JP2018502900A5 - - Google Patents
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- Publication number
- JP2018502900A5 JP2018502900A5 JP2017540966A JP2017540966A JP2018502900A5 JP 2018502900 A5 JP2018502900 A5 JP 2018502900A5 JP 2017540966 A JP2017540966 A JP 2017540966A JP 2017540966 A JP2017540966 A JP 2017540966A JP 2018502900 A5 JP2018502900 A5 JP 2018502900A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyrimidin
- phenyl
- carboxamide
- tetrahydroisoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCC(C)CCC(N(*)C(C)(CC(C)(C)CNC(C)C)O)=*C Chemical compound CCC(C)CCC(N(*)C(C)(CC(C)(C)CNC(C)C)O)=*C 0.000 description 6
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462067070P | 2014-10-22 | 2014-10-22 | |
| US62/067,070 | 2014-10-22 | ||
| US201562204176P | 2015-08-12 | 2015-08-12 | |
| US62/204,176 | 2015-08-12 | ||
| PCT/US2015/056611 WO2016064970A1 (en) | 2014-10-22 | 2015-10-21 | Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502900A JP2018502900A (ja) | 2018-02-01 |
| JP2018502900A5 true JP2018502900A5 (enExample) | 2018-11-22 |
Family
ID=55761466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540966A Pending JP2018502900A (ja) | 2014-10-22 | 2015-10-21 | ジスコイジンドメイン受容体１を標的化する小分子阻害剤およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10370360B2 (enExample) |
| EP (1) | EP3209299A4 (enExample) |
| JP (1) | JP2018502900A (enExample) |
| CN (1) | CN107206004A (enExample) |
| AU (1) | AU2015335980A1 (enExample) |
| CA (1) | CA2965336A1 (enExample) |
| WO (1) | WO2016064970A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3102576T1 (sl) | 2014-02-03 | 2019-08-30 | Vitae Pharmaceuticals, Llc | Inhibitorji dihidropirolopiridina ROR-gama |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| ES2856931T3 (es) | 2015-08-05 | 2021-09-28 | Vitae Pharmaceuticals Llc | Moduladores de ROR-gamma |
| WO2017087608A1 (en) | 2015-11-20 | 2017-05-26 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| CN108276388B (zh) * | 2017-03-10 | 2020-01-14 | 成都医学院 | 1h-吲哚类衍生物及其用途 |
| US12133896B2 (en) | 2017-03-23 | 2024-11-05 | Kaohsiung Medical University | Methods for treating or alleviating a bone-loss related disease or condition by administering a nucleic acid encoding a discoidin domain receptor 1 (DDR1) protein |
| TWI676482B (zh) * | 2017-03-23 | 2019-11-11 | 高雄醫學大學 | 盤基蛋白結構域受體１的抑制劑及活化劑及其用途 |
| CN109963845B (zh) * | 2017-05-23 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 螺环甲酰胺类衍生物、其制备方法及其在医药上的应用 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| KR20200053481A (ko) | 2017-07-24 | 2020-05-18 | 비타이 파마슈티컬즈, 엘엘씨 | RORγ의 억제제 |
| KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
| CN108624590A (zh) * | 2018-04-19 | 2018-10-09 | 西安医学院 | 一种抑制DDR2表达的siRNA及其应用 |
| WO2019243431A1 (en) * | 2018-06-20 | 2019-12-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for treating melanoma |
| CN111217748B (zh) * | 2018-11-23 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 一种螺环二氢异喹啉甲酰胺类衍生物的晶型及其制备方法 |
| US20230227447A1 (en) | 2020-05-25 | 2023-07-20 | Chiesi Farmaceutici S.P.A. | Benzylamine derivatives as ddrs inhibitors |
| GB202010464D0 (en) * | 2020-07-08 | 2020-08-19 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases |
| CN112321591B (zh) * | 2020-11-03 | 2022-11-08 | 中国药科大学 | 盘状结构域受体1蛋白抑制剂、制备方法及应用 |
| WO2022128850A1 (en) * | 2020-12-16 | 2022-06-23 | Galapagos Nv | Novel isoquinoline derivatives and pharmaceutical copositions thereof for the treatment of diseases |
| CN117062812A (zh) * | 2021-03-26 | 2023-11-14 | 奇斯药制品公司 | 作为ddr抑制剂的吲哚啉衍生物 |
| JP2024512595A (ja) | 2021-03-26 | 2024-03-19 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｄｄｒ阻害剤としてのテトラヒドロチエノピリジン誘導体 |
| AU2022246108A1 (en) | 2021-03-26 | 2023-11-09 | Chiesi Farmaceutici S.P.A. | Indoline derivatives as ddr1 and ddr2 inhibitors |
| WO2022200578A1 (en) | 2021-03-26 | 2022-09-29 | Chiesi Farmaceutici S.P.A. | Tetrahydrothieno pyridine derivatives as ddrs inhibitors |
| PT4313293T (pt) * | 2021-11-22 | 2025-07-25 | Chiesi Farm Spa | Derivados de tetraidrotieno piridina como inibidores de ddrs |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU23499A (sh) * | 1996-11-27 | 2001-07-10 | Pfizer Inc. | Inhibitorski amidi apo-b-sekrecije/mtp-a |
| IN188411B (enExample) * | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| JP2007523152A (ja) * | 2004-02-18 | 2007-08-16 | ファイザー・プロダクツ・インク | キナゾリンおよびイソキノリンのテトラヒドロイソキノリニル誘導体 |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| HRP20141239T1 (xx) * | 2009-02-11 | 2015-03-13 | Merck Patent Gmbh | Novi amino azaheterocikliäśki karboksamidi |
| AR081034A1 (es) | 2010-05-11 | 2012-05-30 | Sanofi Aventis | Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central |
| CN103965195B (zh) * | 2013-02-01 | 2016-09-28 | 中国科学院广州生物医药与健康研究院 | 用于盘状结构域受体小分子抑制剂的化合物及其应用 |
| WO2014167444A1 (en) * | 2013-04-08 | 2014-10-16 | Glenmark Pharmaceuticals S.A. | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS |
-
2015
- 2015-10-21 JP JP2017540966A patent/JP2018502900A/ja active Pending
- 2015-10-21 CN CN201580067710.9A patent/CN107206004A/zh active Pending
- 2015-10-21 AU AU2015335980A patent/AU2015335980A1/en not_active Abandoned
- 2015-10-21 CA CA2965336A patent/CA2965336A1/en not_active Abandoned
- 2015-10-21 US US15/521,107 patent/US10370360B2/en active Active
- 2015-10-21 WO PCT/US2015/056611 patent/WO2016064970A1/en not_active Ceased
- 2015-10-21 EP EP15852998.2A patent/EP3209299A4/en not_active Withdrawn
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