JP2018172391A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018172391A5 JP2018172391A5 JP2018106308A JP2018106308A JP2018172391A5 JP 2018172391 A5 JP2018172391 A5 JP 2018172391A5 JP 2018106308 A JP2018106308 A JP 2018106308A JP 2018106308 A JP2018106308 A JP 2018106308A JP 2018172391 A5 JP2018172391 A5 JP 2018172391A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- peptide
- protein
- fab
- hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 235000018102 proteins Nutrition 0.000 claims 24
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 230000000975 bioactive effect Effects 0.000 claims 21
- 150000001413 amino acids Chemical group 0.000 claims 15
- 238000000034 method Methods 0.000 claims 13
- 230000004927 fusion Effects 0.000 claims 12
- 239000012636 effector Substances 0.000 claims 10
- 241000588724 Escherichia coli Species 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000003102 growth factor Substances 0.000 claims 8
- 150000007523 nucleic acids Chemical group 0.000 claims 8
- 102000002265 Human Growth Hormone Human genes 0.000 claims 7
- 108010000521 Human Growth Hormone Proteins 0.000 claims 7
- 239000000854 Human Growth Hormone Substances 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 235000018417 cysteine Nutrition 0.000 claims 7
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 6
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 6
- 101800003838 Epidermal growth factor Proteins 0.000 claims 6
- 102400001368 Epidermal growth factor Human genes 0.000 claims 6
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 claims 6
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 6
- 108010063738 Interleukins Proteins 0.000 claims 6
- 102000015696 Interleukins Human genes 0.000 claims 6
- 102100022831 Somatoliberin Human genes 0.000 claims 6
- 101710142969 Somatoliberin Proteins 0.000 claims 6
- 102000013275 Somatomedins Human genes 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 6
- 229940116977 epidermal growth factor Drugs 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- 210000002540 macrophage Anatomy 0.000 claims 6
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 6
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- 108010050904 Interferons Proteins 0.000 claims 5
- 102000014150 Interferons Human genes 0.000 claims 5
- 108010071390 Serum Albumin Proteins 0.000 claims 5
- 102000007562 Serum Albumin Human genes 0.000 claims 5
- 239000012190 activator Substances 0.000 claims 5
- 229940088598 enzyme Drugs 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 229940079322 interferon Drugs 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 5
- 230000002068 genetic effect Effects 0.000 claims 4
- 210000001322 periplasm Anatomy 0.000 claims 4
- FHZSIZRTNHGLSX-FLMSMKGQSA-N (2s)-1-[(2s)-4-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carboxyl Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 FHZSIZRTNHGLSX-FLMSMKGQSA-N 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 3
- 102000009840 Angiopoietins Human genes 0.000 claims 3
- 108010009906 Angiopoietins Proteins 0.000 claims 3
- 102400000068 Angiostatin Human genes 0.000 claims 3
- 108010079709 Angiostatins Proteins 0.000 claims 3
- 108010064733 Angiotensins Proteins 0.000 claims 3
- 102000015427 Angiotensins Human genes 0.000 claims 3
- 101710095339 Apolipoprotein E Proteins 0.000 claims 3
- 102100029470 Apolipoprotein E Human genes 0.000 claims 3
- 102100033367 Appetite-regulating hormone Human genes 0.000 claims 3
- 102100023995 Beta-nerve growth factor Human genes 0.000 claims 3
