|
US4866042A
(en)
|
1987-11-18 |
1989-09-12 |
Neuwelt Edward A |
Method for the delivery of genetic material across the blood brain barrier
|
|
US6294520B1
(en)
|
1989-03-27 |
2001-09-25 |
Albert T. Naito |
Material for passage through the blood-brain barrier
|
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
JPH0813274B2
(ja)
|
1990-08-13 |
1996-02-14 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド
|
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
|
EP0651759B1
(en)
|
1992-07-23 |
2003-12-10 |
Isis Pharmaceuticals, Inc. |
Novel 2'-o-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof
|
|
CA2145535C
(en)
|
1992-09-25 |
2007-07-17 |
Axel Kahn |
Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain
|
|
DE69435005T2
(de)
|
1993-05-11 |
2008-04-17 |
The University Of North Carolina At Chapel Hill |
Antisense Oligonukleotide die anomales Splicing verhindern und deren Verwendung
|
|
JP3715314B2
(ja)
|
1993-12-24 |
2005-11-09 |
ユニバーシティ オブ ウェールズ カレッジ オブ メディスン |
結節硬化症２遺伝子及びその利用
|
|
US5656612A
(en)
|
1994-05-31 |
1997-08-12 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
FR2727867B1
(fr)
|
1994-12-13 |
1997-01-31 |
Rhone Poulenc Rorer Sa |
Transfert de genes dans les motoneurones medullaires au moyen de vecteurs adenoviraux
|
|
US6166197A
(en)
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
|
BR9707529A
(pt)
|
1996-02-14 |
2000-01-04 |
Isis Pharmaceuticals Inc |
Oligunucleotìdeo especificamente hibridizável com dna ou rna.
|
|
GB9605808D0
(en)
|
1996-03-20 |
1996-05-22 |
Isis Innovation |
CFTR gene regulator
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
USRE44779E1
(en)
|
1997-03-07 |
2014-02-25 |
Santaris Pharma A/S |
Bicyclonucleoside and oligonucleotide analogues
|
|
AU8435698A
(en)
|
1997-06-03 |
1998-12-21 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Regulatory sequences capable of conferring expression of a heterologous dna sequence in endothelial cells in vivo and uses thereof
|
|
US6963589B1
(en)
|
1997-07-03 |
2005-11-08 |
Canon Kabushiki Kaisha |
Information processing apparatus for and method of transmitting and/or receiving broadcast signal
|
|
GB9716231D0
(en)
|
1997-07-31 |
1997-10-08 |
Amersham Int Ltd |
Base analogues
|
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
DE69829760T3
(de)
|
1997-09-12 |
2016-04-14 |
Exiqon A/S |
Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US7045610B2
(en)
|
1998-04-03 |
2006-05-16 |
Epoch Biosciences, Inc. |
Modified oligonucleotides for mismatch discrimination
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
US7071324B2
(en)
|
1998-10-13 |
2006-07-04 |
Brown University Research Foundation |
Systems and methods for sequencing by hybridization
|
|
US20030224514A1
(en)
|
2002-05-31 |
2003-12-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of PPAR-delta expression
|
|
US6436657B1
(en)
|
1998-12-18 |
2002-08-20 |
E. I. Du Pont De Nemours And Company |
