JP4904795B2 - Fatigue improver composition - Google Patents

Fatigue improver composition Download PDF

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JP4904795B2
JP4904795B2 JP2005352088A JP2005352088A JP4904795B2 JP 4904795 B2 JP4904795 B2 JP 4904795B2 JP 2005352088 A JP2005352088 A JP 2005352088A JP 2005352088 A JP2005352088 A JP 2005352088A JP 4904795 B2 JP4904795 B2 JP 4904795B2
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vitamin
fatigue
capsaicin
taurine
caffeine
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JP2007153816A (en
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訓志 阿部
奈緒子 関
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Taisho Pharmaceutical Co Ltd
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Description

本発明は、スポーツや肉体労働に伴う疲労、徹夜等の不規則な生活に伴う疲労、または、ストレスに起因する精神的な疲労を改善するために有効な組成物に関し、医薬品、医薬部外品及び食品の分野で応用可能な発明である。   The present invention relates to a composition effective for improving fatigue associated with sports or physical labor, fatigue associated with irregular life such as staying up all night, or mental fatigue caused by stress. And an invention applicable in the field of food.

疲労は一種の生理現象で、スポーツや肉体労働に起因する疲労、徹夜等の不規則な生活に起因する疲労、またはストレスに起因する精神的な疲労など種々の態様の疲労が知られている。こうした疲労の軽減もしくは改善方法としては、休息や充分な睡眠、マッサージ、温泉療法などが挙げられるが、仕事に追われ、時間の取れない現代人が採る簡便な方法として、ビタミン含有保険薬の服用が挙げられる。   Fatigue is a kind of physiological phenomenon, and various forms of fatigue are known, such as fatigue caused by sports or physical labor, fatigue caused by irregular life such as staying up all night, or mental fatigue caused by stress. These methods of reducing or improving fatigue include rest, sufficient sleep, massage, and hot spring therapy, but taking vitamin-containing insurance drugs as a simple method for modern people who are busy with work and cannot take time. Is mentioned.

このビタミン含有保険薬には有効成分として、ビタミンB類、各種アミノ酸、カフェイン、生薬などが配合されているが(非特許文献1参照)、限られた配合量の中で前記各種疲労に対する充分な改善作用を奏するのは、なかなかに難しいことである。   This vitamin-containing insurance drug contains vitamin Bs, various amino acids, caffeine, herbal medicines, and the like as active ingredients (see Non-Patent Document 1). It is very difficult to achieve an improvement.

そこで、充分な安全性が確認され、各種疲労の改善に有効な薬剤等の開発が希求されていた。   Therefore, sufficient safety has been confirmed, and the development of drugs and the like effective for improving various fatigue has been demanded.

一方、トウガラシ(唐辛子)の辛味の主成分であるカプサイシン(capsaicin)は、体脂肪を燃焼させて肥満を防止したり、代謝を良くして持久力を増進させたり、炭水化物の消化を助けて便秘を解消し美肌作りに貢献したり、免疫賦活作用で発ガン抑制に寄与したりと種々の作用が知られているが(非特許文献2及び3参照)、疲労改善作用の増強に用いられたという報告はない。   On the other hand, capsaicin, the chief ingredient of red pepper, burns body fat to prevent obesity, improves metabolism and increases endurance, and helps digest carbohydrates and constipation It has been used to enhance fatigue-reducing effects, although it has been known to contribute to the creation of beautiful skin by eliminating the skin and contributing to the suppression of carcinogenesis by the immunostimulatory effect (see Non-Patent Documents 2 and 3). There is no report.

薬事審査研究会監修、新指定医薬部外品製造申請の手引、(10) ビタミン含有保健剤 製造(輸入)承認基準、pp 55〜61.薬事日報社、東京 (1999).Supervised by the Pharmaceutical Affairs Research Committee, Application Guide for Newly Designed Quasi-drugs, (10) Criteria for the manufacture (import) of vitamin-containing health products, pp 55-61. Yakuji Nipposha, Tokyo (1999). Kawada T. Watanabe T. Takaishi T. Tanaka T. and Iwai K.: Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proceedings of the Society for Experimental Biology & Medicine. 183(2):250-6, 1986.Kawada T. Watanabe T. Takaishi T. Tanaka T. and Iwai K .: Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization.Proceedings of the Society for Experimental Biology & Medicine. 183 (2): 250-6, 1986. Watanabe T. Kawada T. Kurosawa M. Sato A. and Iwai K.: Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats. American Journal of Physiology. 255(1 Pt 1):E23-7, 1988 Jul.Watanabe T. Kawada T. Kurosawa M. Sato A. and Iwai K .: Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats.American Journal of Physiology.255 (1 Pt 1): E23-7, 1988 Jul.

