JP2018510917A5 - - Google Patents
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- Publication number
- JP2018510917A5 JP2018510917A5 JP2018504078A JP2018504078A JP2018510917A5 JP 2018510917 A5 JP2018510917 A5 JP 2018510917A5 JP 2018504078 A JP2018504078 A JP 2018504078A JP 2018504078 A JP2018504078 A JP 2018504078A JP 2018510917 A5 JP2018510917 A5 JP 2018510917A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cancer
- composition according
- isoty
- capcna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 claims 1
- 108010009063 Proliferating Cell Nuclear Antigen Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000000973 chemotherapeutic Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 230000003211 malignant Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (6)
- 有効成分として、式
の化合物もしくはその置換誘導体、またはその薬学的に許容される塩を含み、さらに１以上の担体、希釈剤もしくは賦形剤またはそれらの組合せを含む、増殖細胞核抗原の癌特異的（関連性）アイソフォーム（ｃａＰＣＮＡ）を発現する悪性細胞の細胞増殖を減少させるための、医薬組成物。
- 癌が乳癌である、請求項１に記載の医薬組成物。
- 癌が膵臓癌である、請求項１に記載の医薬組成物。
- 癌が神経芽腫である、請求項１に記載の医薬組成物。
- 別の化学療法的方法を増強するための、請求項１〜４のいずれか一項に記載の医薬組成物。
- さらなる化学治療剤を含む、請求項１〜４のいずれか一項に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/684,259 US10420840B2 (en) | 2015-04-10 | 2015-04-10 | Anticancer therapeutic agents |
| US14/684,259 | 2015-04-10 | ||
| PCT/US2016/026619 WO2016164707A1 (en) | 2015-04-10 | 2016-04-08 | Anticancer therapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510917A JP2018510917A (ja) | 2018-04-19 |
| JP2018510917A5 true JP2018510917A5 (ja) | 2019-05-09 |
| JP6748704B2 JP6748704B2 (ja) | 2020-09-02 |
Family
ID=57072079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018504078A Active JP6748704B2 (ja) | 2015-04-10 | 2016-04-08 | 抗癌治療剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10420840B2 (ja) |
| EP (2) | EP3878444A1 (ja) |
| JP (1) | JP6748704B2 (ja) |
| CN (1) | CN107404876B (ja) |
| AU (1) | AU2016245886B2 (ja) |
| BR (1) | BR122023024844A2 (ja) |
| CA (1) | CA2978965C (ja) |
| PL (1) | PL3280261T3 (ja) |
| WO (1) | WO2016164707A1 (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2023231620A1 (en) * | 2022-03-07 | 2024-09-12 | City Of Hope | Pcna inhibitors and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5627165A (en) | 1990-06-13 | 1997-05-06 | Drug Innovation & Design, Inc. | Phosphorous prodrugs and therapeutic delivery systems using same |
| US20050037090A1 (en) | 1998-12-23 | 2005-02-17 | Mckearn John P. | Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent |
| WO2006116631A2 (en) * | 2005-04-27 | 2006-11-02 | Indiana University Research And Technology Corporation | Cancer specific pcna isoform binding antibodies and uses thereof |
| CA2612695A1 (en) * | 2005-06-27 | 2007-01-04 | Derek J. Hoelz | Cspcna isoform modifications and uses thereof |
| US8653039B2 (en) * | 2006-02-17 | 2014-02-18 | Robert J. Hickey | Peptide based inhibition of caPCNA interaction in cancer |
| US20090123487A1 (en) | 2007-09-19 | 2009-05-14 | Katia Rothhaar | Precursors and enzymes associated with post translational modification of proteins implicated in isoform generation of PCNA |
| CA2709398C (en) | 2007-12-14 | 2017-11-07 | The Cleveland Clinic Foundation | Use of stromal cell-derived factor 1 for promoting wound healing |
| GB0808282D0 (en) | 2008-05-07 | 2008-06-11 | Medical Res Council | Compounds for use in stabilizing p53 mutants |
| JP2011529079A (ja) * | 2008-07-24 | 2011-12-01 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | 癌のペプチド治療剤 |
| US8278278B2 (en) * | 2008-07-24 | 2012-10-02 | Indiana University Research And Technology Corporation | Cell proliferation reducing cancer specific PCNA peptides |
| WO2012173677A2 (en) * | 2011-03-23 | 2012-12-20 | Indiana University Research And Technology Corporation | Anticancer therapeutic agents |
| JP6966996B2 (ja) * | 2015-09-17 | 2021-11-17 | シティ・オブ・ホープCity of Hope | Ｐｃｎａ阻害剤 |
-
2015
- 2015-04-10 US US14/684,259 patent/US10420840B2/en active Active
-
2016
- 2016-04-08 EP EP20216249.1A patent/EP3878444A1/en active Pending
- 2016-04-08 WO PCT/US2016/026619 patent/WO2016164707A1/en active Application Filing
- 2016-04-08 CN CN201680018509.6A patent/CN107404876B/zh active Active
- 2016-04-08 PL PL16777344T patent/PL3280261T3/pl unknown
- 2016-04-08 AU AU2016245886A patent/AU2016245886B2/en active Active
- 2016-04-08 BR BR122023024844-9A patent/BR122023024844A2/pt not_active Application Discontinuation
- 2016-04-08 EP EP16777344.9A patent/EP3280261B1/en active Active
- 2016-04-08 JP JP2018504078A patent/JP6748704B2/ja active Active
- 2016-04-08 CA CA2978965A patent/CA2978965C/en active Active
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