FI3578201T3 - Menetelmiä ja koostumuksia luonnollisille tappajasoluille - Google Patents
Menetelmiä ja koostumuksia luonnollisille tappajasoluille Download PDFInfo
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- FI3578201T3 FI3578201T3 FIEP19175670.9T FI19175670T FI3578201T3 FI 3578201 T3 FI3578201 T3 FI 3578201T3 FI 19175670 T FI19175670 T FI 19175670T FI 3578201 T3 FI3578201 T3 FI 3578201T3
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- 210000000822 natural killer cell Anatomy 0.000 title claims 18
- 239000000203 mixture Substances 0.000 title claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 239000012636 effector Substances 0.000 claims 9
- 210000000170 cell membrane Anatomy 0.000 claims 7
- 102100030704 Interleukin-21 Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 108010074108 interleukin-21 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 102100036008 CD48 antigen Human genes 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- -1 41BBL Proteins 0.000 claims 1
- 108010038940 CD48 Antigen Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 claims 1
- 102100022339 Integrin alpha-L Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108020003285 Isocitrate lyase Proteins 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 102100030301 MHC class I polypeptide-related sequence A Human genes 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000010445 mica Substances 0.000 claims 1
- 229910052618 mica group Inorganic materials 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Claims (12)
1. — Koostumus käsittäen NK-solujen syöttäjäsoluista puhdistetun plasmamembraa- nivesikkelin, missä NK-solujen syöttäjäsolut ovat säteilytettyjä autologisia tai allo- geenisiä ääreisveren mononukleaarisoluja (PBMCs), RPMI8866:ta, HFWT:tä, K562:ta tai EBV-LCL:ää, jolloin plasmamembraanivesikkeli käsittää vähintään yhtä NK-soluefektoriainetta, ja jolloin vähintään yksi NK-soluefektoriaine on IL-21 tai IL-
15.
2. Patenttivaatimuksen 1 mukainen koostumus, missä plasmamembraanivesikkeli kä- sittää lisäksi vähintään yhtä lisä-NK-soluefektoriainetta, jolloin vähintään yksi lisä- NK-soluefektoriaine on valittu seuraavista sytokiini, adheesiomolekyyli ja NK-soluja aktivoiva aine.
3. Patenttivaatimuksen 2 mukainen koostumus, missä vähintään yksi ylimääräinen NK-soluefektoriaine on valittu seuraavista: IL-2, 41BBL, IL-12, IL-18, MICA, 2B4, LFA-1 ja BCM1/SLAMF2.
4. — Jonkin patenttivaatimuksista 1 - 3 mukainen koostumus, missä vähintään yksi NK- soluefektoriaine on IL21 ja plasmamembraanivesikkeli käsittää lisäksi vähintään yhden tai kaksi muuta NK-soluefektoriainetta, joka on valittu seuraavista IL-15 ja 41BBL.
5. — Jonkin patenttivaatimuksista 1 - 3 mukainen koostumus, missä vähintään yksi NK- soluefektoriaine on IL-15 ja plasmamembraanivesikkeli käsittää lisäksi 41BBL:ää vähintään yhtenä lisä-NK-soluefektoriaineena.
6. Patenttivaatimuksen 4 mukainen koostumus, missä plasmamembraanivesikkeli kä- sittää kalvoon sitoutuneet IL-21:n ja 41BBL:n.
7. Patenttivaatimuksen 6 mukainen koostumus, missä syöttäjäsolut ovat K562-soluja, jotka ovat transfektoitu kalvoon sitoutuneilla IL-21:llä ja 41BBL:llä.
8. — Jonkin patenttivaatimuksen 1-7 mukaisen koostumuksen käyttö NK-solujen stimu- loimiseen tai laajentamiseen NK-solupopulaatiossa in vitro antamalla koostumusta NK-solupopulaatiolle in vitro.
9. Menetelmä laajennettujen NK-solujen populaation tuottamiseksi käsittäen sen, että ensimmäinen NK-solupopulaatio saatetaan kosketukseen in vitro jonkin patentti- vaatimuksista 1-7 mukaisen koostumuksen kanssa.
10. Jonkin patenttivaatimuksista 1-7 mukainen koostumus käytettäväksi syövän, virus- infektioiden, siirrännäinen-vastaan-isäntäsairauden tai multippeliskleroosin hoi- dossa.
