JP2017537622A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017537622A5 JP2017537622A5 JP2017529284A JP2017529284A JP2017537622A5 JP 2017537622 A5 JP2017537622 A5 JP 2017537622A5 JP 2017529284 A JP2017529284 A JP 2017529284A JP 2017529284 A JP2017529284 A JP 2017529284A JP 2017537622 A5 JP2017537622 A5 JP 2017537622A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- acid sequence
- domain
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 51
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 35
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 108091006028 chimera Proteins 0.000 claims 13
- 210000004027 cells Anatomy 0.000 claims 12
- 102100008541 MGMT Human genes 0.000 claims 9
- 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 claims 9
- 230000011664 signaling Effects 0.000 claims 9
- 102000003816 Interleukin-13 Human genes 0.000 claims 8
- 108090000176 Interleukin-13 Proteins 0.000 claims 8
- 210000004962 mammalian cells Anatomy 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 230000027455 binding Effects 0.000 claims 5
- 230000001086 cytosolic Effects 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 230000003612 virological Effects 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 208000003174 Brain Neoplasms Diseases 0.000 claims 3
- 102100019461 CD28 Human genes 0.000 claims 3
- 101700033362 CD28 Proteins 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000000139 costimulatory Effects 0.000 claims 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 2
- 230000001177 retroviral Effects 0.000 claims 2
- 102200008659 DTWD1 E13K Human genes 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 101700001820 E13K Proteins 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 210000000265 Leukocytes Anatomy 0.000 claims 1
- 210000004940 Nucleus Anatomy 0.000 claims 1
- 101710040448 TNFRSF4 Proteins 0.000 claims 1
- 102100013135 TNFRSF4 Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000038129 antigens Human genes 0.000 claims 1
- 108091007172 antigens Proteins 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462086346P | 2014-12-02 | 2014-12-02 | |
US62/086,346 | 2014-12-02 | ||
PCT/US2015/063267 WO2016089916A1 (en) | 2014-12-02 | 2015-12-01 | Methods and compositons for treating cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017537622A JP2017537622A (ja) | 2017-12-21 |
JP2017537622A5 true JP2017537622A5 (da) | 2019-01-10 |
Family
ID=56078487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017529284A Pending JP2017537622A (ja) | 2014-12-02 | 2015-12-01 | がんを治療するための方法及び組成物 |
Country Status (18)
Country | Link |
---|---|
US (2) | US9650428B2 (da) |
EP (1) | EP3227317A4 (da) |
JP (1) | JP2017537622A (da) |
KR (1) | KR20180041087A (da) |
CN (1) | CN107709353A (da) |
AR (1) | AR102879A1 (da) |
AU (1) | AU2015355084A1 (da) |
BR (1) | BR112017011771A2 (da) |
CA (1) | CA2969714A1 (da) |
EA (1) | EA201791210A1 (da) |
HK (1) | HK1251862A1 (da) |
IL (1) | IL252610A0 (da) |
MX (1) | MX2017007272A (da) |
PH (1) | PH12017501031A1 (da) |
SG (2) | SG11201704519YA (da) |
TW (1) | TW201636425A (da) |
UY (1) | UY36418A (da) |
WO (1) | WO2016089916A1 (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2850093B1 (en) | 2012-01-27 | 2019-01-09 | The Board of Trustees of the Leland Stanford Junior University | Therapeutic il-13 polypeptides |
