JP2010539241A5 - - Google Patents
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- Publication number
- JP2010539241A5 JP2010539241A5 JP2010525943A JP2010525943A JP2010539241A5 JP 2010539241 A5 JP2010539241 A5 JP 2010539241A5 JP 2010525943 A JP2010525943 A JP 2010525943A JP 2010525943 A JP2010525943 A JP 2010525943A JP 2010539241 A5 JP2010539241 A5 JP 2010539241A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- inhibitor
- clemizole
- compounds
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*1CCCC1 Chemical compound C*1CCCC1 0.000 description 5
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97330907P | 2007-09-18 | 2007-09-18 | |
| US60/973,309 | 2007-09-18 | ||
| US8875908P | 2008-08-14 | 2008-08-14 | |
| US61/088,759 | 2008-08-14 | ||
| US9253708P | 2008-08-28 | 2008-08-28 | |
| US61/092,537 | 2008-08-28 | ||
| PCT/US2008/076806 WO2009039248A2 (en) | 2007-09-18 | 2008-09-18 | Methods of treating a flaviviridae family viral infection and compositions for treating a flaviviridae family viral infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539241A JP2010539241A (ja) | 2010-12-16 |
| JP2010539241A5 true JP2010539241A5 (enExample) | 2012-11-08 |
| JP5715820B2 JP5715820B2 (ja) | 2015-05-13 |
Family
ID=40468758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525943A Expired - Fee Related JP5715820B2 (ja) | 2007-09-18 | 2008-09-18 | フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8895598B2 (enExample) |
| EP (1) | EP2203168B1 (enExample) |
| JP (1) | JP5715820B2 (enExample) |
| CN (1) | CN101903026B (enExample) |
| AR (1) | AR066165A1 (enExample) |
| AU (1) | AU2008302295B2 (enExample) |
| TW (1) | TW200927102A (enExample) |
| WO (2) | WO2009039248A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010107742A2 (en) * | 2009-03-18 | 2010-09-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a flaviviridae family viral infection |
| EP2203168B1 (en) * | 2007-09-18 | 2014-07-16 | Stanford University | Compositions for treating a flaviviridae family viral infection |
| US9101628B2 (en) | 2007-09-18 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and composition of treating a flaviviridae family viral infection |
| US9149463B2 (en) | 2007-09-18 | 2015-10-06 | The Board Of Trustees Of The Leland Standford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| US8940730B2 (en) | 2007-09-18 | 2015-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| US8975247B2 (en) | 2009-03-18 | 2015-03-10 | The Board Of Trustees Of The Leland Stanford Junion University | Methods and compositions of treating a flaviviridae family viral infection |
| WO2010118286A2 (en) * | 2009-04-09 | 2010-10-14 | Auspex Pharmaceuticals, Inc. | Benzimidazole modulators of h1 receptor and/or ns4b protein activity |
| WO2010132810A1 (en) * | 2009-05-15 | 2010-11-18 | Concert Pharmaceuticals, Inc. | Deuterium modified benzimidazoles |
| RU2407738C1 (ru) * | 2009-07-03 | 2010-12-27 | Общество с ограниченной ответственностью "Интеллектуальный Диалог" | Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний |
| US20120232062A1 (en) * | 2009-10-20 | 2012-09-13 | Eiger Biopharmaceuticals, Inc. | Azaindazoles to treat flaviviridae virus infection |
| US20110165037A1 (en) * | 2010-01-07 | 2011-07-07 | Ismagilov Rustem F | Interfaces that eliminate non-specific adsorption, and introduce specific interactions |
| RU2436786C1 (ru) * | 2010-07-23 | 2011-12-20 | Александр Васильевич Иващенко | Замещенные индолы, противовирусный активный компонент, способ получения и применения |
| WO2012096929A2 (en) * | 2011-01-11 | 2012-07-19 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| CN103582632B (zh) | 2011-03-31 | 2015-08-19 | 拜耳知识产权有限责任公司 | 取代的苯并咪唑 |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| SE1450130A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | Förfaranden för att behandla hcv innefattande minst två direktverkande antivirala agenser, ribavirin men inte interferon |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| EP2583680A3 (en) | 2011-10-21 | 2013-06-12 | Abbvie Inc. | Mono (PSI-7977) or combination treatment of DAAs for use in treating HCV |
