JP2018070468A - Adjuvant - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a particular adjuvant that adjusts in vivo balance and maintains/normalizes the intrinsic functions of mind and body, in order to tackle the problem of homeostasis particularly from the side of a mental care and intracorporeal care.SOLUTION: The present invention can restore in vivo immune balance and can achieve normalization by applying an adjuvant containing extract derived from a material consisting of two or more selected from Ganoderma lucidum, Panax ginseng C.A. Meyer, and Red ginseng, as an active ingredient. As a result, an overall mind-and-body care and prevention from diseases can be achieved in a natural way.SELECTED DRAWING: None

Description

The present invention relates to an immunostimulator that focuses on a homeostasis maintenance function (hereinafter sometimes simply referred to as “homeostasis”).
In more detail, we provide a preparation to normalize the body, including mental care, with an immunostimulatory effect using an extract derived from a material composed of two or more selected from Ganoderma, Ginseng and Red Ginseng. The application form as the immunostimulant constitutes not only systemic care including food and drink form, but also local ones.

People always have a desire to be youthful and beautiful, and in that respect there is no fundamental difference. However, people's living environment has changed greatly. In other words, the modern society is also called a stress society, and although there is a marked difference (improvement) in material abundance compared to the past, external conditions such as the living environment have steadily deteriorated. ing.

Therefore, in recent years, it has become an era in which care and efforts to maintain an internally healthy body and spirit are made even more while paying attention to eating habits. For example, ingestion of health foods and functional foods, aromatherapy, relaxation massage, and the like are also manifestations.

However, on the other hand, in addition to daily harsh labor, the practice of excessive lifestyle change programs, on the other hand, can provoke new harms and health hazards.

In the first place, the person has a function of maintaining the balance of the body, and if the basic cycle such as regular sleep and rest in daily life and nutritional balance by meals are maintained, there is natural healing power, these balances are impaired, Living programs that lead to the inhibition of natural healing power are very dangerous.

Furthermore, it is not uncommon for humans to suffer health problems without knowing about natural or man-made natural disasters. For example, environmental pollution problems such as radioactive contamination due to the earthquake and damage to nuclear facilities and health hazards are deeply problematic.

Although the causal relationship with the disease is a particular difficult problem, the relationship between maintaining immunity and normalization, especially for all people, is the most important aspect.

As mentioned above, human health is because external stimuli (especially visual, olfactory, auditory, taste, and tactile) are transmitted into the brain and maintained by the action of immune cells. This function is automatically provided to humans.

For example, even if human beings are infected with a virus that causes illness, or malignant cells are generated and grow to some extent, they always have a function to maintain the body environment in a normal state. The biological environment is maintained in a comfortable state.

The blood pressure and blood glucose level are kept within a certain range, the airway mucosa is moistened with a certain mucus, and the stomach is kept at a constant pH by gastric acid. Hormone secretion required for life support is also controlled within a certain range. When this balance is lost, it is recognized as diseases such as hypertension, diabetes, cold (cold), gastric ulcer or stomach cancer, and hypothyroidism.

  In this way, each of these regulatory functions is inherent to humans, and even if low-grade skin or internal organ damage occurs, the original regulatory function is not impaired by natural repair through self-regeneration. It has become.

The maintenance of homeostasis is greatly influenced by stress factors, where the endocrine system and the neuropsychiatric system are integrated with the immune system.

  In other words, when the body's balance system is damaged by severe external stimulation, aging, continuous stress, etc. over many years, the self-regulation function will no longer work, and the homeostatic good circulation will be abnormal. As a result, it is considered that various in vivo adjustment functions are hindered due to a decrease in immunity and the like, leading to a decrease in or aggravation of the natural healing and repairing power of the skin, thereby causing pathological and cosmetic problems.

  In view of these circumstances, the present inventor has tackled the problem of homeostasis particularly from the aspects of mental care and in-vivo care, and has continued to search for materials that promote normalization of biological functions, and has conducted intensive research. As a result, the present invention was completed by obtaining new knowledge that an active ingredient derived from a material composed of extracts from Ganoderma, Ginseng and Red Ginseng is optimal as a total care material. is there.

That is, according to the present invention, there is provided an immunostimulant comprising, as an active ingredient, an extract derived from a material composed of two or more selected from ganoderma, ginseng and red ginseng, and by applying the immunostimulator Can normalize the mind and body, the balance is lost.

Ganoderma, ginseng and red ginseng constituted by the present invention are known as pharmaceutical and cosmetic materials and are used in various applications. Also, Ganoderma and Ginseng are disclosed for use as immunostimulants.

