JP2018514534A5 - - Google Patents
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- JP2018514534A5 JP2018514534A5 JP2017555791A JP2017555791A JP2018514534A5 JP 2018514534 A5 JP2018514534 A5 JP 2018514534A5 JP 2017555791 A JP2017555791 A JP 2017555791A JP 2017555791 A JP2017555791 A JP 2017555791A JP 2018514534 A5 JP2018514534 A5 JP 2018514534A5
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- Prior art keywords
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- 239000000203 mixture Substances 0.000 claims description 73
- 239000002245 particle Substances 0.000 claims description 36
- 229960001601 obeticholic acid Drugs 0.000 claims description 32
- ZXERDUOLZKYMJM-ZWECCWDJSA-N obeticholic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)CCC(O)=O)CC[C@H]21 ZXERDUOLZKYMJM-ZWECCWDJSA-N 0.000 claims description 32
- 150000001413 amino acids Chemical class 0.000 claims description 23
- 150000002148 esters Chemical class 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 23
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 11
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 208000019423 liver disease Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 6
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 6
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 6
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 229920000080 bile acid sequestrant Polymers 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 4
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims description 3
- 208000022309 Alcoholic Liver disease Diseases 0.000 claims description 3
- 208000005176 Hepatitis C Diseases 0.000 claims description 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 208000010710 hepatitis C virus infection Diseases 0.000 claims description 3
- 238000010902 jet-milling Methods 0.000 claims description 3
- 230000000750 progressive effect Effects 0.000 claims description 3
- 208000010157 sclerosing cholangitis Diseases 0.000 claims description 3
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 claims description 3
- 229960001661 ursodiol Drugs 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 206010067125 Liver injury Diseases 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 231100000234 hepatic damage Toxicity 0.000 claims description 2
- 230000008818 liver damage Effects 0.000 claims description 2
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 2
- 229920003109 sodium starch glycolate Polymers 0.000 claims description 2
- 239000008109 sodium starch glycolate Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 2
- 229940009976 deoxycholate Drugs 0.000 claims 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 1
- MXBCYQUALCBQIJ-RYVPXURESA-N (8s,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 MXBCYQUALCBQIJ-RYVPXURESA-N 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021143835A JP2021183651A (ja) | 2015-04-27 | 2021-09-03 | オベチコール酸の組成物および使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562153040P | 2015-04-27 | 2015-04-27 | |
| US62/153,040 | 2015-04-27 | ||
| US201662317933P | 2016-04-04 | 2016-04-04 | |
| US62/317,933 | 2016-04-04 | ||
| PCT/US2016/029369 WO2016176208A1 (en) | 2015-04-27 | 2016-04-26 | Compositions of obeticholic acid and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021143835A Division JP2021183651A (ja) | 2015-04-27 | 2021-09-03 | オベチコール酸の組成物および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514534A JP2018514534A (ja) | 2018-06-07 |
| JP2018514534A5 true JP2018514534A5 (OSRAM) | 2019-05-16 |
| JP6941057B2 JP6941057B2 (ja) | 2021-09-29 |
Family
ID=57198868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555791A Active JP6941057B2 (ja) | 2015-04-27 | 2016-04-26 | オベチコール酸の組成物および使用方法 |
