KR20200071363A - Composition for Cartilage Damage Prevention and Regeneration Containing Rosa Canina Extract - Google Patents
Composition for Cartilage Damage Prevention and Regeneration Containing Rosa Canina Extract Download PDFInfo
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- KR20200071363A KR20200071363A KR1020180159023A KR20180159023A KR20200071363A KR 20200071363 A KR20200071363 A KR 20200071363A KR 1020180159023 A KR1020180159023 A KR 1020180159023A KR 20180159023 A KR20180159023 A KR 20180159023A KR 20200071363 A KR20200071363 A KR 20200071363A
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- extract
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- powder
- rose hip
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
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- 239000002994 raw material Substances 0.000 description 1
- 235000019203 rebaudioside A Nutrition 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
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- 235000019192 riboflavin Nutrition 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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- 239000001394 sodium malate Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- 241000894007 species Species 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
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- 239000005720 sucrose Substances 0.000 description 1
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- 210000004233 talus Anatomy 0.000 description 1
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- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/306—Foods, ingredients or supplements having a functional effect on health having an effect on bone mass, e.g. osteoporosis prevention
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/202—Algae extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
Abstract
Description
본 발명은 연골손상방지 내지 재생용 조성물에 관한 것으로, 보다 상세하게는 인체에 부작용이 없고, 식품조성물로써 관능적 특성이 좋으면서, 퇴행성 관절염 내지 연골손상의 예방 및 재생에 효과가 있는 로즈힙을 함유하는 연골손상방지 내지 재생용 조성물에 관한 것이다.The present invention relates to a composition for preventing or regenerating cartilage damage, more specifically, having no side effects on the human body, and having good sensory properties as a food composition, and containing rose hips, which is effective in preventing and regenerating degenerative arthritis or cartilage damage. It relates to a composition for preventing or regenerating cartilage damage.
현대 사회에서 인구의 노령화에 따라 치매, 관절염, 동맥경화 등의 퇴행성 질환 환자들이 증가하고 있고, 이로 인해 노령인구의 사회활동 저해는 본인은 물론 가족들에게까지 경제적, 정신적인 어려움을 가져와 사회적인 문제가 되고 있다. 최근 우리나라는 노령화 사회로 진입함에 따라 55세 이상의 경우 80%, 75세 이상의 경우 거의 대부분이 골 관절 질환이 있는 것으로 알려져 있고, 특히 무릎 골관절염은 발병률이 매우 높고 염증이 계속되면 주위 근육의 위축을 유발하여 관절의 기형까지도 초래할 수 있어 치료경비뿐 아니라 이로 인한 노령인구의 사회활동 저해 등 여러 가지 사회적 손실이 큰 질환이다.In the modern society, degenerative diseases such as dementia, arthritis, and arteriosclerosis are increasing in accordance with the aging of the population. As a result, the social activity of the elderly population is hampered by economic and psychological difficulties not only for the person but also for the family. Is becoming. Recently, as Korea enters an aging society, 80% of people over 55 years of age and almost 75 years of age are known to have bone joint disease. In particular, knee osteoarthritis has a very high incidence rate and causes inflammation of surrounding muscles if inflammation continues. As a result, it can cause deformity of joints, which is a disease that has a great deal of social loss, not only the cost of treatment, but also the inhibition of the social activity of the elderly population.
골관절염 (퇴행성관절염)은 인구 노령화 추세에 따라 임상에서 흔히 볼 수 있는 노인성 질환으로 관절 연골의 퇴행성 변화를 기반으로 병변이 시작되어 운동 시 통증과 부종, 관절 강직감 및 점진적인 운동장애를 일으킨다. 이러한 골관절염의 치료에는 현재 체중감소, 근육강화운동, 단순진통제, 비스테로이드 소염제, 관절내 스테로이드 주사 및 수술 등의 운동요법, 약물요법, 수술요법이 실시되고 있다. 하지만 스테로이드 소염제는 위장관장애 등의 합병증을 일으킬 수 있고, 그 외에 스테로이드제의 관절 내 주사요법은 전신부작용 및 스테로이드의 반복주사에 따른 연골의 파괴, 감염의 위험성이 따르게 되므로 적극적인 치료법이 될 수 없다. 또한 본질적으로 퇴행성 질병의 진행을 억제하거나 차단시켜 줄 수 있는 골관절염의 치료 약물은 부족하고, 예방의 차원의 식품조성물도 거의 없는 실정이다.Osteoarthritis (degenerative arthritis) is a senile disease commonly seen in clinics according to the aging trend of the population, and lesions are initiated based on degenerative changes in joint cartilage, causing pain and swelling during exercise, joint stiffness and progressive movement disorders. In the treatment of osteoarthritis, exercise therapy such as weight loss, muscle strengthening exercise, simple analgesic, nonsteroidal anti-inflammatory drug, intra-articular steroid injection and surgery, drug therapy, and surgical therapy are currently being performed. However, steroid anti-inflammatory agents can cause complications such as gastrointestinal disorders, and in addition, intra-articular injection therapy of steroids cannot be an active treatment because of the risk of cartilage destruction and infection following systemic side effects and repeated injections of steroids. In addition, essentially, there is a shortage of drugs for the treatment of osteoarthritis that can inhibit or block the progression of degenerative diseases, and there is little food composition for prevention.