CN107709353A (zh) | 2014-12-02 | 2018-02-16 | 普拉斯派克特查特凯尔Rwmc有限责任公司 | 治疗癌症的方法和组合物 |
DK3909972T3 (da) * | 2015-06-19 | 2024-04-29 | Sebastian Kobold | Pd1-cd28-fusionsproteiner og disses anvendelse i medicin |
KR102011789B1 (ko) * | 2015-08-05 | 2019-08-19 | 주식회사 셀랩메드 | 키메라 항원 수용체 및 키메라 항원 수용체가 발현된 t 세포 |
US20200095301A1 (en) * | 2016-12-14 | 2020-03-26 | The Board Of Trustees Of The Leland Stanford Junior University | Il-13 superkine: immune cell targeting constructs and methods of use thereof |
CA3051481A1 (en) | 2017-02-07 | 2018-08-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (ple) car t cell tumor targeting (ctct) agents |
WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
WO2018195339A1 (en) | 2017-04-19 | 2018-10-25 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
KR20200100654A (ko) * | 2017-11-20 | 2020-08-26 | 프로스펙트 차터케어 알더블유엠씨, 엘엘씨 디/비/에이 로저 윌리암스 메디컬 센터 | Car-t 세포 기능성을 개선하기 위한 조성물 및 그의 용도 |
MX2020006689A (es) * | 2017-12-20 | 2020-11-06 | Poseida Therapeutics Inc | Composiciones de vcar y metodos de uso. |
CN112055595A (zh) | 2018-01-22 | 2020-12-08 | 恩多塞特公司 | Car t细胞的使用方法 |
CN110144326A (zh) * | 2018-02-12 | 2019-08-20 | 深圳宾德生物技术有限公司 | 一种靶向性抗肿瘤t细胞及其制备方法和应用 |
CN110157674A (zh) * | 2018-02-12 | 2019-08-23 | 深圳宾德生物技术有限公司 | 一种靶向性t淋巴细胞及其制备方法和应用 |
CN108440674A (zh) * | 2018-04-28 | 2018-08-24 | 杭州荣泽生物科技有限公司 | 一种Trop-2特异性嵌合抗原受体细胞制备及其用途 |
BR112023004433A2 (pt) * | 2020-09-11 | 2023-04-11 | Univ Georgia | Ácido nucleico, vetor, segmento genômico viral, vírus, composição farmacêutica, método para induzir ou aumentar uma resposta imune contra o vírus influenza, vírus recombinante, método para induzir uma resposta imune em um sujeito em necessidade e polipeptídeo |
TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
CN113304267B (zh) * | 2021-06-11 | 2022-03-15 | 河南大学 | 肺癌的治疗靶点及其应用 |
CN114014941B (zh) * | 2022-01-10 | 2022-04-12 | 卡瑞济(北京)生命科技有限公司 | 靶向IL13Rα2的嵌合抗原受体及其用途 |
CN116549667B (zh) * | 2023-05-29 | 2024-02-09 | 四川普锐特药业有限公司 | 一种pas修饰的脂质纳米粒、包含其的药物制剂,及其制备方法和用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965126A (en) * | 1996-03-25 | 1999-10-12 | The Penn State Research Foundation | use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents |
JP2004500047A (ja) * | 1999-10-20 | 2004-01-08 | ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン | キメラ免疫原性組成物およびこれらをコードする核酸 |
WO2003073841A2 (en) * | 2002-03-01 | 2003-09-12 | Bristol-Myers Squibb Company | Transgenic non-human mammals expressing constitutively activated tyrosine kinase receptors |
AU2003223497A1 (en) * | 2002-04-05 | 2003-10-27 | Centocor, Inc. | Asthma-related anti-il-13 immunoglobulin derived proteins, compositions, methods and uses |
US7709625B2 (en) * | 2004-06-10 | 2010-05-04 | The Board Of Regents Of The University Of Texas | Methods and compositions for bone marrow stem cell-derived macrophage delivery of genes for gene therapy |
AU2005339587B2 (en) * | 2005-11-16 | 2011-11-03 | Universidad Nacional Autonoma De Mexico | Use of transcriptome-modifying agents and chemotherapy or radiotherapy against cancer |
CN101616685B (zh) * | 2006-03-06 | 2013-07-24 | 阿穆尼克斯运营公司 | 非结构化重组聚合物和其应用 |
US20080206139A1 (en) * | 2006-11-03 | 2008-08-28 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
