JP2018108937A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018108937A5 JP2018108937A5 JP2016221064A JP2016221064A JP2018108937A5 JP 2018108937 A5 JP2018108937 A5 JP 2018108937A5 JP 2016221064 A JP2016221064 A JP 2016221064A JP 2016221064 A JP2016221064 A JP 2016221064A JP 2018108937 A5 JP2018108937 A5 JP 2018108937A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- hydrogen
- substituted alkyl
- optionally
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCC*(OC[C@@](*C(C1O)OC*)O[C@@](CCCCC(*)(*)CCC[C@@]2O[C@](C[C@@]([C@](C*)C3*)OC4C3O[C@](CC)[C@]([*+2])C4)C(*)(*)C(*)C2)C(*)C1(*)O)=CC(S)=O Chemical compound CCC*(OC[C@@](*C(C1O)OC*)O[C@@](CCCCC(*)(*)CCC[C@@]2O[C@](C[C@@]([C@](C*)C3*)OC4C3O[C@](CC)[C@]([*+2])C4)C(*)(*)C(*)C2)C(*)C1(*)O)=CC(S)=O 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016221064A JP6978758B2 (ja) | 2016-11-11 | 2016-11-11 | パラジウム媒介ケトール化 |
| US15/809,845 US10392400B2 (en) | 2016-11-11 | 2017-11-10 | Palladium-mediated ketolization |
| US16/459,120 US10844073B2 (en) | 2016-11-11 | 2019-07-01 | Palladium-mediated ketolization |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016221064A JP6978758B2 (ja) | 2016-11-11 | 2016-11-11 | パラジウム媒介ケトール化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018108937A JP2018108937A (ja) | 2018-07-12 |
| JP2018108937A5 true JP2018108937A5 (https=) | 2019-12-26 |
| JP6978758B2 JP6978758B2 (ja) | 2021-12-08 |
Family
ID=62240368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016221064A Active JP6978758B2 (ja) | 2016-11-11 | 2016-11-11 | パラジウム媒介ケトール化 |
Country Status (2)
| Country | Link |
|---|---|
| US (2) | US10392400B2 (https=) |
| JP (1) | JP6978758B2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| SMT202200455T1 (it) | 2017-04-05 | 2023-01-13 | Harvard College | Composto macrociclico e relativi usi |
| WO2019010363A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | HALICHONDRINES SYNTHESIS |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| WO2019099646A1 (en) | 2017-11-15 | 2019-05-23 | President And Fellows Of Harvard College | Macrocyclic compounds and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| US5352804A (en) | 1993-01-19 | 1994-10-04 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 2 |
| US5426194A (en) | 1993-01-19 | 1995-06-20 | Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 1 |
| JP4454151B2 (ja) | 1998-06-17 | 2010-04-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 大環状類似体及びそれらの使用並びに調製方法 |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| JP2001305734A (ja) * | 2000-04-20 | 2001-11-02 | Fuji Photo Film Co Ltd | 光重合性組成物 |
| JP2003261447A (ja) | 2002-03-07 | 2003-09-16 | Kyosei Seiyaku Kk | 抗腫瘍剤 |
| SI2522663T1 (sl) | 2004-06-03 | 2015-08-31 | Eisai R&D Management Co., Ltd. | Vmesne spojine za pripravo halihondrina B |
| US20060154312A1 (en) | 2004-12-09 | 2006-07-13 | Sergei Agoulnik | Tubulin isotype screening in cancer therapy using halichondrin B analogs |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| CN101657990B (zh) | 2007-03-07 | 2014-03-19 | 交互数字技术公司 | 用于产生和处理MAC-ehs协议数据单元的方法和设备 |
| US20100254996A1 (en) | 2007-06-18 | 2010-10-07 | Medimmune, Llc | Synergistic treatment of cells that express epha2 and erbb2 |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| CN101910180A (zh) | 2007-11-16 | 2010-12-08 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的新颖中间体和用于该中间体的新颖脱磺酰化反应 |
| CA2720632C (en) | 2008-04-04 | 2016-12-20 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
