JP2018515532A5 - - Google Patents

Info

Publication number

JP2018515532A5

JP2018515532A5 JP2017559119A JP2017559119A JP2018515532A5 JP 2018515532 A5 JP2018515532 A5 JP 2018515532A5 JP 2017559119 A JP2017559119 A JP 2017559119A JP 2017559119 A JP2017559119 A JP 2017559119A JP 2018515532 A5 JP2018515532 A5 JP 2018515532A5

Authority

JP

Japan

Prior art keywords

antibody

seq

type

hvr

sequence

Prior art date

2016-05-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 claims 40
• 208000005777 Lupus Nephritis Diseases 0.000 claims 11
• 229940079593 drug Drugs 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 5
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 5
• 239000003862 glucocorticoid Substances 0.000 claims 4
• 239000003018 immunosuppressive agent Substances 0.000 claims 4
• 206010025135 lupus erythematosus Diseases 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 210000003719 b-lymphocyte Anatomy 0.000 claims 3
• 239000003246 corticosteroid Substances 0.000 claims 3
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 3
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 3
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
• GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 2
• 229940125364 angiotensin receptor blocker Drugs 0.000 claims 2
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 2
• 230000001387 anti-histamine Effects 0.000 claims 2
• 239000000739 antihistaminic agent Substances 0.000 claims 2
• 230000017531 blood circulation Effects 0.000 claims 2
• 229960003444 immunosuppressant agent Drugs 0.000 claims 2
• 229940125721 immunosuppressive agent Drugs 0.000 claims 2
• RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 2
• 229960004866 mycophenolate mofetil Drugs 0.000 claims 2
• 230000002093 peripheral effect Effects 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
• 229940123038 Integrin antagonist Drugs 0.000 claims 1
• FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 1
• 230000003276 anti-hypertensive effect Effects 0.000 claims 1
• 230000000078 anti-malarial effect Effects 0.000 claims 1
• 229940030600 antihypertensive agent Drugs 0.000 claims 1
• 239000002220 antihypertensive agent Substances 0.000 claims 1
• 239000003430 antimalarial agent Substances 0.000 claims 1
• 229960002170 azathioprine Drugs 0.000 claims 1
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
• 229960004397 cyclophosphamide Drugs 0.000 claims 1
• 239000000430 cytokine receptor antagonist Substances 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 230000006735 deficit Effects 0.000 claims 1
• ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 1
• 229960000520 diphenhydramine Drugs 0.000 claims 1
• 239000012636 effector Substances 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 230000001861 immunosuppressant effect Effects 0.000 claims 1
• -1 integrin antagonist Substances 0.000 claims 1
• 229960004584 methylprednisolone Drugs 0.000 claims 1
• HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims 1
• 230000004048 modification Effects 0.000 claims 1
• 238000012986 modification Methods 0.000 claims 1
• 229960000951 mycophenolic acid Drugs 0.000 claims 1
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 1
• 229960005489 paracetamol Drugs 0.000 claims 1
• 229960004618 prednisone Drugs 0.000 claims 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1