JP2018512162A5 - - Google Patents
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- JP2018512162A5 JP2018512162A5 JP2017554057A JP2017554057A JP2018512162A5 JP 2018512162 A5 JP2018512162 A5 JP 2018512162A5 JP 2017554057 A JP2017554057 A JP 2017554057A JP 2017554057 A JP2017554057 A JP 2017554057A JP 2018512162 A5 JP2018512162 A5 JP 2018512162A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- dna
- cell
- sequence
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562146618P | 2015-04-13 | 2015-04-13 | |
| US62/146,618 | 2015-04-13 | ||
| PCT/US2016/027253 WO2016168275A1 (en) | 2015-04-13 | 2016-04-13 | Methods and compositions for modifying genomic dna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512162A JP2018512162A (ja) | 2018-05-17 |
| JP2018512162A5 true JP2018512162A5 (enExample) | 2019-05-23 |
| JP6885876B2 JP6885876B2 (ja) | 2021-06-16 |
Family
ID=55806847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554057A Active JP6885876B2 (ja) | 2015-04-13 | 2016-04-13 | ゲノムｄｎａを改変するための方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11608511B2 (enExample) |
| EP (1) | EP3283635B1 (enExample) |
| JP (1) | JP6885876B2 (enExample) |
| KR (2) | KR20170135966A (enExample) |
| CN (1) | CN107980059B (enExample) |
| CA (1) | CA2982759C (enExample) |
| ES (1) | ES2926467T3 (enExample) |
| WO (1) | WO2016168275A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
| EP3353296B1 (en) | 2015-09-24 | 2020-11-04 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| US11597924B2 (en) | 2016-03-25 | 2023-03-07 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| WO2017180694A1 (en) | 2016-04-13 | 2017-10-19 | Editas Medicine, Inc. | Cas9 fusion molecules gene editing systems, and methods of use thereof |
| US11293021B1 (en) | 2016-06-23 | 2022-04-05 | Inscripta, Inc. | Automated cell processing methods, modules, instruments, and systems |
| KR102523318B1 (ko) | 2016-12-16 | 2023-04-18 | 비-모젠 바이오테크놀로지스, 인크. | 증진된 ｈＡＴ 패밀리 트랜스포존 매개 유전자 전달 및 연관된 조성물, 시스템, 및 방법 |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| HUE058668T2 (hu) | 2017-06-30 | 2022-09-28 | Inscripta Inc | Automatizált sejtkezelési eljárások, modulok, berendezések és rendszerek |
| WO2019014564A1 (en) | 2017-07-14 | 2019-01-17 | Editas Medicine, Inc. | SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES |
| US10738327B2 (en) | 2017-08-28 | 2020-08-11 | Inscripta, Inc. | Electroporation cuvettes for automation |
| US11447745B2 (en) | 2017-09-01 | 2022-09-20 | Lonza Walkersville, Inc. | End-to-end cell therapy automation |
| WO2019068022A1 (en) | 2017-09-30 | 2019-04-04 | Inscripta, Inc. | CONTINUOUS FLOW ELECTROPORATION INSTRUMENTATION |
| WO2019190874A1 (en) | 2018-03-29 | 2019-10-03 | Inscripta, Inc. | Automated control of cell growth rates for induction and transformation |
| WO2019200004A1 (en) | 2018-04-13 | 2019-10-17 | Inscripta, Inc. | Automated cell processing instruments comprising reagent cartridges |
| US10526598B2 (en) | 2018-04-24 | 2020-01-07 | Inscripta, Inc. | Methods for identifying T-cell receptor antigens |
| US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
| US10508273B2 (en) | 2018-04-24 | 2019-12-17 | Inscripta, Inc. | Methods for identifying selective binding pairs |
| JP2021527427A (ja) | 2018-06-21 | 2021-10-14 | ビー−モーゲン・バイオテクノロジーズ，インコーポレーテッド | 強化されたｈＡＴファミリーのトランスポゾンが介在する遺伝子導入ならびに関連する組成物、システム、及び方法 |
| AU2019292919A1 (en) | 2018-06-30 | 2021-03-11 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
| US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
| US10532324B1 (en) | 2018-08-14 | 2020-01-14 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
| US11965154B2 (en) | 2018-08-30 | 2024-04-23 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
| WO2020061696A1 (en) | 2018-09-28 | 2020-04-02 | Octane Biotech Inc. | Magnetic separation |
| US11214781B2 (en) | 2018-10-22 | 2022-01-04 | Inscripta, Inc. | Engineered enzyme |
| EP3870697A4 (en) | 2018-10-22 | 2022-11-09 | Inscripta, Inc. | GMO ENZYMES |
