JP2018505882A5 - - Google Patents
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- JP2018505882A5 JP2018505882A5 JP2017541030A JP2017541030A JP2018505882A5 JP 2018505882 A5 JP2018505882 A5 JP 2018505882A5 JP 2017541030 A JP2017541030 A JP 2017541030A JP 2017541030 A JP2017541030 A JP 2017541030A JP 2018505882 A5 JP2018505882 A5 JP 2018505882A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pasi
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- patient
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 102000004965 antibodies Human genes 0.000 claims 9
- 108090001123 antibodies Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 201000004681 psoriasis Diseases 0.000 claims 4
- 102100014203 IL23A Human genes 0.000 claims 2
- 101700036088 IL23A Proteins 0.000 claims 2
- 230000001684 chronic Effects 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
Claims (15)
- 配列番号１８のアミノ酸配列を含む軽鎖及び配列番号１９のアミノ酸配列を含む重鎖を含む抗ＩＬ−２３Ａ抗体を含み、１５０ｍｇの抗ＩＬ−２３Ａ抗体を患者に投与するための、乾癬を処置するための医薬組成物。
- 中等症から重症の慢性尋常性乾癬を処置するための、請求項１記載の医薬組成物。
- 前記の抗ＩＬ−２３Ａ抗体が皮下投与によって投与される、請求項１又は２記載の医薬組成物。
- 患者がPasoriasis Area and Severity Index（ＰＡＳＩ）スコア５０（ＰＡＳＩ ５０）を達成する、請求項１〜３のいずれか一項記載の医薬組成物。
- 患者がＰＡＳＩスコア７５（ＰＡＳＩ ７５）を達成する、請求項１〜４のいずれか一項記載の医薬組成物。
- 患者がＰＡＳＩスコア９０（ＰＡＳＩ ９０）を達成する、請求項１〜５のいずれか一項記載の医薬組成物。
- 患者がＰＡＳＩスコア１００（ＰＡＳＩ １００）を達成する、請求項１〜６のいずれか一項記載の医薬組成物。
- 配列番号１８のアミノ酸配列を含む軽鎖及び配列番号１９のアミノ酸配列を含む重鎖を含む、抗ＩＬ−２３Ａ抗体を含む、乾癬を処置するための医薬組成物であって、
ａ）初回用量として１５０ｍｇの前記の抗ＩＬ−２３Ａ抗体を患者に投与する工程；
ｂ）前記の初回用量が投与された４週間後に、２回目の用量として１５０ｍｇの前記の抗ＩＬ−２３Ａ抗体を患者に投与する工程；及び
ｃ）前記の２回目の用量が投与された１２週間後に、１回目の維持用量として１５０ｍｇの抗ＩＬ−２３Ａ抗体を患者に投与する工程
を含む方法により患者に投与される、医薬組成物。 - 前記方法は、さらに
前記の１回目の維持用量が投与された後に、１２週間毎に、維持用量として１５０ｍｇの前記抗ＩＬ−２３Ａ抗体を投与する工程
を含む、請求項８記載の医薬組成物。 - 前記の方法が、中等症から重症の慢性尋常性乾癬を処置するためのものである、請求項８又は９記載の医薬組成物。
- 前記の抗ＩＬ−２３Ａ抗体が皮下投与によって投与される、請求項８〜１０のいずれか一項記載の医薬組成物。
- 患者がＰＡＳＩスコア５０（ＰＡＳＩ ５０）を達成する、請求項８〜１１のいずれか一項記載の医薬組成物。
- 患者がＰＡＳＩスコア７５（ＰＡＳＩ ７５）を達成する、請求項８〜１２のいずれか一項記載の医薬組成物。
- 患者がＰＡＳＩスコア９０（ＰＡＳＩ ９０）を達成する、請求項８〜１３のいずれか一項記載の医薬組成物。
- 患者がＰＡＳＩスコア１００（ＰＡＳＩ １００）を達成する、請求項８〜１４のいずれか一項記載の医薬組成物。
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562111731P | 2015-02-04 | 2015-02-04 | |
| US62/111,731 | 2015-02-04 | ||
| US201562130876P | 2015-03-10 | 2015-03-10 | |
| US62/130,876 | 2015-03-10 | ||
| US201562135335P | 2015-03-19 | 2015-03-19 | |
| US62/135,335 | 2015-03-19 | ||
| US201562145764P | 2015-04-10 | 2015-04-10 | |
| US62/145,764 | 2015-04-10 | ||
| US201562204520P | 2015-08-13 | 2015-08-13 | |
| US62/204,520 | 2015-08-13 | ||
| US201562235631P | 2015-10-01 | 2015-10-01 | |
| US62/235,631 | 2015-10-01 | ||
| PCT/US2016/016061 WO2016126638A1 (en) | 2015-02-04 | 2016-02-02 | Methods of treating inflammatory diseases |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020078177A Division JP7044824B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
| JP2020078178A Division JP7042297B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
