AU2015373129B2 - Methods of transdifferentiation and methods of use thereof - Google Patents

Methods of transdifferentiation and methods of use thereof Download PDF

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Publication number
AU2015373129B2
AU2015373129B2 AU2015373129A AU2015373129A AU2015373129B2 AU 2015373129 B2 AU2015373129 B2 AU 2015373129B2 AU 2015373129 A AU2015373129 A AU 2015373129A AU 2015373129 A AU2015373129 A AU 2015373129A AU 2015373129 B2 AU2015373129 B2 AU 2015373129B2
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cells
cell
expression
transdifferentiation
another embodiment
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AU2015373129A1 (en
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Sarah Ferber
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Tel HaShomer Medical Research Infrastructure and Services Ltd
Orgenesis Ltd
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Tel HaShomer Medical Research Infrastructure and Services Ltd
Orgenesis Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2501/60—Transcription factors
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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AU2015373129A 2014-12-30 2015-12-30 Methods of transdifferentiation and methods of use thereof Ceased AU2015373129B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098050P 2014-12-30 2014-12-30
US62/098,050 2014-12-30
PCT/IL2015/051267 WO2016108237A1 (en) 2014-12-30 2015-12-30 Methods of transdifferentiation and methods of use thereof

Publications (2)

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AU2015373129A1 AU2015373129A1 (en) 2017-08-03
AU2015373129B2 true AU2015373129B2 (en) 2021-07-15

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US (3) US10179151B2 (enExample)
EP (2) EP3698803B1 (enExample)
JP (1) JP6817943B2 (enExample)
KR (1) KR102487883B1 (enExample)
CN (1) CN107750170B (enExample)
AU (1) AU2015373129B2 (enExample)
BR (1) BR112017014280A2 (enExample)
CA (1) CA2972569A1 (enExample)
CO (1) CO2017006937A2 (enExample)
EA (1) EA035360B1 (enExample)
IL (1) IL253234B (enExample)
MA (1) MA41296A (enExample)
MX (1) MX378321B (enExample)
SG (1) SG11201705344VA (enExample)
WO (1) WO2016108237A1 (enExample)

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