최근의 전 세계적으로 부작용이 적은 천연물 소재의 기능성 식품에 대한 관심이 급격히 증가하고 있다. 예를 들면 대한민국특허공개번호 제10-2008-0074346에는 백복령 추출물, 골담초 추출물, 유황 분말, 마늘추출물 등을 기존 약제성분과 혼합시킨 조성물로 관절염의 국부적인 치료 효과가 있다고 기술되어 있으며, 대한민국특허공개번호 제10-2010-0042337에는 황기, 인삼, 녹각, 도인, 상기생, 위령선, 진교, 몰약, 단삼, 속단, 유향, 홍화, 숙지황 등의 생약제 조성물이 류머티스 관절염 치료에 효과가 있다고 기재되어 있으나, 대개는 연골 재생 및 연골 손상 예방 효과가 매우 미미한 것으로 나타나 보다 효과적인 성분의 추가적인 발굴이 요구되고 있는 실정이다.In recent years, interest in functional foods made of natural ingredients with little side effects has rapidly increased worldwide. For example, in Korean Patent Publication No. 10-2008-0074346, a composition in which Baekbokryeong extract, goldamcho extract, sulfur powder, garlic extract, etc. is mixed with existing pharmaceutical ingredients, it is described that it has a local therapeutic effect of arthritis. No. 10-2010-0042337 describes that herbal medicine compositions such as astragalus, ginseng, rust, doin, rebirth, stomach lines, gin gyo, myrrh, dansam, sokdan, frankincense, safflower, sujihwang, are effective in treating rheumatoid arthritis, but usually The effect of preventing cartilage regeneration and cartilage damage is very insignificant, and further excavation of more effective ingredients is required.
[선행기술문헌][Advanced technical literature]
[특허문헌][Patent Document]
1. 한국공개특허공보 제10-2010-0012913 (2010.02.09.)1. Korean Patent Publication No. 10-2010-0012913 (2010.02.09.)
2. 한국공개특허공보 제10-2010-0042337 (2010.04.26.) 2. Korean Patent Publication No. 10-2010-0042337 (2010.04.26.)
본 발명은 상기와 같이 종래 기술이 지니는 한계를 극복하기 위해 안출된 것으로, 그 주된 목적은 인체에 부작용이 없고, 식품조성물로써 관능적 특성이 좋으면서, 퇴행성 관절염 내지 연골손상의 예방 및 재생에 효과가 있는 로즈힙을 함유하는 연골손상방지 내지 재생용 조성물을 제공함에 있다.The present invention has been devised to overcome the limitations of the prior art as described above, the main purpose of which is that there are no side effects on the human body, good sensory properties as a food composition, and effective in preventing and regenerating degenerative arthritis or cartilage damage. It is to provide a composition for preventing or regenerating cartilage damage containing a rose hip.
상기한 바와 같은 본 발명의 기술적 과제는 다음과 같은 수단에 의해 달성되어진다.The technical problem of the present invention as described above is achieved by the following means.
(1) 로즈힙 추출물을 활성성분으로 함유하는 연골손상방지 내지 재생용 조성물.(1) A composition for preventing or regenerating cartilage damage containing rose hip extract as an active ingredient.
(2) 상기 (1)에 있어서,(2) In the above (1),
식품조성물이고, 상어연골분말 0.1~3.0중량%, 해조 추출분말 0.1~3.0중량%를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.It is a food composition, shark cartilage powder 0.1 to 3.0% by weight, seaweed extract powder further comprising 0.1 to 3.0% by weight of cartilage damage prevention or regeneration composition.
(3) 상기 (2)에 있어서,(3) In the above (2),
석산, 새우풀, 및 용담의 군에서 선택된 적어도 1종의 꽃의 추출분말 0.1~5.0중량%를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.A composition for preventing or regenerating cartilage damage, further comprising 0.1 to 5.0% by weight of an extract powder of at least one flower selected from the group of oxalic acid, prawn grass, and gentian.
(4) 상기 (1)에 있어서, 로즈힙 추출물은,(4) In the above (1), the rose hip extract,
1) 로즈힙 추출액을 제조하는 단계;1) preparing a rose hip extract;
2) 상기 로즈힙 추출액을 농축 및 분무건조하여 분말화하는 단계;를 포함하여 분말화된 것임을 특징으로 하는 연골손상방지 내지 재생용 조성물.2) Concentrating and spray-drying the rose hip extract to powder; a composition for preventing or regenerating cartilage damage, comprising powdering.
(5) 상기 (4)에 있어서,(5) In the above (4),
로즈힙 추출액은 0.01∼2.0mm로 분쇄한 후 로즈힙 중량대비 4∼12배의 정제수 또는 20∼90%의 에탄올을 가하여 추출한 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.The rose hip extract is crushed to 0.01 to 2.0 mm, and the composition for preventing or regenerating cartilage damage is characterized in that it is extracted by adding purified water of 4 to 12 times the weight of rose hip or 20 to 90% ethanol.
(6) 상기 (5)에 있어서,(6) In the above (5),
로즈힙 분쇄물을 20∼80℃에서 1∼24 시간동안 가열하여 1차 추출하고 이를 다시 여과하여 추출 박과 분리하여 1차 추출액을 획득하는 단계를 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.A composition for preventing or regenerating cartilage damage, comprising the step of heating the rose hip pulverized product at 20 to 80° C. for 1 to 24 hours to extract the primary and filtering it again to obtain a primary extract by separating it from the extracted foil. .
(7) 상기 (6)에 있어서,(7) In the above (6),
분리된 추출 박에 다시 최초의 로즈힙 중량대비 2∼8배의 정제수 또는 20∼90%의 에탄올을 가하고, 이를 20∼80℃에서 1∼12 시간동안 가열하여 2차 추출하고 이를 다시 여과하여 2차 추출액을 획득하는 단계를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.To the separated extracting foil, purified water or 20-90% ethanol was added to the initial rose hip 2 to 8 times by weight, and this was heated at 20 to 80°C for 1 to 12 hours to extract it for the second time and filtered again to obtain the second time. A composition for preventing or regenerating cartilage damage, further comprising the step of obtaining an extract.
(8) 상기 (7)에 있어서,(8) In the above (7),
얻어진 상기 로즈힙 1차 추출액과 2차 추출액을 혼합한 후 냉각하여 로즈힙 추출액을 획득하고, 65∼80% Brix 정도로 농축하여 로즈힙 농축액을 얻은 다음, 이를 분무건조하여 로즈힙 추출분말로 만드는 단계를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.After mixing the obtained rose hip primary extract and secondary extract, cooled to obtain a rose hip extract, concentrated to 65-80% Brix to obtain a rose hip concentrate, and further spray-dried to make a rose hip extract powder. Characterized in that the composition for preventing or regenerating cartilage damage.
