JP2020522543A5 - - Google Patents

Download PDF

Info

Publication number
JP2020522543A5
JP2020522543A5 JP2019567598A JP2019567598A JP2020522543A5 JP 2020522543 A5 JP2020522543 A5 JP 2020522543A5 JP 2019567598 A JP2019567598 A JP 2019567598A JP 2019567598 A JP2019567598 A JP 2019567598A JP 2020522543 A5 JP2020522543 A5 JP 2020522543A5
Authority
JP
Japan
Prior art keywords
antibody
seq
motomeko
pharmaceutical composition
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019567598A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020522543A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2018/065071 external-priority patent/WO2018224609A1/en
Publication of JP2020522543A publication Critical patent/JP2020522543A/ja
Publication of JP2020522543A5 publication Critical patent/JP2020522543A5/ja
Priority to JP2023127275A priority Critical patent/JP2023145720A/ja
Pending legal-status Critical Current

Links

JP2019567598A 2017-06-07 2018-06-07 変異IgG六量体に基づく治療用抗体 Pending JP2020522543A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023127275A JP2023145720A (ja) 2017-06-07 2023-08-03 変異IgG六量体に基づく治療用抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762516489P 2017-06-07 2017-06-07
US62/516,489 2017-06-07
US201862614801P 2018-01-08 2018-01-08
US62/614,801 2018-01-08
PCT/EP2018/065071 WO2018224609A1 (en) 2017-06-07 2018-06-07 Therapeutic antibodies based on mutated igg hexamers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023127275A Division JP2023145720A (ja) 2017-06-07 2023-08-03 変異IgG六量体に基づく治療用抗体

Publications (2)

Publication Number Publication Date
JP2020522543A JP2020522543A (ja) 2020-07-30
JP2020522543A5 true JP2020522543A5 (OSRAM) 2021-07-26

Family

ID=62636167

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019567598A Pending JP2020522543A (ja) 2017-06-07 2018-06-07 変異IgG六量体に基づく治療用抗体
JP2023127275A Withdrawn JP2023145720A (ja) 2017-06-07 2023-08-03 変異IgG六量体に基づく治療用抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023127275A Withdrawn JP2023145720A (ja) 2017-06-07 2023-08-03 変異IgG六量体に基づく治療用抗体

Country Status (10)

Country Link
US (1) US20200247897A1 (OSRAM)
EP (1) EP3635005A1 (OSRAM)
JP (2) JP2020522543A (OSRAM)
KR (1) KR20200027944A (OSRAM)
CN (1) CN111328335A (OSRAM)
BR (1) BR112019025328A2 (OSRAM)
MA (1) MA49259A (OSRAM)
MX (1) MX2019014407A (OSRAM)
TW (1) TW201919692A (OSRAM)
WO (1) WO2018224609A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7577446B2 (ja) 2017-02-10 2024-11-05 ジェンマブ ビー.ブイ. ポリペプチドバリアントおよびそれらの使用
BR112020022179A2 (pt) 2018-05-03 2021-02-02 Genmab B.V. primeiro anticorpo, anticorpo, composição, métodos para tratar um indivíduo tendo uma doença, para esgotar uma população de célula e para induzir a proliferação em uma população de célula, e, kit.
WO2020225456A1 (en) * 2019-05-09 2020-11-12 Genmab B.V. Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer
TWI869528B (zh) 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
WO2022018294A1 (en) * 2020-07-23 2022-01-27 Genmab B.V. A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
KR20230142831A (ko) 2021-01-13 2023-10-11 비스테라, 인크. 인간화된 보체 5a 수용체 1 항체 및 이의 사용 방법