本発明の課題は、既存のビタミン含有保険薬に配合されているタウリン(2−アミノエタンスルホン酸)、ビタミンB類及びカフェインの有する疲労改善作用を増強し、安全で有効な疲労改善用組成物を提供することである。   An object of the present invention is to enhance the fatigue improving action of taurine (2-aminoethanesulfonic acid), vitamin Bs and caffeine, which are blended in an existing vitamin-containing insurance, and a safe and effective composition for improving fatigue. Is to provide things.

本発明者らは、上記課題を解決するために鋭意研究を重ねた結果、タウリン(2−アミノエタンスルホン酸)、ビタミンB類(ビタミンB2リン酸エステル、塩酸ピリドキシン、ニコチン酸アミド)及びカフェインを含有する液剤にカプサイシンを添加することにより、タウリン等の有する疲労改善作用が著しく増強されることを見出した。   As a result of intensive studies to solve the above problems, the present inventors have found that taurine (2-aminoethanesulfonic acid), vitamin Bs (vitamin B2 phosphate ester, pyridoxine hydrochloride, nicotinamide) and caffeine It has been found that the fatigue improving action of taurine or the like is remarkably enhanced by adding capsaicin to a liquid containing sucrose.

かかる知見に基づき完成した本発明の態様は、(a)2−アミノエタンスルホン酸、ビタミンB類及びカフェイン、並びに、(b)カプサイシン、を含有することを特徴とする疲労改善剤組成物である。   An aspect of the present invention completed based on such findings is a fatigue ameliorating agent composition comprising (a) 2-aminoethanesulfonic acid, vitamins B and caffeine, and (b) capsaicin. is there.

本発明により、タウリン、ビタミンB類及びカフェインの有する疲労改善作用が増強され、安全で有効な疲労改善剤組成物を提供することが可能となった。   According to the present invention, the fatigue improving action of taurine, vitamin Bs and caffeine is enhanced, and it is possible to provide a safe and effective fatigue improving agent composition.

本発明の疲労改善剤組成物は、2−アミノエタンスルホン酸、ビタミンB類及びカフェイン、並びに、カプサイシンを含んで構成されている。   The fatigue ameliorating agent composition of the present invention comprises 2-aminoethanesulfonic acid, vitamins B and caffeine, and capsaicin.

「2−アミノエタンスルホン酸(タウリン)」の有効投与量は成人(体重60kg)1日当たり200〜20,000mgである。   The effective dose of “2-aminoethanesulfonic acid (taurine)” is 200 to 20,000 mg per day for an adult (body weight 60 kg).

「ビタミンB類」としては、ビタミンB1、ビタミンB2、ビタミンB6、ビタミンB12及びビタミンB複合体が挙げられ、これらは塩やエステルであってもよい。例えば、塩酸チアミン、ビタミンB2リン酸エステル、塩酸ピリドキシン、ニコチン酸アミド、パントテン酸カルシウムが挙げられる。   Examples of “vitamin B” include vitamin B1, vitamin B2, vitamin B6, vitamin B12, and vitamin B complex, and these may be salts and esters. Examples include thiamine hydrochloride, vitamin B2 phosphate ester, pyridoxine hydrochloride, nicotinamide, and calcium pantothenate.

ビタミンB類の有効投与量は成人(体重60kg)1日当たり5〜500mgである。   The effective dose of vitamin B is 5 to 500 mg per day for adults (body weight 60 kg).

「カフェイン」の有効投与量は成人(体重60kg)1日当たり10〜1,000mgである。   The effective dose of “caffeine” is 10 to 1,000 mg per day for an adult (body weight 60 kg).

