JP2018504411A5 - - Google Patents
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- Publication number
- JP2018504411A5 JP2018504411A5 JP2017538575A JP2017538575A JP2018504411A5 JP 2018504411 A5 JP2018504411 A5 JP 2018504411A5 JP 2017538575 A JP2017538575 A JP 2017538575A JP 2017538575 A JP2017538575 A JP 2017538575A JP 2018504411 A5 JP2018504411 A5 JP 2018504411A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- hydrate
- acceptable salt
- alkyl
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 32
- 239000000651 prodrug Substances 0.000 claims 16
- 229940002612 prodrug Drugs 0.000 claims 16
- 239000012453 solvate Substances 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 206010011878 Deafness Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940126574 aminoglycoside antibiotic Drugs 0.000 claims 1
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 210000002768 hair cell Anatomy 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- -1 salt hydrates Chemical class 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562113245P | 2015-02-06 | 2015-02-06 | |
| US62/113,245 | 2015-02-06 | ||
| PCT/US2016/016880 WO2016127123A2 (en) | 2015-02-06 | 2016-02-05 | Compounds and methods for preventing or treating sensory hair cell death |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504411A JP2018504411A (ja) | 2018-02-15 |
| JP2018504411A5 true JP2018504411A5 (enExample) | 2019-03-14 |
| JP6697808B2 JP6697808B2 (ja) | 2020-05-27 |
Family
ID=56564889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538575A Active JP6697808B2 (ja) | 2015-02-06 | 2016-02-05 | 感覚有毛細胞の死を防ぐまたは処置するための化合物と方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9493482B2 (enExample) |
| EP (1) | EP3253766B1 (enExample) |
| JP (1) | JP6697808B2 (enExample) |
| KR (1) | KR102557184B1 (enExample) |
| CN (1) | CN107438613B (enExample) |
| AU (1) | AU2016215023B2 (enExample) |
| CA (1) | CA2974395C (enExample) |
| DK (1) | DK3253766T3 (enExample) |
| ES (1) | ES2760373T3 (enExample) |
| WO (1) | WO2016127123A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2760373T3 (es) | 2015-02-06 | 2020-05-13 | Univ Washington | Compuestos y procedimientos para prevenir o tratar la muerte de células ciliadas sensoriales |
| EP3366683A1 (en) | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
| US11779573B2 (en) | 2017-09-01 | 2023-10-10 | University Of Washington | Crystalline forms of compounds for preventing or treating sensory hair cell death |
| WO2020033322A1 (en) * | 2018-08-06 | 2020-02-13 | Fred Hutchinson Cancer Research Center | Hearing loss-protective compounds and methods thereof |
| WO2022020114A2 (en) | 2020-07-10 | 2022-01-27 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
| KR102848315B1 (ko) * | 2022-10-27 | 2025-08-20 | 고려대학교 산학협력단 | 암모늄 락테이트를 유효성분으로 포함하는 난청 예방 또는 치료용 약학 조성물 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES457780A1 (es) | 1977-04-14 | 1978-08-16 | Made Labor Sa | Un procedimiento para la obtencion de 7,10-dimetil-5,9-imi- no-4,5,8,9 - tetrahidrocicloocta (b) tiofenos. |
| ES462993A1 (es) | 1977-10-07 | 1978-06-01 | Made Labor Sa | Un procedimiento para la obtencion simultanea de 6,7,10-tri-metil-5,9-imino-4,5,8,9-tetrahidrocicloocta(b)furano y de alfa-2,4,5-trimetilfuro(2,3-f)morfano. |
| US4174396A (en) | 1978-04-03 | 1979-11-13 | Laboratories Made, S.A. | 7,10-Dimethyl-5,9-imino-4,5,8,9-tetrahydro-cyclooct[b]thiophenes and a process for obtaining it |
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4624848A (en) | 1984-05-10 | 1986-11-25 | Ciba-Geigy Corporation | Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use |
| GB8518301D0 (en) | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
| JPH0778017B2 (ja) | 1985-12-28 | 1995-08-23 | 住友製薬株式会社 | パルス的かつ持続放出性製剤 |
