JP2018513107A5 - - Google Patents
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- JP2018513107A5 JP2018513107A5 JP2017542390A JP2017542390A JP2018513107A5 JP 2018513107 A5 JP2018513107 A5 JP 2018513107A5 JP 2017542390 A JP2017542390 A JP 2017542390A JP 2017542390 A JP2017542390 A JP 2017542390A JP 2018513107 A5 JP2018513107 A5 JP 2018513107A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutical composition
- disorder
- disease
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(C1)=CC=C1C(C(N([C@@](C1)C(NCC(CC(c2cnc(C(F)(F)F)nc2)N=C2)=C2F)=O)C2(CC2)[C@@]1F)=N)=* Chemical compound *C(C1)=CC=C1C(C(N([C@@](C1)C(NCC(CC(c2cnc(C(F)(F)F)nc2)N=C2)=C2F)=O)C2(CC2)[C@@]1F)=N)=* 0.000 description 3
- KNUQIWPBVMPOGX-WILYLXEWSA-N C[C@@H]([C@@H](C[C@H]1C(NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2OC(F)(F)F)=O)F)N1S(c(cc1)ccc1F)(=O)=O Chemical compound C[C@@H]([C@@H](C[C@H]1C(NCc2cc(-c3cnc(C(F)(F)F)nc3)ncc2OC(F)(F)F)=O)F)N1S(c(cc1)ccc1F)(=O)=O KNUQIWPBVMPOGX-WILYLXEWSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2015/073102 | 2015-02-15 | ||
| CN2015073102 | 2015-02-15 | ||
| CNPCT/CN2015/076318 | 2015-04-10 | ||
| CN2015076318 | 2015-04-10 | ||
| CN2016071061 | 2016-01-15 | ||
| CNPCT/CN2016/071061 | 2016-01-15 | ||
| PCT/EP2016/052950 WO2016128529A1 (en) | 2015-02-15 | 2016-02-12 | 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513107A JP2018513107A (ja) | 2018-05-24 |
| JP2018513107A5 true JP2018513107A5 (https=) | 2019-03-22 |
| JP6700291B2 JP6700291B2 (ja) | 2020-05-27 |
Family
ID=55349845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017542390A Active JP6700291B2 (ja) | 2015-02-15 | 2016-02-12 | １−（ｈｅｔ）アリールスルホニル−（ピロリジン又はピペリジン）−２−カルボキサミド誘導体、及びｔｒｐａ１拮抗薬としてのそれらの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10179782B2 (https=) |
| EP (1) | EP3256463B1 (https=) |
| JP (1) | JP6700291B2 (https=) |
| KR (1) | KR20170118166A (https=) |
| CN (1) | CN107922392B (https=) |
| AU (1) | AU2016217851A1 (https=) |
| BR (1) | BR112017017052A2 (https=) |
| CA (1) | CA2975196A1 (https=) |
| CL (1) | CL2017001987A1 (https=) |
| CO (1) | CO2017007679A2 (https=) |
| CR (1) | CR20170367A (https=) |
| EA (1) | EA033497B1 (https=) |
| IL (1) | IL253478A0 (https=) |
| MX (1) | MX2017010300A (https=) |
| PE (1) | PE20180177A1 (https=) |
| PH (1) | PH12017501478A1 (https=) |
| PT (1) | PT3256463T (https=) |
| SG (1) | SG11201706451TA (https=) |
| TW (1) | TW201639829A (https=) |
| WO (1) | WO2016128529A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
| MX368615B (es) | 2012-09-25 | 2019-10-09 | Hoffmann La Roche | Derivados bicíclicos como inhibidores de la autotaxina (atx) que son inhibidores de la producción de ácido lisofosfatídico (lpa) y el uso de los mismos. |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| DK3074400T3 (en) | 2013-11-26 | 2018-01-15 | Hoffmann La Roche | Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors |
| EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| TWI676626B (zh) * | 2014-04-23 | 2019-11-11 | 美商美國禮來大藥廠 | 抑制瞬時受體電位ａ１離子通道 |
| TWI735416B (zh) | 2014-10-06 | 2021-08-11 | 美商維泰克斯製藥公司 | 囊腫纖維化症跨膜傳導調節蛋白之調節劑 |