「カプサイシン(capsaicin)」とは、トウガラシ Capsicum annuum L. の果実中に、2%内外含有される辛味成分で、皮膚、粘膜などに塗布すると、その局所は血管が拡張され充血がみられる。消化管運動を亢進し少量で唾液、胃酸の分泌を促進するが、多量では逆に抑制する(薬科学大辞典より)。カプサイシンには、化学合成したり、天然物から抽出したカプサイシンそのものの他、トウガラシ等植物の原末、エキスに含有されている場合も含まれる。ここで、エキスの抽出溶媒としては、水、アルコール(メタノール、エタノール、プロパノール、イソプロパノール、ブタノールなど)、酢酸エチル、アセトン、ヘキサン、またはそれらの混液などが挙げられ、通常用いられる方法でエキスを製造することができる。   "Capsaicin" is a pungent component contained in capsicum annuum L., 2% inside and outside, and when applied to the skin, mucous membrane, etc., blood vessels are dilated and hyperemia is observed in the region. Increases gastrointestinal motility and promotes the secretion of saliva and gastric acid in small amounts, but conversely suppresses in large amounts (from the Pharmaceutical Sciences Dictionary). Capsaicin includes not only capsaicin which is chemically synthesized or extracted from natural products, but also contained in plant powders and extracts such as pepper. Here, the extraction solvent for the extract includes water, alcohol (methanol, ethanol, propanol, isopropanol, butanol, etc.), ethyl acetate, acetone, hexane, or a mixture thereof, and the extract is produced by a commonly used method. can do.

カプサイシンの有効投与量は成人(体重60kg)1日当たり、カプサイシン換算で0.01〜100mgである。   The effective dose of capsaicin is 0.01 to 100 mg in terms of capsaicin per day for an adult (body weight 60 kg).

本発明の疲労改善剤組成物は、タウリン、ビタミンB類、カフェイン及びカプサイシンを配合し、必要に応じて他の公知の添加剤、例えば、賦形剤、崩壊剤、結合剤、滑沢剤、抗酸化剤、コーティング剤、着色剤、矯味矯臭剤、界面活性剤、可塑剤等を添加して常法により、顆粒剤、散剤、カプセル剤、錠剤、ドライシロップ剤、液剤等の経口製剤として提供することができる。   The fatigue ameliorating agent composition of the present invention contains taurine, vitamin Bs, caffeine and capsaicin, and if necessary, other known additives such as excipients, disintegrants, binders, lubricants. , Antioxidants, coatings, coloring agents, flavoring agents, surfactants, plasticizers, etc., and provided as oral preparations such as granules, powders, capsules, tablets, dry syrups, and liquids by conventional methods can do.

また、必要に応じて他の生理活性成分、カリウム、カルシウム、マグネシウム、鉄、亜鉛等のミネラル、ビタミンA、C、D、E、K、P、葉酸、パントテン酸、リポ酸、ユビキノン等のビタミン類(誘導体も含む)、アルギニン、プロリン、バリン、ロイシン、イソロイシン、テアニン等のアミノ酸類、ホルモン、栄養成分、香料等を配合することにより、嗜好性をもたせることもできる。   If necessary, other physiologically active ingredients, minerals such as potassium, calcium, magnesium, iron and zinc, vitamins A, C, D, E, K, P, folic acid, pantothenic acid, lipoic acid, ubiquinone and other vitamins It is also possible to provide palatability by blending amino acids (including derivatives), amino acids such as arginine, proline, valine, leucine, isoleucine, and theanine, hormones, nutrients, and fragrances.

