JP2010539241A5 - - Google Patents

Download PDF

Info

Publication number
JP2010539241A5
JP2010539241A5 JP2010525943A JP2010525943A JP2010539241A5 JP 2010539241 A5 JP2010539241 A5 JP 2010539241A5 JP 2010525943 A JP2010525943 A JP 2010525943A JP 2010525943 A JP2010525943 A JP 2010525943A JP 2010539241 A5 JP2010539241 A5 JP 2010539241A5
Authority
JP
Japan
Prior art keywords
group
inhibitor
clemizole
compounds
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010525943A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010539241A (ja
JP5715820B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/076806 external-priority patent/WO2009039248A2/en
Publication of JP2010539241A publication Critical patent/JP2010539241A/ja
Publication of JP2010539241A5 publication Critical patent/JP2010539241A5/ja
Application granted granted Critical
Publication of JP5715820B2 publication Critical patent/JP5715820B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010525943A 2007-09-18 2008-09-18 フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物 Expired - Fee Related JP5715820B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US97330907P 2007-09-18 2007-09-18
US60/973,309 2007-09-18
US8875908P 2008-08-14 2008-08-14
US61/088,759 2008-08-14
US9253708P 2008-08-28 2008-08-28
US61/092,537 2008-08-28
PCT/US2008/076806 WO2009039248A2 (en) 2007-09-18 2008-09-18 Methods of treating a flaviviridae family viral infection and compositions for treating a flaviviridae family viral infection

Publications (3)

Publication Number Publication Date
JP2010539241A JP2010539241A (ja) 2010-12-16
JP2010539241A5 true JP2010539241A5 (enExample) 2012-11-08
JP5715820B2 JP5715820B2 (ja) 2015-05-13

Family

ID=40468758

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010525943A Expired - Fee Related JP5715820B2 (ja) 2007-09-18 2008-09-18 フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物

Country Status (8)