(9) 상기 (1)에 있어서,(9) In the above (1),
식품조성물이고, 상어연골분말 0.1~3.0중량%; 해조 추출분말 0.1~3.0중량%; 및, 석산, 새우풀, 및 용담의 군에서 선택된 적어도 1종의 꽃의 추출분말 0.1~5.0중량%;를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.Food composition, shark cartilage powder 0.1 to 3.0% by weight; Seaweed extract powder 0.1-3.0 wt%; And, seoksan, shrimp grass, and at least one selected from the group of gentian flower extract powder 0.1 ~ 5.0% by weight; cartilage damage prevention or regeneration composition further comprising.
(10) 상기 (1)에 있어서,(10) In the above (1),
식품조성물이고, 상어연골분말 0.1~3.0중량%; 해조 추출분말 0.1~3.0중량%; 및, 석산, 새우풀, 및 용담으로 이루어진 꽃의 추출분말 0.1~5.0중량%;를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.Food composition, shark cartilage powder 0.1 to 3.0% by weight; Seaweed extract powder 0.1-3.0 wt%; And, cartilage damage prevention or regeneration composition, characterized in that it further comprises: 0.1 to 5.0% by weight of the extracted powder of seoksan, shrimp, and gentian flowers.
본 발명의 식품조성물은 인체에 부작용이 없고, 식품조성물로써 관능적 특성이 좋으면서, 퇴행성 관절염 내지 연골손상의 예방 및 재생에 탁월한 효과를 갖는 고부가가치의 식품조성물을 제공한다.The food composition of the present invention provides a high value-added food composition that has no side effects on the human body, has good sensory properties as a food composition, and has excellent effects in preventing and regenerating degenerative arthritis or cartilage damage.
상기 목적을 달성하기 위하여, 본 발명에 따른 로즈힙을 함유하는 연골손상방지 내지 재생용 조성물은 본 발명 로즈힙 추출분말과 함께, 0.1중량%의 상어연골분말, 0.1중량%의 해조(다시마, 미역 등) 분말을 더 포함한다.To achieve the above object, the composition for preventing or regenerating cartilage damage containing rose hips according to the present invention is combined with the rose hip extract powder of the present invention, 0.1% by weight of shark cartilage powder, 0.1% by weight of seaweed (Dashima, seaweed, etc.) Contains more powder.
바람직하게는 본 발명의 조성물은 석산, 새우풀, 및 용담의 군에서 선택된 적어도 1종의 추출분말을 더 포함한다.Preferably, the composition of the present invention further comprises at least one extract powder selected from the group of quarries, shrimp paste, and gentian.
본 발명의 로즈힙 추출분말을 함유하는 식품조성물의 제조과정은,The manufacturing process of the food composition containing the rose hip extract powder of the present invention,
(1) 로즈힙 추출액을 제조하는 단계;(1) preparing a rose hip extract;
(2) 상기 로즈힙 추출액을 농축 및 분무건조하여 분말화하는 단계;를 포함하여 구성됨을 특징으로 한다.(2) concentrating and spray-drying the rose hip extract to powder;
본 발명 로즈힙 추출분말 제조공정의 상기 (1)에서, 로즈힙을 0.01∼2.0mm로 분쇄한 후 로즈힙 중량대비 4∼12배의 정제수 또는 20∼90%의 에탄올을 가한다. 바람직하게는 로즈힙 분쇄물을 20∼80℃에서 1∼24 시간동안 가열하여 1차 추출하고 이를 다시 여과하여 추출 박과 분리하여 1차 추출액을 획득한다. 분리된 추출박에 다시 최초의 로즈힙 중량대비 2∼8배의 정제수 또는 20∼90%의 에탄올을 가한다. 이를 20∼80℃에서 1∼12 시간동안 가열하여 2차 추출하고 이를 다시 여과하여 2차 추출액을 획득한다. 먼저 얻어진 상기 로즈힙 1차 추출액과 2차 추출액을 혼합한 후 냉각하여 로즈힙 추출액을 획득한다.In the above-mentioned (1) of the manufacturing process of the rose hip extract powder of the present invention, after crushing the rose hip to 0.01 to 2.0 mm, purified water or 4 to 12 times the weight of rose hips or 20 to 90% ethanol is added. Preferably, the rose hip pulverized material is first extracted by heating at 20 to 80° C. for 1 to 24 hours, and this is filtered again to separate from the extracted foil to obtain a primary extract. To the separated extract foil, purified water or 2 to 8 times the original rose hip weight or 20 to 90% ethanol was added again. This was heated at 20-80° C. for 1-12 hours to extract secondarily and filtered again to obtain a second extract. First, the rose hip primary extract and the secondary extract obtained are mixed and cooled to obtain a rose hip extract.
본 발명 로즈힙 추출분말 제조공정의 상기 (2)에서, 상기 제 1공정에서 획득한 로즈힙 추출액을 65∼80% Brix 정도로 농축하여 로즈힙 농축액을 얻은 다음, 이를 통상의 분무건조방식으로 분무건조하여 로즈힙 추출분말을 획득한다.In (2) of the rose hip extract powder manufacturing process of the present invention, the rose hip extract obtained in the first step is concentrated to about 65-80% Brix to obtain a rose hip concentrate, and then spray dried using a conventional spray drying method to extract the rose hip The powder is obtained.
상어연골분말은 시판되는 것을 구입하여 사용하면 되고, 해조분말이나, 석산, 새우풀, 및 용담의 군에서 선택된 적어도 1종의 꽃의 추출분말은 상기 로즈힙의 추출분말의 제조공정에서와 동일한 과정을 통해 제조하는 것으로 충분하다.The shark cartilage powder can be purchased and used as a commercially available one, and the extract powder of at least one flower selected from the group of seaweed powder, oxalic acid, shrimp grass, and gentian is the same as in the manufacturing process of the rose hip extract powder. It is enough to manufacture through.
