JP6697808B2 - 感覚有毛細胞の死を防ぐまたは処置するための化合物と方法 - Google Patents

感覚有毛細胞の死を防ぐまたは処置するための化合物と方法 Download PDF

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JP6697808B2
JP6697808B2 JP2017538575A JP2017538575A JP6697808B2 JP 6697808 B2 JP6697808 B2 JP 6697808B2 JP 2017538575 A JP2017538575 A JP 2017538575A JP 2017538575 A JP2017538575 A JP 2017538575A JP 6697808 B2 JP6697808 B2 JP 6697808B2
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alkyl
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pharmaceutically acceptable
compounds
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JP2018504411A5 (enExample
JP2018504411A (ja
Inventor
サイモン，ジュリアン
ジョンソン，グラハム
ダブリュ． ラベル，エドウィン
ダブリュ． ラベル，エドウィン
ダブリュ． ライブル，デイビッド
ダブリュ． ライブル，デイビッド
ディー． ゴンザレス，マリオ
ディー． ゴンザレス，マリオ
シー． メルツァー，ピーター
シー． メルツァー，ピーター
ミャオ，ウェイシ
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University of Washington
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University of Washington
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2017538575A 2015-02-06 2016-02-05 感覚有毛細胞の死を防ぐまたは処置するための化合物と方法 Active JP6697808B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562113245P 2015-02-06 2015-02-06
US62/113,245 2015-02-06
PCT/US2016/016880 WO2016127123A2 (en) 2015-02-06 2016-02-05 Compounds and methods for preventing or treating sensory hair cell death

Publications (3)

Publication Number Publication Date
JP2018504411A JP2018504411A (ja) 2018-02-15
JP2018504411A5 JP2018504411A5 (enExample) 2019-03-14
JP6697808B2 true JP6697808B2 (ja) 2020-05-27

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JP2017538575A Active JP6697808B2 (ja) 2015-02-06 2016-02-05 感覚有毛細胞の死を防ぐまたは処置するための化合物と方法

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Country Link
US (2) US9493482B2 (enExample)
EP (1) EP3253766B1 (enExample)
JP (1) JP6697808B2 (enExample)
KR (1) KR102557184B1 (enExample)
CN (1) CN107438613B (enExample)
AU (1) AU2016215023B2 (enExample)
CA (1) CA2974395C (enExample)
DK (1) DK3253766T3 (enExample)
ES (1) ES2760373T3 (enExample)
WO (1) WO2016127123A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3253766B1 (en) 2015-02-06 2019-09-04 University of Washington Compounds and methods for preventing or treating sensory hair cell death
EP3366683A1 (en) 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers
KR20200086257A (ko) * 2017-09-01 2020-07-16 유니버시티 오브 워싱톤 감각 모 세포 사멸 예방 또는 치료용 화합물의 결정질 형태
WO2020033322A1 (en) * 2018-08-06 2020-02-13 Fred Hutchinson Cancer Research Center Hearing loss-protective compounds and methods thereof
WO2022020114A2 (en) 2020-07-10 2022-01-27 Ting Therapeutics Llc Methods for the prevention and treatment of hearing loss
KR102848315B1 (ko) * 2022-10-27 2025-08-20 고려대학교 산학협력단 암모늄 락테이트를 유효성분으로 포함하는 난청 예방 또는 치료용 약학 조성물

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US4174396A (en) 1978-04-03 1979-11-13 Laboratories Made, S.A. 7,10-Dimethyl-5,9-imino-4,5,8,9-tetrahydro-cyclooct[b]thiophenes and a process for obtaining it
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Also Published As

Publication number Publication date
WO2016127123A2 (en) 2016-08-11
EP3253766B1 (en) 2019-09-04
KR20180003530A (ko) 2018-01-09
HK1246791A1 (en) 2018-09-14
JP2018504411A (ja) 2018-02-15
AU2016215023B2 (en) 2019-12-19
AU2016215023A1 (en) 2017-09-07
WO2016127123A3 (en) 2016-10-27
CN107438613B (zh) 2020-08-25
US10399994B2 (en) 2019-09-03
KR102557184B1 (ko) 2023-07-18
EP3253766A2 (en) 2017-12-13
US9493482B2 (en) 2016-11-15
DK3253766T3 (da) 2019-12-09
US20160229869A1 (en) 2016-08-11
CA2974395A1 (en) 2016-08-11
CN107438613A (zh) 2017-12-05
ES2760373T3 (es) 2020-05-13
EP3253766A4 (en) 2018-07-25
CA2974395C (en) 2023-08-22
US20180022756A1 (en) 2018-01-25

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