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
AU751659B2 (en) 1997-05-02 2002-08-22 Genentech Inc. A method for making multispecific antibodies having heteromultimeric and common components
US6355271B1 (en) 1999-02-03 2002-03-12 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
US6281005B1 (en) 1999-05-14 2001-08-28 Copernicus Therapeutics, Inc. Automated nucleic acid compaction device
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
DE10043437A1 (de) 2000-09-04 2002-03-28 Horst Lindhofer Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites
IL161686A0 (en) 2001-11-01 2004-09-27 Uab Research Foundation Combinations of antibodies selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and other therapeutic agents
EP3050963B1 (en) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
AU2007227292B2 (en) 2006-03-17 2012-04-12 Biogen Ma Inc. Stabilized polypeptide compositions
CA2646965C (en) 2006-03-24 2016-06-21 Jonathan H. Davis Engineered heterodimeric protein domains
AT503902B1 (de) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw Verfahren zur manipulation von immunglobulinen
KR101799337B1 (ko) 2007-06-21 2017-12-20 마크로제닉스, 인크. 공유결합형 디아바디 및 이것의 사용
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
ES2563027T3 (es) 2008-01-07 2016-03-10 Amgen Inc. Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática
EP2540740B1 (en) 2008-06-17 2014-09-10 Apogenix GmbH Multimeric TNF receptors
SG10201407908VA (en) 2008-12-19 2015-01-29 Macrogenics Inc Covalent diabodies and uses thereof
EP2424567B1 (en) 2009-04-27 2018-11-21 OncoMed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
US20120070432A1 (en) 2009-05-28 2012-03-22 Amgen Inc. Treatment of pancreatic cancer using a dr5 agonist in combination with gemcitabine
MX368932B (es) 2009-06-26 2019-10-22 Regeneron Pharma Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original.
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
US9150663B2 (en) 2010-04-20 2015-10-06 Genmab A/S Heterodimeric antibody Fc-containing proteins and methods for production thereof
WO2011143545A1 (en) 2010-05-14 2011-11-17 Rinat Neuroscience Corporation Heterodimeric proteins and methods for producing and purifying them
JP5997154B2 (ja) 2010-08-16 2016-09-28 ノビミューン エスアー 多重特異性多価抗体の生成方法
WO2012025530A1 (en) 2010-08-24 2012-03-01 F. Hoffmann-La Roche Ag Bispecific antibodies comprising a disulfide stabilized - fv fragment
RU2013110876A (ru) 2010-08-24 2014-09-27 Рош Гликарт Аг Активируемые биспецифические антитела
RU2604490C2 (ru) 2010-11-05 2016-12-10 Займворкс Инк. ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ
CN102250246A (zh) 2011-06-10 2011-11-23 常州亚当生物技术有限公司 抗VEGF/PDGFRβ双特异性抗体及其应用
UA117901C2 (uk) 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
CN102654260B (zh) 2011-09-29 2014-09-03 北京京东方光电科技有限公司 一种背光源和液晶显示器
PL2794905T3 (pl) 2011-12-20 2020-11-02 Medimmune, Llc Zmodyfikowane polipeptydy dla rusztowań przeciwciał dwuswoistych
CN120383672A (zh) 2012-04-20 2025-07-29 美勒斯公司 用于产生免疫球蛋白样分子的方法和手段
JP6514103B2 (ja) * 2012-07-06 2019-05-15 ゲンマブ ビー.ブイ. 三重変異を有する二量体タンパク質
EP2684896A1 (en) 2012-07-09 2014-01-15 International-Drug-Development-Biotech Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
KR20220156667A (ko) * 2013-01-10 2022-11-25 젠맵 비. 브이 인간 IgG1 Fc 영역 변이체 및 그의 용도
CA3007031A1 (en) * 2015-12-01 2017-06-08 Genmab B.V. Anti-death receptor antibodies and methods of use thereof

Similar Documents

Publication Publication Date Title
US11103579B2 (en) Combination of DR5 agonist and anti-PD-1 antagonist and methods of use
JP2020522543A5 (OSRAM)
JP2019500869A5 (OSRAM)
JP7126941B2 (ja) がんを治療するための抗pd-1抗体と二重特異性抗cd20/抗cd3抗体の組合せ
JP2019501151A5 (OSRAM)
CN108602889A (zh) 医治急性成淋巴细胞性白血病的双特异性抗cd20/抗cd3抗体
JP2020501531A5 (OSRAM)
CN113825527A (zh) 用于在治疗癌症中增强效力的pd-1抑制剂和lag-3抑制剂的组合
JP7548924B2 (ja) がんの処置における増強された有効性のためのil-4/il-13経路阻害剤
ES2951864T3 (es) Combinación de un anticuerpo biespecífico ERBB-2/ERBB-3 con terapia endocrina para el cáncer de mama
JPWO2020232019A5 (OSRAM)
RU2836467C2 (ru) Ингибиторы пути il-4/il-13 для повышенной эффективности при лечении злокачественных новообразований
CN121175334A (zh) 在治疗癌症中的使用pd-l1抑制剂的新辅助免疫疗法
CA3009161C (en) Combination of anti-pd-1 antibodies and bispecific anti-cd20/anti-cd3 antibodies to treat cancer
CN116615238A (zh) 用于治疗癌症和减轻细胞因子释放综合征的抗体组合
CN120152716A (zh) 包括抗cd19抗体和ezh2调节剂的治疗
NZ743316A (en) Anti-dr5 antibodies and methods of use thereof
RU2019128199A (ru) 1-(4-амино-5-бром-6-(1h-пиразол-1-ил)пиримидин-2-ил)-1h-пиразол-4-ол и его применение в лечении рака
NZ743316B2 (en) Anti-dr5 antibodies and methods of use thereof
EA042623B1 (ru) Комбинация антител к pd-1 и биспецифических антител к cd20/cd3 для лечения злокачественной опухоли