- 101000645291 Bos taurus Metalloproteinase inhibitor 2 Proteins 0.000 claims 3
- 108010074051 C-Reactive Protein Proteins 0.000 claims 3
- 102100032752 C-reactive protein Human genes 0.000 claims 3
- 102000014914 Carrier Proteins Human genes 0.000 claims 3
- 102100025841 Cholecystokinin Human genes 0.000 claims 3
- 101800001982 Cholecystokinin Proteins 0.000 claims 3
- 102100022641 Coagulation factor IX Human genes 0.000 claims 3
- 102100023804 Coagulation factor VII Human genes 0.000 claims 3
- 229940122097 Collagenase inhibitor Drugs 0.000 claims 3
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 claims 3
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims 3
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 claims 3
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 claims 3
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 claims 3
- 102000003951 Erythropoietin Human genes 0.000 claims 3
- 108090000394 Erythropoietin Proteins 0.000 claims 3
- 108010076282 Factor IX Proteins 0.000 claims 3
- 108010023321 Factor VII Proteins 0.000 claims 3
- 108010054218 Factor VIII Proteins 0.000 claims 3
- 102000001690 Factor VIII Human genes 0.000 claims 3
- 108010054265 Factor VIIa Proteins 0.000 claims 3
- 108010071289 Factor XIII Proteins 0.000 claims 3
- 108010073385 Fibrin Proteins 0.000 claims 3
- 102000009123 Fibrin Human genes 0.000 claims 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 3
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 3
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 3
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 3
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 3
- 108700012941 GNRH1 Proteins 0.000 claims 3
- 108090001053 Gastrin releasing peptide Proteins 0.000 claims 3
- 102000004862 Gastrin releasing peptide Human genes 0.000 claims 3
- 102000051325 Glucagon Human genes 0.000 claims 3
- 108060003199 Glucagon Proteins 0.000 claims 3
- 108010088406 Glucagon-Like Peptides Proteins 0.000 claims 3
- 102000003886 Glycoproteins Human genes 0.000 claims 3
- 108090000288 Glycoproteins Proteins 0.000 claims 3
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 3
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 3
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 3
- 102000001554 Hemoglobins Human genes 0.000 claims 3
- 108010054147 Hemoglobins Proteins 0.000 claims 3
- 102000007625 Hirudins Human genes 0.000 claims 3
- 108010007267 Hirudins Proteins 0.000 claims 3
- 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- 102000001617 Interferon Receptors Human genes 0.000 claims 3
- 108010054267 Interferon Receptors Proteins 0.000 claims 3
- 102000004407 Lactalbumin Human genes 0.000 claims 3
- 108090000942 Lactalbumin Proteins 0.000 claims 3
- 108010063045 Lactoferrin Proteins 0.000 claims 3
- 102000010445 Lactoferrin Human genes 0.000 claims 3
- 102000016267 Leptin Human genes 0.000 claims 3
- 108010092277 Leptin Proteins 0.000 claims 3
- 108010073521 Luteinizing Hormone Proteins 0.000 claims 3
- 102000009151 Luteinizing Hormone Human genes 0.000 claims 3
- 102000004083 Lymphotoxin-alpha Human genes 0.000 claims 3
- 108090000542 Lymphotoxin-alpha Proteins 0.000 claims 3
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims 3
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 3
- 102000003982 Parathyroid hormone Human genes 0.000 claims 3
- 108090000445 Parathyroid hormone Proteins 0.000 claims 3
- 108010001014 Plasminogen Activators Proteins 0.000 claims 3
- 102000001938 Plasminogen Activators Human genes 0.000 claims 3
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 3