Polynucleotides encoding aminomethyltransferases
|
|
KR100573231B1
(ko)
|
1999-02-12 |
2006-04-24 |
상꾜 가부시키가이샤 |
신규 뉴클레오시드 및 올리고뉴클레오티드 유사체
|
|
HK1048639A1
(zh)
|
1999-03-18 |
2003-04-11 |
埃克西库恩公司 |
木-lna类似物
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
US6734291B2
(en)
|
1999-03-24 |
2004-05-11 |
Exiqon A/S |
Synthesis of [2.2.1]bicyclo nucleosides
|
|
AU3418800A
(en)
|
1999-03-24 |
2000-10-09 |
Exiqon A/S |
Improved synthesis of (2.2.1)bicyclo nucleosides
|
|
US6383752B1
(en)
|
1999-03-31 |
2002-05-07 |
Hybridon, Inc. |
Pseudo-cyclic oligonucleobases
|
|
AU776362B2
(en)
|
1999-05-04 |
2004-09-09 |
Roche Innovation Center Copenhagen A/S |
L-ribo-LNA analogues
|
|
US6083482A
(en)
|
1999-05-11 |
2000-07-04 |
Icn Pharmaceuticals, Inc. |
Conformationally locked nucleosides and oligonucleotides
|
|
US6531591B1
(en)
|
1999-07-07 |
2003-03-11 |
Exiqon A/S |
Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
|
|
JP4151751B2
(ja)
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
|
US6677445B1
(en)
|
1999-08-27 |
2004-01-13 |
Chiron Corporation |
Chimeric antisense oligonucleotides and cell transfecting formulations thereof
|
|
US6187586B1
(en)
|
1999-12-29 |
2001-02-13 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of AKT-3 expression
|
|
US6784291B2
(en)
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
US6809194B1
(en)
|
2000-05-10 |
2004-10-26 |
Chiron Corporation |
Akt3 inhibitors
|
|
JP2004504038A
(ja)
|
2000-07-13 |
2004-02-12 |
ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン |
多発性嚢胞腎疾患の検出と治療
|
|
AU2001282522A1
(en)
|
2000-08-29 |
2002-03-13 |
Takeshi Imanishi |
Novel nucleoside analogs and oligonucleotide derivatives containing these analogs
|
|
ES2300366T3
(es)
|
2000-09-02 |
2008-06-16 |
Grunenthal Gmbh |
Oligonucleotidos antisentido contra el vr1.
|
|
ATE325806T1
(de)
|
2000-10-04 |
2006-06-15 |
Santaris Pharma As |
Verbesserte synthese von purin-blockierten nukleinsäure-analoga
|
|
JP2002345489A
(ja)
|
2000-11-03 |
2002-12-03 |
Astrazeneca Ab |
化学物質
|
|
DE60202681T2
(de)
|
2001-07-12 |
2006-01-12 |
Santaris Pharma A/S |
Verfahren zur herstellung des lna phosphoramidite
|
|
US7037658B2
(en)
|
2001-08-16 |
2006-05-02 |
Regents Of University Of Michigan |
Methods and compositions for detecting variant ADAMTS13 genes
|
|
CA2459347C
(en)
|
2001-09-04 |
2012-10-09 |
Exiqon A/S |
Locked nucleic acid (lna) compositions and uses thereof
|
|
US6936589B2
(en)
|
2001-09-28 |
2005-08-30 |
Albert T. Naito |
Parenteral delivery systems
|
|
JP2005508196A
(ja)
|
2001-11-07 |
2005-03-31 |
アプレラ コーポレイション |
核酸分析の汎用ヌクレオチド
|
|
AU2003211953A1
(en)
|
2002-02-13 |
2003-09-04 |
Takeshi Imanishi |
Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof
|
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
|
ES2290448T3
(es)
|
2002-05-08 |
2008-02-16 |
Santaris Pharma A/S |
Sistesis de derivados de acidos nucleicos bloqueados.
