JP7460352B2 - Liquid or semi-solid compositions - Google Patents

Description

The present invention relates to a liquid or semi-solid composition, etc.

Processed garlic products are known to have effects such as fatigue recovery, nourishing and tonic effects, enhancing gastric contraction, promoting metabolism, promoting blood flow, and promoting the absorption of vitamins. Processed garlic products are also known to reduce the side effects of some medicines, such as reducing the side effects of antihistamines (drowsiness) when used in combination with antihistamines (Patent Document 1), and reducing fever, inflammation, and pain relief. It is known that when used in combination with antipyretic and antiinflammatory analgesics, the side effects (such as gastric mucosal damage) can be reduced (Patent Document 2).
As described above, processed garlic products have various useful properties and are therefore widely used in fields such as pharmaceuticals, quasi-drugs, and health foods.

However, not only garlic itself but also processed garlic products have a strong odor. Therefore, the use and administration of a composition containing processed garlic products is accompanied by an unpleasant feeling, which is a major factor in impairing the quality stability of the composition and, ultimately, its commercial value. Therefore, various means have been investigated to suppress or reduce the unpleasant odor derived from processed garlic products. Specifically, for example, a method in which garlic is left in a low-oxygen or anoxic condition at 1 to 40°C for one week to one year (Patent Document 3), a method in which garlic is kept at 20°C or higher for seven days or more and then treated at a hydrostatic pressure of 300 MPa or more under a temperature condition of 0 to 65°C (Patent Document 4), and a method in which a solid preparation containing processed garlic products is stored in a sealed container together with activated carbon to suppress the unpleasant odor in the container (Patent Document 5) have been reported.

Furthermore, since the processed garlic product is a component derived from plants, when it is included in a liquid or semi-solid composition, the formation of precipitates over time may become a problem.

JP 2005-330245 A International Publication No. 2004/050110 pamphlet International Publication No. 2004/077963 pamphlet Japanese Patent Application Publication No. 6-335360 JP2009-78981A

An object of the present invention is to provide a new means for suppressing unpleasant odors derived from processed garlic products and suppressing the formation of precipitates derived from processed garlic products.

The inventors conducted extensive research to solve the above problems and discovered that erythritol has the effect of suppressing the unpleasant odor of processed garlic products and the formation of precipitates, and that by incorporating processed garlic products and erythritol in the same liquid or semi-solid composition, the unpleasant odor and formation of precipitates originating from processed garlic products in the composition can be suppressed, thus completing the present invention.

That is, the present invention provides a liquid or semi-solid composition containing processed garlic and erythritol.
The present invention also provides a method for suppressing unpleasant odors and/or precipitation originating from processed garlic products, which comprises the step of incorporating erythritol into a liquid or semi-solid composition containing processed garlic products.

According to the present invention, the unpleasant odor derived from processed garlic products is suppressed, and the formation of precipitates derived from processed garlic products is also suppressed, so that a liquid or semi-solid composition with good quality stability and high commercial value can be obtained. can be provided.

Hereinafter, in this specification, "w/v %" means percentage by mass to volume, and specifically means the mass (g) of each component contained per 100 mL of the composition.
First, the invention in the form of a "composition" will be described in detail below.

In the present invention, the "processed garlic product" may be any product obtained by processing garlic (Allium sativum). There is no particular limitation on the part of garlic used, and the whole plant or any part thereof (above ground, below ground, bulb, leaves, stem, flower, etc.) or a combination of two or more of these may be used, with the bulb being preferred.
Examples of "processing" include cutting, heating, drying, crushing, extraction, etc., and the type of processing is not particularly limited. Specific examples include heat treatment; drying raw garlic and then powdering it; extraction treatment with a solvent, etc. Examples of extraction solvents include alcohols such as methanol, ethanol, isopropanol, n-butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, etc.; ethers such as diethyl ether; ketones such as acetone and ethyl methyl ketone; esters such as ethyl acetate; nitriles such as acetonitrile; alkanes or cycloalkanes such as pentane, hexane, cyclopentane, cyclohexane; halogenoalkanes such as dichloromethane and chloroform; aromatic hydrocarbons such as benzene and toluene; dimethylformamide; dimethyl sulfoxide; water (including hot water); edible vegetable oils such as rapeseed oil, olive oil, and soybean oil.
In the present invention, "processed garlic" includes processed garlic, garlic extract, garlic extract, dried garlic, etc., and processed garlic is preferred. Examples of processed garlic include Oxoamidin (registered trademark), Oxoamidin (registered trademark) powder, and Oxoresin (registered trademark) powder (all from Riken Chemical Industry Co., Ltd.).