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 3
- 101800004937 Protein C Proteins 0.000 claims 3
- 102000017975 Protein C Human genes 0.000 claims 3
- 102000003743 Relaxin Human genes 0.000 claims 3
- 108090000103 Relaxin Proteins 0.000 claims 3
- 101800001700 Saposin-D Proteins 0.000 claims 3
- 102100037505 Secretin Human genes 0.000 claims 3
- 108010086019 Secretin Proteins 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- 108010023197 Streptokinase Proteins 0.000 claims 3
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 3
- 108010012715 Superoxide dismutase Proteins 0.000 claims 3
- 102000000479 TCF Transcription Factors Human genes 0.000 claims 3
- 108010016283 TCF Transcription Factors Proteins 0.000 claims 3
- 108090000190 Thrombin Proteins 0.000 claims 3
- 102000003790 Thrombin receptors Human genes 0.000 claims 3
- 108010079274 Thrombomodulin Proteins 0.000 claims 3
- 102100026966 Thrombomodulin Human genes 0.000 claims 3
- 102000011923 Thyrotropin Human genes 0.000 claims 3
- 108010061174 Thyrotropin Proteins 0.000 claims 3
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 3
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 208000026935 allergic disease Diseases 0.000 claims 3
- 230000007815 allergy Effects 0.000 claims 3
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 108091008324 binding proteins Proteins 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 230000008468 bone growth Effects 0.000 claims 3
- 230000001413 cellular effect Effects 0.000 claims 3
- DDPFHDCZUJFNAT-PZPWKVFESA-N chembl2104402 Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 DDPFHDCZUJFNAT-PZPWKVFESA-N 0.000 claims 3
- 229940107137 cholecystokinin Drugs 0.000 claims 3
- 239000002442 collagenase inhibitor Substances 0.000 claims 3
- 210000002808 connective tissue Anatomy 0.000 claims 3
- 102000026898 cytokine binding proteins Human genes 0.000 claims 3
- 108091008470 cytokine binding proteins Proteins 0.000 claims 3
- 108700032313 elcatonin Proteins 0.000 claims 3
- 229960000756 elcatonin Drugs 0.000 claims 3
- 229940105423 erythropoietin Drugs 0.000 claims 3
- 229960004222 factor ix Drugs 0.000 claims 3
- 229940012413 factor vii Drugs 0.000 claims 3
- 229940012414 factor viia Drugs 0.000 claims 3
- 229960000301 factor viii Drugs 0.000 claims 3
- 229940012444 factor xiii Drugs 0.000 claims 3
- 229950003499 fibrin Drugs 0.000 claims 3
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 3
- 108010077689 gamma-aminobutyryl-2-methyltryptophyl-2-methyltryptophyl-2-methyltryptophyl-lysinamide Proteins 0.000 claims 3
- PUBCCFNQJQKCNC-XKNFJVFFSA-N gastrin-releasingpeptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)C1=CNC=N1 PUBCCFNQJQKCNC-XKNFJVFFSA-N 0.000 claims 3
- 229960004666 glucagon Drugs 0.000 claims 3
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 3
- 229940006607 hirudin Drugs 0.000 claims 3
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 3
- 239000005556 hormone Substances 0.000 claims 3
- 229940051026 immunotoxin Drugs 0.000 claims 3
- 230000002637 immunotoxin Effects 0.000 claims 3
- 239000002596 immunotoxin Substances 0.000 claims 3
- 231100000608 immunotoxin Toxicity 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 102000002467 interleukin receptors Human genes 0.000 claims 3
- 108010093036 interleukin receptors Proteins 0.000 claims 3
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 3
- 229940078795 lactoferrin Drugs 0.000 claims 3
- 235000021242 lactoferrin Nutrition 0.000 claims 3
- 229940039781 leptin Drugs 0.000 claims 3
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 3
