JP2018502574A5 - - Google Patents
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- JP2018502574A5 JP2018502574A5 JP2017535829A JP2017535829A JP2018502574A5 JP 2018502574 A5 JP2018502574 A5 JP 2018502574A5 JP 2017535829 A JP2017535829 A JP 2017535829A JP 2017535829 A JP2017535829 A JP 2017535829A JP 2018502574 A5 JP2018502574 A5 JP 2018502574A5
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- Prior art keywords
- cells
- human
- population
- infecting
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 31
- 238000000034 method Methods 0.000 claims 14
- 210000005260 human cell Anatomy 0.000 claims 12
- 239000013604 expression vector Substances 0.000 claims 9
- 108091023040 Transcription factor Proteins 0.000 claims 8
- 102000040945 Transcription factor Human genes 0.000 claims 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims 6
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 210000003494 hepatocyte Anatomy 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 101100129232 Danio rerio mafaa gene Proteins 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 4
- 108090001061 Insulin Proteins 0.000 claims 4
- 101150051019 Klrg1 gene Proteins 0.000 claims 4
- 101150084866 MAFA gene Proteins 0.000 claims 4
- 101710144033 Pancreas/duodenum homeobox protein 1 Proteins 0.000 claims 4
- 102100041030 Pancreas/duodenum homeobox protein 1 Human genes 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 229940125396 insulin Drugs 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 108050000588 Neurogenic differentiation factor 1 Proteins 0.000 claims 3
- 102100032063 Neurogenic differentiation factor 1 Human genes 0.000 claims 3
- 102000051325 Glucagon Human genes 0.000 claims 2
- 108060003199 Glucagon Proteins 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 102100028098 Homeobox protein Nkx-6.1 Human genes 0.000 claims 2
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 230000005014 ectopic expression Effects 0.000 claims 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 2
- 229960004666 glucagon Drugs 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 230000003914 insulin secretion Effects 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 1
- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 1
- 102100034452 Alternative prion protein Human genes 0.000 claims 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 1
- 102100025422 Bone morphogenetic protein receptor type-2 Human genes 0.000 claims 1
- 108010075254 C-Peptide Proteins 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100027043 Discoidin, CUB and LCCL domain-containing protein 2 Human genes 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 102100023607 Homer protein homolog 1 Human genes 0.000 claims 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
- 101000924727 Homo sapiens Alternative prion protein Proteins 0.000 claims 1
- 101000934635 Homo sapiens Bone morphogenetic protein receptor type-2 Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000911787 Homo sapiens Discoidin, CUB and LCCL domain-containing protein 2 Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101001048469 Homo sapiens Homer protein homolog 1 Proteins 0.000 claims 1
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims 1
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims 1
- 101000604998 Homo sapiens Lysosome-associated membrane glycoprotein 3 Proteins 0.000 claims 1
- 101000573901 Homo sapiens Major prion protein Proteins 0.000 claims 1
- 101000612089 Homo sapiens Pancreas/duodenum homeobox protein 1 Proteins 0.000 claims 1
- 101000955481 Homo sapiens Phosphatidylcholine translocator ABCB4 Proteins 0.000 claims 1
- 101000659879 Homo sapiens Thrombospondin-1 Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 101000639146 Homo sapiens Vesicle-associated membrane protein 4 Proteins 0.000 claims 1
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 1
- 102100032816 Integrin alpha-6 Human genes 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- 102100038213 Lysosome-associated membrane glycoprotein 3 Human genes 0.000 claims 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 208000016222 Pancreatic disease Diseases 0.000 claims 1