For example, with respect to Kazuno Ganoderma, a technique for a functional composition having an immunostimulatory effect by combination with a specific lactic acid bacterium has been disclosed (Patent Document 1). In addition, yesterday, an excellent use of macrophage phagocytosis and the use of Kakuno Ganoderma which has a cancer growth-inhibiting action are disclosed (Patent Document 2).

About ginseng, the example applied to the composition of the raw material (kefir grain origin) which is a milk fermentation product and the raw material (nattokinase) derived from natto is disclosed (patent document 3). In addition,

Red ginseng has not been used as an immunostimulatory material, but it has been used as a health food to alleviate various diseases such as peripheral blood circulation disorders by using it together with Simon mochi and for the addition of liver function improving agents, especially for visceral diseases The technique of the health food mix | blended as an ingredient is indicated (patent documents 4 and patent documents 5, respectively).

However, all of these conventional techniques are applied to specific diseases and symptoms, and as in the present invention, are immunostimulants (compositions) that focus on homeostasis. There is no example using a material composed of two or more kinds selected from carrots and red ginseng.

JP 2004-51504 A JP 2007-99666 A Republication 2002-76240 Japanese Patent Laid-Open No. 2005-27534 JP 2003-135023 A

  In view of the above problems, an object of the present invention is to provide a specific immunostimulant that adjusts the in-vivo balance and maintains and normalizes the original functions of the mind and body.

  As a result of intensive studies to solve the above problems, the present inventor has broken down by providing a composition using a material composed of two or more specific types selected from Ganoderma, Ginseng and Red Ginseng. It was found that the homeostasis maintenance function can be normalized, and the present invention has been completed.

  An important factor in developing a material that contributes to the restoration of the homeostasis maintenance function is an appropriate immunostimulatory force that can dispel the sense of incongruity in daily life. Therefore, on the premise of giving priority to so-called quality of life, a process in which the target disease is gradually improved and cured while emphasizing mental care that feels a little bit comfortable when applied is important.

As a result of screening that emphasized this point, the inventors have found a desired effect in the use of a material composed of two or more kinds selected from ganoderma, ginseng and red ginseng, and completed the present invention.

That is, according to the present invention, the immunostimulant described in the following (1) to (4) is provided.

(1) An immunostimulant comprising as an active ingredient an extract derived from a material composed of two or more selected from ganoderma, ginseng and red ginseng.
(2) The immunosuppressive agent according to claim 1, wherein each extract derived from Ganoderma, Ginseng and Red Ginseng is liquid.
(3) The blending weight ratio of each extract derived from Ganoderma, Ginseng and Red Ginseng is 0.8 to 1.2 for Ginseng Extract and 0 for Red Ginseng Extract. The immunostimulant according to claim 2, wherein the immunostimulant is .3 to 0.6.
(4) The immunostimulant according to any one of claims 1 to 3, which is used for diseases of abnormal hormone secretion.

  According to the present invention, by applying an immunostimulant containing as an active ingredient an extract derived from a material composed of two or more selected from ganoderma, ginseng and red ginseng, the immune balance in the body is restored. Normalization. As a result, overall psychosomatic care and disease prevention can be achieved in a natural manner.

  Hereinafter, specific modes for carrying out the present invention will be described in detail. However, the technical scope of the present invention is not limited to the specific modes disclosed below.

  In this invention, the extract derived from the raw material comprised from 2 or more types chosen from Ganoderma, Ginseng, and Red ginseng can be used as an active ingredient.

  Ganoderma is a mushroom that has been prized since ancient times. Among them, Kano Ganoderma is a rare species of Ganoderma that occurs only once in 100,000. This is why it is called a phantom mushroom. Kazuno Ganoderma is rich in β-glucan. Therefore, it is preferable to use Kazuno Ganoderma among the Reishi in terms of effect.

For the ganoderma of the present invention, it is preferable to use an extract obtained by extracting the fruit body with powder or the like, or using the mycelium material itself with an aqueous solvent. As the aqueous solvent, water and / or an extract extracted with a lower alcohol can be used, and ethanol is preferable as the lower alcohol. Particularly preferred is a water extract.

Ginseng is a perennial plant belonging to the family Araceae, whose main medicinal site is the root and whose useful component is a saponin group called ginsenoside, which has been taken for a long time.

In the present invention, an extract obtained by chopping roots and extracting with alcohol is used. A particularly preferred extraction solvent is ethanol.

  Red ginseng is a material that is naturally dried until it turns red without peeling the skin of ginseng, and the ingredients are condensed by steaming and drying, so it is a material with higher potency than ginseng. In the present invention, as with ginseng, an extract extracted with alcohol, preferably ethanol, is used.

  As a result of various investigations, the weight ratio of each extract derived from Ganoderma, Ginseng and Red Ginseng is preferably 0.8 to 1.2 per ginseng extract. And the red ginseng extract is 0.3 to 0.6.