상기와 같이 얻어진 로즈힙 추출분말 90~99.8중량%, 상어연골분말 0.1~3.0중량%, 해조(다시마, 미역 등) 추출분말 0.1~3.0중량%, 석산, 새우풀, 및 용담의 군에서 선택된 적어도 1종의 꽃의 추출분말 0.1~5.0중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 1.0∼3.0g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조한다.Rose hip extract powder obtained as above 90-99.8% by weight, shark cartilage powder 0.1-3.0% by weight, seaweed (Tashima, seaweed, etc.) extracted powder 0.1-3.0% by weight, at least 1 selected from the group of seoksan, shrimp, and gentian 0.1 to 5.0% by weight of the extract powder of the species flowers are blended and then uniformly mixed and packed in a filter cloth so that the total weight is 1.0 to 3.0g to prepare a food composition containing the rose hip extract powder.
상기 본 발명의 식품조성물은 분말로 제형화한 것을 예시하고 있으나, 이에 한정되는 것은 아니며, 이와 같이 얻어진 분말을 원료성분으로 하여 다양한 제형으로 추가적으로 제조되어질 수 있고, 예로 겔 혹은 액상의 음료 타입으로 제형화가 가능하다.The food composition of the present invention is exemplified as being formulated into a powder, but is not limited thereto, and the powder thus obtained may be additionally prepared in various formulations as a raw material component, for example, a gel or liquid beverage type formulation Painter is possible.
겔로 제조할 경우에는 상기 로즈힙 추출분말이 함유된 식품조성물(10~40중량%)에, 덱스트린(40~60중량%), 기타 다양한 첨가물(0.1~10중량%) 및 정제수(잔량)를 혼합하여 겔타입의 기능성 식품을 10㎖ 들이 용기에 충전하고 살균처리하여 최종 제품으로 제조할 수 있다.In the case of gel preparation, dextrin (40-60% by weight), various other additives (0.1-10% by weight) and purified water (remaining amount) are mixed with the food composition containing the rose hip extract powder (10-40% by weight). A gel-type functional food can be filled into a 10 ml container and sterilized to produce a final product.
이와는 달리 본 발명에 따른 식품조성물을 액상의 음료조성물로 제조하는 경우에는, 또한 바람직하게는 적당한 pH 조절제 내지 완충제 등을 이용하여, 적당한 pH 로 조절할 수 있다. 여기서, pH 조절제 내지 완충제로서는, 대표적으로는, 구연산, 주석산, 사과산, 젖산, 탄산 등의 약산 및 그들의 염류, 예를 들면 구연산 나트륨, 구연산 암모늄, 주석산 나트륨, 사과산 나트륨, 젖산 나트륨, 젖산 칼슘, 탄산 나트륨, 탄산수소 나트륨 등을 예시할 수 있다. 인산수소 나트륨도 상기 pH 조절제 내지 완충제로서 사용할 수 있다. 이들의 산 및 그 염류는, 단독으로 사용되어도 좋고, 2종 이상 병용되어도 좋다. 이들의 배합 비율은, 수득하는 음료가 상기 적당한 pH 범위를 유지하는 범위에서 적절히 결정된다. 통상 조성물 중량의 약 2중량% 이하, 바람직하게는 약 0∼0.1중량%이다. On the other hand, when preparing the food composition according to the present invention as a liquid beverage composition, it is also possible to adjust to a suitable pH, preferably by using a suitable pH adjusting agent or buffer. Here, as a pH adjusting agent or a buffer, representatively, weak acids such as citric acid, tartaric acid, malic acid, lactic acid, carbonic acid and their salts, for example, sodium citrate, ammonium citrate, sodium tartrate, sodium malate, sodium lactate, calcium lactate, carbonic acid Sodium, sodium hydrogen carbonate, and the like. Sodium hydrogen phosphate can also be used as the pH adjuster to buffer. These acids and salts thereof may be used alone or in combination of two or more. The blending ratio of these is appropriately determined within a range in which the resulting beverage maintains the appropriate pH range. It is usually about 2% by weight or less of the weight of the composition, preferably about 0 to 0.1% by weight.
또한, 상기 음료 등의 식품 형태의 본 발명 조성물 중에는, 일반적인 음료 등과 마찬가지로, 각종의 당질 내지 감미료 등을 첨가 배합할 수 있다. 당질로서는, 글루코오즈, 프럭토오즈 등의 단당류; 말토오즈, 수크로오즈 등의 2당류; 덱스트린, 시클로덱스트린 등의 다당류(단 LS를 제외함); 크실리톨, 에리트리톨, 소르비톨 등의 당알코올류; 슈가에스테르 등을 예시할 수 있다. 감미료로서는, 천연감미료(레바우디오사이드A(Rebaudioside A) 등의 스테비어 추출물, 소르마틴(sormatin), 글리시리친(glycyrrhizin) 등), 합성 감미료(사카린, 아스파탐 등) 등을 예시할 수 있다. 이들 당질 내지 감미료의 배합 비율은, 통상 수득하는 음료의 약 10중량% 이하, 바람직하게는 약 0.5∼10중량% 이하이다. In addition, in the composition of the present invention in the form of food such as the beverage, various sugars, sweeteners, and the like can be added and blended as in the case of general beverages. Examples of the sugar include monosaccharides such as glucose and fructose; Disaccharides such as maltose and sucrose; Polysaccharides such as dextrin and cyclodextrin (excluding LS); Sugar alcohols such as xylitol, erythritol, and sorbitol; Sugar esters and the like. As sweeteners, natural sweeteners (such as stevia extracts such as Rebaudioside A, sormatin, glycyrrhizin, etc.), synthetic sweeteners (saccharin, aspartame, etc.) can be exemplified. . The blending ratio of these sugars and sweeteners is usually about 10% by weight or less, and preferably about 0.5-10% by weight or less of the beverage obtained.