The content of the processed garlic product in the composition of the present invention is not particularly limited, and may be determined by appropriate consideration. For example, the content is preferably 0.0002 to 10 w/v%, more preferably 0.002 to 1 w/v%, and 0.02 to 0. Particularly preferred is one containing 5 w/v%.

In the present invention, "erythritol" may be produced by a known method, or a commercially available product may be used. Examples of such commercially available products include erythritol (San-Ei Gen F.F.I. Co., Ltd.).

The amount of erythritol contained in the composition of the present invention is not particularly limited, and may be determined through appropriate consideration. In the present invention, from the viewpoint of suppressing the unpleasant odor and precipitation caused by processed garlic products, the amount is preferably 0.001 to 10 w/v% relative to the total volume of the liquid or semi-solid composition, more preferably 0.01 to 5 w/v%, and particularly preferably 0.1 to 1 w/v%.

The mass ratio of the processed garlic product and erythritol in the composition of the present invention is not particularly limited, and may be determined by appropriate consideration. In the present invention, from the viewpoint of suppressing the unpleasant odor and precipitate formation derived from the processed garlic product, it is preferable that 0.1 to 50 parts by mass of erythritol be contained per 1 part by mass of the processed garlic product, and 0.1 to 50 parts by mass of erythritol is contained. It is more preferable to contain 5 to 40 parts by weight, even more preferably to contain 0.75 to 30 parts by weight, and particularly preferably to contain 1 to 20 parts by weight.

In the present invention, the properties of the "liquid or semi-solid composition" are not particularly limited, and may be any of a solution, a colloidal solution (sol (suspension or emulsion)), a gel, etc. Furthermore, the type and properties of the solvent or base are not particularly limited, and may be hydrophilic or hydrophobic such as oily, and further, multiple different types of solvents and bases may be appropriately mixed and emulsified for use. Specific examples of such solvents and bases include the components exemplified as additives below.

Furthermore, from the viewpoint of suppressing the unpleasant odor and precipitation of processed garlic products, it is preferable for the liquid or semi-solid composition of the present invention to contain water in addition to processed garlic products and erythritol (note that in this specification, a composition containing water is referred to as a "water-containing composition").
Here, the content of water in the composition is not particularly limited, but from the viewpoint of the effect of suppressing the unpleasant odor and precipitation of processed garlic products, it is preferably 1% by mass or more, more preferably 60 to 99.99% by mass, even more preferably 80 to 99.9% by mass, and particularly preferably 90 to 99.5% by mass.
When the liquid or semi-solid composition of the present invention is a water-containing composition, the pH of the composition (25° C.) is preferably 2-6, more preferably 2-5, and particularly preferably 3-4.

Further, the liquid or semi-solid composition of the present invention may contain ethanol in addition to the processed garlic product and erythritol. By using ethanol, the feeling of using and taking the composition is improved. Note that water and ethanol may be used in combination.
When using ethanol, the content of ethanol in the composition is preferably 1 w/v% or less, particularly preferably 0.01 to 0.5 w/v%, based on the total volume of the composition.

In the present invention, the dosage form to which the liquid or semi-solid composition is applied is not particularly limited, and depending on the purpose of use etc., for example, the dosage form described in the 17th revised Japanese Pharmacopoeia, General Rules for Preparations, etc. You can choose from the shapes as appropriate.
In the present invention, the dosage form of the liquid or semi-solid composition is preferably a dosage form selected from the group consisting of oral liquid preparations, syrup preparations, and oral jelly preparations (jelly-like drops). It is particularly preferable that there be.

In addition, when a liquid or semi-solid composition is formulated as a specific dosage form, a known means may be applied for each dosage form, such as placing the liquid or semi-solid composition in a container (e.g., a bottle, a can, a plastic container, etc.) as appropriate depending on the dosage form (a liquid or semi-solid composition placed in a container is referred to as a "product" in this specification). In addition, in the present invention, the material of the container is not particularly limited, but glass is preferable.

