JP2017527544A5 - - Google Patents

Info

Publication number

JP2017527544A5

JP2017527544A5 JP2017506827A JP2017506827A JP2017527544A5 JP 2017527544 A5 JP2017527544 A5 JP 2017527544A5 JP 2017506827 A JP2017506827 A JP 2017506827A JP 2017506827 A JP2017506827 A JP 2017506827A JP 2017527544 A5 JP2017527544 A5 JP 2017527544A5

Authority

JP

Japan

Prior art keywords

antigen

antibody

binding fragment

chain variable

variable region

Prior art date

2015-08-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000427 antigen Substances 0.000 claims 19
• 102000036639 antigens Human genes 0.000 claims 19
• 108091007433 antigens Proteins 0.000 claims 19
• 239000012634 fragment Substances 0.000 claims 19
• 229940106189 ceramide Drugs 0.000 claims 15
• 201000010099 disease Diseases 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 230000005855 radiation Effects 0.000 claims 4
• 230000006907 apoptotic process Effects 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 208000011580 syndromic disease Diseases 0.000 claims 3
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
• 210000001185 bone marrow Anatomy 0.000 claims 2
• 208000024908 graft versus host disease Diseases 0.000 claims 2
• 238000007913 intrathecal administration Methods 0.000 claims 2
• 230000002285 radioactive effect Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 230000000890 antigenic effect Effects 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000007912 intraperitoneal administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 230000006654 negative regulation of apoptotic process Effects 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 238000011200 topical administration Methods 0.000 claims 1