또한, 식품 형태의 본 발명 조성물에는, 필요에 따라서, 예를 들면 하기의 첨가제의 1종 또는 2종 이상을 첨가 배합할 수도 있다. 상기 첨가제에는, 예를 들면 그레이프프루트, 사과, 오렌지, 레몬, 파인애플, 바나나, 배 등의 각종 과즙(농축 과즙, 분말 과즙 등이어도 좋다); 비타민류 및 프로비타민류(팔미트산 레티놀, 비스벤티아민(bisbentiamine), 리보플라빈, 염산 피리독신, 시아노코발아민(cyanocobalamine), 아스코르빈산 나트륨, 니코틴산 아미드, 판토텐산 칼슘, 엽산, 비오틴, 콜레칼시페롤(cholecalciferol), 중주석산 콜린, 토코페롤, β-카로틴 등의 수용성 및 지용성 비타민류); 향미료(레몬플레이버, 오렌지플레이버, 그레이프프루트플레이버, 바닐라 에센스 등); 아미노산, 핵산 및 그들의 염류(글루탐산, 글루탐산나트륨, 글리신, 알라닌, 아스파라긴산, 아스파라긴산 나트륨, 이노신산 등); 식물 섬유(폴리덱스트로오즈, 펙틴, 크산탄 고무, 아라비아 고무검, 알긴산 등); 미네랄 내지 미량 원소(염화 나트륨, 초산 나트륨, 황산 마그네슘, 염화 칼륨, 염화 마그네슘, 탄산 마그네슘, 염화 칼슘, 인산 2칼륨, 인산 1나트륨, 글리세로인산 칼슘, 구연산제1철 나트륨, 구연산철 암모늄, 구연산철, 황산망간, 황산구리, 요오드화나트륨, 솔빈산칼륨, 아연, 망간, 구리, 요오드, 코발트 등) 등이 포함된다.In addition, if necessary, for example, one or two or more of the following additives may be added to the composition of the present invention in the form of food. Examples of the additives include various juices such as grapefruit, apple, orange, lemon, pineapple, banana, and pear (concentrated juice, powder juice, etc.); Vitamins and provitamins (retinol palmitate, bisbentiamine, riboflavin, pyridoxine hydrochloride, cyanocobalamine, sodium ascorbate, nicotinic acid amide, calcium pantothenate, folic acid, biotin, cholecalcici Water-soluble and fat-soluble vitamins such as cholecalciferol, choline citrate, tocopherol, and β-carotene); Spices (lemon flavor, orange flavor, grapefruit flavor, vanilla essence, etc.); Amino acids, nucleic acids and their salts (glutamic acid, sodium glutamate, glycine, alanine, aspartic acid, sodium aspartate, inosinic acid, etc.); Plant fiber (polydextrose, pectin, xanthan rubber, gum arabic gum, alginic acid, etc.); Mineral to trace elements (sodium chloride, sodium acetate, magnesium sulfate, potassium chloride, magnesium chloride, magnesium carbonate, calcium chloride, dipotassium phosphate, monosodium phosphate, calcium glycerophosphate, ferric sodium citrate, ammonium citrate, citric acid Iron, manganese sulfate, copper sulfate, sodium iodide, potassium sorbate, zinc, manganese, copper, iodine, cobalt, etc.).
본 발명의 식품조성물은, 상기 각 성분을 혼합하여 조제된다. 그 조제 방법은 특별히 제한되는 것은 아니고, 필요한 성분을 모두 동시에 혼합해도 좋고, 또한 유성 성분과 수성 성분의 양자를 사용하는 경우에는, 미리 유성 성분을 적당한 유제에 용해하고, 이것과 수용성 성분의 수용액을 유화제를 이용하여 유화할 수도 있다. 상기 유화 조작은, 일반적인 방법에 따라서, 통상의 유화 분산기, 예를 들면 호모믹서, 고압 호모디나이저 등을 이용하여, 완전 통과 방식 또는 순환 방식에 따라서 실시할 수 있다. 또한, 상기 각 성분의 혼합 내지 유화는, 통상 상온하에서 실시되지만, 가온 조작을 채용할 수도 있다. 이렇게 해서 조제되는 본 발명 조성물은, 이것을 적당한 용기에 충전 후, 통상적인 방법에 따라서, 가열 멸균, 무균 여과 등에 의해 멸균한 후 제품으로 제공된다. The food composition of the present invention is prepared by mixing the above components. The preparation method is not particularly limited, and all necessary components may be mixed at the same time, and when both oily and aqueous components are used, the oily component is previously dissolved in a suitable oily agent, and an aqueous solution of this and water-soluble components is prepared. It can also be emulsified using an emulsifier. The emulsification operation can be carried out in accordance with a general method, using a conventional emulsifying and dispersing machine, for example, a homomixer, a high pressure homogenizer, or the like, in a full-pass method or a circulating method. In addition, although mixing or emulsification of each component is usually performed at room temperature, a heating operation can also be employed. The composition of the present invention thus prepared is provided as a product after filling it in a suitable container and sterilizing it by heat sterilization, aseptic filtration, or the like according to a conventional method.
이하 본 발명의 내용을 실시 예에 의해 보다 상세하게 설명하기로 한다. 다만 이들 실시 예는 본 발명의 내용을 이해하기 위해 제시되는 것일 뿐 본 발명의 권리범위가 이들 실시 예에 한정되어지는 것으로 해석되어져서는 아니된다.Hereinafter, the contents of the present invention will be described in more detail by examples. However, these examples are only presented to understand the contents of the present invention and should not be construed as limiting the scope of the present invention to these examples.