The composition of the present invention may contain drugs other than the above-mentioned components as pharmaceutical components. Such drugs include, for example, vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, aminocarboxylic acids, sterols, calcium salts, magnesium salts, iron salts, glucuronic acids, chondroitins, sugars, etc. Examples include one or more selected from the group consisting of alcohols, glycosides, thioctic acids, crude drugs, and the like.

Examples of vitamin A include vitamin A oil, retinol acetate, retinol palmitate, cod liver oil, and liver oil.
Examples of B vitamins include vitamin B1 such as bis-thiamine nitrate, thiamine chloride hydrochloride, thiamine disulfide, thiamine dicetyl sulfate, thiamine nitrate, octotiamine, shikotiamine, setotiamine hydrochloride hydrate, bis-ibutiamine, bis-bentiamine, fursultiamine, fursultiamine hydrochloride, prosultiamine, and benfotiamine; vitamin B2 such as flavin adenine dinucleotide sodium, riboflavin, riboflavin butyrate, and riboflavin sodium phosphate; vitamin B3 such as nicotinamide; vitamin B5 such as panthenol, calcium pantothenate, and sodium pantothenate; vitamin B6 such as pyridoxal phosphate hydrate and pyridoxine hydrochloride; vitamin B7 such as biotin; vitamin B9 such as folic acid; and vitamin B12 such as hydroxocobalamin hydrochloride, cyanocobalamin, hydroxocobalamin, and hydroxocobalamin acetate.
Examples of vitamin C include ascorbic acid, calcium ascorbate, and sodium ascorbate.
Examples of vitamin D include ergocalciferol and cholecalciferol.
Examples of vitamin E include d-α-tocopherol succinate, dl-α-tocopherol succinate, d-α-tocopherol acetate, tocopherol, d-α-tocopherol, tocopherol succinate calcium, tocopherol acetate, and the like.

Examples of aminocarboxylic acids include L-arginine hydrochloride, L-isoleucine, carnitine chloride, glycine, L-glutamic acid, diisopropylamine dichloroacetate, choline bitartrate, taurine, L-threonine, L-valine, and L-histidine. Examples include hydrochloride hydrate, DL-methionine, yoclecithin, L-lysine hydrochloride, L-leucine, L-cysteine, L-cysteine hydrochloride hydrate, orotic acid, choline orotate, and the like.
Examples of sterols include ursodeoxycholic acid, gamma oryzanol, dehydrocholic acid, and the like.
Examples of calcium salts, magnesium salts, and iron salts include calcium citrate, calcium glycerophosphate, calcium gluconate hydrate, calcium carbonate, precipitated calcium carbonate, calcium lactate hydrate, anhydrous calcium hydrogen phosphate, and calcium hydrogen phosphate. Hydrates, ammonium iron citrate, ferrous fumarate, magnesium carbonate, and the like.

Examples of glucuronic acids include glucuronolactone, glucuronic acid, and glucuronic acid amide.
Examples of chondroitins include sodium chondroitin sulfate.
Examples of sugar alcohols include inositol, gluconic acid and salts thereof.
Examples of glycosides include glycyrrhizinic acid, sodium glycyrrhizinate, and rutin hydrate.
Examples of thioctic acids include thioctic acid and thioctic acid amide.
Examples of herbal medicines include acacia, fennel, sedge, guarana, licorice, cinnamon, red ginseng, saffron, hawthorn, dioscorea, peony root, rose hip, ginger, Chinese laurel, hawthorn, Chinese laurel, Chinese clove, tangerine, angelica tree, Japanese laurel, Eucommia ulmoides, carrot, poria oleracea, muira puama, bamboo shoot, yakuchi, coix seed, longan fruit, and royal jelly.

The composition of the present invention may contain additives used in the pharmaceutical field, quasi-drug field, food field, etc. depending on its dosage form, administration method, etc. Examples of such additives include sweeteners, pH adjusters, antioxidants, colorants, fragrances, corrigents, preservatives, and the like.