| US4968509A (en) | 1987-07-27 | 1990-11-06 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
| IL92966A (en) | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
| US5017381A (en) | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
| ES2111065T5 (es) | 1991-04-16 | 2005-06-16 | Nippon Shinyaku Company, Limited | Procedimiento para producir una dispersion solida. |
| ATE195075T1 (de) | 1991-11-22 | 2000-08-15 | Procter & Gamble Pharma | Risedronat enthaltende arzneimittel mit verzögerter wirkstoffabgabe |
| US5229135A (en) | 1991-11-22 | 1993-07-20 | Prographarm Laboratories | Sustained release diltiazem formulation |
| US5461140A (en) | 1992-04-30 | 1995-10-24 | Pharmaceutical Delivery Systems | Bioerodible polymers for solid controlled release pharmaceutical compositions |
| US5260068A (en) | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
| WO1994008568A1 (fr) | 1992-10-16 | 1994-04-28 | Nippon Shinyaku Co., Ltd. | Procede pour fabriquer des matrices de cire |
| US5260069A (en) | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| US5686105A (en) | 1993-10-19 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US5567441A (en) | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
| CA2220451A1 (en) | 1995-05-17 | 1996-11-21 | Cedars-Sinai Medical Center | Methods and compositions for improving digestion and absorption in the small intestine |
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| US6395300B1 (en) | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| US6465014B1 (en) | 2001-03-21 | 2002-10-15 | Isp Investments Inc. | pH-dependent sustained release, drug-delivery composition |
| ATE304545T1 (de) | 2001-06-29 | 2005-09-15 | Novo Nordisk As | Verfahren zur hemmung von tyrosinphosphatase 1b und/oder t-zellenprotein-tyrosinphosphatase und/oder anderen ptpasen mit einem asp-rest in position 48 |
| EP1670804A2 (en) | 2003-09-10 | 2006-06-21 | GPC Biotech AG | Heterobicyclic compounds as pharmaceutically active agents |
| GB0324653D0 (en) | 2003-10-22 | 2003-11-26 | Syngenta Participations Ag | Fungicides |
| EP1684762A4 (en) | 2003-11-13 | 2009-06-17 | Ambit Biosciences Corp | UREA DERIVATIVES AS MODULATORS OF KINASE |
| US20060188445A1 (en) * | 2005-02-22 | 2006-08-24 | Fred Hutchinson Cancer Research Center | Assay for compounds that protect against sensory hair cell death and compounds identified by same |
| US8338623B2 (en) | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| US20110158911A1 (en) * | 2009-07-01 | 2011-06-30 | Trustees Of Dartmouth College | Methods for Screening for Antibiotic Compounds |
| WO2014052914A1 (en) | 2012-09-28 | 2014-04-03 | University Of Washington Through Its Center For Commercialization | Compounds and methods for preventing, treating and/or protecting against sensory hair cell death |
| ES2760373T3 (es) | 2015-02-06 | 2020-05-13 | Univ Washington | Compuestos y procedimientos para prevenir o tratar la muerte de células ciliadas sensoriales |
-
2016
- 2016-02-05 ES ES16747385T patent/ES2760373T3/es active Active
- 2016-02-05 WO PCT/US2016/016880 patent/WO2016127123A2/en not_active Ceased
- 2016-02-05 CA CA2974395A patent/CA2974395C/en active Active
- 2016-02-05 EP EP16747385.9A patent/EP3253766B1/en active Active
- 2016-02-05 US US15/017,472 patent/US9493482B2/en active Active
- 2016-02-05 CN CN201680020455.7A patent/CN107438613B/zh active Active
- 2016-02-05 AU AU2016215023A patent/AU2016215023B2/en active Active
- 2016-02-05 KR KR1020177025003A patent/KR102557184B1/ko active Active
- 2016-02-05 US US15/547,438 patent/US10399994B2/en active Active
- 2016-02-05 DK DK16747385T patent/DK3253766T3/da active
- 2016-02-05 JP JP2017538575A patent/JP6697808B2/ja active Active
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