11. Koostumus käytettäväksi patenttivaatimuksen 10 mukaisesti, jolloin käyttö on syö- vän hoitoa ja jolloin koostumus annetaan yhdistelmänä vähintään yhden syöpää hoitavan aineen kanssa.
12. Jonkin patenttivaatimuksista 1-7 mukainen koostumus, missä plasmamembraa- nivesikkeli ympäröi mikropartikkelia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261665591P | 2012-06-28 | 2012-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3578201T3 true FI3578201T3 (fi) | 2023-05-05 |
Family
ID=49783918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP19175670.9T FI3578201T3 (fi) | 2012-06-28 | 2013-06-28 | Menetelmiä ja koostumuksia luonnollisille tappajasoluille |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US9623082B2 (fi) |
| EP (3) | EP3578201B1 (fi) |
| AU (3) | AU2013282353B2 (fi) |
| CA (1) | CA2877968A1 (fi) |
| DK (1) | DK3578201T3 (fi) |
| ES (1) | ES2943932T3 (fi) |
| FI (1) | FI3578201T3 (fi) |
| HR (1) | HRP20230424T1 (fi) |
| HU (1) | HUE061931T2 (fi) |
| LT (1) | LT3578201T (fi) |
| PL (1) | PL3578201T3 (fi) |
| PT (1) | PT3578201T (fi) |
| RS (1) | RS64172B1 (fi) |
| SG (2) | SG11201408697QA (fi) |
| SI (1) | SI3578201T1 (fi) |
| WO (1) | WO2014005072A1 (fi) |
Families Citing this family (36)
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|---|---|---|---|---|
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| EP2824112B1 (en) * | 2013-07-10 | 2016-12-21 | Miltenyi Biotec GmbH | Method for inducing proliferation of Natural Killer cells by mobile nanomatrices |
| US10428305B2 (en) | 2014-05-15 | 2019-10-01 | National University Of Singapore | Modified natural killer cells that express IL15 and uses thereof |
| CN113151167A (zh) | 2014-10-27 | 2021-07-23 | 弗罗里达中央大学研究基金会 | 自然杀伤细胞的方法和组合物 |
| EP3138905A1 (en) * | 2015-09-04 | 2017-03-08 | Miltenyi Biotec GmbH | Method for natural killer cell expansion |
| EP3443001A4 (en) | 2016-04-11 | 2020-04-29 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| SG11201903032SA (en) * | 2016-10-05 | 2019-05-30 | University Of Central Florida Research Foundation Inc | Methods and compositions related to nk cell and anti-pdl1 cancer therapies |
| US10300089B2 (en) * | 2016-11-08 | 2019-05-28 | University Of Central Florida Research Foundation, Inc. | Methods for high scale therapeutic production of memory NK cells |
| JP7270253B2 (ja) | 2017-03-27 | 2023-05-10 | ナショナル ユニヴァーシティ オブ シンガポール | ナチュラルキラー細胞のエクスビボ拡大及び活性化のための刺激細胞株 |
| MX2019011514A (es) | 2017-03-27 | 2020-01-27 | Nat Univ Singapore | Receptores quimericos nkg2d truncados y usos de los mismos en inmunoterapia con celulas asesinas naturales. |
| US11684637B2 (en) * | 2017-05-25 | 2023-06-27 | University Of Central Florida Research Foundation, Inc. | Oncolytic viruses for sensitizing tumor cells to killing by natural killer cells |
| SG11202007221QA (en) | 2018-02-01 | 2020-08-28 | Nkmax Co Ltd | Method of producing natural killer cells and composition for treating cancer |
| SG11202008008UA (en) * | 2018-02-21 | 2020-09-29 | Univ Texas | Universal antigen presenting cells and uses thereof |
| EP3806888B1 (en) | 2018-06-12 | 2024-01-31 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| CN109627342B (zh) * | 2018-12-10 | 2022-12-06 | 苏州近岸蛋白质科技股份有限公司 | 应用于nk细胞培养的蛋白质、培养基配方组合及制备方法 |