さらに、インヨウカク(イカリソウ)、茴香、エゾウコギ(刺五加、五加皮)、黄蓍、黄ゴン、黄精、黄連、遠志、何首烏、霍香、葛根、カノコソウ、乾姜、甘草、桔梗、枳実、羌活、枸杞子、枸杞葉、ケツジツ、桂皮、肉桂、桂枝、苦参、苦楝皮、玄参、紅花、紅参、香附子、厚朴、呉茱萸、胡麻、胡蘆巴、虎杖根、細辛、石榴、山梔子、山茱萸、山査子、鎖陽、山椒、山奈、山扁豆、山稜、酸棗仁、西洋山査子、生姜、縮砂、蛇床子、女貞子、芍薬、沙参、菖蒲根、升麻、地黄、熟地黄、沈香、川キュウ、川骨、川楝皮、蒼朮、菖蒲根、石斛、石菖根、蘇葉、蒼朮、大蒜、大棗、大豆(イソフラボンでも可)、沢瀉、竹節人参、茶葉、丁字(母丁香、公丁香)、陳皮、当帰、杜仲、党参、橙皮、人参、巴戟天、反鼻、麦門冬、白朮、ブラックコホッシュ、茯苓、覆盆子、防己、蒲公英、補骨脂、ムイラプアマ、木香、牡丹皮、レッドクローバー、ローズヒップ、益母草、益智、良姜、竜眼肉、ヨクイニン、ローヤルゼリー等を本発明の効果を損なわない範囲で配合することもできる。   In addition, Yakukaku (Ikarisou), Ayaka, Ezokogi (Sashigoka, Gokahide), Jaundice, Yellow Gon, Yellow spirit, Huang Ren, Distant, What neck, Ayaka, Kakkon, Kanokosou, Psoriasis, Licorice, Kikyo, Kakimi,羌活 、 枸杞 子 、 枸杞 葉 、 ケ ジ 、 桂皮 、 肉桂 、 桂枝 、 bittern, bitter rind, ginseng, safflower, red ginseng, garlic, Kobok, 茱萸 茱萸, sesame, cucumber, tiger cane, fine Spicy, sarcophagus, yam, yam, yam, yamako, chain yang, yam, yamana, yam, ridge, mountain ridge, soy sauce, western yam, ginger, shredded sand, snake bed, sadako, glaze, sasan, sone, sesame, Ground yellow, maturity yellow, agarwood, river cucumber, river bone, river husk, persimmon, root, stalagmite, sarcophagus, soba, persimmon, large persimmon, large persimmon, soybean (isoflavone is also acceptable), saw potato, bamboo ginseng, tea leaves , Cing (mother cinder, public cicada), Chen leather, Toki, Tochu, Party ginseng, Orange peel, Carrot, Brahma, Anti-nose, Mumon winter, White birch, Bra The effects of the present invention are impaired in the effects of the present invention such as wolfberry, cocoon, bon bonsai, self-prevention, Koei Sakaki, bone substitute, muirapuama, wood incense, peony skin, red clover, rose hips, benevolent grass, masochist, ryokan, longan meat, yakuinin, royal jelly, etc. It can also be blended in a range not included.

以下に実施例及び試験例を挙げ、本発明をさらに詳細に説明する。なお、生薬の配合量は原生薬換算量を示す。   Hereinafter, the present invention will be described in more detail with reference to examples and test examples. The compounding amount of the crude drug represents the equivalent amount of the drug substance.

実施例1
タウリン 4000 mg
ビタミンB2リン酸エステル 20 mg
塩酸ピリドキシン 20 mg
ニコチン酸アミド 80 mg
無水カフェイン 200 mg
カプサイシン 200 mg
上記に示す量のタウリン、ビタミンB2リン酸エステル、塩酸ピリドキシン、ニコチン酸アミド及び無水カフェインを180mLの精製水に溶解させたのち、適量のエタノールに溶解させたカプサイシンを加え、さらに精製水により200mLにメスアップして、液剤を得た。
Example 1
Taurine 4000 mg
Vitamin B2 phosphate 20 mg
Pyridoxine hydrochloride 20 mg
Nicotinamide 80 mg
Anhydrous caffeine 200 mg
Capsaicin 200 mg
After dissolving taurine, vitamin B 2 phosphate ester, pyridoxine hydrochloride, nicotinamide and anhydrous caffeine in the amounts shown above in 180 mL of purified water, add capsaicin dissolved in an appropriate amount of ethanol, and further with purified water. The volume was made up to 200 mL to obtain a solution.

実施例2
タウリン 1000 mg
ビタミンB1硝酸塩 5 mg
ビタミンB2リン酸エステル 5 mg
ビタミンB6 5 mg
イノシトール 50 mg
ニコチン酸アミド 20 mg
無水カフェイン 50 mg
トウガラシエキス 50 μL
上記に示す量のトウガラシエキスを除く成分を90mLの精製水に溶解させたのち、トウガラシエキスを加え、さらに精製水により100mLにメスアップして、液剤を得た。
Example 2
Taurine 1000 mg
Vitamin B1 nitrate 5 mg
Vitamin B2 phosphate 5 mg
Vitamin B6 5 mg
Inositol 50 mg
Nicotinamide 20 mg
Anhydrous caffeine 50 mg
Red pepper extract 50 μL
Components other than the above-mentioned amount of red pepper extract were dissolved in 90 mL of purified water, then red pepper extract was added, and further diluted to 100 mL with purified water to obtain a solution.