[실시예 1] 로즈힙 추출분말의 제조[Example 1] Preparation of rose hip extract powder
로즈힙을 2회 세척한 후 잘게 분쇄하였다. 상기 로즈힙 분쇄물에 로즈힙 분쇄물 중량대비 10배의 정수 또는 70%의 에탄올을 가하여 60℃에서 2시간동안 방치하여 1차 추출하고, 이를 여과하여 로즈힙 1차 추출액을 얻었다. 상기 추출액으로부터 분리한 나머지 분리박에 다시 최초의 로즈힙 분쇄물 중량대비 8배의 정수 또는 70%의 에탄올을 가한 후 60℃에서 1시간동안 방치하여 2차 추출하고, 이를 여과하여 로즈힙 2차 추출액을 얻었다.The rose hips were washed twice and then crushed. To the rose hip pulverized product, 10 times of the weight of the rose hip pulverized product, or 70% ethanol, was added and left for 2 hours at 60°C to extract first, and filtered to obtain a rose hip primary extract. To the remaining separation foil separated from the extract, the first rose hip pulverized water was added with 8 times the weight of water or 70% ethanol, and then left to stand at 60° C. for 1 hour for secondary extraction and filtered to extract the rose hip secondary extract. Got.
상기의 1차 추출액과 2차 추출액을 혼합한 후 농축하여(65∼80% Brix) 제조한 로즈힙 추출액을 분무건조하여 로즈힙 추출분말을 제조하였다.After mixing the first extract and the second extract and then concentrating (65-80% Brix), the rose hip extract was spray dried to prepare a rose hip extract powder.
[실시예 2] 본 발명 로즈힙 추출분말 함유 식품조성물의 제조[Example 2] Preparation of food composition containing rose hip extract powder of the present invention
상기 실시예 1에서 제조한 로즈힙 추출분말 99.8중량%, 상어연골분말 0.1중량%, 해조(다시마) 추출분말 0.1중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 2.5g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조하였다.Rose hip extract powder prepared in Example 1, 99.8% by weight, shark cartilage powder 0.1% by weight, seaweed (Tashima) extract powder 0.1% by weight, then uniformly mixed and packed in a filter cloth so that the total weight is 2.5g To prepare a food composition containing rose hip extract powder.
[실시예 3] 본 발명 로즈힙 추출분말 함유 식품조성물의 제조[Example 3] Preparation of food composition containing rose hip extract powder of the present invention
상기 실시예 1에서 제조한 로즈힙 추출분말 99.7중량%, 상어연골분말 0.1중량%, 해조(다시마) 추출분말 0.1중량% 및 석산 꽃 추출분말 0.1중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 2.5g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조하였다.Rose hip extract powder prepared in Example 1, 99.7% by weight, shark cartilage powder 0.1% by weight, seaweed (Tashima) extract powder 0.1% by weight and oxalic acid extract powder 0.1% by weight were mixed and uniformly mixed and the total weight A food composition containing rose hip extract powder was prepared by filling and packing the filter cloth to be 2.5 g.
[실시예 4] 본 발명 로즈힙 추출분말 함유 식품조성물의 제조[Example 4] Preparation of food composition containing rose hip extract powder of the present invention
상기 실시예 1에서 제조한 로즈힙 추출분말 99.7중량%, 상어연골분말 0.1중량%, 해조(다시마) 추출분말 0.1중량% 및 새우풀 꽃 추출분말 0.1중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 2.5g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조하였다.Rose hip extract powder prepared in Example 1, 99.7% by weight, shark cartilage powder 0.1% by weight, seaweed (Tashima) extract powder 0.1% by weight and shrimp grass flower extract powder 0.1% by weight and then uniformly mixed them and total weight A food composition containing rosehip extract powder was prepared by filling and packaging the filter cloth so that the amount was 2.5 g.
[실시예 5] 본 발명 로즈힙 추출분말 함유 식품조성물의 제조[Example 5] Preparation of food composition containing rose hip extract powder of the present invention
상기 실시예 1에서 제조한 로즈힙 추출분말 99.7중량%, 상어연골분말 0.1중량%, 해조(다시마) 추출분말 0.1중량% 및 용담 꽃 추출분말 0.1중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 2.5g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조하였다.Rose hip extract powder prepared in Example 1, 99.7% by weight, shark cartilage powder 0.1% by weight, seaweed (Tashima) extract powder 0.1% by weight and gentian flower extract powder 0.1% by weight, and then uniformly mixed them and the total weight A food composition containing rose hip extract powder was prepared by filling and packing the filter cloth to be 2.5 g.
[실시예 6] 본 발명 로즈힙 추출분말 함유 식품조성물의 제조[Example 6] Preparation of food composition containing rose hip extract powder of the present invention
상기 실시예 1에서 제조한 로즈힙 추출분말 99.6중량%, 상어연골분말 0.1중량%, 해조(다시마) 추출분말 0.1중량%, 및 석산과 새우풀 꽃 추출분말 각 0.1중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 2.5g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조하였다.Rosehip extract powder prepared in Example 1, 99.6% by weight, shark cartilage powder 0.1% by weight, seaweed (Tashima) extract powder 0.1% by weight, and seoksan and shrimp grass flower extract powder, each 0.1% by weight, and then uniformly mixed them The mixture was packed in a filter cloth so that the total weight was 2.5 g, and a food composition containing rose hip extract powder was prepared.
[실시예 7] 본 발명 로즈힙 추출분말 함유 식품조성물의 제조[Example 7] Preparation of food composition containing rose hip extract powder of the present invention
상기 실시예 1에서 제조한 로즈힙 추출분말 99.6중량%, 상어연골분말 0.1중량%, 해조(다시마) 추출분말 0.1중량%, 및 석산과 용담 꽃 추출분말 각 0.1중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 2.5g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조하였다.Rosehip extract powder prepared in Example 1, 99.6% by weight, shark cartilage powder 0.1% by weight, seaweed (Tashima) extract powder 0.1% by weight, and seoksan and gentian flower extract powder, each 0.1% by weight, and then uniformly mixed them And the packing was packed in a filter cloth so that the total weight is 2.5g to prepare a food composition containing rose hip extract powder.
[실시예 8] 본 발명 로즈힙 추출분말 함유 식품조성물의 제조[Example 8] Preparation of food composition containing rose hip extract powder of the present invention
상기 실시예 1에서 제조한 로즈힙 추출분말 99.6중량%, 상어연골분말 0.1중량%, 해조(다시마) 추출분말 0.1중량%, 및 새우풀과 용담 꽃 추출분말 각 0.1중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 2.5g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조하였다.Rosehip extract powder prepared in Example 1, 99.6% by weight, shark cartilage powder 0.1% by weight, seaweed (Tashima) extract powder 0.1% by weight, and shrimp grass and gentian flower extract powder, each 0.1% by weight, and then uniformly mixed them The mixture was packed in a filter cloth so that the total weight was 2.5 g, and a food composition containing rose hip extract powder was prepared.