| JP2021143835A Pending JP2021183651A (ja) | 2015-04-27 | 2021-09-03 | オベチコール酸の組成物および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021143835A Pending JP2021183651A (ja) | 2015-04-27 | 2021-09-03 | オベチコール酸の組成物および使用方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US10052337B2 (OSRAM) |
| EP (3) | EP3971199A1 (OSRAM) |
| JP (2) | JP6941057B2 (OSRAM) |
| KR (1) | KR20170140325A (OSRAM) |
| CN (1) | CN107531742A (OSRAM) |
| AU (2) | AU2016255045B2 (OSRAM) |
| BR (1) | BR112017023161A2 (OSRAM) |
| CA (1) | CA2983609C (OSRAM) |
| CL (1) | CL2017002727A1 (OSRAM) |
| CO (1) | CO2017011535A2 (OSRAM) |
| CR (1) | CR20170492A (OSRAM) |
| EA (1) | EA201792354A1 (OSRAM) |
| EC (1) | ECSP17078433A (OSRAM) |
| IL (2) | IL294575A (OSRAM) |
| MA (1) | MA41999A (OSRAM) |
| MX (1) | MX2017013805A (OSRAM) |
| NI (1) | NI201700128A (OSRAM) |
| PE (1) | PE20180690A1 (OSRAM) |
| PH (1) | PH12017501956A1 (OSRAM) |
| SG (2) | SG10202003110PA (OSRAM) |
| SV (1) | SV2017005555A (OSRAM) |
| TN (1) | TN2017000452A1 (OSRAM) |
| TW (1) | TWI723017B (OSRAM) |
| WO (1) | WO2016176208A1 (OSRAM) |
| ZA (1) | ZA201707981B (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| PE20180690A1 (es) * | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
| ES2901598T3 (es) * | 2016-03-31 | 2022-03-23 | Intercept Pharmaceuticals Inc | Comprimido recubierto con película que tiene una alta estabilidad química del ingrediente activo |
| CA3020698A1 (en) * | 2016-04-13 | 2017-10-19 | Intercept Pharmaceuticals, Inc. | Methods of treating or preventing hepatocellular carcinoma |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| AU2017290710A1 (en) * | 2016-06-29 | 2019-01-24 | Menlo Therapeutics Inc. | Use of neurokinin-1 antagonists to treat a variety of pruritic conditions |
| EP3534976A4 (en) | 2016-11-04 | 2020-09-16 | Children's Hospital Medical Center | PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE |
| CN108072729A (zh) * | 2016-11-18 | 2018-05-25 | 华北制药集团新药研究开发有限责任公司 | 一种测定奥贝胆酸片溶出度的方法 |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| CN108614038B (zh) * | 2016-12-13 | 2022-05-17 | 亚宝药业集团股份有限公司 | 一种测定奥贝胆酸原料药有关物质的方法 |
| CN106645497A (zh) * | 2017-01-03 | 2017-05-10 | 山东省药学科学院 | 一种奥贝胆酸及其制剂中有关物质的检测方法 |
| TW201832768A (zh) * | 2017-03-07 | 2018-09-16 | 英特賽普醫藥品公司 | 治療癌症的方法 |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| CN111050772A (zh) * | 2017-07-24 | 2020-04-21 | 英特塞普特医药品公司 | 同位素标记的胆汁酸衍生物 |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| WO2019106043A1 (en) * | 2017-11-29 | 2019-06-06 | Hexal Ag | Pharmaceutical composition comprising obeticholic acid |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| CN108572251B (zh) * | 2018-05-31 | 2020-01-17 | 中国科学院昆明动物研究所 | 肝硬化早期小分子标志物及其应用 |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
| US11524029B2 (en) | 2018-08-13 | 2022-12-13 | Viscera Labs, Inc. | Therapeutic composition and methods |
| WO2020056158A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| JP2022506782A (ja) * | 2018-11-08 | 2022-01-17 | インターセプト ファーマシューティカルズ， インコーポレイテッド | オベチコール酸の使用方法 |
| CN109432431B (zh) * | 2018-12-14 | 2020-06-30 | 中国药科大学 | 一种含有sumo抑制剂的组合物及应用 |
| CN109655571B (zh) * | 2019-01-08 | 2021-07-13 | 丽珠集团新北江制药股份有限公司 | 一种奥贝胆酸的高效液相色谱分析方法 |
| CN109620812B (zh) * | 2019-01-16 | 2023-07-21 | 浙江华海药业股份有限公司 | 一种奥贝胆酸组合物的制备方法 |
| AU2020247991A1 (en) * | 2019-03-26 | 2021-10-21 | Intercept Pharmaceuticals, Inc. | Methods of diagnosis and treatment of liver diseases using obeticholic acid |
| WO2020198576A1 (en) * | 2019-03-28 | 2020-10-01 | The Board Of Trustees Of The University Of Illinois | Methods of modulating regulatory t cells |