- 101150075928 Pax4 gene Proteins 0.000 claims 1
- 102100039032 Phosphatidylcholine translocator ABCB4 Human genes 0.000 claims 1
- 108091027981 Response element Proteins 0.000 claims 1
- 102100036034 Thrombospondin-1 Human genes 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 102100031489 Vesicle-associated membrane protein 4 Human genes 0.000 claims 1
- 102000013814 Wnt Human genes 0.000 claims 1
- 230000004156 Wnt signaling pathway Effects 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 102000005396 glutamine synthetase Human genes 0.000 claims 1
- 108020002326 glutamine synthetase Proteins 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000003897 hepatic stem cell Anatomy 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- 210000005229 liver cell Anatomy 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 208000024691 pancreas disease Diseases 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 210000004991 placental stem cell Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
- 210000004989 spleen cell Anatomy 0.000 claims 1
- 210000003954 umbilical cord Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462098050P | 2014-12-30 | 2014-12-30 | |
| US62/098,050 | 2014-12-30 | ||
| PCT/IL2015/051267 WO2016108237A1 (en) | 2014-12-30 | 2015-12-30 | Methods of transdifferentiation and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502574A JP2018502574A (ja) | 2018-02-01 |
| JP2018502574A5 true JP2018502574A5 (enExample) | 2018-03-15 |
| JP6817943B2 JP6817943B2 (ja) | 2021-01-20 |
Family
ID=56284403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017535829A Expired - Fee Related JP6817943B2 (ja) | 2014-12-30 | 2015-12-30 | 分化転換方法及びその使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10179151B2 (enExample) |
| EP (2) | EP3240576B1 (enExample) |
| JP (1) | JP6817943B2 (enExample) |
| KR (1) | KR102487883B1 (enExample) |
| CN (1) | CN107750170B (enExample) |
| AU (1) | AU2015373129B2 (enExample) |
| BR (1) | BR112017014280A2 (enExample) |
| CA (1) | CA2972569A1 (enExample) |
| CO (1) | CO2017006937A2 (enExample) |
| EA (1) | EA035360B1 (enExample) |
| IL (1) | IL253234B (enExample) |
| MA (1) | MA41296A (enExample) |
| MX (1) | MX378321B (enExample) |
| SG (1) | SG11201705344VA (enExample) |
| WO (1) | WO2016108237A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201510209SA (en) | 2013-06-13 | 2016-01-28 | Orgenesis Ltd | Cell populations, methods of transdifferention and methods of use thereof |
| US10231817B2 (en) | 2013-09-24 | 2019-03-19 | Giner Life Sciences, Inc. | System for gas treatment of a cell implant |
| MA41296A (fr) | 2014-12-30 | 2017-11-07 | Orgenesis Ltd | Procédés de transdifférenciation et procédés d'utilisation de ceux-ci |
| WO2017192717A1 (en) | 2016-05-05 | 2017-11-09 | Southwest Research Institute | Three-dimensional bioreactor for cell expansion and related applications |
| US11033666B2 (en) | 2016-11-15 | 2021-06-15 | Giner Life Sciences, Inc. | Percutaneous gas diffusion device suitable for use with a subcutaneous implant |
| WO2018204867A1 (en) | 2017-05-04 | 2018-11-08 | Giner, Inc. | Robust, implantable gas delivery device and methods, systems and devices including same |
| EP3635106A4 (en) | 2017-05-08 | 2021-01-06 | Orgenesis Ltd. | POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE |
| WO2018220623A1 (en) * | 2017-05-29 | 2018-12-06 | Orgenesis Ltd. | Compositions and methods for providing cell replacement therapy |
| JP2020537522A (ja) | 2017-10-13 | 2020-12-24 | イーエムベーアー−インスティテュート フュール モレクラレ バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング | 体細胞の増強された再プログラミング |
| WO2019171377A1 (en) * | 2018-03-06 | 2019-09-12 | Orgenesis Inc | Three dimensional clusters of transdifferentiated cells, compositions and methods thereof |
| US11149244B2 (en) | 2018-04-04 | 2021-10-19 | Southwest Research Institute | Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy |
| WO2020068840A1 (en) | 2018-09-24 | 2020-04-02 | Southwest Research Institute | Three-dimensional bioreactors |
| EP3816276A1 (en) * | 2019-10-31 | 2021-05-05 | Unicyte Islet AG | Viable pancreatic islet-like cell structures and a method of preparing thereof |
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