[실시예 9] 본 발명 로즈힙 추출분말 함유 식품조성물의 제조[Example 9] Preparation of food composition containing rose hip extract powder of the present invention
상기 실시예 1에서 제조한 로즈힙 추출분말 99.6중량%, 상어연골분말 0.1중량%, 해조(다시마) 추출분말 0.1중량%, 및 석산, 새우풀 및 용담 꽃 추출분말 각 0.1중량%를 배합한 다음 이들을 균일하게 혼합하고 총 중량이 2.5g이 되도록 여과포에 충전 포장하여 로즈힙 추출분말이 함유된 식품조성물을 제조하였다.Rose hip extract powder prepared in Example 1, 99.6% by weight, shark cartilage powder 0.1% by weight, seaweed (Tashima) extract powder 0.1% by weight, and quarries, shrimp grass and gentian flower extract powder, each 0.1% by weight, and then blending them The mixture was uniformly mixed and packed in a filter cloth so that the total weight was 2.5 g, thereby preparing a food composition containing rose hip extract powder.
[실시예 10] 겔타입 식품조성물[Example 10] Gel type food composition
하기 표 1의 조성에 따라 각 성분을 혼합하여 겔타입의 기능성 식품을 10㎖ 들이 용기에 충전하고 살균처리하여 최종 제품으로 제조하였다.According to the composition of Table 1 below, each component was mixed to fill a 10 ml container with a gel-type functional food and sterilized to prepare a final product.
[실시예 11] 음료타입 식품조성물[Example 11] Beverage type food composition
하기 표 2의 조성에 따라각 성분을 혼합하여 음료타입의 기능성 식품을 35㎖ 들이 용기에 충전하고 살균처리하여 최종 제품으로 제조하였다.Each component was mixed according to the composition of Table 2 below to fill a 35 ml container with a beverage-type functional food and sterilized to prepare a final product.
[실험예 2] 관절염 모델동물에 의한 효과시험[Experimental Example 2] Effect test by arthritis model animal
류머티즘성 관절염의 동물모델로서 이용되는 MRL/lpr 마우스에 아래의 시험구에 실시예 1, 실시예 2 및 실시예 9와 비교예 1(니혼 크레아샤제 마우스 등의 사료 CE-2)의 각 시료를 투여하였다[각 시료는 통상시료에 1000㎎/㎏체중/일이 되도록 혼합하여 투여]. 각 군 10마리를 이용하여 72일간 사육하였다. 사육기간 중의 시료 및 물은 자유섭취시켰다.MRL/lpr mice used as animal models of rheumatoid arthritis, each sample of Example 1, Example 2 and Example 9 and Comparative Example 1 (Feed CE-2 from Nippon Crease Co., Ltd. mice, etc.) in the following test spheres. [Each sample was mixed with a normal sample so as to be 1000 mg/kg body weight/day]. Breeding was carried out for 72 days using 10 animals in each group. Samples and water were freely consumed during the breeding period.
시험기간 중의 류머티즘성 관절염의 병상을, 관절의 종창의 정도를 4단계로 평가하여, 스코어화하였다(스코어가 클수록 류머티즘성 관절염이 진행된 상태를 나타낸다). 그 변화를 하기 표 3에 나타내었다.The pathology of rheumatoid arthritis during the test period was evaluated and scored in four stages for the degree of swelling of the joint (larger score indicates rheumatoid arthritis progression). The changes are shown in Table 3 below.
실험결과 실시예 1, 2 및 9에서는 시험기간이 진행됨에 따라 류머티즘성 관절염의 병상이 완화되어 스코어가 억제되었다. 한편, 비교예 1에서는 실시예에 비하여 스코어가 증대된 것으로 나타났다.Experimental Results In Examples 1, 2 and 9, as the test period progressed, the pathology of rheumatoid arthritis was relieved and the score was suppressed. On the other hand, in Comparative Example 1, it was found that the score was increased compared to the Example.
[실험예 3] 임상실험[Experimental Example 3] Clinical Trial
실시예 1, 실시예 2, 실시예 9에 의해 제조된 조성물을 퇴행성 관절염을 진단받은 60 대 성인 남, 여 각각 20명을 대상으로 퇴행성관절염의 일반적인 항목으로 하여 퇴행성관절염 개선 실험을 하였다. 실시예로 만든 충진된 제품을 하루에 3 번 매일 2개월간 복용하였다.Degenerative arthritis improvement experiments were performed using the composition prepared in Examples 1, 2, and 9 as a general item of degenerative arthritis in 20 men and women in their 60s who were diagnosed with degenerative arthritis. The filled product made in the example was taken 3 times a day for 2 months every day.
1 : 전혀 효과가 없다. 2 : 별로 효과가 없다. 3 : 보통이다. 4 : 조금 효과가 있다. 5 : 아주 효과가 있다.1: It has no effect at all. 2: Not very effective. 3: Normal. 4: It works a little. 5: Very effective.
상기 표 4에 나타낸 바와 같이, 퇴행성관절염의 일반적인 항목을 검사한 결과, 실시예 1, 실시예 2 및 실시예 9는 매우 우수한 퇴행성관절염 개선 효과를 나타내고 있음을 알 수 있다.As shown in Table 4 above, as a result of examining the general items of degenerative arthritis, it can be seen that Examples 1, 2, and 9 show very good degenerative arthritis improvement effects.
[실험예 3] 관능평가[Experimental Example 3] Sensory evaluation
상기 실시예의 각 샘플을 30인의 미각이 우수한 패널을 대상으로 5점 척도법으로 수행한 관능평가 결과는 하기 표 5에서와 같으며 모든 검사항목에서 우수한 것으로 평가되었다.The sensory evaluation results of each sample of the Example performed by a 5-point scale method on a panel with excellent taste of 30 persons are as shown in Table 5 below, and were evaluated as excellent in all test items.