| WO2020123716A1 (en) | 2018-12-11 | 2020-06-18 | Obsidian Therapeutics, Inc. | Membrane bound il12 compositions and methods for tunable regulation |
| BR112021013971A2 (pt) * | 2019-01-24 | 2021-11-16 | Univ Central Florida Res Found Inc | Composições e métodos para estimular células natural killer |
| EP3917580A4 (en) * | 2019-01-28 | 2022-11-23 | University of Rhode Island Board of Trustees | EPITOPE ATTACHMENT MEDIATED BY A PHLIP® PEPTIDE AT THE LEVEL OF CELLULAR SURFACES |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| CN113966397A (zh) | 2019-03-08 | 2022-01-21 | 黑曜石疗法公司 | 人碳酸酐酶2组合物和用于可调调节的方法 |
| US20220267398A1 (en) | 2019-06-12 | 2022-08-25 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| CN114450308A (zh) | 2019-06-12 | 2022-05-06 | 黑曜石疗法公司 | 用于调节性调控的ca2组合物和方法 |
| CN114173794A (zh) * | 2019-06-25 | 2022-03-11 | 希望之城 | Pdl1阳性nk细胞癌症治疗 |
| CN112391349B (zh) * | 2019-08-19 | 2023-05-23 | 刘韬 | 滋养层细胞株及其制备方法和体外诱导扩增nk细胞的方法 |
| US20230092895A1 (en) | 2019-08-30 | 2023-03-23 | Obsidian Therapeutics, Inc. | Tandem cd19 car-based compositions and methods for immunotherapy |
| US11058725B2 (en) | 2019-09-10 | 2021-07-13 | Obsidian Therapeutics, Inc. | CA2 compositions and methods for tunable regulation |
| WO2021093881A1 (zh) * | 2019-11-14 | 2021-05-20 | 上海鑫湾生物科技有限公司 | 用于调控酸性环境免疫应答的组合物、其制备方法和用途 |
| EP3914699A4 (en) * | 2019-12-09 | 2023-03-29 | ImmunityBio, Inc. | SCREENING OF CELLULAR CLONES EXPRESSING POLYGENIC TRANSGENES BY POSITIVE SELECTION NOT DEPENDENT ON ANTIBIOTICS |
| CN115210250A (zh) | 2020-01-08 | 2022-10-18 | 黑曜石疗法公司 | 用于可调节性调控转录的组合物和方法 |
| WO2021188974A1 (en) * | 2020-03-20 | 2021-09-23 | Orgenesis Inc. | Ribonucleases for treating viral infections |
| WO2021201677A1 (en) | 2020-04-01 | 2021-10-07 | Kiadis Pharma Intellectual Property B.V. | Compositions and methods targeting influenza |
| WO2021201679A1 (en) | 2020-04-01 | 2021-10-07 | Kiadis Pharma Intellectual Property B.V. | Compositions and methods targeting coronaviruses |
| CN115461451A (zh) * | 2020-06-09 | 2022-12-09 | 社会福祉法人三星生命公益财团 | 用于激活和增幅nk细胞的经基因改造的细胞株以及其用途 |
| US20240141295A1 (en) | 2020-08-31 | 2024-05-02 | City Of Hope | Novel cell lines, methods of producing natural killer cells and uses thereof |
| WO2022150392A1 (en) | 2021-01-05 | 2022-07-14 | City Of Hope | Natural killer cells engineered to reduce or eliminate cbl-b and uses thereof |
| KR20240036997A (ko) * | 2022-09-14 | 2024-03-21 | 재단법인 한국마이크로의료로봇연구원 | 사이토카인 활성 강화된 자연살해세포 유래 엑소좀의 암 치료용 생물학적 조성물 및 이의 용도 |
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| AR083044A1 (es) * | 2010-09-27 | 2013-01-30 | Regeneron Pharma | Anticuerpos anti-cd48 y usos de los mismos |
| WO2012177788A1 (en) * | 2011-06-20 | 2012-12-27 | La Jolla Institute For Allergy And Immunology | Modulators of 4-1bb and immune responses |
| WO2013177187A2 (en) * | 2012-05-22 | 2013-11-28 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il-2 and therapeutic agents |
| WO2013175237A1 (en) | 2012-05-24 | 2013-11-28 | Ucl Business Plc | Composition comprising a cd2 ligation agent and a nkg2d ligation agent |
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