Country Link
US (3) US8895598B2 (enExample)
EP (1) EP2203168B1 (enExample)
JP (1) JP5715820B2 (enExample)
CN (1) CN101903026B (enExample)
AR (1) AR066165A1 (enExample)
AU (1) AU2008302295B2 (enExample)
TW (1) TW200927102A (enExample)
WO (2) WO2009039246A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8940730B2 (en) 2007-09-18 2015-01-27 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions of treating a Flaviviridae family viral infection
US9149463B2 (en) 2007-09-18 2015-10-06 The Board Of Trustees Of The Leland Standford Junior University Methods and compositions of treating a Flaviviridae family viral infection
US9101628B2 (en) 2007-09-18 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Methods and composition of treating a flaviviridae family viral infection
TW200927102A (en) * 2007-09-18 2009-07-01 Univ Stanford Methods of treating a flaviviridae family viral infection, compositions for treating a flaviviridae family viral infection, and screening assays for identifying compositions for treating a flaviviridae family viral infection
JP2012520885A (ja) * 2009-03-18 2012-09-10 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー フラビウイルス科ウイルス感染症を治療する方法および組成物
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
US20100284970A1 (en) * 2009-04-09 2010-11-11 Auspex Pharmaceuticals, Inc. Benzimidazole modulators of h1 receptor and/or ns4b protein
WO2010132810A1 (en) * 2009-05-15 2010-11-18 Concert Pharmaceuticals, Inc. Deuterium modified benzimidazoles
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
US20120232062A1 (en) * 2009-10-20 2012-09-13 Eiger Biopharmaceuticals, Inc. Azaindazoles to treat flaviviridae virus infection
US20110165037A1 (en) * 2010-01-07 2011-07-07 Ismagilov Rustem F Interfaces that eliminate non-specific adsorption, and introduce specific interactions
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
CN107141309A (zh) 2011-01-11 2017-09-08 桑诺维恩药品公司 杂芳基化合物及其使用方法
JP6001049B2 (ja) 2011-03-31 2016-10-05 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH Mps−1キナーゼ阻害剤としての置換ベンズイミダゾール類
CN104023726A (zh) 2011-10-21 2014-09-03 艾伯维公司 用于治疗hcv的一种或多种daa的联合治疗(例如,与abt-072或abt-333)
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
CA2811203C (en) 2011-10-21 2015-05-05 Abbvie Inc. Methods for treating hcv
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
AU2012347785B2 (en) 2011-12-06 2017-03-16 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating viral diseases
CA2874303C (en) * 2012-06-11 2020-10-13 Ucb Biopharma Sprl Tnf -alpha modulating benz imidazoles
CN103585616B (zh) * 2013-08-14 2015-05-27 南京工业大学 二肽类似物的用途
PT3035926T (pt) 2013-08-19 2020-09-01 Univ California Compostos e métodos para tratar um distúrbio epiléptico
WO2015050998A2 (en) 2013-10-01 2015-04-09 The Broad Institute, Inc. Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte
SI3261640T1 (sl) * 2015-02-25 2022-10-28 The Regents Of The University Of California 5HT agonisti za zdravljenje epilepsijskih motenj
TWI881480B (zh) * 2015-06-30 2025-04-21 美商伊格集團國際股份有限公司 克立咪唑(clemizole)化合物於預防及治療肝癌之用途
EP3436004B1 (en) * 2016-04-01 2024-12-11 Janssen Pharmaceuticals, Inc. Substituted indole compound derivatives as dengue viral replication inhibitors
US10653678B2 (en) 2016-04-11 2020-05-19 Genfit Methods of treatment for cholestatic and fibrotic diseases
PT3442580T (pt) 2016-04-11 2020-12-23 Genfit Métodos de tratamento para doenças colestáticas e fibróticas
JP7129703B2 (ja) 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
WO2018129702A1 (zh) * 2017-01-13 2018-07-19 史仅 蚊虫叮咬瘙痒寨卡等病毒预防医疗器具
CN108096562B (zh) * 2017-12-25 2021-05-11 武汉百药联科科技有限公司 20s蛋白酶体抑制剂在制备治疗日本乙型脑炎病毒感染的药物中的用途
WO2019126860A1 (pt) * 2017-12-29 2019-07-04 Instituto Butantan Composição farmacêutica para o tratamento de infecção causada por vírus da família flaviviridae, e, uso da composição
CN108660253B (zh) * 2018-04-17 2022-05-31 广东省妇幼保健院(广东省妇产医院、广东省儿童医院) 一种基于悬浮微珠阵列系统检测虫媒介病毒的探针、引物、检测试剂盒及检测方法
CN109020895B (zh) * 2018-08-07 2020-04-24 枣庄学院 一种金属催化的1-苄胺基取代苯并咪唑的合成方法
PT3860998T (pt) 2018-10-05 2024-04-02 Annapurna Bio Inc Compostos e composições para o tratamento de condições associadas à atividade do recetor apj
US20200323830A1 (en) * 2019-04-09 2020-10-15 Tremeau Pharmaceuticals, Inc. Treatment of viral hemorrhagic fevers with etoricoxib
US11926817B2 (en) 2019-08-09 2024-03-12 Nutcracker Therapeutics, Inc. Microfluidic apparatus and methods of use thereof
US20230241037A1 (en) * 2020-03-09 2023-08-03 1Globe Health Institute, Nanjing Cross-linked medication for treatment of coronaviral infection and method of treatment
CN111393372B (zh) * 2020-05-12 2022-08-26 中国药科大学 一种苯并咪唑衍生物及其制备方法和用途
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
JP7856338B2 (ja) * 2021-07-30 2026-05-11 エピジェニクス セラピューティクス インコーポレーテッド クレミゾール製剤
CN119486727A (zh) * 2022-05-20 2025-02-18 小利兰·斯坦福大学托管委员会 用于治疗脂肪肝和病毒感染的方法和组合物
CN119707828B (zh) * 2024-12-18 2025-12-05 江苏天和制药股份有限公司 一种盐酸克立咪唑的合成方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2689853A (en) * 1954-09-21 Certain i
US2684327A (en) * 1951-11-02 1954-07-20 United Chromium Inc Bright nickel plating
GB1045534A (en) * 1963-02-09 1966-10-12 Schering Ag New 1-benzyl-5,6-dialkoxy benzimidazoles and a process for their manufacture
DE1620449C3 (de) * 1964-07-23 1974-02-21 Schering Ag, 1000 Berlin Und 4619 Bergkamen Substituierte Benzimidazole und Verfahren zu ihrer Herstellung
US3428634A (en) * 1965-03-13 1969-02-18 Acraf 3-tertiary amino alkoxy-1-hydrocarbon indazoles
DE2436883C2 (de) * 1974-07-29 1985-08-22 Schering AG, 1000 Berlin und 4709 Bergkamen Benzimidazol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4269835A (en) * 1979-12-13 1981-05-26 Whittle Barry J Nasal composition for relieving nasal distress
PE27997A1 (es) 1994-04-29 1997-09-20 Lilly Co Eli Antagonistas de receptores de taquicininas
US5552426A (en) * 1994-04-29 1996-09-03 Eli Lilly And Company Methods for treating a physiological disorder associated with β-amyloid peptide
ATE238998T1 (de) * 1997-02-25 2003-05-15 Us Gov Health & Human Serv Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore
US6211177B1 (en) * 1998-11-24 2001-04-03 Cell Pathways, Inc. Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives
US6770666B2 (en) * 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
US6476062B2 (en) * 2000-03-30 2002-11-05 Schering Corporation Chemokine receptor antagonists
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP1322325A4 (en) 2000-07-20 2004-09-15 Merck & Co Inc INHIBITION OF PROCESSING AND REPLICATION OF HEPATITIS C VIRUS
WO2002076451A1 (en) * 2001-03-22 2002-10-03 Ucb, S.A. Use of certain substituted pyrrolidones such as piracetam in the treatment of viral and other diseases
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
EP1465635A4 (en) 2002-01-10 2005-04-13 Neurogen Corp MELANIN-CONCENTRATING HORMONIC RECEPTOR LIGANDS: SUBSTITUTED 2- (4-BENZYL-PIPERAZIN-1-YLMETHYL) AND 2- (4-BENZYL-DIAZEPAN-1-YLMETHYL) -1H-BENZOIMIDAZOLE ANALOGUES
WO2004073614A2 (en) * 2003-02-14 2004-09-02 Combinatorx, Incorporated Combination therapy for the treatment of immunoinflammatory disorders
PL1611088T3 (pl) * 2003-04-07 2009-11-30 Pharmacyclics Inc Hydroksamiany jako środki terapeutyczne
CA2534649A1 (en) 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
US7582428B2 (en) 2003-08-22 2009-09-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for identifying anti-HCV agents
TW200522932A (en) * 2003-09-15 2005-07-16 Combinatorx Inc Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
EP1686949A2 (en) * 2003-11-24 2006-08-09 Viropharma Incorporated Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
CN1922150A (zh) 2004-02-27 2007-02-28 霍夫曼-拉罗奇有限公司 吲唑衍生物以及含有它们的药物组合物
GB0416728D0 (en) 2004-07-27 2004-09-01 7Tm Pharma As Medicinal use of receptor ligands
BRPI0513811A (pt) * 2004-07-27 2008-07-15 Gilead Sciences Inc imidazo [4,5-d] pirimidinas, seus usos e processos de preparação
WO2006135383A2 (en) 2004-08-04 2006-12-21 Myriad Genetics, Inc. Indazoles
JP5846711B2 (ja) * 2005-06-09 2016-01-20 メダ アーベー 炎症性疾患の治療のための方法及び組成物
US7872037B2 (en) 2006-03-02 2011-01-18 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
MX2008011968A (es) 2006-03-31 2008-10-01 Astrazeneca Ab Compuestos biciclicos de bencimidazol y su uso como potenciadores del receptor metabotropico de glutamato.
WO2007117465A2 (en) 2006-03-31 2007-10-18 Abbott Laboratories Indazole compounds
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
DE102007028521A1 (de) 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
US9101628B2 (en) * 2007-09-18 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Methods and composition of treating a flaviviridae family viral infection
TW200927102A (en) * 2007-09-18 2009-07-01 Univ Stanford Methods of treating a flaviviridae family viral infection, compositions for treating a flaviviridae family viral infection, and screening assays for identifying compositions for treating a flaviviridae family viral infection