Examples of sweeteners include white sugar, glucose, fructose, invert sugar, lactose, honey, trehalose, sucralose, saccharin and its salts, aspartame, acesulfame potassium, and stevia extract.
Examples of the pH adjuster include organic acids such as citric acid and malic acid; inorganic acids such as hydrochloric acid; and inorganic bases such as sodium hydroxide.
Examples of the antioxidant include ascorbic acid and its salts, erythorbic acid and its salts, edetic acid and its salts, sodium bisulfite, propyl gallate, and the like.
Examples of the coloring agent include tar pigment, iron sesquioxide, caramel, and the like.
Examples of fragrances include apple flavor.
Examples of the flavoring agent include citric acid and its salts, L-glutamic acid and its salts, povidone, l-menthol, and the like.
Examples of preservatives include benzoic acid and its salts, parabens, and the like.

In the present invention, the method for producing the composition is not particularly limited, and may vary depending on the types and amounts of ingredients to be mixed, properties of the composition, dosage form, route of administration, use, etc., for example, according to the 17th edition of the Japanese Pharmacopoeia, It can be produced by a known method described in .

The route of administration (route of administration) of the composition of the present invention is not particularly limited, and includes oral and parenteral routes such as transdermal and vaginal. In the present invention, oral is preferred.

The liquid or semi-solid composition of the present invention contains a processed garlic product having fatigue recovery effects and nutritional tonic effects, and therefore can be used as a medical drug, an OTC drug, a quasi-drug, a food, etc. Specifically, for example, the following (A) to (F):
(a) Maintaining or improving physical strength, physical resistance, or concentration;
(a) Relief and prevention of fatigue;
(c) Improvement and prevention of physical disorders associated with a frail constitution (including frailty due to aging);
(d) Improvement and prevention of physical disorders associated with malnutrition in daily life;
(E) Nutritional supplementation during periods of reduced physical strength during or after illness, during debilitating illnesses accompanied by fever, during periods of loss of appetite, during pregnancy and lactation, or before and after childbirth;
(F) Eye fatigue;
In the present invention, it is particularly preferable for the drug or quasi-drug to have one or more of the following efficacy or effects: (a) to (e).

Next, the invention in the aspect of "a method for suppressing unpleasant odor" will be described in detail below.
The present invention also relates to a method for suppressing unpleasant odors derived from processed garlic products, which includes the step of incorporating erythritol into a liquid or semi-solid composition containing processed garlic products.
In such an embodiment, the method for incorporating the processed garlic product and erythritol into the liquid or semi-solid composition, the order in which they are incorporated, etc. are not particularly limited, and a composition containing both components can be created directly or indirectly. It is fine if it is done.
In addition, in this aspect of the invention, the meanings of various words, the content of each component, etc. are all the same as explained for the above-mentioned "composition" of the present invention.

Next, the embodiment of the invention relating to the "method for inhibiting precipitation" will be described in detail below.
The present invention also relates to a method for inhibiting the formation of precipitates derived from processed garlic, which comprises the step of incorporating erythritol into a liquid or semi-solid composition containing processed garlic.
In such an embodiment, the method for incorporating processed garlic and erythritol into a liquid or semi-solid composition, the order in which they are incorporated, etc. are not particularly limited, as long as a composition containing both components is produced directly or indirectly.
In this embodiment of the invention, the meanings of various terms, the contents of each component, etc. are all the same as those explained for the "composition" of the present invention described above.

In addition, the present specification discloses the following aspects, for example, although it is not limited thereto.
[1A] A liquid or semi-solid composition containing processed garlic and erythritol.
[2A] The composition described in [1A], which is a formulation for oral administration.
[3A] The composition described in [1A] or [2A], which is an oral liquid preparation.

[1B] A method for suppressing unpleasant odors derived from processed garlic, comprising a step of incorporating erythritol into a liquid or semi-solid composition containing processed garlic.
[2B] The method described in [1B], wherein the composition is a formulation for oral administration.
[3B] The method according to [1B] or [2B], wherein the composition is an oral liquid.

[1C] A method for suppressing the formation of a precipitate derived from a processed garlic product, the method comprising the step of incorporating erythritol into a liquid or semi-solid composition containing the processed garlic product.
[2C] The method according to [1C], wherein the composition is a preparation for oral administration.
[3C] The method according to [1C] or [2C], wherein the composition is an oral liquid preparation.

EXAMPLES Hereinafter, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited to these in any way.

