JP2017538722A - 置換ヌクレオシド、ヌクレオチド、及びそのアナログ - Google Patents
置換ヌクレオシド、ヌクレオチド、及びそのアナログ Download PDFInfo
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- JP2017538722A JP2017538722A JP2017532656A JP2017532656A JP2017538722A JP 2017538722 A JP2017538722 A JP 2017538722A JP 2017532656 A JP2017532656 A JP 2017532656A JP 2017532656 A JP2017532656 A JP 2017532656A JP 2017538722 A JP2017538722 A JP 2017538722A
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- 150000003212 purines Chemical class 0.000 description 1
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 description 1
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- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
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- MHYGQXWCZAYSLJ-UHFFFAOYSA-N tert-butyl-chloro-diphenylsilane Chemical compound C=1C=CC=CC=1[Si](Cl)(C(C)(C)C)C1=CC=CC=C1 MHYGQXWCZAYSLJ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Genetics & Genomics (AREA)
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- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
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| PCT/US2015/066193 WO2016100569A1 (en) | 2014-12-19 | 2015-12-16 | Substituted nucleosides, nucleotides and analogs thereof |
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| JP2023514182A (ja) * | 2020-02-18 | 2023-04-05 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス化合物 |
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| SG10201610936RA (en) | 2011-12-22 | 2017-02-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| US9598457B2 (en) | 2012-12-21 | 2017-03-21 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| AU2014248116A1 (en) | 2013-04-05 | 2015-11-12 | Alios Biopharma, Inc. | Hepatitis C viral infection treatment using a combination of compounds |
| HK1224229A1 (zh) * | 2013-06-26 | 2017-08-18 | Alios Biopharma, Inc. | 取代的核苷，核苷酸及其类似物 |
| EP3424938B1 (en) | 2013-06-26 | 2020-07-22 | Janssen BioPharma, Inc. | 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof |
| JP6562908B2 (ja) | 2013-10-11 | 2019-08-21 | ヤンセン バイオファーマ インク． | 置換ヌクレオシド、置換ヌクレオチドおよびその類似体 |
| TN2016000566A1 (en) | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
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| HK1243714A1 (zh) | 2014-10-28 | 2018-07-20 | Alios Biopharma, Inc. | 制备取代的核苷类似物的方法 |
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| EA036776B1 (ru) | 2015-03-11 | 2020-12-21 | Янссен Байофарма, Инк. | Соединения азапиридона и способы их применения |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
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| CN110248951B (zh) | 2017-02-01 | 2022-10-28 | 阿堤亚制药公司 | 用于治疗丙型肝炎病毒的核苷酸半硫酸盐 |
| CA3075950A1 (en) * | 2017-09-18 | 2019-03-21 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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| EP3934760A1 (en) | 2019-03-06 | 2022-01-12 | GlaxoSmithKline Intellectual Property (No.2) Limited | Compounds useful in hiv therapy |
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| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
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| BR112023026356A2 (pt) | 2021-06-17 | 2024-03-05 | Atea Pharmaceuticals Inc | Método para tratar vírus da hepatite c ou uma condição resultante de uma infecção por hepatite c, combinação, uso da combinação, composição farmacêutica, e, kit para o tratamento de vírus da hepatite c |
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| EP4426315A1 (en) | 2021-11-01 | 2024-09-11 | Immunic AG | Medical use of n4-hydroxy citicoline compounds |
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| US9598457B2 (en) | 2012-12-21 | 2017-03-21 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TW201526899A (zh) | 2013-02-28 | 2015-07-16 | Alios Biopharma Inc | 醫藥組成物 |
| WO2014164533A1 (en) | 2013-03-11 | 2014-10-09 | Vertex Pharmaceuticals Incorporated | Methods of stereoselective synthesis of substituted nucleoside analogs |
| AU2014248116A1 (en) | 2013-04-05 | 2015-11-12 | Alios Biopharma, Inc. | Hepatitis C viral infection treatment using a combination of compounds |
| EP3424938B1 (en) | 2013-06-26 | 2020-07-22 | Janssen BioPharma, Inc. | 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof |
| HK1224229A1 (zh) | 2013-06-26 | 2017-08-18 | Alios Biopharma, Inc. | 取代的核苷，核苷酸及其类似物 |
| JP6562908B2 (ja) | 2013-10-11 | 2019-08-21 | ヤンセン バイオファーマ インク． | 置換ヌクレオシド、置換ヌクレオチドおよびその類似体 |
| MA39317A1 (fr) * | 2014-02-06 | 2018-01-31 | Riboscience Llc | Dérivés de nucléosides à substitution 4'-difluorométhyle utilisés en tant qu'inhibiteurs de la réplication de l'arn du virus de la grippe |
| WO2015143712A1 (en) * | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| BR112016029994A2 (pt) | 2014-06-24 | 2017-08-22 | Alios Biopharma Inc | métodos de preparação de análogos de nucleotídeo substituídos |
| HUE051986T2 (hu) * | 2014-06-24 | 2021-04-28 | Janssen Biopharma Inc | Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra |
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-
2015
- 2015-12-15 MA MA041213A patent/MA41213A/fr unknown
- 2015-12-16 WO PCT/US2015/066193 patent/WO2016100569A1/en not_active Ceased
- 2015-12-16 MX MX2017008184A patent/MX2017008184A/es unknown
- 2015-12-16 CN CN201580076647.5A patent/CN107250145A/zh active Pending
- 2015-12-16 AU AU2015364630A patent/AU2015364630A1/en not_active Abandoned
- 2015-12-16 US US14/971,926 patent/US9890188B2/en not_active Expired - Fee Related
- 2015-12-16 CA CA2970936A patent/CA2970936A1/en not_active Abandoned
- 2015-12-16 JP JP2017532656A patent/JP2017538722A/ja not_active Withdrawn
- 2015-12-16 EP EP15871022.8A patent/EP3233879A4/en not_active Withdrawn
- 2015-12-16 HK HK18105072.0A patent/HK1245800A1/zh unknown
- 2015-12-18 TW TW104142822A patent/TW201625658A/zh unknown
-
2017
- 2017-07-18 ZA ZA2017/04876A patent/ZA201704876B/en unknown
-
2018
- 2018-01-30 US US15/884,052 patent/US20180155384A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023514182A (ja) * | 2020-02-18 | 2023-04-05 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス化合物 |
| JP7429799B2 (ja) | 2020-02-18 | 2024-02-08 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3233879A1 (en) | 2017-10-25 |
| US20160176910A1 (en) | 2016-06-23 |
| ZA201704876B (en) | 2020-01-29 |
| EP3233879A4 (en) | 2018-09-19 |
| CA2970936A1 (en) | 2016-06-23 |
| HK1245800A1 (zh) | 2018-08-31 |
| WO2016100569A1 (en) | 2016-06-23 |
| MA41213A (fr) | 2017-10-24 |
| AU2015364630A1 (en) | 2017-07-06 |
| US9890188B2 (en) | 2018-02-13 |
| MX2017008184A (es) | 2018-03-06 |
| US20180155384A1 (en) | 2018-06-07 |
| TW201625658A (zh) | 2016-07-16 |
| CN107250145A (zh) | 2017-10-13 |
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