| JP2020078179A Division JP7042298B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505882A JP2018505882A (ja) | 2018-03-01 |
| JP2018505882A5 true JP2018505882A5 (ja) | 2019-03-14 |
| JP6758304B2 JP6758304B2 (ja) | 2020-09-23 |
Family
ID=55453266
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541030A Active JP6758304B2 (ja) | 2015-02-04 | 2016-02-02 | 炎症性疾患の処置法 |
| JP2020078178A Active JP7042297B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
| JP2020078179A Active JP7042298B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
| JP2020078177A Active JP7044824B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
| JP2022042417A Pending JP2022081644A (ja) | 2015-02-04 | 2022-03-17 | 炎症性疾患の処置法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020078178A Active JP7042297B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
| JP2020078179A Active JP7042298B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
| JP2020078177A Active JP7044824B2 (ja) | 2015-02-04 | 2020-04-27 | 炎症性疾患の処置法 |
| JP2022042417A Pending JP2022081644A (ja) | 2015-02-04 | 2022-03-17 | 炎症性疾患の処置法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20160222102A1 (ja) |
| EP (1) | EP3253794A1 (ja) |
| JP (5) | JP6758304B2 (ja) |
| KR (1) | KR20170120616A (ja) |
| CN (2) | CN113559258A (ja) |
| AU (2) | AU2016215535B2 (ja) |
| BR (1) | BR112017014684A2 (ja) |
| CA (1) | CA2972995A1 (ja) |
| CL (1) | CL2017001960A1 (ja) |
| EA (1) | EA201791734A1 (ja) |
| IL (2) | IL307578A (ja) |
| MX (3) | MX2017010037A (ja) |
| PH (1) | PH12017501378A1 (ja) |
| SG (2) | SG11201705728RA (ja) |
| WO (1) | WO2016126638A1 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6126532B2 (ja) | 2010-11-04 | 2017-05-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗ｉｌ−２３抗体 |
| MX368653B (es) | 2012-05-03 | 2019-10-10 | Boehringer Ingelheim Int | Anticuerpos anti-il-23p19. |
| US10507241B2 (en) | 2014-07-24 | 2019-12-17 | Boehringer Ingelheim International Gmbh | Biomarkers useful in the treatment of IL-23A related diseases |
| TWI711629B (zh) | 2014-09-03 | 2020-12-01 | 德商包林格因蓋爾漢國際股份有限公司 | 靶向IL-23A與TNF-α之化合物及其用途 |
| IL307578A (en) * | 2015-02-04 | 2023-12-01 | Boehringer Ingelheim Int | Methods for treating inflammatory diseases |
| AU2017250583A1 (en) * | 2016-04-15 | 2018-08-16 | Boehringer Ingelheim International Gmbh | Methods of treating inflammatory diseases |
| AU2017336799B2 (en) * | 2016-09-30 | 2023-08-31 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-IL23 specific antibody |
| CN106778030B (zh) * | 2017-01-10 | 2023-04-07 | 广州和康医疗技术有限公司 | 一种强直性脊柱炎病情监测管理系统及其监测管理方法 |
| EP3883607A4 (en) | 2018-11-20 | 2022-08-17 | Janssen Biotech, Inc. | SAFE AND EFFECTIVE PROCESS FOR TREATING PSORIASIS WITH A SPECIFIC ANTI-IL-23 ANTIBODY |
| CN111378045B (zh) * | 2018-12-28 | 2022-08-02 | 长春金赛药业有限责任公司 | 二价双特异性抗体及其制备方法、编码基因、宿主细胞、组合物 |
