JP2018158949A5 - - Google Patents
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- Publication number
- JP2018158949A5 JP2018158949A5 JP2018132781A JP2018132781A JP2018158949A5 JP 2018158949 A5 JP2018158949 A5 JP 2018158949A5 JP 2018132781 A JP2018132781 A JP 2018132781A JP 2018132781 A JP2018132781 A JP 2018132781A JP 2018158949 A5 JP2018158949 A5 JP 2018158949A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoropyrrolidin
- cyclopropylamino
- dihydroquinoline
- fluoroethyl
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 claims 4
- 125000006317 cyclopropyl amino group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- NDCFBPDNHOZORS-UHFFFAOYSA-N 1,2-dihydroquinoline-3-carboxylic acid Chemical compound C1=CC=C2NCC(C(=O)O)=CC2=C1 NDCFBPDNHOZORS-UHFFFAOYSA-N 0.000 claims 1
- YQHZQIJEMFMUGH-DFIJPDEKSA-N 7-[(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxoquinoline-3-carboxylic acid;hydrochloride Chemical compound Cl.C([C@@H]1[C@H](F)CN(C1)C1=C(C2=C(C(C(C(O)=O)=CN2CCF)=O)C=C1F)OC)NC1CC1 YQHZQIJEMFMUGH-DFIJPDEKSA-N 0.000 claims 1
- YSERWNSSJVQJNF-UHFFFAOYSA-N 8-methoxy-4-oxo-1H-quinoline-3-carboxylic acid hydrochloride Chemical compound Cl.COC=1C=CC=C2C(C(=CNC12)C(=O)O)=O YSERWNSSJVQJNF-UHFFFAOYSA-N 0.000 claims 1
- OBAPBKQMRWCKOX-UHFFFAOYSA-N Cl.OC(=O)C1=CNc2ccccc2C1 Chemical compound Cl.OC(=O)C1=CNc2ccccc2C1 OBAPBKQMRWCKOX-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011246209 | 2011-11-10 | ||
| JP2011246209 | 2011-11-10 | ||
| JP2012071739 | 2012-03-27 | ||
| JP2012071739 | 2012-03-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015165879A Division JP6514069B2 (ja) | 2011-11-10 | 2015-08-25 | ７−｛（３ｓ、４ｓ）−３−［（シクロプロピルアミノ）メチル］−４−フルオロピロリジン−１−イル｝−６−フルオロ−１−（２−フルオロエチル）−８−メトキシ−４−オキソ−１、４−ジヒドロキノリン−３−カルボン酸塩酸塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018158949A JP2018158949A (ja) | 2018-10-11 |
| JP2018158949A5 true JP2018158949A5 (https=) | 2019-05-30 |
| JP6818719B2 JP6818719B2 (ja) | 2021-01-20 |
Family
ID=48289529
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013542858A Active JP5871948B2 (ja) | 2011-11-10 | 2012-11-09 | ７−｛（３ｓ、４ｓ）−３−［（シクロプロピルアミノ）メチル］−４−フルオロピロリジン−１−イル｝−６−フルオロ−１−（２−フルオロエチル）−８−メトキシ−４−オキソ−１、４−ジヒドロキノリン−３−カルボン酸の結晶 |
| JP2015165879A Active JP6514069B2 (ja) | 2011-11-10 | 2015-08-25 | ７−｛（３ｓ、４ｓ）−３−［（シクロプロピルアミノ）メチル］−４−フルオロピロリジン−１−イル｝−６−フルオロ−１−（２−フルオロエチル）−８−メトキシ−４−オキソ−１、４−ジヒドロキノリン−３−カルボン酸塩酸塩 |
| JP2017092125A Active JP6349435B2 (ja) | 2011-11-10 | 2017-05-08 | ７−｛（３ｓ、４ｓ）−３−［（シクロプロピルアミノ）メチル］−４−フルオロピロリジン−１−イル｝−６−フルオロ−１−（２−フルオロエチル）−８−メトキシ−４−オキソ−１、４−ジヒドロキノリン−３−カルボン酸の結晶 |
| JP2018132781A Active JP6818719B2 (ja) | 2011-11-10 | 2018-07-13 | ７−｛（３ｓ、４ｓ）−３−［（シクロプロピルアミノ）メチル］−４−フルオロピロリジン−１−イル｝−６−フルオロ−１−（２−フルオロエチル）−８−メトキシ−４−オキソ−１、４−ジヒドロキノリン−３−カルボン酸の結晶 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013542858A Active JP5871948B2 (ja) | 2011-11-10 | 2012-11-09 | ７−｛（３ｓ、４ｓ）−３−［（シクロプロピルアミノ）メチル］−４−フルオロピロリジン−１−イル｝−６−フルオロ−１−（２−フルオロエチル）−８−メトキシ−４−オキソ−１、４−ジヒドロキノリン−３−カルボン酸の結晶 |