♪-1. 아주나쁘다. 2. 나쁘다. 3. 보통이다. 4. 좋다. 5. 아주좋다.♪-1. It is very bad. 2. It is bad. 3. It is normal. 4. Good. 5. Very good.
Claims (10)
식품조성물이고, 상어연골분말 0.1~3.0중량%, 해조 추출분말 0.1~3.0중량%를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.According to claim 1,
It is a food composition, shark cartilage powder 0.1 to 3.0% by weight, seaweed extract powder 0.1 to 3.0% by weight further comprising cartilage damage prevention or regeneration composition.
석산, 새우풀, 및 용담의 군에서 선택된 적어도 1종의 꽃의 추출분말 0.1~5.0중량%를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.According to claim 2,
A composition for preventing or regenerating cartilage damage, further comprising 0.1 to 5.0% by weight of an extract powder of at least one flower selected from the group of oxalic acid, prawn grass, and gentian.
(1) 로즈힙 추출액을 제조하는 단계;
(2) 상기 로즈힙 추출액을 농축 및 분무건조하여 분말화하는 단계;를 포함하여 분말화된 것임을 특징으로 하는 연골손상방지 내지 재생용 조성물.According to claim 1, Rose hip extract,
(1) preparing a rose hip extract;
(2) condensing and spray-drying the rose hip extract to powder; a composition for preventing or regenerating cartilage damage, comprising being powdered.
로즈힙 추출액은 0.01∼2.0mm로 분쇄한 후 로즈힙 중량대비 4∼12배의 정제수 또는 20∼90%의 에탄올을 가하여 추출한 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.The method of claim 4,
The rose hip extract is crushed to 0.01 to 2.0 mm, and the composition for preventing or regenerating cartilage damage is characterized in that it is extracted by adding 4 to 12 times purified water or 20 to 90% ethanol compared to the weight of rose hip.
로즈힙 분쇄물을 20∼80℃에서 1∼24 시간동안 가열하여 1차 추출하고 이를 다시 여과하여 추출 박과 분리하여 1차 추출액을 획득하는 단계를 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.The method of claim 5,
A composition for preventing or regenerating cartilage damage, comprising the step of heating the rose hip pulverized product at 20 to 80° C. for 1 to 24 hours to extract the primary and filtering it again to obtain a primary extract by separating it from the extracted foil. .
분리된 추출 박에 다시 최초의 로즈힙 중량대비 2∼8배의 정제수 또는 20∼90%의 에탄올을 가하고, 이를 20∼80℃에서 1∼12 시간동안 가열하여 2차 추출하고 이를 다시 여과하여 2차 추출액을 획득하는 단계를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.The method of claim 6,
To the separated extraction foil, purified water or 20-90% ethanol was added to the original rose hips 2 to 8 times the weight of the original rose, and heated at 20 to 80°C for 1 to 12 hours to perform secondary extraction and filtered again to secondary A composition for preventing or regenerating cartilage damage, further comprising the step of obtaining an extract.
얻어진 상기 로즈힙 1차 추출액과 2차 추출액을 혼합한 후 냉각하여 로즈힙 추출액을 획득하고, 65∼80% Brix 정도로 농축하여 로즈힙 농축액을 얻은 다음, 이를 분무건조하여 로즈힙 추출분말로 만드는 단계를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.The method of claim 7,
After mixing the obtained rose hip primary extract and secondary extract, cooled to obtain a rose hip extract, concentrated to 65-80% Brix to obtain a rose hip concentrate, and further spray-dried to make a rose hip extract powder. A composition for preventing or regenerating cartilage damage, characterized in that.
식품조성물이고, 상어연골분말 0.1~3.0중량%; 해조 추출분말 0.1~3.0중량%; 및, 석산, 새우풀, 및 용담의 군에서 선택된 적어도 1종의 꽃의 추출분말 0.1~5.0중량%;를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.According to claim 1,
Food composition, shark cartilage powder 0.1 to 3.0% by weight; Seaweed extract powder 0.1-3.0 wt%; And, cartilage damage prevention or regeneration composition, characterized in that it further comprises 0.1 to 5.0% by weight of extracted powder of at least one flower selected from the group of seoksan, shrimp, and gentian.
식품조성물이고, 상어연골분말 0.1~3.0중량%; 해조 추출분말 0.1~3.0중량%; 및, 석산, 새우풀, 및 용담으로 이루어진 꽃의 추출분말 0.1~5.0중량%;를 더 포함하는 것을 특징으로 하는 연골손상방지 내지 재생용 조성물.
According to claim 1,
Food composition, shark cartilage powder 0.1 to 3.0% by weight; Seaweed extract powder 0.1-3.0 wt%; And, cartilage damage prevention or regeneration composition, characterized in that it further comprises; 0.1 to 5.0% by weight of the extracted powder of seoksan, shrimp, and gentian flowers.
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| KR20050119488A (en) * | 2004-06-16 | 2005-12-21 | (주)주신알앤디 | Composition for preventation and treatment of degenerative arthritis |
| KR20090002427A (en) * | 2007-06-28 | 2009-01-09 | 민 자 강 | A method for wine material make use of shark cartilage |
| KR20140073432A (en) * | 2012-12-05 | 2014-06-16 | 주식회사 뉴트리플랜 | Composition comprising an combined extract of dog rose and green tea seed as a main component for preventing and treating arthritis |
| KR20150105714A (en) * | 2014-03-10 | 2015-09-18 | (주)네이쳐푸드 | composition for health functional food improving joint health |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022030719A1 (en) * | 2020-08-03 | 2022-02-10 | (주)앗코스텍 | Composition for improving, treating, or preventing muscle disease, or improving muscle function, containing rose hip as acitve ingredient |
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| Publication number | Publication date |
|---|---|
| KR102125628B1 (en) | 2020-06-23 |
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