JP2018513681A - 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系 - Google Patents

細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系 Download PDF

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JP2018513681A
JP2018513681A JP2017552079A JP2017552079A JP2018513681A JP 2018513681 A JP2018513681 A JP 2018513681A JP 2017552079 A JP2017552079 A JP 2017552079A JP 2017552079 A JP2017552079 A JP 2017552079A JP 2018513681 A JP2018513681 A JP 2018513681A
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protein
sequence
dna
integrase
cas9
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JP2018513681A5 (enExample
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シャイフ，フェルフ
川村哲也
モー，グロリア
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Exeligen Scientific inc
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Exeligen Scientific inc
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Priority to JP2021110120A priority Critical patent/JP7882491B2/ja
Priority to JP2023121860A priority patent/JP7599740B2/ja
Priority to JP2024205951A priority patent/JP2025065094A/ja
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
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JP2017552079A 2015-03-31 2016-03-31 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系 Pending JP2018513681A (ja)

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JP2021110120A JP7882491B2 (ja) 2015-03-31 2021-07-01 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
JP2023121860A JP7599740B2 (ja) 2015-03-31 2023-07-26 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
JP2024205951A JP2025065094A (ja) 2015-03-31 2024-11-27 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系

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US201562140454P 2015-03-31 2015-03-31
US62/140,454 2015-03-31
US201562210451P 2015-08-27 2015-08-27
US62/210,451 2015-08-27
US201562240359P 2015-10-12 2015-10-12
US62/240,359 2015-10-12
PCT/US2016/025426 WO2016161207A1 (en) 2015-03-31 2016-03-31 Cas 9 retroviral integrase and cas 9 recombinase systems for targeted incorporation of a dna sequence into a genome of a cell or organism

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JP2017552079A Pending JP2018513681A (ja) 2015-03-31 2016-03-31 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
JP2021110120A Active JP7882491B2 (ja) 2015-03-31 2021-07-01 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
JP2023121860A Active JP7599740B2 (ja) 2015-03-31 2023-07-26 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
JP2024205951A Pending JP2025065094A (ja) 2015-03-31 2024-11-27 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系

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JP2021110120A Active JP7882491B2 (ja) 2015-03-31 2021-07-01 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
JP2023121860A Active JP7599740B2 (ja) 2015-03-31 2023-07-26 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
JP2024205951A Pending JP2025065094A (ja) 2015-03-31 2024-11-27 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系

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US (2) US20180080051A1 (enExample)
EP (2) EP4600366A3 (enExample)
JP (4) JP2018513681A (enExample)
KR (3) KR102894634B1 (enExample)
CN (1) CN108124453B (enExample)
DK (1) DK3277805T3 (enExample)
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Cited By (8)

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JP2022513376A (ja) * 2018-10-22 2022-02-07 ユニバーシティ オブ ロチェスター レトロウイルスインテグラーゼ－Ｃａｓ９融合タンパク質を使用した指向性非相同ＤＮＡ挿入によるゲノム編集
JP2022521432A (ja) * 2019-02-25 2022-04-07 ユニバーシティ オブ マサチューセッツ Ｄｎａ結合ドメイントランスアクチベーター及びその使用
JP2022532939A (ja) * 2019-05-23 2022-07-20 クリスティアナ ケア ヘルス サービシズ，インコーポレーテッド がんを処置するためのｎｒｆ２の遺伝子ノックアウト
JP2022533268A (ja) * 2019-05-23 2022-07-21 クリスティアナ ケア ヘルス サービシズ，インコーポレーテッド がんを処置するためのバリアントｎｒｆ２の遺伝子ノックアウト
JP2022540318A (ja) * 2019-06-11 2022-09-15 ウニベルシタット ポンペウ ファブラ 標的遺伝子編集構築物およびそれを使用する方法
JP2023535025A (ja) * 2020-07-24 2023-08-15 ユニバーシティ オブ マサチューセッツ Ｄｎａ結合ドメイントランス活性化因子およびその使用
JP2023553701A (ja) * 2020-12-16 2023-12-25 ウニベルシタット ポンペウ ファブラ 先天性筋ジストロフィーの処置のための治療用ｌａｍａ２ペイロード
JP2023554504A (ja) * 2020-12-16 2023-12-27 ユニバーシタット ポンペウ ファブラ プログラム可能なトランスポザーゼおよびその使用

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