  By applying the immunostimulant according to the present invention, the balance in the body is gradually adjusted, and mental and physical care progresses at the same time. First, fatigue and fatigue are removed, and the comfort of the body is restored and can be maintained thereafter. Particularly effective for hormone secretion disorders. Among them, the application effect is great in a state where metabolism is inactive due to abnormal secretion of thyroid hormone. Thyroid hormone is active in the metabolism of the whole body such as “brain”, “heart”, “bone”, “muscle” and “skin”, and also works to regulate nerves and activities, but once it goes wrong It seems that the immunostimulatory action of the composition of the present invention is optimally involved in the process until these balance adjustment functions are normalized.

  Both the oral and parenteral forms of application in the present invention are acceptable. As oral forms, food and drink, etc., for example, it can be freely formulated and used in known forms such as capsules, tablets, granules, powders, syrups, liquids, etc., but from the viewpoint of rapid efficacy and effectiveness A liquid form is preferred.

Specific examples of foods and drinks include, for example, nutritional supplements such as drinks and supplements, foods for specified health use, functional foods, health foods, and various general processing of soft drinks, soups, cookies, candy, gummies, gums, etc. Food. As the excipient at that time, any liquid and solid raw materials acceptable for internal use can be widely used.

  As oral supplements such as food and drink, a known nutritional tonic or blood circulation promoter may be used in combination as long as the effects of the present invention are not impaired. Nourishing tonics are beneficial to users who have a feeling of fatigue in the recovery process of the homeostasis maintenance function, and blood circulation promoters are beneficial as adjuvants for immunostimulatory effects.

Examples of the nourishing tonic include supon extract, rotifer extract, gourd tincture, rokjou style extract, Ezokogi extract, Tochu extract, and kashu extract.

Examples of the blood circulation promoter include glucosyl hesperidin, citrulline, vitamin E nicotinate, nicotinic acid, nicotinic acid amide, benzyl nicotinate, ginger tincture, chili pepper tincture, and rosemary acid.

When applied externally, the combination use of a known percutaneous absorption enhancer is optional, and the formulation is designed according to the site of use. These applications maintain and promote the improving effect of the absorbed immunostimulant. Of course, the effect is the same in oral application such as food and drink, but further expectation can be expected when oral such as food and drink is used in combination with external use.

The external preparation of the present invention includes forms acceptable as pharmaceuticals, quasi drugs, and cosmetics, and the dosage form is not particularly limited as long as it does not impair the object of the present invention. Examples thereof include known forms such as creams, ointments, emulsions, liniments, pastes, lotions, emulsions, essences, gels and tonics.

  As the formulation base (excipient) at the time of formulation design, any liquid and solid raw materials acceptable for skin application can be used widely. At that time, various general-purpose additives such as a humectant, a preservative, and an antioxidant can be added as necessary.

Examples of humectants include urea, glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, mannitol, polyethylene glycol, dipropylene glycol and other polyhydric alcohols, ceramides, heparin-like substances, glucosamine, fucoidan, Examples include trimethylglycine, betaine, seaweed extract (Arge colloid) and the like.

  Examples of the preservative include benzoate, sorbate, dehydroacetate, p-hydroxybenzoate, benzalkonium chloride, hinokitiol, resorcin, ethanol, phenoxyethanol, and the like.

  Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, propyl gallate, ascorbic acid and the like.

  In addition to the active ingredient of the present invention, other functional ingredients usually used in external preparations can be arbitrarily blended within a range not impairing the effects and purposes of the present invention. Specifically, for example, lysozyme chloride, glycyrrhizic acid or salts thereof, anti-inflammatory agents such as allantoin, immunostimulants such as beta glucan, glucosyl hesperidin, citrulline, vitamin E nicotinate, nicotinic acid, nicotinic acid amide, benzyl nicotinate, Peripheral vasodilators such as ginger tincture, assembly extract, red pepper tincture, antibacterial agents such as hinokitiol, benzalkonium chloride, undecylenic acid, placenta extract, liver extract, oyster extract, altea extract, onionis extract, Chinese mugwort extract, Kidachi aloe extract, Japanese persimmon (banana peel) extract, Japanese cabbage extract, Japanese persimmon root extract, Sasayuri extract, Western yarrow extract, Western southern anemone (dry seed) extract, Sage extract, Celery extract , Soybean extract, tachijako Various extracts derived from animals, plants, and microorganisms such as extract, chimpi extract, toad extract, dandelion extract, button extract, macabu extract, melissa extract, yuzu extract, resveratrol, lactic acid bacteria culture extract, etc. Products, and extracts obtained by fermenting vegetables, fruits and wild grasses (hereinafter referred to as wild grass fermented extracts), honey, and the like. Examples of the raw material for the fermented wildflower extract include mugwort, dokudami, yellow aloe vera, turmeric, wolfberry, pigeon, hypericum grass, kumazasa, litchi, dandelion root, gypsophila, peach leaves, ginkgo biloba leaves, edible sugano seeds, nindo , Fig leaf, hub grass, safflower, elephant oak, flax leaf, lacanca, eucommia leaf, enmay grass, loquat leaf, morohaya, wolfberry leaf, red-breasted, red-backed wrinkle, plantain, tulsi, daylily, pine leaf, nanten leaf, cedar, amadokoroko , Cypress, mussels tree, tsuruna, yam, oyster leaf, chamomile, karin, perilla leaf, mandarin peel, ginger, mulberry leaf, senshinren, kumquat, onion rind, ginseng, red root, jujube, salacia, Pepper, yew, rooibos, amla, tsu Horsetail, Hashamame, Muirabuama, Ibonashi ヅ Rafji, Cat's Claw, Kombu, Funori, Citrus, Apple, Pineapple, Grape, Fig, Ume, Melon, Grapefruit, Lemon, Apricot, Carrot, Onion, Parsley, Burdock, Garlic, Rakanju , Cabbage, shiitake and the like can be appropriately selected and used according to the application.