[Test Example 1] Evaluation of the effect of suppressing unpleasant odors The compositions of Example 1 and Comparative Example 1 below were each prepared, and their odors (the odor felt when the nose was brought within about 10 cm of the composition/the odor escaping from the mouth to the nose when the composition was held in the mouth) were evaluated.
The evaluation was made on a four-point scale: 0: no unpleasant odor from processed garlic products at all, 1: almost no unpleasant odor from processed garlic products, 2: unpleasant odor from processed garlic products is felt, 3: unpleasant odor from processed garlic products is felt strongly. The evaluation was made by five men in their 20s to 40s, and the average value was calculated.
The composition of Example 1 and the composition of Comparative Example 1 were evaluated on the same day with an interval of one hour.
The results are shown in Table 1.

[Example 1]
Example: 500 mg of processed garlic (Oxoamidine powder: Riken Kagaku Kogyo Co., Ltd.), 800 mg of erythritol (Erythritol T: Mitsubishi Chemical Foods Co., Ltd.) and 30 mg of sodium benzoate were dissolved and dispersed in purified water to a total volume of 100 mL. A liquid composition of No. 1 was obtained.
[Comparative example 1]
A liquid composition of Comparative Example 1 was obtained in the same manner as in Example 1 except that erythritol was not blended.

As is clear from Table 1, in the composition of Comparative Example 1 which does not contain erythritol, the unpleasant odor derived from processed garlic products was felt to be strong both when brought close to the nose and when put in the mouth. In the composition of Example 1 containing erythritol, no unpleasant odor derived from processed garlic products was detected in any case.
Furthermore, since erythritol itself is said to be an odorless ingredient (Pharmaceutical Additives Standard 2013, published by Yakuji Nippo Co., Ltd.), the suppressing effect on the unpleasant odor derived from processed garlic products confirmed in Table 1 is This suggests that the effect is completely different from masking due to the odor of other components.

From the above test results, erythritol has the effect of suppressing the unpleasant odor of processed garlic products, and by containing processed garlic products and erythritol in the same liquid or semi-solid composition, It has become clear that unpleasant odors originating from processed garlic products can be suppressed.

[Test Example 2] Stability Test The compositions (liquid compositions) of Example 1 and Comparative Example 1 described in Test Example 1 were prepared. While each of the obtained compositions was stored at 25° C., the presence or absence of precipitate formation was periodically visually evaluated to confirm which composition showed precipitate formation first. Cases in which precipitate formation was observed first were marked as x, and cases in which no precipitate formation was observed up to this precipitate formation were marked as ○.
The results are shown in Table 2.

[Test Example 3] Stability test Part 2
The compositions (liquid compositions) of Example 2 and Comparative Example 2 below were prepared, and in the same manner as in Test Example 2, it was confirmed which composition was observed to form a precipitate first.
The results are shown in Table 3.

[Example 2]
1000 mg of processed garlic (Oxoamidine powder: Riken Kagaku Kogyo Co., Ltd.), 4000 mg of erythritol (Erythritol T: Mitsubishi Chemical Foods Co., Ltd.), 1000 mg of ethanol, and 30 mg of sodium benzoate were dissolved and dispersed in purified water to a total volume of 100 mL. , the liquid composition of Example 2 was obtained.
[Comparative example 2]
A liquid composition of Comparative Example 2 was obtained in the same manner as in Example 2 except that erythritol was not blended.

As is clear from Tables 2 and 3, when the liquid composition containing the processed garlic product further contains erythritol (Examples 1 and 2), when it does not contain erythritol (Comparative Examples 1 and 2) It became clear that the formation of precipitates was suppressed compared to

The results of Test Examples 2 and 3 above demonstrate that erythritol has the effect of suppressing the formation of precipitates derived from processed garlic products in liquid or semi-solid compositions.

[Production Examples 1 to 10]
A liquid composition (oral liquid preparation) containing the ingredients and amounts listed in Tables 4 and 5 below in 100 mL was produced by a conventional method, and this was placed in a glass bottle to produce the products of Production Examples 1 to 10, respectively. I got it.

The present invention provides a liquid or semi-solid composition that contains processed garlic products that have fatigue recovery effects and nutritional tonic effects, and has good quality stability and high commercial value, with the unpleasant odor and precipitation caused by processed garlic products suppressed, and can be used in the pharmaceutical industry, food industry, etc.

Claims (2)

A method for suppressing the formation of a precipitate derived from a processed garlic product, the method comprising the step of incorporating erythritol into a liquid or semi-solid composition containing the processed garlic product. The method of claim 1 , wherein the composition is an oral liquid.