JP2020533308A5 - - Google Patents
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- Publication number
- JP2020533308A5 JP2020533308A5 JP2020513753A JP2020513753A JP2020533308A5 JP 2020533308 A5 JP2020533308 A5 JP 2020533308A5 JP 2020513753 A JP2020513753 A JP 2020513753A JP 2020513753 A JP2020513753 A JP 2020513753A JP 2020533308 A5 JP2020533308 A5 JP 2020533308A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- composition
- compound
- substituted
- needed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *N([C@](CC(c1cc(C(O*)=O)ccc1)O)O*)C(O*)=O Chemical compound *N([C@](CC(c1cc(C(O*)=O)ccc1)O)O*)C(O*)=O 0.000 description 5
- ZDUQJTVUWQHXBF-ARLHGKGLSA-N CC(C)C(C[C@H](c1nc(C(O)=O)c[s]1)OC(C)=O)N(C)C(OC(C)(C)C)=O Chemical compound CC(C)C(C[C@H](c1nc(C(O)=O)c[s]1)OC(C)=O)N(C)C(OC(C)(C)C)=O ZDUQJTVUWQHXBF-ARLHGKGLSA-N 0.000 description 1
- OZMJKQBMQWNYBS-VXGBXAGGSA-N CC(C)[C@@H](C[C@H](c1nc(C(O)=O)c[s]1)O)N(C)C(OC(C)(C)C)=O Chemical compound CC(C)[C@@H](C[C@H](c1nc(C(O)=O)c[s]1)O)N(C)C(OC(C)(C)C)=O OZMJKQBMQWNYBS-VXGBXAGGSA-N 0.000 description 1
- OZMJKQBMQWNYBS-RYUDHWBXSA-N CC(C)[C@H](C[C@@H](c1nc(C(O)=O)c[s]1)O)N(C)C(OC(C)(C)C)=O Chemical compound CC(C)[C@H](C[C@@H](c1nc(C(O)=O)c[s]1)O)N(C)C(OC(C)(C)C)=O OZMJKQBMQWNYBS-RYUDHWBXSA-N 0.000 description 1
- KACQRESHTOZOHT-HVEKOLDVSA-N CCOC(C1=CSC(C)([C@H](CC(C(C)C)N(C)C(OC(C)(C)C)=O)O)N1)=O Chemical compound CCOC(C1=CSC(C)([C@H](CC(C(C)C)N(C)C(OC(C)(C)C)=O)O)N1)=O KACQRESHTOZOHT-HVEKOLDVSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023022825A JP2023053386A (ja) | 2017-09-08 | 2023-02-16 | チューブリシンおよびそれらの中間体の調製のためのプロセス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556234P | 2017-09-08 | 2017-09-08 | |
| US62/556,234 | 2017-09-08 | ||
| PCT/US2018/050095 WO2019051322A1 (en) | 2017-09-08 | 2018-09-07 | PROCESS FOR THE PREPARATION OF TUBULYSINS AND INTERMEDIATES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023022825A Division JP2023053386A (ja) | 2017-09-08 | 2023-02-16 | チューブリシンおよびそれらの中間体の調製のためのプロセス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533308A JP2020533308A (ja) | 2020-11-19 |
| JP2020533308A5 true JP2020533308A5 (https=) | 2021-10-14 |
Family
ID=63963374
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513753A Ceased JP2020533308A (ja) | 2017-09-08 | 2018-09-07 | チューブリシンおよびそれらの中間体の調製のためのプロセス |
| JP2023022825A Pending JP2023053386A (ja) | 2017-09-08 | 2023-02-16 | チューブリシンおよびそれらの中間体の調製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023022825A Pending JP2023053386A (ja) | 2017-09-08 | 2023-02-16 | チューブリシンおよびそれらの中間体の調製のためのプロセス |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11389543B2 (https=) |
| EP (1) | EP3679036A1 (https=) |
| JP (2) | JP2020533308A (https=) |
| KR (1) | KR20200051733A (https=) |
| CN (1) | CN111601803A (https=) |
| AU (1) | AU2018329951B2 (https=) |
| BR (1) | BR112020004495A2 (https=) |
| CA (1) | CA3073766A1 (https=) |
| EA (1) | EA202090670A1 (https=) |
| IL (1) | IL272837B2 (https=) |
| MA (1) | MA50124A (https=) |
| MX (1) | MX2020001928A (https=) |
| SG (1) | SG11202001543XA (https=) |
| TW (2) | TWI820038B (https=) |
| WO (1) | WO2019051322A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200051733A (ko) * | 2017-09-08 | 2020-05-13 | 시애틀 지네틱스, 인크. | 튜불리신 및 그 중간물의 제조 공정 |