  The immunostimulant (composition) obtained in the present invention is applied daily, preferably between meals when taken in an oral form such as food and drink, and applied to the affected area at least once a day for external use. Good to do. Ideally, take it daily orally and continue internal care, and take external care when using. That is, it is preferable in terms of effect that oral care is the main and external care is the secondary.

  As described above, according to the present invention, there is provided a specific immunostimulant that adjusts the in-vivo balance and maintains / normalizes the original function of the mind and body, thereby restoring the original homeostatic function.・ It is demonstrated.

Hereinafter, the present invention will be described more specifically by way of examples (manufacturing examples and test examples and formulation examples of effects), but the scope of the present invention is not limited to these examples.
<Production Example 1> Kazuno Ganoderma Extract 5 kg of water was added to 100 g of dried Kanocho Ganoderma fruit body, extracted at 60 ° C. for 48 hours, and filtered to obtain Kazuno Ganoderma extract.
<Production Example 2> Ginseng Extract 5 kg of ethanol was added to 500 g of dried ginseng, extracted by heating at 40 ° C. for 12 hours, and filtered to obtain a ginseng extract.
<Production Example 3> Red ginseng extract 5 kg of ethanol was added to 500 g of dried red ginseng, heated and extracted at 40 ° C. for 12 hours, and filtered to obtain a ginseng extract.

<Test Example 1>
a) Test method The drink (Prescription Example 9) of the present invention was taken twice a day in the morning and evening twice a day for 60 women (35 to 55 years old) who were unwell with unexplained physical condition and feeling tired for 2 months. Later, the degree of improvement in fatigue was examined. Taking half of the drinks of the present invention, and the other half of the drinks containing no active ingredient (only the base) were evaluated.
About evaluation, the improvement degree was determined by the improvement rate with respect to the start time of taking this invention and a base with the following method.

b) Test results and discussion As a result of determining the degree of improvement in fatigue before use of the drink, a clear improvement effect was recognized in the drink of the present invention. In addition, no side effects were observed after continuous use. The results are shown in Table 1.

<Criteria>
Remarkably improved: Fatigue disappeared by 70% or more compared to the start of the test. Remarkably improved: Fatigue disappeared slightly in the range of 40% to 70% compared to the start of the test. Fatigue decreased from 20% to 40% compared to the start of the test. No disappearance in the range: Deterioration with little change in fatigue compared to the start of the test Deterioration: Increased fatigue observed compared to the start of the test
As is clear from the above results, it has been proved that the immunostimulant of the present invention has an improvement effect since excellent fatigue is lost.

Although the formulation example of this invention is given to the following, the scope of the present invention is not limited to the following formulation example.

Table 2 shows an example of a drink formulation. All of these five formulations had the intended effect of the present invention.

Table 3 shows an example of lotion preparation. All of these five formulations had the intended effect of the present invention.

Claims (4)

An immunostimulant comprising, as an active ingredient, an extract derived from a material composed of two or more selected from ganoderma, ginseng and red ginseng. 2. The immunosuppressive agent according to claim 1, wherein each extract derived from Ganoderma, Ginseng and Red Ginseng is liquid. The combination weight ratio of each extract derived from Ganoderma, Ginseng and Red Ginseng is 0.8 to 1.2 for Ginseng Extract and 0.3 to 0.3 for Ginseng Extract per 1 weight of Ganoderma Extract. The immunostimulant according to claim 2, which is 0.6. The immunostimulant according to any one of claims 1 to 3, which is used for a hormone secretion abnormality disease.