516966 A5 JP 2018516966A5 JP 2017564349 A JP2017564349 A JP 2017564349A JP 2017564349 A JP2017564349 A JP 2017564349A JP 2018516966 A5 JP2018516966 A5 JP 2018516966A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- ligand
- molecule
- cell surface
- surface receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003446 ligand Substances 0.000 claims 36
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 35
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 35
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 34
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 34
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 22
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 20
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 229960003301 nivolumab Drugs 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 229940034982 antineoplastic agent Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 229950003135 margetuximab Drugs 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022000413A JP2022050522A (ja) | 2015-06-12 | 2022-01-05 | 癌の治療のための併用療法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562175039P | 2015-06-12 | 2015-06-12 | |
| US62/175,039 | 2015-06-12 | ||
| US201562211109P | 2015-08-28 | 2015-08-28 | |
| US62/211,109 | 2015-08-28 | ||
| US201562242640P | 2015-10-16 | 2015-10-16 | |
| US62/242,640 | 2015-10-16 | ||
| PCT/US2016/036608 WO2016201051A1 (en) | 2015-06-12 | 2016-06-09 | Combination therapy for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022000413A Division JP2022050522A (ja) | 2015-06-12 | 2022-01-05 | 癌の治療のための併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018516966A JP2018516966A (ja) | 2018-06-28 |
| JP2018516966A5 true JP2018516966A5 (OSRAM) | 2019-06-27 |
Family
ID=57504564
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564349A Ceased JP2018516966A (ja) | 2015-06-12 | 2016-06-09 | 癌の治療のための併用療法 |
| JP2022000413A Pending JP2022050522A (ja) | 2015-06-12 | 2022-01-05 | 癌の治療のための併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022000413A Pending JP2022050522A (ja) | 2015-06-12 | 2022-01-05 | 癌の治療のための併用療法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11078279B2 (OSRAM) |
| EP (1) | EP3307240A4 (OSRAM) |
| JP (2) | JP2018516966A (OSRAM) |
| KR (1) | KR20180021774A (OSRAM) |
| CN (2) | CN116898963A (OSRAM) |
| AU (2) | AU2016276706B2 (OSRAM) |
| BR (1) | BR112017026704A2 (OSRAM) |
| CA (1) | CA2988602A1 (OSRAM) |
| CL (1) | CL2017003131A1 (OSRAM) |
| GE (1) | GEP20217271B (OSRAM) |
| HK (1) | HK1247129A1 (OSRAM) |
| IL (1) | IL256224B (OSRAM) |
| MX (1) | MX2017016071A (OSRAM) |
| MY (1) | MY194621A (OSRAM) |
| PH (1) | PH12017502270A1 (OSRAM) |
| RU (1) | RU2733315C2 (OSRAM) |
| TW (1) | TWI870335B (OSRAM) |
| UA (1) | UA125207C2 (OSRAM) |
| WO (1) | WO2016201051A1 (OSRAM) |
| ZA (1) | ZA201708225B (OSRAM) |
Families Citing this family (20)
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|---|---|---|---|---|
| DK2247304T3 (en) * | 2008-04-02 | 2016-09-26 | Macrogenics Inc | Her2 / neu-specific antibodies and methods of use thereof |
| KR102702287B1 (ko) * | 2012-05-15 | 2024-09-04 | 브리스톨-마이어스 스큅 컴퍼니 | Pd-1/pd-l1 신호전달을 방해하는 것에 의한 암 면역요법 |
| TWI870335B (zh) * | 2015-06-12 | 2025-01-21 | 美商宏觀基因股份有限公司 | 變異的嵌合4d5抗體及其與抗pd-1抗體聯合用於治療癌症的應用 |
| SG10202010506TA (en) * | 2015-07-30 | 2020-11-27 | Macrogenics Inc | Pd-1-binding molecules and methods of use thereof |
| HK1251475A1 (zh) * | 2015-10-08 | 2019-02-01 | Macrogenics, Inc. | 用於癌症治疗的联合疗法 |