| US20230002440A1 (en) * | 2018-09-07 | 2023-01-05 | Seattle Genetics, Inc. | Alternative processes for the preparation of tubulysins and intermediates thereof |
| BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10230872A1 (de) * | 2002-07-09 | 2004-01-22 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von substituierten Thiazol-2-ylmethylestern |
| ES2708763T3 (es) | 2005-07-07 | 2019-04-11 | Seattle Genetics Inc | Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C |
| EP2032606B1 (en) | 2006-05-30 | 2013-11-27 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| ES2649941T3 (es) | 2007-02-23 | 2018-01-16 | Aileron Therapeutics, Inc. | Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol |
| US20100047841A1 (en) * | 2007-02-27 | 2010-02-25 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Synthesis of desacetoxytubulysin h and analogs thereof |
| AU2013229786B2 (en) | 2012-03-08 | 2017-06-22 | Halozyme, Inc. | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof |
| CN104640572B (zh) | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物，偶联方法，及其用途 |
| WO2013173337A2 (en) | 2012-05-15 | 2013-11-21 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| EP2708243A1 (en) * | 2012-09-17 | 2014-03-19 | OntoChem GmbH | Receptor ligand linked cytotoxic molecules |
| MX369022B (es) | 2013-05-31 | 2019-10-25 | Genentech Inc | Anticuerpos anti-ácido teicoico de la pared celular y conjugados. |
| RU2687044C2 (ru) | 2013-05-31 | 2019-05-06 | Дженентек, Инк. | Антитела против стеночной тейхоевой кислоты и их конъюгаты |
| FI3900742T3 (fi) * | 2014-09-11 | 2024-08-16 | Seagen Inc | Tertiääristä amiinia sisältävien lääkeaineiden kohdennettu antaminen |
| AU2015358532C1 (en) * | 2014-12-03 | 2020-10-29 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| US10808007B2 (en) * | 2015-02-25 | 2020-10-20 | William Marsh Rice University | Desacetoxytubulysin H and analogs thereof |
| KR20200051733A (ko) * | 2017-09-08 | 2020-05-13 | 시애틀 지네틱스, 인크. | 튜불리신 및 그 중간물의 제조 공정 |
-
2018
- 2018-09-07 KR KR1020207009940A patent/KR20200051733A/ko not_active Ceased
- 2018-09-07 EP EP18792575.5A patent/EP3679036A1/en not_active Withdrawn
- 2018-09-07 MA MA050124A patent/MA50124A/fr unknown
- 2018-09-07 US US16/645,369 patent/US11389543B2/en active Active
- 2018-09-07 TW TW107131484A patent/TWI820038B/zh not_active IP Right Cessation
- 2018-09-07 BR BR112020004495-4A patent/BR112020004495A2/pt not_active Application Discontinuation
- 2018-09-07 EA EA202090670A patent/EA202090670A1/ru unknown
- 2018-09-07 IL IL272837A patent/IL272837B2/en unknown
- 2018-09-07 MX MX2020001928A patent/MX2020001928A/es unknown
- 2018-09-07 WO PCT/US2018/050095 patent/WO2019051322A1/en not_active Ceased
- 2018-09-07 SG SG11202001543XA patent/SG11202001543XA/en unknown
- 2018-09-07 TW TW112136966A patent/TW202428569A/zh unknown
- 2018-09-07 CA CA3073766A patent/CA3073766A1/en active Pending
- 2018-09-07 AU AU2018329951A patent/AU2018329951B2/en not_active Ceased
- 2018-09-07 JP JP2020513753A patent/JP2020533308A/ja not_active Ceased
- 2018-09-07 CN CN201880062053.2A patent/CN111601803A/zh active Pending
-
2022
- 2022-06-08 US US17/835,841 patent/US20220323601A1/en not_active Abandoned
-
2023
- 2023-02-16 JP JP2023022825A patent/JP2023053386A/ja active Pending
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