| KR20210108406A (ko) | 2018-12-21 | 2021-09-02 | 론자 워커스빌 아이엔씨. | 바이러스 벡터의 자동화된 생산 |
| US11714096B2 (en) | 2018-12-21 | 2023-08-01 | Octane Biotech Inc. | Carousel for modular biologic production units |
| US11773365B2 (en) | 2019-02-08 | 2023-10-03 | Lonza Walkersville, Inc. | Cell concentration methods and devices for use in automated bioreactors |
| CN113631713A (zh) | 2019-03-25 | 2021-11-09 | 因思科瑞普特公司 | 酵母中的同时多重基因组编辑 |
| US11001831B2 (en) | 2019-03-25 | 2021-05-11 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
| US10837021B1 (en) | 2019-06-06 | 2020-11-17 | Inscripta, Inc. | Curing for recursive nucleic acid-guided cell editing |
| WO2020257395A1 (en) | 2019-06-21 | 2020-12-24 | Inscripta, Inc. | Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli |
| US10927385B2 (en) | 2019-06-25 | 2021-02-23 | Inscripta, Inc. | Increased nucleic-acid guided cell editing in yeast |
| CN114729292A (zh) | 2019-10-24 | 2022-07-08 | 奥克泰生物科技股份有限公司 | 具有经改进的细胞接触表面的细胞培养室 |
| JP2023501443A (ja) | 2019-11-11 | 2023-01-18 | ロンザ ウォーカーズヴィル，インコーポレーテッド | 自動化された細胞処理のための品質制御方法 |
| WO2021102059A1 (en) | 2019-11-19 | 2021-05-27 | Inscripta, Inc. | Methods for increasing observed editing in bacteria |
| KR20250033331A (ko) | 2019-12-10 | 2025-03-07 | 인스크립타 인코포레이티드 | 신규 mad 뉴클레아제 |
| US10704033B1 (en) | 2019-12-13 | 2020-07-07 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| CA3157127A1 (en) | 2019-12-18 | 2021-06-24 | Aamir MIR | Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells |
| US10689669B1 (en) | 2020-01-11 | 2020-06-23 | Inscripta, Inc. | Automated multi-module cell processing methods, instruments, and systems |
| KR20220133257A (ko) | 2020-01-27 | 2022-10-04 | 인스크립타 인코포레이티드 | 전기천공 모듈 및 기구 |
| US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
| US11787841B2 (en) | 2020-05-19 | 2023-10-17 | Inscripta, Inc. | Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli |
| WO2022060749A1 (en) | 2020-09-15 | 2022-03-24 | Inscripta, Inc. | Crispr editing to embed nucleic acid landing pads into genomes of live cells |
| CN112195193A (zh) * | 2020-09-30 | 2021-01-08 | 上海交通大学 | 单链dna在基因转染中的应用 |
| US11512297B2 (en) | 2020-11-09 | 2022-11-29 | Inscripta, Inc. | Affinity tag for recombination protein recruitment |
| CA3204158A1 (en) | 2021-01-04 | 2022-07-07 | Juhan Kim | Mad nucleases |
| US11332742B1 (en) | 2021-01-07 | 2022-05-17 | Inscripta, Inc. | Mad nucleases |
| US11884924B2 (en) | 2021-02-16 | 2024-01-30 | Inscripta, Inc. | Dual strand nucleic acid-guided nickase editing |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| KR960700740A (ko) | 1993-03-23 | 1996-02-24 | 라차아드 엘 콘 | 세포내 생물학적 활성 물질의 캡슐화 방법 및 장치(method and apparatus for encapsulation of biologic ally-active substances in cells) |
| JPH0844143A (ja) | 1993-06-29 | 1996-02-16 | Toshiba Corp | 帯電装置並びに該帯電装置を備えた画像形成装置 |
| US6773669B1 (en) | 1995-03-10 | 2004-08-10 | Maxcyte, Inc. | Flow electroporation chamber and method |
| CN1195997A (zh) | 1995-03-10 | 1998-10-14 | 恩特雷麦德有限公司 | 流式电穿孔室和方法 |
| US6074605A (en) | 1995-03-10 | 2000-06-13 | Entremed, Inc. | Flow electroporation chamber and method |
| US5720921A (en) | 1995-03-10 | 1998-02-24 | Entremed, Inc. | Flow electroporation chamber and method |
| EP0824594B1 (en) * | 1995-05-04 | 2005-04-06 | The United States of America as Representend by The Secretary of the Navy | Improved methods for transfecting t cells |
| US7067318B2 (en) * | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6090617A (en) | 1996-12-05 | 2000-07-18 | Entremed, Inc. | Flow electroporation chamber with electrodes having a crystalline metal nitride coating |
| ATE332077T1 (de) | 1997-02-28 | 2006-07-15 | Kirin Brewery | Transgene mäuse die ein menschliche antikörper exprimieren |
| WO2002022834A2 (en) | 2000-09-15 | 2002-03-21 | Deltagen, Inc. | Methods of producing cells and animals comprising targeted gene modifications |
| WO2002026966A2 (en) | 2000-09-29 | 2002-04-04 | Ecole Polytechnique Federale De Lausanne | Transfection using plasmid preparations |