| WO2012096926A2 (en) | 2011-01-10 | 2012-07-19 | President And Fellows Of Harvard College | Method for delivering agents into cells using bacterial toxins |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| JP2015501818A (ja) | 2011-12-16 | 2015-01-19 | アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． | ３−（（２ｓ，５ｓ）−４−メチレン−５−（３−オキソプロピル）テトラヒドロフラン−２−イル）プロパノール誘導体およびそれらの有用な中間体を調製する方法 |
| CA2860446C (en) | 2011-12-29 | 2017-01-10 | Alphora Research Inc. | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
| US9278979B2 (en) | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
| EP3016957A4 (en) | 2013-07-03 | 2016-11-30 | Alphora Res Inc | SYNTHETIC METHOD FOR THE PRODUCTION OF CYCLIC C1-KETO ANALOGUE OF HALICHONDRIN B AND USEFUL INTERMEDIATE PRODUCTS, INCLUDING INTERMEDIATE PRODUCTS WITH -SO2- (P-TOLYL) GROUPS |
| BR112016009452B1 (pt) | 2013-11-04 | 2022-06-07 | Eisai R&D Management Co., Ltd | Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários |
| EP3077399B1 (en) | 2013-12-06 | 2019-02-20 | Eisai R&D Management Co., Ltd. | Methods useful in the synthesis of halichondrin b analogs |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10208058B2 (en) | 2014-09-09 | 2019-02-19 | Cipla Limited | Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| MX392296B (es) | 2015-05-07 | 2025-03-24 | Eisai R&D Man Co Ltd | Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina. |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| SMT202200455T1 (it) | 2017-04-05 | 2023-01-13 | Harvard College | Composto macrociclico e relativi usi |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| WO2019010363A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | HALICHONDRINES SYNTHESIS |
-
2016
- 2016-11-11 JP JP2016221064A patent/JP6978758B2/ja active Active
-
2017
- 2017-11-10 US US15/809,845 patent/US10392400B2/en active Active
-
2019
- 2019-07-01 US US16/459,120 patent/US10844073B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018108937A5 (https=) | ||
| EA021854B1 (ru) | Дисахариновая, дифумаровокислая, ди-1-гидрокси-2-нафтойнокислая и монобензойнокислая соли 4-(диметиламино)бутил-2-(4-((2-амино-4-метил-6-(пентиламино)пиримидин-5-ил)метил)фенил)ацетата | |
| CN104402862B (zh) | 艾立替尼的制备方法 | |
| WO2016012470A1 (en) | New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid | |
| CA2722016A1 (en) | Substituted dihydropyrazolones as inhibitors of hif-prolyl-4-hydroxylases | |
| ES2594252T3 (es) | Compuesto de quinolona y composición farmacéutica | |
| RU2009110413A (ru) | Способ получения производных 3-дигалогенметил-пиразол-4-карбоновой кислоты | |
| KR102142797B1 (ko) | 피리디닐아미노피리미딘 유도체의 메실레이트 염의 결정질 형태, 그의 제조 방법, 및 그의 용도 | |
| JP2010529986A5 (https=) | ||
| WO2009125841A1 (ja) | ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法 | |
| JPH06234741A (ja) | 置換４−フエニルピリドン及び４−フエニル−２−アルコキシピリジン | |
| WO2021231335A1 (en) | Novel intermediates and synthesis for endochin-like quinolone compounds | |
| WO2013018371A1 (ja) | ビアリールエステル誘導体、及びそれを含む医薬 | |
| CN105418610A (zh) | 一种10-羟基吴茱萸碱类抗肿瘤化合物及其制备方法和应用 | |
| CN101544670B (zh) | 一种糖精阿德福韦酯及制备方法 | |
| JP2019523230A (ja) | 抗転移性２Ｈ‐セレノフェノ［３，２‐ｈ］クロメン、それらの合成、および同薬剤の使用方法 | |
| JP2008542359A5 (https=) | ||
| Le Anh et al. | Synthesis and Molecular Structure of Dibenzo [4-(α-Thienyl-and α-Pyrrolyl) pyrido] aza-14-crown-4 Ethers | |
| JP2020533308A5 (https=) | ||
| CN108794517B (zh) | 一种精氨酸酶抑制剂及其制备方法与用途 | |
| Luo et al. | Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol | |
| JP2010513510A5 (https=) | ||
| TWI439463B (zh) | 青蒿素之二聚衍生物及其在抗癌治療之應用 | |
| Diwischek et al. | Cerulenin analogues as inhibitors of efflux pumps in drug‐resistant Candida albicans | |
| CN104829669A (zh) | 具有细胞毒活性的2’,5’-双脱氧-5-氟尿嘧啶核苷衍生物、生产方法和应用 |