JP2018512453A5 - - Google Patents
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- Publication number
- JP2018512453A5 JP2018512453A5 JP2018501147A JP2018501147A JP2018512453A5 JP 2018512453 A5 JP2018512453 A5 JP 2018512453A5 JP 2018501147 A JP2018501147 A JP 2018501147A JP 2018501147 A JP2018501147 A JP 2018501147A JP 2018512453 A5 JP2018512453 A5 JP 2018512453A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- alkylene
- compound
- absent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562136857P | 2015-03-23 | 2015-03-23 | |
| US62/136,857 | 2015-03-23 | ||
| PCT/US2016/023664 WO2016154241A1 (en) | 2015-03-23 | 2016-03-23 | Inhibitors of hepatitis c virus polymerase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512453A JP2018512453A (ja) | 2018-05-17 |
| JP2018512453A5 true JP2018512453A5 (enExample) | 2019-05-09 |
| JP6741747B2 JP6741747B2 (ja) | 2020-08-19 |
Family
ID=55759915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501147A Active JP6741747B2 (ja) | 2015-03-23 | 2016-03-23 | Ｃ型肝炎ウイルスポリメラーゼの阻害剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10464914B2 (enExample) |
| EP (1) | EP3274340B1 (enExample) |
| JP (1) | JP6741747B2 (enExample) |
| KR (1) | KR20170137113A (enExample) |
| CN (1) | CN107567442B (enExample) |
| AU (1) | AU2016235246B2 (enExample) |
| CA (1) | CA2979555C (enExample) |
| DK (1) | DK3274340T3 (enExample) |
| EA (1) | EA033622B1 (enExample) |
| ES (1) | ES2748974T3 (enExample) |
| IL (1) | IL254243B (enExample) |
| MX (1) | MX379015B (enExample) |
| NZ (1) | NZ735093A (enExample) |
| PH (1) | PH12017501687A1 (enExample) |
| PL (1) | PL3274340T3 (enExample) |
| SG (1) | SG11201707527YA (enExample) |
| TW (1) | TWI731854B (enExample) |
| WO (1) | WO2016154241A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI731854B (zh) * | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
| TWI833753B (zh) * | 2018-05-09 | 2024-03-01 | 美商共結晶製藥公司 | 用於治療hcv之組合療法 |
| CN112745216A (zh) * | 2019-10-30 | 2021-05-04 | 常州锐博生物科技有限公司 | 一种4-溴甲基苯甲酸甲酯及其衍生物的制备方法 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CN114181187A (zh) * | 2021-11-24 | 2022-03-15 | 上海应用技术大学 | 一种4-甲磺酰胺基丁酰胺化合物的制备方法 |
| CN116283512B (zh) * | 2023-02-24 | 2025-04-25 | 博诺康源(北京)药业科技有限公司 | 一种合成维兰特罗及其盐的方法 |
| WO2025111414A1 (en) * | 2023-11-21 | 2025-05-30 | Katholieke Universiteit Leuven | Trpm3-modulating benzofuran derivatives |
| CN119350612B (zh) * | 2024-12-24 | 2025-10-24 | 浙江爱索拓标记医药科技有限公司 | 一种放射性同位素碳-14标记聚乙二醇单甲醚的合成方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184425A (zh) | 1995-03-20 | 1998-06-10 | 伊莱利利公司 | 5－取代－3－(1,2,3,6－四氢吡啶－4－基)－和3－(哌啶－4－基)－1h－吲哚:新型5－ht1f激动剂 |
| US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| CN101624391A (zh) | 2001-06-11 | 2010-01-13 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
| US6887877B2 (en) | 2001-06-11 | 2005-05-03 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| EP1321463B1 (en) | 2001-12-21 | 2007-08-08 | Virochem Pharma Inc. | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections |
| WO2004041201A2 (en) * | 2002-11-01 | 2004-05-21 | Viropharma Incorporated | Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases |
| EP1569929B9 (en) | 2002-12-10 | 2011-09-14 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| US20040192707A1 (en) | 2002-12-10 | 2004-09-30 | Laval Chan Chun Kong | Compounds and methods for the treatment or prevention of Flavivirus infections |
| CN100413861C (zh) | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| US20070293484A1 (en) | 2004-05-20 | 2007-12-20 | Sugen, Inc. | Thiophene Heteroaryl Amines |