| US7029916B2 (en) | 2001-02-21 | 2006-04-18 | Maxcyte, Inc. | Apparatus and method for flow electroporation of biological samples |
| DK2574662T3 (da) | 2001-08-22 | 2021-09-20 | Maxcyte Inc | Fremgangsmåde til elektroporation af biologiske prøver |
| US20040115784A1 (en) | 2002-09-30 | 2004-06-17 | Maxcyte, Inc. | Apparatus and method for streaming electroporation |
| EP1597390A4 (en) | 2003-02-18 | 2006-12-27 | Maxcyte Inc | LOADING CELLS WITH ANTIGENES BY ELECTROPORATION |
| US8409861B2 (en) * | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US20080311095A1 (en) | 2007-05-23 | 2008-12-18 | Sangamo Biosciences, Inc. | Methods and compositions for increased transgene expression |
| EP1766057B1 (en) | 2004-05-12 | 2014-12-17 | Maxcyte, Inc. | Methods and devices related to a regulated flow electroporation chamber |
| US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| SG163592A1 (en) | 2004-07-23 | 2010-08-30 | Immunomedics Inc | Methods and compositions for increasing longevity and protein yield from a cell culture |
| WO2007030674A2 (en) | 2005-09-07 | 2007-03-15 | Maxcyte, Inc. | Use of nucleases to improve viability and enhance transgene expression in transfected cells |
| WO2007118208A2 (en) | 2006-04-10 | 2007-10-18 | The Regents Of The University Of California | Systems for collection of single cells and colonies |
| JP6039552B2 (ja) | 2010-07-01 | 2016-12-07 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 高産生細胞株を選択するための改良された方法 |
| BR112013001685B1 (pt) * | 2010-07-23 | 2021-10-13 | Sigma-Aldrich Co. Llc | Método para editar pelo menos uma sequência cromossômica endógena em uma célula pela inserção de uma sequência na sequência cromossômica |
| US8895264B2 (en) | 2011-10-27 | 2014-11-25 | Sangamo Biosciences, Inc. | Methods and compositions for modification of the HPRT locus |
| WO2013139994A1 (en) | 2012-03-23 | 2013-09-26 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | A novel method of producing an oocyte carrying a modified target sequence in its genome |
| JP6559063B2 (ja) * | 2012-05-07 | 2019-08-14 | サンガモ セラピューティクス， インコーポレイテッド | 導入遺伝子のヌクレアーゼ媒介標的化組み込みのための方法および組成物 |
| MX2014015204A (es) | 2012-06-12 | 2015-08-07 | Genentech Inc | Metodos y composiciones para generar alelos con inactivacion condicional. |
| CN102839214A (zh) | 2012-09-06 | 2012-12-26 | 许汉鹏 | 筛选真核细胞基因组内特定基因调控相关机制和分子的方法 |
| EP3763810A3 (en) * | 2012-10-10 | 2021-07-14 | Sangamo Therapeutics, Inc. | T cell modifying compounds and uses thereof |
| JP6683598B2 (ja) | 2013-03-15 | 2020-04-22 | マックスサイト インコーポレーティッド | 安定なトランスフェクトされた細胞を生成するための方法および組成物 |
| CN103224947B (zh) * | 2013-04-28 | 2015-06-10 | 陕西师范大学 | 一种基因打靶系统 |
| ES2883131T3 (es) * | 2013-05-29 | 2021-12-07 | Cellectis | Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN |
| DK3309248T3 (da) * | 2013-05-29 | 2021-08-02 | Cellectis | Fremgangsmåde til manipulering af T-celler til immunterapi under anvendelse af et RNA-guidet CAS-nuklease-system |
| JP6665088B2 (ja) | 2013-06-17 | 2020-03-13 | ザ・ブロード・インスティテュート・インコーポレイテッド | 配列操作のための最適化されたＣＲＩＳＰＲ−Ｃａｓ二重ニッカーゼ系、方法および組成物 |
| CN106687585B (zh) | 2014-04-14 | 2021-11-02 | 美克斯细胞有限公司 | 用于修饰基因组dna的方法和组合物 |
| US10570418B2 (en) | 2014-09-02 | 2020-02-25 | The Regents Of The University Of California | Methods and compositions for RNA-directed target DNA modification |
-
2016
- 2016-04-13 ES ES16718143T patent/ES2926467T3/es active Active
- 2016-04-13 US US15/566,320 patent/US11608511B2/en active Active
- 2016-04-13 EP EP16718143.7A patent/EP3283635B1/en active Active
- 2016-04-13 JP JP2017554057A patent/JP6885876B2/ja active Active
- 2016-04-13 WO PCT/US2016/027253 patent/WO2016168275A1/en not_active Ceased
- 2016-04-13 CA CA2982759A patent/CA2982759C/en active Active
- 2016-04-13 KR KR1020177032721A patent/KR20170135966A/ko not_active Ceased
- 2016-04-13 KR KR1020257013453A patent/KR20250058073A/ko active Pending
- 2016-04-13 CN CN201680031891.4A patent/CN107980059B/zh active Active
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