| JP2022550312A (ja) * | 2019-09-30 | 2022-12-01 | ノバルティス アーゲー | Ｆｘｒアゴニストの使用を含む処置 |
| WO2021176430A1 (ru) * | 2020-03-06 | 2021-09-10 | Актив Трєнд Лимитєд | Применение группы маркеров для диагностики и коррекции лечения первичного билиарного холангита, фармацевтическая композиция и твердая дозированная форма для лечения первичного билиарного холангита |
| CN111518152B (zh) * | 2020-04-23 | 2022-11-22 | 江西青峰药业有限公司 | 一种3α,7α-二羟基-6α-乙基-5β-胆烷-24-醛的制备方法及其应用 |
| WO2021231539A1 (en) * | 2020-05-13 | 2021-11-18 | Children's Hospital Medical Center | Alleviation of liver injury by activating the signaling pathway mediated by farnesoid x receptor |
| CN111690731B (zh) * | 2020-05-22 | 2021-09-28 | 河南大学 | Fxr激动剂在治疗肝性脑病中的应用 |
| CN111812264B (zh) * | 2020-07-09 | 2021-06-15 | 苏州旭辉检测有限公司 | 一种去氧胆酸类化合物的生物样品分析方法 |
| WO2022051321A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a fxr agonist |
| WO2022076683A1 (en) * | 2020-10-07 | 2022-04-14 | Intercept Pharmaceuticals, Inc. | Methods of treating coronaviral infection with obeticholic acid |
| CN113143950B (zh) * | 2021-05-17 | 2023-04-18 | 河北医科大学第二医院 | 一种治疗肝病的药物组合物及其应用 |
| WO2023147141A1 (en) * | 2022-01-28 | 2023-08-03 | Intercept Pharmaceuticals, Inc. | Combination therapy |
| WO2023181077A1 (en) * | 2022-03-24 | 2023-09-28 | Zenvision Pharma Llp | Stable liquid composition comprising obeticholic acid or salts thereof |
| US12343351B2 (en) | 2022-03-25 | 2025-07-01 | Rutgers, The State University Of New Jersey | Pulmonary function treatment |
| AU2023257308A1 (en) * | 2022-04-21 | 2024-10-10 | Intercept Pharmaceuticals, Inc. | Uses of farnesoid x receptor agonists |
| WO2024043842A1 (en) * | 2022-08-22 | 2024-02-29 | Pharmactive Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical compositions comprising chenodeoxycholic acid (cdca) as active ingredient and other relevant excipients |
| WO2024104960A1 (en) | 2022-11-15 | 2024-05-23 | Synthon B.V. | Stable formulation comprising obeticholic acid |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| ZA876640B (en) | 1986-09-26 | 1988-03-08 | Warner-Lambert Company | Treated lipid regulator |
| UA72207C2 (uk) | 1998-04-07 | 2005-02-15 | Брістол- Майєрс Сквібб Фарма Компані | Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення |
| US7078376B1 (en) * | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
| US7138390B2 (en) * | 2001-03-12 | 2006-11-21 | Intercept Pharmaceuticals | Steroids as agonists for FXR |
| CN100350977C (zh) | 2001-06-14 | 2007-11-28 | 大塚制药株式会社 | 药物组合物 |
| US6933380B2 (en) | 2001-10-19 | 2005-08-23 | Yung-Zip Chemical Ind. Co., Ltd. | Excipients containing low residual solvent and method for producing the same |
| JP2006509722A (ja) * | 2002-07-03 | 2006-03-23 | エスペリオン セラピューティクス，インコーポレイテッド | 脂質代謝異常を治療するためのパンテチン含有組成物 |
| US20050101505A1 (en) * | 2003-11-06 | 2005-05-12 | Daniel Wood | Liquid laundry detergent composition having improved color-care properties |
| GB0402492D0 (en) | 2004-02-04 | 2004-03-10 | Pfizer Ltd | Pharmaceutically active compounds |
| GB0425758D0 (en) * | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| CA2614409C (en) * | 2005-07-07 | 2014-05-20 | Nanotherapeutics, Inc | Process for milling and preparing powders and compositions produced thereby |
| DE102007009242A1 (de) | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit magensaftresistenter Wirkstoff-Matix |
| RU2011139643A (ru) * | 2009-03-17 | 2013-04-27 | Акскан Фарма, Инк. | Способ лечения неалкогольного стеатогепатита повышенными дозами урсодезоксихолевой кислоты |
| US20120160944A1 (en) | 2009-04-24 | 2012-06-28 | Aaron Dodd | Method for the production of commercial nanoparticle and micro particle powders |