| AU2016229268B2 (en) | 2015-03-06 | 2020-09-10 | Pharmakea, Inc. | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof |
| EP3265445B1 (en) | 2015-03-06 | 2021-05-05 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| WO2017003862A1 (en) * | 2015-07-01 | 2017-01-05 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ａｔｘ阻害剤としての二環式化合物 |
| AU2016328436B2 (en) | 2015-09-24 | 2020-05-14 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual ATX/CA inhibitors |
| WO2017050732A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| MA43978A (fr) | 2016-02-05 | 2018-12-12 | Ea Pharma Co Ltd | Dérivé de sulfonamide hétérocyclique et médicament le contenant |
| EP3487853B1 (en) * | 2016-07-20 | 2022-06-08 | F. Hoffmann-La Roche AG | Bicyclic proline compounds |
| EP3487849A1 (en) | 2016-07-20 | 2019-05-29 | H. Hoffnabb-La Roche Ag | Sulfonylcycloalkyl carboxamide compounds as trpa1 modulators |
| WO2018029288A1 (en) * | 2016-08-12 | 2018-02-15 | F. Hoffmann-La Roche Ag | Sulfonyl pyridyl trp inhibitors |
| CA3036064A1 (en) | 2016-09-07 | 2018-03-15 | Pharmakea, Inc. | Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making |
| WO2018048942A1 (en) | 2016-09-07 | 2018-03-15 | Pharmakea, Inc. | Uses of a lysyl oxidase-like 2 inhibitor |
| CN110267948B (zh) | 2016-12-09 | 2023-12-08 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调控剂的调节剂、药物组合物、治疗方法和制备所述调节剂的方法 |
| WO2018109155A1 (en) | 2016-12-16 | 2018-06-21 | Galderma Research & Development | Trpa1 antagonists for use in the treatment of atopic dermatitis |
| UY37556A (es) | 2017-01-10 | 2018-07-31 | Bayer Ag | Derivados heterocíclicos como pesticidas |
| RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
| AU2018279646B2 (en) | 2017-06-08 | 2023-04-06 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| MA49631A (fr) | 2017-07-17 | 2020-05-27 | Vertex Pharma | Méthodes de traitement de la fibrose kystique |
| TWI799435B (zh) | 2017-08-02 | 2023-04-21 | 美商維泰克斯製藥公司 | 製備化合物之製程 |
| US10654829B2 (en) | 2017-10-19 | 2020-05-19 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
| KR102716244B1 (ko) | 2017-12-08 | 2024-10-14 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법 |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| TW202000201A (zh) | 2018-02-20 | 2020-01-01 | 瑞士商赫孚孟拉羅股份公司 | 製備1-芳基磺醯基-吡咯啶-2-甲醯胺瞬時受體電位通道拮抗劑化合物及其結晶型式之方法 |
| US10710994B2 (en) | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| WO2020116296A1 (ja) | 2018-12-07 | 2020-06-11 | ユニマテック株式会社 | 含フッ素ピリミジン化合物およびその製造方法 |
| CN110156834A (zh) * | 2019-06-05 | 2019-08-23 | 镇江市高等专科学校 | 一种黄色荧光铜(i)配合物及其制备方法和应用 |
| US12448362B2 (en) | 2020-05-19 | 2025-10-21 | Unimatec Co., Ltd. | Fluorine-containing pyrimidine compound and fluorine-containing pyrimidinone compound |
| FR3114235A1 (fr) | 2020-09-18 | 2022-03-25 | Université Grenoble Alpes | Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer |
| CA3198930A1 (en) * | 2020-11-19 | 2022-05-27 | Acousia Therapeutics Gmbh | Non-aqueous gel composition |
| IT202100015098A1 (it) | 2021-06-09 | 2022-12-09 | Flonext S R L | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