実施例3
タウリン 2000 mg
塩酸フルスルチアミン 7 mg
ビタミンB2リン酸エステル 5 mg
ビタミンB6 5 mg
イノシトール 50 mg
ニコチン酸アミド 30 mg
塩化カルニチン 50 mg
無水カフェイン 50 mg
トウガラシエキス 100 μL
上記に示す量のトウガラシエキスを除く成分を90mLの精製水に溶解させたのち、トウガラシエキスを加え、さらに精製水により100mLにメスアップして、液剤を得た。
Example 3
Taurine 2000 mg
Fursultiamine hydrochloride 7 mg
Vitamin B2 phosphate 5 mg
Vitamin B6 5 mg
Inositol 50 mg
Nicotinamide 30 mg
Carnitine chloride 50 mg
Anhydrous caffeine 50 mg
Capsicum extract 100 μL
Components other than the above-mentioned amount of red pepper extract were dissolved in 90 mL of purified water, then red pepper extract was added, and further diluted to 100 mL with purified water to obtain a solution.

実施例4
タウリン 1000 mg
ビタミンB2リン酸エステル 5 mg
塩酸ピリドキシン 5 mg
無水カフェイン 50 mg
イカリ草 1000 mg
トウキ(当帰) 50 mg
ニンジン(人参) 600 mg
オウギ(黄耆) 600 mg
カンゾウ(甘草) 150 mg
オウセイ(黄精) 600 mg
タイソウ(大棗) 300 mg
ショウキョウ(生姜) 75 mg
サイコ(柴胡) 150 mg
ハンピ(反鼻) 250 mg
ムイラプアマ 300 mg
トウガラシエキス 100 μL
上記に示す量のトウガラシエキスを除く成分を45mLの精製水に溶解させたのち、トウガラシエキスを加え、さらに精製水により50mLにメスアップして、液剤を得た。
Example 4
Taurine 1000 mg
Vitamin B2 phosphate 5 mg
Pyridoxine hydrochloride 5 mg
Anhydrous caffeine 50 mg
Squid grass 1000 mg
Touki (Today) 50 mg
Carrot (carrot) 600 mg
Ougi (Twilight) 600 mg
Licorice (licorice) 150 mg
Horsetail (yellow spirit) 600 mg
Taisou 300mg
Ginger (ginger) 75 mg
Psycho (Shibako) 150 mg
Hampi (antinasal) 250 mg
Muirapuama 300 mg
Capsicum extract 100 μL
The components excluding the above-mentioned amount of pepper extract were dissolved in 45 mL of purified water, added with pepper extract, and further diluted to 50 mL with purified water to obtain a solution.

実施例5
タウリン 1000 mg
ビタミンB2リン酸エステル 5 mg
塩酸ピリドキシン 5 mg
無水カフェイン 50 mg
ロクジョウ(鹿茸) 300 mg
イカリ草 1000 mg
トウチュウカソウ(冬虫夏草) 150 mg
クコシ(枸杞子) 200 mg
ジオウ(地黄) 200 mg
トウキ(当帰) 200 mg
ニンジン(人参) 600 mg
オウギ(黄耆) 300 mg
カンゾウ(甘草) 150 mg
オウセイ(黄精) 300 mg
ブクリョウ(茯苓) 300 mg
ケイヒ(桂皮) 150 mg
ハンピ(反鼻) 300 mg
ムイラプアマ 300 mg
トウガラシエキス 100 μL
上記に示す量のトウガラシエキスを除く成分を45mLの精製水に溶解させたのち、トウガラシエキスを加え、さらに精製水により50mLにメスアップして、液剤を得た。
Example 5
Taurine 1000 mg
Vitamin B2 phosphate 5 mg
Pyridoxine hydrochloride 5 mg
Anhydrous caffeine 50 mg
Rokjou 300 mg
Squid grass 1000 mg
Euphorbiaceae (Cycium Cordyceps) 150 mg
Kukosi 200 mg
Giant (ground yellow) 200 mg
Touki (home delivery) 200 mg
Carrot (carrot) 600 mg
Ougi (Twilight) 300 mg
Licorice (licorice) 150 mg
Horsetail (yellow spirit) 300 mg
Bukuryo (茯苓) 300 mg
Keihi (cinnamon) 150 mg
Hampi (antinasal) 300 mg
Muirapuama 300 mg
Capsicum extract 100 μL
The components excluding the above-mentioned amount of pepper extract were dissolved in 45 mL of purified water, added with pepper extract, and further diluted to 50 mL with purified water to obtain a solution.

