JP2018504122A5 - - Google Patents
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- JP2018504122A5 JP2018504122A5 JP2017539018A JP2017539018A JP2018504122A5 JP 2018504122 A5 JP2018504122 A5 JP 2018504122A5 JP 2017539018 A JP2017539018 A JP 2017539018A JP 2017539018 A JP2017539018 A JP 2017539018A JP 2018504122 A5 JP2018504122 A5 JP 2018504122A5
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Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6800859B2 (ja) | 2015-01-26 | 2020-12-16 | フェイト セラピューティクス，インコーポレイテッド | 造血細胞分化を誘導するための方法および組成物 |
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| EP3371314B1 (en) | 2015-11-04 | 2023-07-05 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
| KR20250033315A (ko) | 2015-11-04 | 2025-03-07 | 페이트 세러퓨틱스, 인코포레이티드 | 조혈 세포 분화를 유도하기 위한 방법 및 조성물 |
| WO2017127755A1 (en) | 2016-01-20 | 2017-07-27 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
| CN116376826A (zh) | 2016-01-20 | 2023-07-04 | 菲特治疗公司 | 用来在过继性免疫疗法中进行免疫细胞调节的组合物和方法 |
| US9918994B2 (en) | 2016-03-04 | 2018-03-20 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for muscle regeneration using prostaglandin E2 |
| WO2018106595A1 (en) | 2016-12-05 | 2018-06-14 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
| KR102698911B1 (ko) | 2017-06-09 | 2024-08-23 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 근육 질환을 예방하거나 치료하기 위한 조성물 및 방법 |
| US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
| CN107714717A (zh) * | 2017-10-11 | 2018-02-23 | 刘志强 | 聚肌胞苷酸在制备治疗或预防结肠炎的药物中的应用 |
| DK3752598T3 (da) * | 2018-02-16 | 2022-11-21 | Nextcell Pharma Ab | Allogen sammensætning |
| US20210353679A1 (en) * | 2018-10-10 | 2021-11-18 | North Carolina State University | Pd-l1 presenting platelets reverse new-onset type 1 diabetes |
| CN113474002A (zh) * | 2018-10-12 | 2021-10-01 | 索尔克生物学研究所 | 逃避免疫检测和自身免疫的细胞、胰岛和类器官、其生产方法及其用途 |
| CN109706180A (zh) * | 2019-01-11 | 2019-05-03 | 杭州荣泽生物科技有限公司 | 一种脐带间充质干细胞过表达ido增强免疫抑制的方法及应用 |
| CA3128871A1 (en) * | 2019-02-09 | 2020-08-13 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Genetically modified hematopoietic stem and progenitor cells (hspcs) and mesenchymal cells as a platform to reduce or prevent metastasis, treat autoimmune and inflammatory disorders, and rebalance the immune milieu_and dysregulated niches |
| WO2021007180A1 (en) * | 2019-07-05 | 2021-01-14 | Case Western Reserve University | Priming media and methods for stem cell culture and therapy |
| US20230119606A1 (en) * | 2020-02-18 | 2023-04-20 | Octagon Therapeutics, Inc. | Immune cell modulators |
| EP4171589A4 (en) * | 2020-06-26 | 2024-07-17 | The Children's Medical Center Corporation | Methods and compositions for treating multiple sclerosis |
| KR20230037044A (ko) * | 2020-07-08 | 2023-03-15 | 더 잭슨 래보라토리 | 인간 hla-a201 제한 유전자를 발현하는 트랜스제닉 마우스 모델 |
| JPWO2022202352A1 (cg-RX-API-DMAC7.html) | 2021-03-24 | 2022-09-29 | ||
| KR20220162394A (ko) * | 2021-06-01 | 2022-12-08 | 에스씨엠생명과학 주식회사 | 기능강화 줄기세포 및 조절 t 세포를 포함하는 아토피 피부염 예방 또는 치료용 병용투여 조성물 |
| WO2025043075A1 (en) * | 2023-08-24 | 2025-02-27 | The Johns Hopkins University | Methods of treating myocardial infarction, ischemia, and ischemia reperfusion injury |
| WO2025199431A1 (en) * | 2024-03-22 | 2025-09-25 | Colorado State University Research Foundation | Innate immune pathway activated mesenchymal stromal cells for treatment of musculoskeletal disorders or conditions |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US5677136A (en) | 1994-11-14 | 1997-10-14 | Systemix, Inc. | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| WO2000038663A2 (en) | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Ep4 receptor agonists for treatment of dry eye |