| MY171759A (en) | 2011-12-06 | 2019-10-28 | Univ Leland Stanford Junior | Methods and compositions for treating viral diseases |
| US9550737B2 (en) * | 2012-06-11 | 2017-01-24 | Ucb Biopharma Sprl | TNF -α modulating benzimidazoles |
| CN103585616B (zh) * | 2013-08-14 | 2015-05-27 | 南京工业大学 | 二肽类似物的用途 |
| EP3636264A1 (en) | 2013-08-19 | 2020-04-15 | The Regents of the University of California | Compounds and methods for treating an epileptic disorder |
| WO2015050998A2 (en) | 2013-10-01 | 2015-04-09 | The Broad Institute, Inc. | Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte |
| HUE059559T2 (hu) | 2015-02-25 | 2022-12-28 | Univ California | 5HT agonisták az epilepsziás rendellenességek kezelésére |
| IL310969A (en) | 2015-06-30 | 2024-04-01 | Eiger Group Int Inc | Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions |
| CN109069482B (zh) * | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| US10653678B2 (en) | 2016-04-11 | 2020-05-19 | Genfit | Methods of treatment for cholestatic and fibrotic diseases |
| SG10202004425XA (en) | 2016-04-11 | 2020-06-29 | Genfit | Methods of treatment for cholestatic and fibrotic diseases |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| WO2018129702A1 (zh) * | 2017-01-13 | 2018-07-19 | 史仅 | 蚊虫叮咬瘙痒寨卡等病毒预防医疗器具 |
| CN108096562B (zh) * | 2017-12-25 | 2021-05-11 | 武汉百药联科科技有限公司 | 20s蛋白酶体抑制剂在制备治疗日本乙型脑炎病毒感染的药物中的用途 |
| WO2019126860A1 (pt) * | 2017-12-29 | 2019-07-04 | Instituto Butantan | Composição farmacêutica para o tratamento de infecção causada por vírus da família flaviviridae, e, uso da composição |
| CN108660253B (zh) * | 2018-04-17 | 2022-05-31 | 广东省妇幼保健院(广东省妇产医院、广东省儿童医院) | 一种基于悬浮微珠阵列系统检测虫媒介病毒的探针、引物、检测试剂盒及检测方法 |
| CN109020895B (zh) * | 2018-08-07 | 2020-04-24 | 枣庄学院 | 一种金属催化的1-苄胺基取代苯并咪唑的合成方法 |
| HUE066335T2 (hu) | 2018-10-05 | 2024-07-28 | Annapurna Bio Inc | Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére |
| WO2020210373A1 (en) * | 2019-04-09 | 2020-10-15 | Tremeau Pharmaceuticals, Inc. | Treatment of viral hemorrhagic fevers with etoricoxib |
| CN214973877U (zh) | 2019-08-09 | 2021-12-03 | 胡桃钳医疗公司 | 用于形成治疗性多核苷酸的微流体设备及微流体路径装置 |
| CN115884770B (zh) * | 2020-03-09 | 2025-03-18 | 南京强新生物医药有限公司 | 治疗冠状病毒感染的联用药物及治疗方法 |
| CN111393372B (zh) * | 2020-05-12 | 2022-08-26 | 中国药科大学 | 一种苯并咪唑衍生物及其制备方法和用途 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| EP4376808A1 (en) * | 2021-07-30 | 2024-06-05 | Epygenix Therapeutics, Inc. | Clemizole formulation |
| JP2025518536A (ja) * | 2022-05-20 | 2025-06-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 脂肪肝及びウイルス感染症を治療するための方法及び組成物 |
| CN119707828B (zh) * | 2024-12-18 | 2025-12-05 | 江苏天和制药股份有限公司 | 一种盐酸克立咪唑的合成方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2689853A (en) * | 1954-09-21 | Certain i | ||
| US2684327A (en) | 1951-11-02 | 1954-07-20 | United Chromium Inc | Bright nickel plating |
| GB1045534A (en) | 1963-02-09 | 1966-10-12 | Schering Ag | New 1-benzyl-5,6-dialkoxy benzimidazoles and a process for their manufacture |
| DE1620450C3 (de) | 1964-07-23 | 1976-01-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 1 - (2- Hydroxybenzyl) -2-piperazinomethylbenzimidazole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US3428634A (en) | 1965-03-13 | 1969-02-18 | Acraf | 3-tertiary amino alkoxy-1-hydrocarbon indazoles |
| DE2436883C2 (de) | 1974-07-29 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Benzimidazol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US4269835A (en) | 1979-12-13 | 1981-05-26 | Whittle Barry J | Nasal composition for relieving nasal distress |
| US5552426A (en) | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
| CZ104795A3 (en) | 1994-04-29 | 1996-02-14 | Lilly Co Eli | Benzimidazole derivative, process of its preparation, its use for preparing a pharmaceutical preparation and the pharmaceutical composition containing thereof |