実施例6
タウリン 1000 mg
ビタミンB2リン酸エステル 5 mg
塩酸ピリドキシン 5 mg
無水カフェイン 50 mg
ロクジョウ(鹿茸) 300 mg
イカリ草 1000 mg
トウチュウカソウ(冬虫夏草) 300 mg
トチュウ(杜仲) 300 mg
ニクジュヨウ 500 mg
トシシ(菟糸子) 300 mg
ジャショウシ(蛇床子) 300 mg
カイクジン(海狗腎) 100 mg
ジオウ(地黄) 300 mg
ニンジン(人参) 600 mg
カンゾウ(甘草) 100 mg
サンヤク(山薬) 300 mg
ゴミシ(五味子) 300 mg
サンシュユ(山茱萸) 500 mg
ブクリョウ(茯苓) 300 mg
ハンピ(反鼻) 250 mg
ムイラプアマ 300 mg
トウガラシエキス 100 μL
上記に示す量のトウガラシエキスを除く成分を45mLの精製水に溶解させたのち、トウガラシエキスを加え、さらに精製水により50mLにメスアップして、液剤を得た。
Example 6
Taurine 1000 mg
Vitamin B2 phosphate 5 mg
Pyridoxine hydrochloride 5 mg
Anhydrous caffeine 50 mg
Rokjou 300 mg
Squid grass 1000 mg
Euphorbiaceae (Cycium Cordyceps) 300 mg
Eucommia 300 mg
Nikujuyo 500 mg
Toshishi (boiled silkworm) 300 mg
Jashoushi (snake bed) 300 mg
Kaikujin (sea shark kidney) 100 mg
Giant (ground yellow) 300 mg
Carrot (carrot) 600 mg
Licorice (licorice) 100 mg
Sanyaku (Yakuyaku) 300 mg
Garbage (Gomiko) 300 mg
Sanshuyu 500 mg
Bukuryo (茯苓) 300 mg
Hampi (antinasal) 250 mg
Muirapuama 300 mg
Capsicum extract 100 μL
The components excluding the above-mentioned amount of pepper extract were dissolved in 45 mL of purified water, added with pepper extract, and further diluted to 50 mL with purified water to obtain a solution.

試験例1
ddY系雄性マウス(4週齢、日本エスエルシー株式会社から購入)に下表1に記載の液剤を14日間反復経口投与した後に、マウスの体重の8質量%に相当する錘をつけて水温を10℃に維持した水槽中で強制遊泳させて、5秒以上沈むまでの時間を測定した。なお、1群当たりのマウスは15匹で実験を行った。
Test example 1
After repeated oral administration of the solutions shown in Table 1 below to ddY male mice (4 weeks old, purchased from Japan SLC Co., Ltd.) for 14 days, a weight corresponding to 8% by mass of the body weight of the mice is attached and the water temperature is adjusted. After forced swimming in a water tank maintained at 10 ° C., the time until sinking for 5 seconds or more was measured. The experiment was performed with 15 mice per group.

Figure 0004904795
Figure 0004904795

各群の平均遊泳時間、標準誤差及び群間の有意差検定結果は図1に示したとおりである。本発明にかかる薬剤Cは、薬剤A及びBに比し遊泳時間が長く、優れた疲労改善作用を有することが示唆された。   The average swimming time of each group, the standard error, and the significant difference test result between groups are as shown in FIG. It was suggested that the drug C according to the present invention has a longer swimming time than the drugs A and B and has an excellent fatigue improving action.

本発明により、安全で、有効な疲労改善作用を有する医薬品、医薬部外品及び食品の開発が期待される。   According to the present invention, development of safe, effective pharmaceuticals, quasi-drugs and foods having an effect of improving fatigue is expected.

対照、薬剤A、B及びCを投与したマウスの強制遊泳時間を示すグラフである。It is a graph which shows the forced swimming time of the mouse | mouth which administered control and the chemical | medical agent A, B, and C.

Claims (1)

(a)2−アミノエタンスルホン酸、ビタミンB類及びカフェイン、並びに、(b)カプサイシン、を含有することを特徴とする疲労改善剤組成物。
A fatigue improver composition comprising (a) 2-aminoethanesulfonic acid, vitamins B and caffeine, and (b) capsaicin.
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