| JP2015165879A Active JP6514069B2 (ja) | 2011-11-10 | 2015-08-25 | ７−｛（３ｓ、４ｓ）−３−［（シクロプロピルアミノ）メチル］−４−フルオロピロリジン−１−イル｝−６−フルオロ−１−（２−フルオロエチル）−８−メトキシ−４−オキソ−１、４−ジヒドロキノリン−３−カルボン酸塩酸塩 |
| JP2017092125A Active JP6349435B2 (ja) | 2011-11-10 | 2017-05-08 | ７−｛（３ｓ、４ｓ）−３−［（シクロプロピルアミノ）メチル］−４−フルオロピロリジン−１−イル｝−６−フルオロ−１−（２−フルオロエチル）−８−メトキシ−４−オキソ−１、４−ジヒドロキノリン−３−カルボン酸の結晶 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9090587B2 (https=) |
| EP (2) | EP3112359B1 (https=) |
| JP (4) | JP5871948B2 (https=) |
| KR (2) | KR102162208B1 (https=) |
| CN (2) | CN103930414B (https=) |
| AU (1) | AU2016273899B2 (https=) |
| BR (1) | BR112014010765B1 (https=) |
| CA (1) | CA2855022C (https=) |
| ES (2) | ES2621664T3 (https=) |
| IN (1) | IN2014DN03277A (https=) |
| MX (1) | MX375073B (https=) |
| NZ (1) | NZ623808A (https=) |
| RU (2) | RU2615509C2 (https=) |
| SA (1) | SA112330992B1 (https=) |
| SG (2) | SG11201401817TA (https=) |
| TW (1) | TWI547492B (https=) |
| WO (1) | WO2013069297A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12594418B2 (en) | 2011-03-10 | 2026-04-07 | Electrocore, Inc. | Devices and methods for nerve stimulation |
| SA112330992B1 (ar) * | 2011-11-10 | 2015-09-13 | كيورين فارماسوتيكال كو.، ليمتد | صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي |
| JP6349306B2 (ja) * | 2013-04-25 | 2018-06-27 | 杏林製薬株式会社 | 錠剤 |
| US9687453B2 (en) * | 2013-04-25 | 2017-06-27 | Kyorin Pharmaceutical Co., Ltd. | Solid pharmaceutical composition |
| CA2910112C (en) | 2013-04-25 | 2021-02-16 | Kyorin Pharmaceutical Co., Ltd. | Solid pharmaceutical composition |
| GB201402071D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| US10154993B2 (en) * | 2014-10-23 | 2018-12-18 | Kyorin Pharmaceutical Co., Ltd. | Solid pharmaceutical composition |
| EP3210608A4 (en) * | 2014-10-23 | 2018-06-20 | Kyorin Pharmaceutical Co., Ltd. | Solid pharmaceutical composition |
| US20180042918A1 (en) * | 2015-03-13 | 2018-02-15 | Kyorin Pharmaceutical Co., Ltd. | Respiratory infection treating agent |
| JP6031217B1 (ja) | 2015-06-02 | 2016-11-24 | 杏林製薬株式会社 | 水性液剤 |
| WO2016195020A1 (ja) * | 2015-06-02 | 2016-12-08 | 杏林製薬株式会社 | 水性液剤 |
| JP6031216B1 (ja) * | 2015-06-02 | 2016-11-24 | 杏林製薬株式会社 | 水性液剤 |
| US20210137913A1 (en) | 2017-06-16 | 2021-05-13 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for aspiration pneumonia, lung suppuration, or lung abscess |
| TW202415375A (zh) | 2017-06-16 | 2024-04-16 | 日商杏林製藥股份有限公司 | 吸入性肺炎、肺化膿症或肺膿瘍之治療劑 |
| GB201808575D0 (en) | 2018-05-24 | 2018-07-11 | Galapagos Nv | Methods for the treatment of psoriatic arthrits |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA944369B (en) * | 1993-08-27 | 1995-02-13 | Hokuriku Seuyaku Co Ltd | 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative |
| CN1158846A (zh) * | 1995-05-09 | 1997-09-10 | 昆山市康壮达兽药厂 | 盐酸氟哌酸的合成工艺 |
| US20030119060A1 (en) | 2001-08-10 | 2003-06-26 | Desrosiers Peter J. | Apparatuses and methods for creating and testing pre-formulations and systems for same |
| JPWO2003076428A1 (ja) * | 2002-03-08 | 2005-07-07 | 第一製薬株式会社 | キノロンカルボン酸誘導体 |
| WO2005026147A1 (ja) | 2003-09-10 | 2005-03-24 | Kyorin Pharmaceutical Co., Ltd. | ７−（４−置換−３−シクロプロピルアミノメチル−１−ピロリジニル）キノロンカルボン酸誘導体 |
| CN101003540A (zh) * | 2006-01-18 | 2007-07-25 | 广州白云山制药股份有限公司广州白云山制药总厂 | 一种抗感染化合物和用途 |
| SA112330992B1 (ar) * | 2011-11-10 | 2015-09-13 | كيورين فارماسوتيكال كو.، ليمتد | صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي |
-
2012
- 2012-11-07 SA SA112330992A patent/SA112330992B1/ar unknown
- 2012-11-09 SG SG11201401817TA patent/SG11201401817TA/en unknown
- 2012-11-09 CA CA2855022A patent/CA2855022C/en not_active Expired - Fee Related
- 2012-11-09 TW TW101141841A patent/TWI547492B/zh active
- 2012-11-09 EP EP16177827.9A patent/EP3112359B1/en not_active Not-in-force
- 2012-11-09 NZ NZ623808A patent/NZ623808A/en not_active IP Right Cessation
- 2012-11-09 ES ES12846895.6T patent/ES2621664T3/es active Active
- 2012-11-09 CN CN201280055120.0A patent/CN103930414B/zh active Active
- 2012-11-09 IN IN3277DEN2014 patent/IN2014DN03277A/en unknown
- 2012-11-09 BR BR112014010765-3A patent/BR112014010765B1/pt not_active IP Right Cessation
- 2012-11-09 RU RU2014123567A patent/RU2615509C2/ru active
- 2012-11-09 MX MX2017006000A patent/MX375073B/es unknown
- 2012-11-09 WO PCT/JP2012/007195 patent/WO2013069297A1/ja not_active Ceased
- 2012-11-09 KR KR1020197015481A patent/KR102162208B1/ko active Active
- 2012-11-09 US US14/352,141 patent/US9090587B2/en not_active Expired - Fee Related
- 2012-11-09 CN CN201510329284.3A patent/CN104945375B/zh active Active
- 2012-11-09 SG SG10201608167UA patent/SG10201608167UA/en unknown
- 2012-11-09 JP JP2013542858A patent/JP5871948B2/ja active Active
- 2012-11-09 RU RU2017109814A patent/RU2017109814A/ru unknown
- 2012-11-09 KR KR1020147012681A patent/KR20140098074A/ko not_active Ceased
- 2012-11-09 ES ES16177827T patent/ES2747303T3/es active Active
- 2012-11-09 EP EP12846895.6A patent/EP2778159B1/en not_active Not-in-force
-
2015
- 2015-06-17 US US14/741,713 patent/US9328089B2/en not_active Ceased
- 2015-08-25 JP JP2015165879A patent/JP6514069B2/ja active Active
-
2016
- 2016-12-14 AU AU2016273899A patent/AU2016273899B2/en not_active Ceased
-
2017
- 2017-05-08 JP JP2017092125A patent/JP6349435B2/ja active Active
-
2018
- 2018-05-02 US US15/969,342 patent/USRE47785E1/en not_active Expired - Fee Related
- 2018-07-13 JP JP2018132781A patent/JP6818719B2/ja active Active
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