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 3
- 229940040129 luteinizing hormone Drugs 0.000 claims 3
- 230000006510 metastatic growth Effects 0.000 claims 3
- 229940053128 nerve growth factor Drugs 0.000 claims 3
- 229960001319 parathyroid hormone Drugs 0.000 claims 3
- 239000000199 parathyroid hormone Substances 0.000 claims 3
- 229940127126 plasminogen activator Drugs 0.000 claims 3
- 229960000856 protein c Drugs 0.000 claims 3
- 239000002464 receptor antagonist Substances 0.000 claims 3
- 229940044551 receptor antagonist Drugs 0.000 claims 3
- 239000002461 renin inhibitor Substances 0.000 claims 3
- 229940086526 renin-inhibitors Drugs 0.000 claims 3
- 229960002101 secretin Drugs 0.000 claims 3
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 claims 3
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- 229960005202 streptokinase Drugs 0.000 claims 3
- 229960004072 thrombin Drugs 0.000 claims 3
- 108010093640 thrombin receptor peptide SFLLRNP Proteins 0.000 claims 3
- 102000003390 tumor necrosis factor Human genes 0.000 claims 3
- 229960005356 urokinase Drugs 0.000 claims 3
- 235000021241 α-lactalbumin Nutrition 0.000 claims 3
- HFDKKNHCYWNNNQ-YOGANYHLSA-N 75976-10-2 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 HFDKKNHCYWNNNQ-YOGANYHLSA-N 0.000 claims 2
- 102000002723 Atrial Natriuretic Factor Human genes 0.000 claims 2
- 101800001288 Atrial natriuretic factor Proteins 0.000 claims 2
- 108060001064 Calcitonin Proteins 0.000 claims 2
- 102000055006 Calcitonin Human genes 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 2
- 108010056852 Myostatin Proteins 0.000 claims 2
- 101710160107 Outer membrane protein A Proteins 0.000 claims 2
- 102000018886 Pancreatic Polypeptide Human genes 0.000 claims 2
- 101710172711 Structural protein Proteins 0.000 claims 2
- 101000983124 Sus scrofa Pancreatic prohormone precursor Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 108091023040 Transcription factor Proteins 0.000 claims 2
- 102000040945 Transcription factor Human genes 0.000 claims 2
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims 2
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- -1 antibodies Substances 0.000 claims 2
- 229960000182 blood factors Drugs 0.000 claims 2
- 229960004015 calcitonin Drugs 0.000 claims 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 2
- 229950008486 carperitide Drugs 0.000 claims 2
- NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000000411 inducer Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000001338 necrotic effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 210000004100 adrenal gland Anatomy 0.000 claims 1
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims 1
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 1
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims 1
- 230000001147 anti-toxic effect Effects 0.000 claims 1
- 230000001054 cortical effect Effects 0.000 claims 1
- 150000001945 cysteines Chemical class 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 108010021724 tonin Proteins 0.000 claims 1
- 230000005760 tumorsuppression Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20130104112 | 2013-08-30 | ||
| KR10-2013-0104112 | 2013-08-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538860A Division JP6422977B2 (ja) | 2013-08-30 | 2014-08-29 | 抗血清アルブミンfabエフェクター部分融合コンストラクト、およびその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018172391A JP2018172391A (ja) | 2018-11-08 |
| JP2018172391A5 true JP2018172391A5 (enExample) | 2019-02-14 |
| JP6800180B2 JP6800180B2 (ja) | 2020-12-16 |