Similar Documents

Publication Publication Date Title
JP2011521903A5 (enExample)
JP2011518835A5 (enExample)
CA2490200A1 (en) 2' and 3'-nucleoside prodrugs for treating flaviviridae infections
RU2483073C2 (ru) Фосфадиазиновые ингибиторы iv полимеразы hcv
AR066165A1 (es) Metodos de tratamiento de una infeccion viral de la familia flaviviridae, composiciones para el tratamiento de una infeccion viral de la familia flaviviridae y ensayos de control para identificar composiciones para el tratamiento de una infeccion viral de la familia flaviviridae
JP2014514308A5 (enExample)
ES2671478T3 (es) Derivados de 2'-etinil nucleósidos para el tratamiento de infecciones virales
ES2680550T3 (es) Combinaciones de inhibidores del virus de la hepatitis C
RU2011133741A (ru) Модифицированные 2'- и 3'-нуклеозиды и их применение для получения лекарственного средства для лечения инфекций flaviviridae
JP2012504126A5 (enExample)
JP2005524632A5 (enExample)
JP2008518943A5 (enExample)
JP2016518359A5 (enExample)
JP2013521279A5 (enExample)
JP2013517286A5 (enExample)
JP2015525220A5 (enExample)
JP2012519691A5 (enExample)
JP2014503516A5 (enExample)
HRP20140219T1 (hr) Analozi karba-nukleozida za antivirusno lijeäśenje
JP2010532352A5 (enExample)
JP2012504632A5 (enExample)
JP2012513479A5 (enExample)
JP2011511841A5 (enExample)
JP2011528713A5 (enExample)
JP2005533824A5 (enExample)