| DK1132086T3 (da) | 2000-01-31 | 2006-08-28 | Pfizer Prod Inc | Anvendelse af prostaglandin (PGE2) selektive receptor 4 (EP4) agonister til behandling af akut og kronisk nyresvigt |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| EP1501918A4 (en) * | 2002-04-12 | 2006-03-29 | Med College Georgia Res Inst | ANTIGEN PRESENTING CELL POPULATIONS AND THEIR USE AS REAGENTS TO INCREASE OR REDUCE IMMUNO TOLERANCE |
| US7763251B2 (en) * | 2002-04-12 | 2010-07-27 | Medical College Of Georgia Research Institute, Inc. | Kits to assess the risk of tumor progression |
| US6747037B1 (en) | 2003-06-06 | 2004-06-08 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
| WO2005040391A1 (en) * | 2003-10-27 | 2005-05-06 | Murdoch Childrens Research Institute | Compositions and methods for differentiating stem cells |
| US7592177B2 (en) | 2003-11-10 | 2009-09-22 | The Scripps Research Institute | Compositions and methods for inducing cell dedifferentiation |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| DE102005062741A1 (de) | 2005-12-22 | 2007-06-28 | Bayer Schering Pharma Ag | Fluorene und Carbazole als Liganden des EP2 Rezeptors |
| WO2008054825A2 (en) * | 2006-11-03 | 2008-05-08 | Aastrom Biosciences, Inc. | Mixed cell populations for tissue repair and separation technique for cell processing |
| MX352541B (es) | 2007-04-07 | 2017-11-29 | Whitehead Inst Biomedical Res | Reprogramación de células somáticas. |
| EP2581441A1 (en) * | 2007-08-09 | 2013-04-17 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
| WO2009032194A1 (en) | 2007-08-31 | 2009-03-12 | Whitehead Institute For Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| CA2718904C (en) | 2008-03-17 | 2017-01-03 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| RU2573912C2 (ru) * | 2008-10-08 | 2016-01-27 | Интрексон Корпорейшн | Сконструированные клетки, экспрессирующие множественные иммуномодуляторы, и их применения |
| ES2845641T3 (es) | 2008-11-06 | 2021-07-27 | Univ Indiana Res & Tech Corp | Materiales y métodos para mejorar procedimientos de injerto funcionante de células madre hematopoyéticas |
| ES2645869T3 (es) | 2008-12-17 | 2017-12-11 | The Scripps Research Institute | Generación y mantenimiento de células madre |
| WO2010108028A2 (en) | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same |
| AU2010276194B2 (en) * | 2009-07-24 | 2012-02-02 | Immune Design Corp | Lentiviral vectors pseudotyped with a Sindbis virus envelope glycoprotein |
| JP5808331B2 (ja) | 2009-10-16 | 2015-11-10 | ザ スクリプス リサーチ インスティテュート | 多能性細胞の誘導法 |
| CA2780572A1 (en) * | 2009-11-13 | 2011-05-19 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Modulated programmed death ligand-1 |
| CA2782757C (en) * | 2009-12-08 | 2017-07-18 | Yong Zhao | Stem cell immune modulation methods of use and apparatus |
| RU2612788C2 (ru) * | 2010-03-23 | 2017-03-13 | Интрексон Корпорейшн | Векторы, условно экспрессирующие терапевтические белки, клетки-хозяева, содержащие указанные векторы, и их применение |
| MX342017B (es) * | 2010-03-26 | 2016-09-09 | Dartmouth College | Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos. |
| BR112013003366A2 (pt) * | 2010-08-12 | 2020-08-04 | Fate Therapeutics, Inc. | terapia aperfeiçoada de células tronco hematopoiéticas e progenitoras |
| WO2013040552A2 (en) * | 2011-09-16 | 2013-03-21 | Georgia Health Sciences University | Methods of promoting immune tolerance |
| EP3785767A1 (en) * | 2011-12-02 | 2021-03-03 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
| US20150139994A1 (en) * | 2013-11-12 | 2015-05-21 | The Regents Of The University Of California | Compositions and methods for preventing allogeneic immune rejection |
| JP2018520688A (ja) * | 2015-07-21 | 2018-08-02 | ザ チルドレンズ メディカル センター コーポレーション | Ｐｄ−ｌ１発現造血幹細胞およびその使用 |
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2020
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