| US20250064846A1 (en) * | 2022-01-07 | 2025-02-27 | The Johns Hopkins University | Treatment and prevention of trigeminal neuralgia |
| AR131541A1 (es) | 2023-01-07 | 2025-04-09 | Syngenta Crop Protection Ag | Compuestos de carboxamida novedosos |
| WO2025109114A1 (en) | 2023-11-24 | 2025-05-30 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| WO2025124698A1 (en) | 2023-12-12 | 2025-06-19 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| TW202542165A (zh) | 2023-12-19 | 2025-11-01 | 瑞士商愛杜西亞製藥有限公司 | 大環食慾素激動劑 |
| WO2025149637A1 (en) | 2024-01-12 | 2025-07-17 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| PY2501648A (es) | 2024-01-12 | 2025-10-31 | Syngenta Crop Protection Ag | Nuevos compuestos de carboxamida |
| WO2025155669A1 (en) * | 2024-01-17 | 2025-07-24 | The Jackson Laboratory | Trpc3 inhibitors and uses thereof |
| WO2026008750A1 (en) | 2024-07-05 | 2026-01-08 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010141805A1 (en) * | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
| EP2520566A1 (en) | 2011-05-06 | 2012-11-07 | Orion Corporation | New Pharmaceutical Compounds |
| WO2013108857A1 (ja) * | 2012-01-17 | 2013-07-25 | 味の素株式会社 | 複素環アミド誘導体及びそれを含有する医薬 |
| JP6301842B2 (ja) * | 2012-12-18 | 2018-03-28 | Ｅａファーマ株式会社 | 複素環アミド誘導体及びそれを含有する医薬 |
| US9394308B2 (en) * | 2013-01-18 | 2016-07-19 | Merck Sharp & Dohme Corp. | Inhibiting the transient receptor potential A1 ion channel |
| TW201441225A (zh) * | 2013-01-18 | 2014-11-01 | Cubist Pharm Inc | 瞬時受體電位ａ１離子通道之抑制 |
| PL3055302T3 (pl) | 2013-10-11 | 2019-05-31 | Hoffmann La Roche | Podstawione związki heterocykliczne sulfonamidowe użyteczne jako modulatory TRPA1 |
| CN106458952B (zh) | 2014-01-28 | 2019-09-27 | Ea制药株式会社 | 杂环磺酰胺衍生物及含有所述杂环磺酰胺衍生物的药物 |
-
2016
- 2016-02-12 JP JP2017542390A patent/JP6700291B2/ja active Active
- 2016-02-12 AU AU2016217851A patent/AU2016217851A1/en not_active Abandoned
- 2016-02-12 WO PCT/EP2016/052950 patent/WO2016128529A1/en not_active Ceased
- 2016-02-12 EA EA201791836A patent/EA033497B1/ru not_active IP Right Cessation
- 2016-02-12 PE PE2017001378A patent/PE20180177A1/es unknown
- 2016-02-12 MX MX2017010300A patent/MX2017010300A/es unknown
- 2016-02-12 BR BR112017017052-3A patent/BR112017017052A2/pt not_active IP Right Cessation
- 2016-02-12 US US15/042,310 patent/US10179782B2/en active Active
- 2016-02-12 SG SG11201706451TA patent/SG11201706451TA/en unknown
- 2016-02-12 KR KR1020177025946A patent/KR20170118166A/ko not_active Withdrawn
- 2016-02-12 CN CN201680009724.XA patent/CN107922392B/zh active Active
- 2016-02-12 PT PT167039908T patent/PT3256463T/pt unknown
- 2016-02-12 CA CA2975196A patent/CA2975196A1/en not_active Abandoned
- 2016-02-12 CR CR20170367A patent/CR20170367A/es unknown
- 2016-02-12 EP EP16703990.8A patent/EP3256463B1/en active Active
- 2016-02-15 TW TW105104384A patent/TW201639829A/zh unknown
-
2017
- 2017-07-13 IL IL253478A patent/IL253478A0/en unknown
- 2017-07-28 CO CONC2017/0007679A patent/CO2017007679A2/es unknown
- 2017-08-03 CL CL2017001987A patent/CL2017001987A1/es unknown
- 2017-08-15 PH PH12017501478A patent/PH12017501478A1/en unknown
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