EP2331566B1 (en) * | 2008-08-26 | 2015-10-07 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
US9273283B2 (en) * | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
ES2621874T3 (es) * | 2010-03-26 | 2017-07-05 | Memorial Sloan-Kettering Cancer Center | Anticuerpos para MUC16 y métodos de uso de los mismos |
WO2014090985A1 (en) * | 2012-12-13 | 2014-06-19 | Universität Leipzig | T-cell modulation by exon skipping |
PL2956175T3 (pl) * | 2013-02-15 | 2018-05-30 | The Regents Of The University Of California | Chimeryczny receptor antygenowy i sposoby jego zastosowania |
JP2016513458A (ja) * | 2013-03-10 | 2016-05-16 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | 化学療法耐性免疫細胞 |
ES2792849T3 (es) * | 2014-02-10 | 2020-11-12 | Univ Emory | Expresión de polipéptido químico con receptores de linfocitos variables en células inmunes y usos para tratar el cáncer |
CN107709353A (zh) | 2014-12-02 | 2018-02-16 | 普拉斯派克特查特凯尔Rwmc有限责任公司 | 治疗癌症的方法和组合物 |
-
2015
- 2015-12-01 CN CN201580074883.3A patent/CN107709353A/zh active Pending
- 2015-12-01 BR BR112017011771A patent/BR112017011771A2/pt not_active Application Discontinuation
- 2015-12-01 MX MX2017007272A patent/MX2017007272A/es unknown
- 2015-12-01 EP EP15865800.5A patent/EP3227317A4/en not_active Withdrawn
- 2015-12-01 SG SG11201704519YA patent/SG11201704519YA/en unknown
- 2015-12-01 SG SG10202103475XA patent/SG10202103475XA/en unknown
- 2015-12-01 AU AU2015355084A patent/AU2015355084A1/en not_active Abandoned
- 2015-12-01 JP JP2017529284A patent/JP2017537622A/ja active Pending
- 2015-12-01 CA CA2969714A patent/CA2969714A1/en not_active Abandoned
- 2015-12-01 US US14/956,299 patent/US9650428B2/en not_active Expired - Fee Related
- 2015-12-01 KR KR1020177018139A patent/KR20180041087A/ko unknown
- 2015-12-01 WO PCT/US2015/063267 patent/WO2016089916A1/en active Application Filing
- 2015-12-01 EA EA201791210A patent/EA201791210A1/ru unknown
- 2015-12-02 TW TW104140317A patent/TW201636425A/zh unknown
- 2015-12-02 AR ARP150103939A patent/AR102879A1/es unknown
- 2015-12-02 UY UY0001036418A patent/UY36418A/es not_active Application Discontinuation
-
2017
- 2017-05-09 US US15/590,961 patent/US20180072789A1/en not_active Abandoned
- 2017-06-01 IL IL252610A patent/IL252610A0/en unknown
- 2017-06-02 PH PH12017501031A patent/PH12017501031A1/en unknown
-
2018
- 2018-08-16 HK HK18110565.4A patent/HK1251862A1/zh unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2017537622A5 (da) | ||
JP2022109953A5 (da) | ||
Heidbuechel et al. | Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies | |
JP2018529380A5 (da) | ||
JP7395249B2 (ja) | 細胞 | |
JP2023091037A (ja) | Gタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 | |
JP2018516092A5 (da) | ||
JP2019500894A5 (da) | ||
JP2019150066A5 (da) | ||
JP2023139070A5 (da) | ||
JP2018529363A5 (da) | ||
JP2018518459A5 (da) | ||
JP2017500869A5 (da) | ||
JP2016502512A5 (da) | ||
JP2020513754A5 (da) | ||
JP2017526361A5 (da) | ||
JP2016534717A5 (da) | ||
JP2017529067A5 (da) | ||
JP2016519068A5 (da) | ||
JP2017537919A5 (da) | ||
RU2016124278A (ru) | Клетка | |
IL292650A (en) | Chimeric antigen receptor T cells target il13ra2 | |
JP2018509163A5 (da) | ||
JP2018518990A5 (da) | ||
JP2018531014A5 (da) |