| US10954301B2 (en) | 2015-12-14 | 2021-03-23 | Macrogenics, Inc. | Bispecific molecules having immunoreactivity with PD-1 and CTLA-4, and methods of use thereof |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| EP3504234A4 (en) | 2016-09-29 | 2020-12-02 | Beijing Hanmi Pharmaceutical Co., Ltd. | CONSTRUCTIONS OF HETERODIMERIC IMMUNOGLOBULINS AND THEIR PREPARATION PROCESSES |
| KR102247704B1 (ko) | 2016-11-18 | 2021-05-03 | 북경한미약품 유한공사 | 항 pd-1/항 her2 천연항체 구조 형태의 헤테로다이머 계의 이중특이성 항체 및 그 제조방법 |
| WO2019153200A1 (zh) * | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
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| EP4349411A3 (en) | 2018-06-20 | 2024-06-19 | Incyte Corporation | Anti-pd-1 antibodies and uses thereof |
| EP4008351A4 (en) * | 2019-08-02 | 2023-08-09 | CTTQ-Akeso (ShangHai) Biomed. Tech. Co., Ltd. | ANTI-PD-1 ANTIBODIES AND MEDICAL USE THEREOF |
| US12151004B2 (en) * | 2020-01-31 | 2024-11-26 | University Of Saskatchewan | Methods and compositions for targeting disease related cell surface receptors using radiolabeled and/or cytotoxin labelled antibodies |
| WO2021188473A1 (en) * | 2020-03-16 | 2021-09-23 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Delta opioid receptor antagonists reprogram immunosuppressive microenvironment to boost immunotherapy |
| CN116635024A (zh) * | 2020-10-14 | 2023-08-22 | 维里迪安治疗公司 | 用于治疗甲状腺眼病的组合物和方法 |
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| CN120813375A (zh) | 2023-01-30 | 2025-10-17 | 凯玛布有限公司 | 抗体 |
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2016
- 2016-06-08 TW TW105118272A patent/TWI870335B/zh active
- 2016-06-09 CA CA2988602A patent/CA2988602A1/en not_active Abandoned
- 2016-06-09 GE GEAP201614669A patent/GEP20217271B/en unknown
- 2016-06-09 US US15/580,969 patent/US11078279B2/en active Active
- 2016-06-09 MX MX2017016071A patent/MX2017016071A/es unknown
- 2016-06-09 JP JP2017564349A patent/JP2018516966A/ja not_active Ceased
- 2016-06-09 CN CN202310857374.4A patent/CN116898963A/zh active Pending
- 2016-06-09 AU AU2016276706A patent/AU2016276706B2/en not_active Ceased
- 2016-06-09 UA UAA201712418A patent/UA125207C2/uk unknown
- 2016-06-09 BR BR112017026704A patent/BR112017026704A2/pt not_active IP Right Cessation
- 2016-06-09 HK HK18106874.8A patent/HK1247129A1/zh unknown
- 2016-06-09 RU RU2018100424A patent/RU2733315C2/ru active
- 2016-06-09 EP EP16808255.0A patent/EP3307240A4/en active Pending
- 2016-06-09 MY MYPI2017001812A patent/MY194621A/en unknown
- 2016-06-09 WO PCT/US2016/036608 patent/WO2016201051A1/en not_active Ceased
- 2016-06-09 KR KR1020187000058A patent/KR20180021774A/ko not_active Ceased
- 2016-06-09 CN CN201680033835.4A patent/CN107708666A/zh active Pending
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2017
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- 2017-12-10 IL IL256224A patent/IL256224B/en unknown
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2021
- 2021-06-18 US US17/351,724 patent/US20220041725A1/en not_active Abandoned
- 2021-08-06 AU AU2021212139A patent/AU2021212139A1/en not_active Abandoned
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2022
- 2022-01-05 JP JP2022000413A patent/JP2022050522A/ja active Pending
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2025
- 2025-03-20 US US19/085,484 patent/US20250215088A1/en active Pending
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