Family
ID=52586989
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538860A Active JP6422977B2 (ja) | 2013-08-30 | 2014-08-29 | 抗血清アルブミンfabエフェクター部分融合コンストラクト、およびその製造方法 |
| JP2018106308A Active JP6800180B2 (ja) | 2013-08-30 | 2018-06-01 | 抗血清アルブミンfabエフェクター部分融合コンストラクト、およびその製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538860A Active JP6422977B2 (ja) | 2013-08-30 | 2014-08-29 | 抗血清アルブミンfabエフェクター部分融合コンストラクト、およびその製造方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9879077B2 (enExample) |
| EP (2) | EP3039038B1 (enExample) |
| JP (2) | JP6422977B2 (enExample) |
| KR (2) | KR101576561B1 (enExample) |
| CN (1) | CN105899532B (enExample) |
| AU (1) | AU2014312456B2 (enExample) |
| BR (1) | BR112016004355A2 (enExample) |
| CA (1) | CA2922618C (enExample) |
| DK (1) | DK3039038T3 (enExample) |
| ES (1) | ES2866848T3 (enExample) |
| MX (1) | MX371328B (enExample) |
| PH (1) | PH12016500403A1 (enExample) |
| PL (1) | PL3039038T3 (enExample) |
| RU (1) | RU2661087C2 (enExample) |
| UA (1) | UA117493C2 (enExample) |
| WO (1) | WO2015030539A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108623691B (zh) * | 2017-03-17 | 2020-05-15 | 北京比洋生物技术有限公司 | IgG样长效免疫融合蛋白及其应用 |
| KR20210022004A (ko) * | 2018-06-18 | 2021-03-02 | 안위타 바이오사이언시스, 인코포레이티드 | 항-메소텔린 작제물 및 이의 용도 |
| EP3930687A4 (en) | 2019-02-25 | 2023-06-07 | The University of Chicago | METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| KR102485892B1 (ko) * | 2020-04-09 | 2023-01-09 | 주식회사 에이프릴바이오 | 고양이 과립구 집락 자극인자 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질 및 이의 용도 |
| KR20220044057A (ko) * | 2020-09-29 | 2022-04-06 | 주식회사 에이프릴바이오 | 인터루킨-18 결합 단백질 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질, 및 이의 용도 |
| JP2025520393A (ja) * | 2022-06-15 | 2025-07-03 | ユーシービー バイオファルマ エスアールエル | フォリスタチン-fc融合タンパク質 |
| KR20240048577A (ko) * | 2022-10-04 | 2024-04-16 | 주식회사 에이프릴바이오 | 난포자극 호르몬 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질 및 이의 용도 |
| CN118393137B (zh) * | 2024-07-01 | 2024-08-20 | 广东赛尔生物科技有限公司 | 一种肠道保护菌的检测试剂盒及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW517061B (en) * | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
| DK1517921T3 (da) * | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| GB0315450D0 (en) * | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| KR20120133403A (ko) * | 2004-06-01 | 2012-12-10 | 도만티스 리미티드 | 증강된 혈청 반감기를 가지는 이특이성 융합 항체 |
| CN101031588A (zh) * | 2004-06-01 | 2007-09-05 | 多曼蒂斯有限公司 | 药物组合物,融合物和结合物 |
| CA2578613A1 (en) * | 2004-08-11 | 2007-01-25 | Trubion Pharmaceuticals, Inc. | Binding domain fusion proteins |
| BRPI0516577A (pt) * | 2004-10-05 | 2008-09-16 | Genentech Inc | agentes terapêuticos com toxicidade diminuìda |
| BRPI0518762A2 (pt) * | 2004-12-02 | 2008-12-09 | Domantis Ltd | fusço de droga, conjugado de droga, Ácido nucleico recombinante ou isolado, construÇço de Ácido nucleico, cÉlula hospedeira, mÉtodo para produzir a fusço de droga, composiÇço farmacÊutica, mÉtodo para tratamento de um indivÍduo tendo uma doenÇa inflamatària, uso de um conjugado de droga ou fusço de droga, e, composiÇço de droga |
| CN101155832B (zh) * | 2005-02-08 | 2013-02-06 | 一般财团法人化学及血清疗法研究所 | 抗体的改良方法 |
| KR20100021627A (ko) * | 2007-06-08 | 2010-02-25 | 다우 글로벌 테크놀로지스 인크. | Ch1 도메인의 절단에 의한 가용성 항체 단편의 발현 |
| ES2667729T3 (es) * | 2007-09-26 | 2018-05-14 | Ucb Biopharma Sprl | Fusiones de anticuerpos con doble especificidad |
| MX2010011145A (es) * | 2008-04-11 | 2011-04-11 | Merrimack Pharmaceuticals Inc | Enlazadores de la albumina de suero humana y conjugados de la misma. |
