JP2017537625A5 - - Google Patents

Info

Publication number

JP2017537625A5

JP2017537625A5 JP2017529381A JP2017529381A JP2017537625A5 JP 2017537625 A5 JP2017537625 A5 JP 2017537625A5 JP 2017529381 A JP2017529381 A JP 2017529381A JP 2017529381 A JP2017529381 A JP 2017529381A JP 2017537625 A5 JP2017537625 A5 JP 2017537625A5

Authority

JP

Japan

Prior art keywords

cells

medium

activator

cell

combination

Prior art date

2015-12-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 17
• 210000001744 T-lymphocyte Anatomy 0.000 claims 13
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
• 239000012190 activator Substances 0.000 claims 4
• 239000002609 medium Substances 0.000 claims 4
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 4
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
• 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical group O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 230000001093 anti-cancer Effects 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 229960000684 cytarabine Drugs 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 239000012636 effector Substances 0.000 claims 2
• 239000012894 fetal calf serum Substances 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 230000003211 malignant effect Effects 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
• 229940122361 Bisphosphonate Drugs 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
• 102000000588 Interleukin-2 Human genes 0.000 claims 1
• 108010002350 Interleukin-2 Proteins 0.000 claims 1
• 150000004663 bisphosphonates Chemical group 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 210000003162 effector t lymphocyte Anatomy 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 238000002955 isolation Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 239000012679 serum free medium Substances 0.000 claims 1
• XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 1
• 229960004276 zoledronic acid Drugs 0.000 claims 1