| TW202123965A (zh) * | 2019-09-09 | 2021-07-01 | 德商百靈佳殷格翰國際股份有限公司 | 抗-il-23p19抗體調配物 |
| WO2023144699A1 (en) * | 2022-01-25 | 2023-08-03 | Sun Pharmaceutical Industries Limited | Methods for treatment of subjects with plaque psoriasis of the scalp |
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| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
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| JP6126532B2 (ja) | 2010-11-04 | 2017-05-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗ｉｌ−２３抗体 |
| MX368653B (es) * | 2012-05-03 | 2019-10-10 | Boehringer Ingelheim Int | Anticuerpos anti-il-23p19. |
| US9803010B2 (en) * | 2012-06-27 | 2017-10-31 | Merck Sharp & Dohme Corp. | Crystalline anti-human IL-23p19 antibodies |
| AU2014238148A1 (en) * | 2013-03-15 | 2015-10-08 | Amgen Inc. | Methods for treating psoriasis using an anti-IL-23 antibody |
| IL307578A (en) * | 2015-02-04 | 2023-12-01 | Boehringer Ingelheim Int | Methods for treating inflammatory diseases |
| JP7090014B2 (ja) * | 2018-11-07 | 2022-06-23 | 株式会社ミツバ | ロータ、モータ、ブラシレスワイパーモータ及びロータの製造方法 |
-
2016
- 2016-02-02 IL IL307578A patent/IL307578A/en unknown
- 2016-02-02 EP EP16707997.9A patent/EP3253794A1/en active Pending
- 2016-02-02 EA EA201791734A patent/EA201791734A1/ru unknown
- 2016-02-02 MX MX2017010037A patent/MX2017010037A/es unknown
- 2016-02-02 CN CN202110769475.7A patent/CN113559258A/zh active Pending
- 2016-02-02 JP JP2017541030A patent/JP6758304B2/ja active Active
- 2016-02-02 AU AU2016215535A patent/AU2016215535B2/en active Active
- 2016-02-02 CA CA2972995A patent/CA2972995A1/en active Pending
- 2016-02-02 KR KR1020177024896A patent/KR20170120616A/ko not_active Application Discontinuation
- 2016-02-02 SG SG11201705728RA patent/SG11201705728RA/en unknown
- 2016-02-02 CN CN201680008402.3A patent/CN107206081A/zh active Pending
- 2016-02-02 WO PCT/US2016/016061 patent/WO2016126638A1/en active Application Filing
- 2016-02-02 SG SG10202103879YA patent/SG10202103879YA/en unknown
- 2016-02-02 US US15/013,008 patent/US20160222102A1/en active Pending
- 2016-02-02 BR BR112017014684A patent/BR112017014684A2/pt active Search and Examination
-
2017
- 2017-06-22 IL IL253118A patent/IL253118A0/en unknown
- 2017-08-01 CL CL2017001960A patent/CL2017001960A1/es unknown
- 2017-08-01 PH PH12017501378A patent/PH12017501378A1/en unknown
- 2017-08-03 MX MX2022006575A patent/MX2022006575A/es unknown
- 2017-08-03 MX MX2022006573A patent/MX2022006573A/es unknown
-
2020
- 2020-04-27 JP JP2020078178A patent/JP7042297B2/ja active Active
- 2020-04-27 JP JP2020078179A patent/JP7042298B2/ja active Active
- 2020-04-27 JP JP2020078177A patent/JP7044824B2/ja active Active
-
2021
- 2021-12-16 AU AU2021286378A patent/AU2021286378A1/en active Pending
-
2022
- 2022-03-17 JP JP2022042417A patent/JP2022081644A/ja active Pending
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