| WO2010035012A1 (en) * | 2008-09-26 | 2010-04-01 | Ucb Pharma S.A. | Biological products |
| US8685895B2 (en) * | 2008-12-05 | 2014-04-01 | Carolyn Enever | Methods for selecting protease resistant polypeptides |
| CN102612376A (zh) * | 2009-08-06 | 2012-07-25 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内功效的生长激素 |
| GB201005063D0 (en) * | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| BR112012007374A2 (pt) * | 2009-09-30 | 2019-09-24 | Glaxo Group Ltd | composição, formulação oral, injetável, inalável ou nebulizável, e, ácido nucleico isolado ou recombinante |
| EP2710042A2 (en) * | 2011-05-16 | 2014-03-26 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| SG11201401649VA (en) * | 2011-11-11 | 2014-07-30 | Ucb Pharma Sa | Albumin binding antibodies and binding fragments thereof |
-
2014
- 2014-08-29 JP JP2016538860A patent/JP6422977B2/ja active Active
- 2014-08-29 DK DK14839630.2T patent/DK3039038T3/da active
- 2014-08-29 CN CN201480056265.1A patent/CN105899532B/zh active Active
- 2014-08-29 PL PL14839630T patent/PL3039038T3/pl unknown
- 2014-08-29 EP EP14839630.2A patent/EP3039038B1/en active Active
- 2014-08-29 EP EP19192902.5A patent/EP3632930A1/en not_active Withdrawn
- 2014-08-29 WO PCT/KR2014/008106 patent/WO2015030539A1/en not_active Ceased
- 2014-08-29 RU RU2016105586A patent/RU2661087C2/ru active
- 2014-08-29 BR BR112016004355A patent/BR112016004355A2/pt not_active Application Discontinuation
- 2014-08-29 ES ES14839630T patent/ES2866848T3/es active Active
- 2014-08-29 UA UAA201601685A patent/UA117493C2/uk unknown
- 2014-08-29 CA CA2922618A patent/CA2922618C/en active Active
- 2014-08-29 MX MX2016002539A patent/MX371328B/es active IP Right Grant
- 2014-08-29 AU AU2014312456A patent/AU2014312456B2/en active Active
- 2014-09-01 KR KR1020140115673A patent/KR101576561B1/ko active Active
-
2015
- 2015-09-25 KR KR1020150136164A patent/KR20150118565A/ko not_active Ceased
-
2016
- 2016-02-29 PH PH12016500403A patent/PH12016500403A1/en unknown
- 2016-02-29 US US15/056,299 patent/US9879077B2/en active Active
-
2017
- 2017-09-27 US US15/717,528 patent/US10618953B2/en active Active
-
2018
- 2018-06-01 JP JP2018106308A patent/JP6800180B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018172391A5 (enExample) | ||
| RU2016105586A (ru) | Гибридная конструкция, включающая антигенсвязывающий фрагмент, специфичный к сывороточному альбумину и эффекторный компонент, и способы ее получения | |
| JP6689329B2 (ja) | 免疫グロブリンFc変異体 | |
| JP6952221B2 (ja) | コイルドコイルの免疫グロブリン融合タンパク質およびその組成物 | |
| KR101200659B1 (ko) | 세 말단 반응기를 갖는 비펩타이드성 중합체를 이용한 생리활성 폴리펩타이드 약물 결합체 | |
| AU2005311099B2 (en) | Bispecific domain antibodies targeting serum albumin and GLP-1 or PYY | |
| Kontermann | Strategies for extended serum half-life of protein therapeutics | |
| Strohl | Fusion proteins for half-life extension of biologics as a strategy to make biobetters | |
| ES2623925T3 (es) | Proteínas de fusión de inmunoglobulina | |
| RU2005120239A (ru) | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ Fc-ОБЛАСТЬ ИММУНОГЛОБУЛИНА В КАЧЕСТВЕ НОСИТЕЛЯ | |
| CN106661128A (zh) | 构建氨基末端免疫球蛋白融合蛋白的方法及其组合物 | |
| JP2007537992A5 (enExample) | ||
| JP2007536211A5 (enExample) | ||
| AU2023324967A1 (en) | Masking polypeptides, activatable novel prodrugs and methods of use thereof | |
| IL293078A (en) | A polymer of multi-functional, multi-specific biomolecules with prolonged in vivo duration | |
| Chang et al. | Advances and challenges in developing cytokine fusion proteins as improved therapeutics | |
| TH2201000302A (th) | วิธีการใหม่สำหรับการเตรียมคอนจูเกตยาที่ออกฤทธิ์ยาวนานโดยการเตรียมตัวกลาง |