| DE102004061746A1 (de) | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| US7569600B2 (en) | 2005-05-13 | 2009-08-04 | Virochem Pharma Inc. | Compounds and methods for the treatment of prevention of Flavivirus infections |
| PE20070814A1 (es) | 2005-12-22 | 2007-08-16 | Smithkline Beecham Corp | Compuestos derivados de 2-carboxitiofeno como inhibidores de la polimerasa del virus de la hepatitis c (hcv) |
| WO2008017688A1 (en) | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
| TW200815384A (en) | 2006-08-25 | 2008-04-01 | Viropharma Inc | Combination therapy method for treating hepatitis C virus infection and pharmaceutical compositions for use therein |
| WO2008043791A2 (en) | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
| CN102675279A (zh) | 2006-11-15 | 2012-09-19 | Viro化学制药公司 | 用于治疗或预防黄病毒属感染的噻吩类似物 |
| WO2008059042A1 (en) | 2006-11-17 | 2008-05-22 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti viral agents |
| GB0707092D0 (en) | 2007-04-12 | 2007-05-23 | Smithkline Beecham Corp | Compounds |
| GB0712393D0 (en) | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
| GB0718435D0 (en) * | 2007-09-21 | 2007-10-31 | Northern Health And Social Car | Wpund care formulation |
| ES2377280T3 (es) | 2008-02-14 | 2012-03-26 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
| WO2009137500A1 (en) * | 2008-05-05 | 2009-11-12 | Wyeth | 6-substituted benzofuran compounds to treat infection with hepatitis c virus |
| WO2011106929A1 (en) | 2010-03-02 | 2011-09-09 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus ns5b polymerase |
| AR080433A1 (es) * | 2010-03-02 | 2012-04-11 | Merck Sharp & Dohme | Derivados de benzofurancarboxamidas utiles para tratar o prevenir infecciones por vhc y composiciones farmaceuticas que los contienen. |
| US8324239B2 (en) * | 2010-04-21 | 2012-12-04 | Novartis Ag | Furopyridine compounds and uses thereof |
| TW201221131A (en) * | 2010-11-18 | 2012-06-01 | Glaxo Group Ltd | Compounds |
| TW201307334A (zh) | 2010-12-17 | 2013-02-16 | Cocrystal Discovery Inc | Ｃ型肝炎病毒聚合酶抑制劑 |
| WO2014055142A1 (en) | 2012-06-20 | 2014-04-10 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
| TWI731854B (zh) * | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
-
2016
- 2016-03-21 TW TW105108618A patent/TWI731854B/zh not_active IP Right Cessation
- 2016-03-23 CA CA2979555A patent/CA2979555C/en active Active
- 2016-03-23 WO PCT/US2016/023664 patent/WO2016154241A1/en not_active Ceased
- 2016-03-23 JP JP2018501147A patent/JP6741747B2/ja active Active
- 2016-03-23 CN CN201680017709.XA patent/CN107567442B/zh active Active
- 2016-03-23 EP EP16717211.3A patent/EP3274340B1/en active Active
- 2016-03-23 NZ NZ735093A patent/NZ735093A/en not_active IP Right Cessation
- 2016-03-23 SG SG11201707527YA patent/SG11201707527YA/en unknown
- 2016-03-23 EA EA201792094A patent/EA033622B1/ru not_active IP Right Cessation
- 2016-03-23 US US15/556,653 patent/US10464914B2/en active Active
- 2016-03-23 AU AU2016235246A patent/AU2016235246B2/en not_active Ceased
- 2016-03-23 KR KR1020177030184A patent/KR20170137113A/ko not_active Abandoned
- 2016-03-23 MX MX2017012238A patent/MX379015B/es unknown
- 2016-03-23 DK DK16717211.3T patent/DK3274340T3/da active
- 2016-03-23 PL PL16717211T patent/PL3274340T3/pl unknown
- 2016-03-23 ES ES16717211T patent/ES2748974T3/es active Active
-
2017
- 2017-08-31 IL IL254243A patent/IL254243B/en active IP Right Grant
- 2017-09-14 PH PH12017501687A patent/PH12017501687A1/en unknown
-
2019
- 2019-09-25 US US16/582,468 patent/US10947210B2/en not_active Expired - Fee Related
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