| AU2011244783B2 (en) | 2010-04-20 | 2015-11-12 | Cipla Limited | Pharmaceutical compositions |
| ES2822375T3 (es) * | 2012-06-19 | 2021-04-30 | Intercept Pharmaceuticals Inc | Preparación de la forma no cristalina del ácido obeticólico |
| US9814733B2 (en) * | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| CN105592846A (zh) | 2013-03-15 | 2016-05-18 | 持田制药株式会社 | 用于治疗非酒精性脂肪性肝炎的组合物和方法 |
| HRP20180931T1 (hr) | 2013-05-14 | 2018-10-05 | Intercept Pharmaceuticals, Inc. | 11-hidroksil-6-supstituirani-derivati žučnih kiselina i njihovi aminokiselinski konjugati kao modulatori receptora za farnezoid x |
| LT3043865T (lt) * | 2013-09-11 | 2021-04-26 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Hepatito b viruso infekcijos gydymo būdai ir farmacinė kompozicija |
| CN105801653B (zh) | 2014-12-30 | 2018-04-17 | 苏州晶云药物科技有限公司 | 奥贝胆酸的晶型a及其制备方法 |
| PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
-
2016
- 2016-04-24 PE PE2017002334A patent/PE20180690A1/es unknown
- 2016-04-26 AU AU2016255045A patent/AU2016255045B2/en active Active
- 2016-04-26 IL IL294575A patent/IL294575A/en unknown
- 2016-04-26 EA EA201792354A patent/EA201792354A1/ru unknown
- 2016-04-26 KR KR1020177033948A patent/KR20170140325A/ko not_active Withdrawn
- 2016-04-26 MX MX2017013805A patent/MX2017013805A/es unknown
- 2016-04-26 CR CR20170492A patent/CR20170492A/es unknown
- 2016-04-26 SG SG10202003110PA patent/SG10202003110PA/en unknown
- 2016-04-26 EP EP21189718.6A patent/EP3971199A1/en not_active Withdrawn
- 2016-04-26 MA MA041999A patent/MA41999A/fr unknown
- 2016-04-26 BR BR112017023161-1A patent/BR112017023161A2/pt not_active Application Discontinuation
- 2016-04-26 CA CA2983609A patent/CA2983609C/en active Active
- 2016-04-26 TN TNP/2017/000452A patent/TN2017000452A1/en unknown
- 2016-04-26 US US15/139,138 patent/US10052337B2/en active Active
- 2016-04-26 WO PCT/US2016/029369 patent/WO2016176208A1/en not_active Ceased
- 2016-04-26 CN CN201680023889.2A patent/CN107531742A/zh active Pending
- 2016-04-26 EP EP16787000.5A patent/EP3288958A4/en not_active Withdrawn
- 2016-04-26 JP JP2017555791A patent/JP6941057B2/ja active Active
- 2016-04-26 IL IL255269A patent/IL255269B/en unknown
- 2016-04-26 SG SG11201708606VA patent/SG11201708606VA/en unknown
- 2016-04-26 EP EP24154375.0A patent/EP4371616A3/en active Pending
- 2016-04-27 TW TW105113063A patent/TWI723017B/zh active
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2017
- 2017-10-26 CL CL2017002727A patent/CL2017002727A1/es unknown
- 2017-10-26 PH PH12017501956A patent/PH12017501956A1/en unknown
- 2017-10-26 NI NI201700128A patent/NI201700128A/es unknown
- 2017-10-27 SV SV2017005555A patent/SV2017005555A/es unknown
- 2017-11-10 CO CONC2017/0011535A patent/CO2017011535A2/es unknown
- 2017-11-23 ZA ZA2017/07981A patent/ZA201707981B/en unknown
- 2017-11-24 EC ECIEPI201778433A patent/ECSP17078433A/es unknown
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2018
- 2018-07-09 US US16/030,141 patent/US10646499B2/en active Active
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2019
- 2019-01-15 US US16/248,512 patent/US10751349B2/en active Active
- 2019-10-08 US US16/596,741 patent/US20200046736A1/en not_active Abandoned
- 2019-10-08 US US16/596,216 patent/US20200046735A1/en not_active Abandoned
- 2019-10-09 US US16/597,412 patent/US20200054650A1/en not_active Abandoned
-
2020
- 2020-02-11 US US16/787,796 patent/US10758549B2/en active Active
- 2020-07-16 AU AU2020205315A patent/AU2020205315A1/en not_active Abandoned
-
2021
- 2021-09-03 JP JP2021143835A patent/JP2021183651A/ja active Pending
- 2021-12-06 US US17/542,923 patent/US20220133745A1/en not_active Abandoned
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