| CA2281927C (en) * | 1997-02-25 | 2004-01-27 | Christopher J. Michejda | Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase |
| US6211177B1 (en) | 1998-11-24 | 2001-04-03 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives |
| US6770666B2 (en) * | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
| US6476062B2 (en) | 2000-03-30 | 2002-11-05 | Schering Corporation | Chemokine receptor antagonists |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| EP1322325A4 (en) | 2000-07-20 | 2004-09-15 | Merck & Co Inc | INHIBITION OF PROCESSING AND REPLICATION OF HEPATITIS C VIRUS |
| EP1392290B1 (en) | 2001-03-22 | 2005-05-18 | Ucb, S.A. | Use of certain substituted pyrrolidones such as piracetam in the treatment of viral and other diseases |
| AR035543A1 (es) * | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| US7160879B2 (en) | 2002-01-10 | 2007-01-09 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues |
| JP2006517969A (ja) | 2003-02-14 | 2006-08-03 | コンビナトアールエックス インコーポレーティッド | 免疫炎症性障害の治療のための組み合わせ療法 |
| HRP20090487T1 (hr) | 2003-04-07 | 2009-12-31 | Pharmacyclics | Hidroksamati kao terapeutski agensi |
| BRPI0413234A (pt) | 2003-08-01 | 2006-10-03 | Genelabs Tech Inc | derivados de imidazola bicìclica contra flaviviridae |
| US7582428B2 (en) * | 2003-08-22 | 2009-09-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for identifying anti-HCV agents |
| US20050192261A1 (en) | 2003-09-15 | 2005-09-01 | Jost-Price Edward R. | Methods and reagents for the treatment of immunoinflammatory disorders |
| EP1686949A2 (en) * | 2003-11-24 | 2006-08-09 | Viropharma Incorporated | Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases |
| RU2006134022A (ru) | 2004-02-27 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные индазола и содержащие их фармацевтические композиции |
| CN101027303A (zh) * | 2004-07-27 | 2007-08-29 | 吉里德科学公司 | 咪唑并[4,5-d]嘧啶类、其应用和制备方法 |
| GB0416728D0 (en) | 2004-07-27 | 2004-09-01 | 7Tm Pharma As | Medicinal use of receptor ligands |
| WO2006135383A2 (en) | 2004-08-04 | 2006-12-21 | Myriad Genetics, Inc. | Indazoles |
| EP1888033B1 (en) * | 2005-06-09 | 2014-02-19 | Meda AB | Method and composition for treating inflammatory disorders |
| EP1988776B1 (en) | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| CN101437519A (zh) | 2006-03-31 | 2009-05-20 | 艾博特公司 | 吲唑化合物 |
| BRPI0711040A2 (pt) | 2006-03-31 | 2011-08-23 | Astrazeneca Ab | uso de um composto, método para o tratamento ou prevenção de distúrbios, composto, e, composição farmacêutica |
| US20080161324A1 (en) * | 2006-09-14 | 2008-07-03 | Johansen Lisa M | Compositions and methods for treatment of viral diseases |
| DE102007028521A1 (de) | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | Indazolamidderivate |
| EP2203168B1 (en) | 2007-09-18 | 2014-07-16 | Stanford University | Compositions for treating a flaviviridae family viral infection |
| US9101628B2 (en) | 2007-09-18 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and composition of treating a flaviviridae family viral infection |
-
2008
- 2008-09-18 EP EP08832123.7A patent/EP2203168B1/en not_active Not-in-force
- 2008-09-18 AR ARP080104066A patent/AR066165A1/es unknown
- 2008-09-18 WO PCT/US2008/076806 patent/WO2009039248A2/en not_active Ceased
- 2008-09-18 JP JP2010525943A patent/JP5715820B2/ja not_active Expired - Fee Related
- 2008-09-18 WO PCT/US2008/076804 patent/WO2009039246A2/en not_active Ceased
- 2008-09-18 TW TW097135844A patent/TW200927102A/zh unknown
- 2008-09-18 AU AU2008302295A patent/AU2008302295B2/en not_active Ceased
- 2008-09-18 CN CN200880116387XA patent/CN101903026B/zh not_active Expired - Fee Related
- 2008-09-18 US US12/678,014 patent/US8895598B2/en not_active Expired - Fee Related
- 2008-09-18 US US12/677,989 patent/US9061010B2/en not_active Expired - Fee Related
-
2014
- 2014-09-23 US US14/493,529 patent/US20150044169A1/en not_active Abandoned
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