JP2018515530A5 - - Google Patents
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- Publication number
- JP2018515530A5 JP2018515530A5 JP2017559086A JP2017559086A JP2018515530A5 JP 2018515530 A5 JP2018515530 A5 JP 2018515530A5 JP 2017559086 A JP2017559086 A JP 2017559086A JP 2017559086 A JP2017559086 A JP 2017559086A JP 2018515530 A5 JP2018515530 A5 JP 2018515530A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- starch
- acid
- microparticles
- polyinosinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 60
- 239000011859 microparticle Substances 0.000 claims description 57
- 229920002472 Starch Polymers 0.000 claims description 29
- 239000002253 acid Substances 0.000 claims description 29
- 239000008107 starch Substances 0.000 claims description 29
- 235000019698 starch Nutrition 0.000 claims description 29
- 230000009385 viral infection Effects 0.000 claims description 13
- 206010062106 Respiratory tract infection viral Diseases 0.000 claims description 11
- 208000036142 Viral infection Diseases 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 241000430519 Human rhinovirus sp. Species 0.000 claims description 4
- 206010061494 Rhinovirus infection Diseases 0.000 claims description 4
- 210000002345 respiratory system Anatomy 0.000 claims description 4
- 241000712461 unidentified influenza virus Species 0.000 claims description 4
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 230000015788 innate immune response Effects 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 19
- 229940115272 polyinosinic:polycytidylic acid Drugs 0.000 description 19
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15167129 | 2015-05-11 | ||
| EP15167129.4 | 2015-05-11 | ||
| PCT/IB2016/000890 WO2016181226A1 (en) | 2015-05-11 | 2016-05-10 | Polyinosinic-polycytidylic acid (poly(i:c)) pea starch formulation for the prevention and/or treatment of upper respiratory tract infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018515530A JP2018515530A (ja) | 2018-06-14 |
| JP2018515530A5 true JP2018515530A5 (enExample) | 2019-06-13 |
Family
ID=53174864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559086A Pending JP2018515530A (ja) | 2015-05-11 | 2016-05-10 | 上気道感染症の予防および／または治療のためのポリイノシン酸−ポリシチジル酸（ポリ（ｉ：ｃ））のエンドウマメデンプン製剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180353533A1 (enExample) |
| EP (1) | EP3294268A1 (enExample) |
| JP (1) | JP2018515530A (enExample) |
| KR (1) | KR20180004233A (enExample) |
| CN (1) | CN107820423A (enExample) |
| AU (1) | AU2016259869A1 (enExample) |
| CA (1) | CA2983659A1 (enExample) |
| HK (1) | HK1251926A1 (enExample) |
| MA (1) | MA44384A (enExample) |
| RU (1) | RU2017142710A (enExample) |
| TW (1) | TW201705963A (enExample) |
| WO (1) | WO2016181226A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112423771B (zh) * | 2018-07-20 | 2023-05-09 | 株式会社资生堂 | 病毒灭活剂 |
| CU20200110A7 (es) * | 2020-12-23 | 2022-08-09 | Ct Ingenieria Genetica Biotecnologia | Péptidos para el tratamiento de infecciones respiratorias de origen viral |
| KR102439760B1 (ko) | 2021-03-09 | 2022-09-02 | 주식회사 오라팜 | 상기도 감염균 질환 예방 및 치료를 위한 조성물 |
| KR102451861B1 (ko) | 2021-03-09 | 2022-10-07 | 주식회사 오라팜 | 급성 호흡기 바이러스 및 로타바이러스 감염 질환 예방 및 치료를 위한 조성물 |
| CN114917242A (zh) * | 2022-05-31 | 2022-08-19 | 复旦大学附属中山医院 | 合成双链rna类似物经滴鼻预防呼吸道传播病毒的应用及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| CN101229378A (zh) * | 2005-05-05 | 2008-07-30 | 国家淀粉及化学投资控股公司 | 用于送递活性剂的组合物 |
| JP2009209086A (ja) * | 2008-03-04 | 2009-09-17 | Masami Moriyama | 粘膜投与型ワクチン |
| CN101757018A (zh) * | 2008-12-24 | 2010-06-30 | 天津瑞普生物技术股份有限公司 | 一种用于畜禽的聚肌胞干粉及其制备方法 |
| CN102988303A (zh) * | 2011-09-15 | 2013-03-27 | 天津泽世德生物医药有限公司 | 一种多聚肌苷酸多聚胞苷酸冻干粉针的制备方法 |
| US9682096B2 (en) * | 2012-05-02 | 2017-06-20 | Janssen R & D Ireland | Polyinosinic-polycytidylic acid (poly (I:C)) formulations for the treatment of upper respiratory tract infections |
| TWI643082B (zh) * | 2013-09-03 | 2018-12-01 | 美商新思科技股份有限公司 | 一種佈線出一解決路徑之方法及系統 |
| WO2015067632A1 (en) * | 2013-11-06 | 2015-05-14 | Janssen Sciences Ireland Uc | Polylnosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
-
2016
- 2016-05-10 US US15/573,227 patent/US20180353533A1/en not_active Abandoned
- 2016-05-10 CN CN201680040346.1A patent/CN107820423A/zh active Pending
- 2016-05-10 KR KR1020177035145A patent/KR20180004233A/ko not_active Withdrawn
- 2016-05-10 WO PCT/IB2016/000890 patent/WO2016181226A1/en not_active Ceased
- 2016-05-10 AU AU2016259869A patent/AU2016259869A1/en not_active Abandoned
- 2016-05-10 CA CA2983659A patent/CA2983659A1/en not_active Abandoned
- 2016-05-10 HK HK18111254.8A patent/HK1251926A1/zh unknown
- 2016-05-10 JP JP2017559086A patent/JP2018515530A/ja active Pending
- 2016-05-10 RU RU2017142710A patent/RU2017142710A/ru not_active Application Discontinuation
- 2016-05-10 EP EP16753457.7A patent/EP3294268A1/en not_active Withdrawn
- 2016-05-10 MA MA044384A patent/MA44384A/fr unknown
- 2016-05-11 TW TW105114594A patent/TW201705963A/zh unknown
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