|
|
AU2003247610A1
(en)
|
2002-06-21 |
2004-01-06 |
Ptc Therapeutics, Inc. |
METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
|
|
US7169594B2
(en)
|
2002-08-12 |
2007-01-30 |
Regents Of The University Of Michigan |
Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
|
|
EP1529105B1
(en)
*
|
2002-08-12 |
2012-10-03 |
Société de commercialisation des produits de la recherche appliquée SOCPRA Sciences Santé et Humaines s.e.c. |
Methods to reprogram splice site selection in pre-messenger rnas
|
|
AU2003295387A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
|
EP1562971B1
(en)
|
2002-11-05 |
2014-02-12 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
EP2752488B1
(en)
|
2002-11-18 |
2020-02-12 |
Roche Innovation Center Copenhagen A/S |
Antisense design
|
|
US7217807B2
(en)
|
2002-11-26 |
2007-05-15 |
Rosetta Genomics Ltd |
Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
|
|
AU2004220556B2
(en)
|
2003-03-07 |
2009-05-07 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
|
AU2003225410A1
(en)
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
EP2141234B1
(en)
|
2003-03-21 |
2016-04-27 |
Roche Innovation Center Copenhagen A/S |
Short Interfering RNA (siRNA) Analogues
|
|
CN101273051B
(zh)
|
2003-04-13 |
2012-04-18 |
安龙制药公司 |
聚合寡核苷酸前体药物
|
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
US20070009899A1
(en)
|
2003-10-02 |
2007-01-11 |
Mounts William M |
Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases
|
|
GB0326578D0
(en)
|
2003-11-14 |
2003-12-17 |
Univ Belfast |
Cancer diagnosis and therapy
|
|
US20050221354A1
(en)
|
2004-02-18 |
2005-10-06 |
Wyeth |
Nucleic acid arrays for monitoring expression profiles of drug target genes
|
|
EP2322650A1
(en)
|
2004-05-14 |
2011-05-18 |
Rosetta Genomics Ltd |
MicroRNAs and uses thereof
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US20070087376A1
(en)
|
2004-08-30 |
2007-04-19 |
Potashkin Judith A |
Splice variants of pre-mRNA transcripts as biomarkers in idiopathic neurodegenerative diseases
|
|
WO2006055786A2
(en)
|
2004-11-19 |
2006-05-26 |
Acadia Pharmaceuticals Inc. |
Methods to identify ligands of hormone nuclear receptors
|
|
US7838657B2
(en)
*
|
2004-12-03 |
2010-11-23 |
University Of Massachusetts |
Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
|
|
US8211864B2
(en)
|
2005-01-26 |
2012-07-03 |
Medical College Of Georgia Research Institute |
Compositions and methods for the intracellular disruption of VEGF and VEGFR-2 by intraceptors
|
|
WO2007094755A2
(en)
|
2005-02-04 |
2007-08-23 |
Massachusetts Institute Of Technology |
Compositions and methods for modulating cognitive function
|
|
CA2635198C
(en)
|
2005-04-01 |
2019-11-12 |
University Of Florida Research Foundation, Inc |
Biomarkers of liver injury
|
|
CA2606351C
(en)
|
2005-06-17 |
2016-12-13 |
Baxter International Inc. |
Adamts13-comprising compositions having thrombolytic activity
|
|
US8361977B2
(en)
|
2005-06-23 |
2013-01-29 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of SMN2 splicing
|
|
RS63964B1
(sr)
|
2005-08-23 |
2023-03-31 |
Univ Pennsylvania |
Rnk koja sadrži modifikovane nukleozide i postupci za njenu upotrebu
|
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
US8258109B2
(en)
|
2005-10-20 |
2012-09-04 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of LMNA expression
|
|
WO2007048628A2
(en)
|
2005-10-28 |
2007-05-03 |
Max Planck Gesellschaft |
Structures of active guide rna molecules and method of selection
|
|
WO2007048629A2
(en)
|
2005-10-28 |
2007-05-03 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Modulation of rna silencing efficiency by argonaute proteins
|
|
US20100022495A1
(en)
|
2005-11-01 |
2010-01-28 |
President And Fellows Of Harvard College |
Modulating endoplasmic reticulum stress in the treatment of tuberous sclerosis
|
|
US7785834B2
(en)
|
2005-11-10 |
2010-08-31 |
Ercole Biotech, Inc. |
Soluble TNF receptors and their use in treatment of disease
|
|
EP1792981A1
(en)
|
2005-12-02 |
2007-06-06 |
Humboldt-Universität zu Berlin |
Microginin producing proteins and nucleic acids encoding a microginin gene cluster as well as methods for creating microginins
|
|
JP5425474B2
(ja)
|
2006-01-26 |
2014-02-26 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
ハンチンチン対する、組成物及びその使用
|
|
JP5213723B2
(ja)
|
2006-01-27 |
2013-06-19 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
マイクロｒｎａの調節に使用するためのオリゴマー化合物及び組成物
|
|
CA2640171C
(en)
|
2006-01-27 |
2014-10-28 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
US8007790B2
(en)
|
2006-04-03 |
2011-08-30 |
Stowers Institute For Medical Research |
Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
|
|
CA3044969A1
(en)
|
2006-05-05 |
2007-12-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gene expression
|
|
JP5441688B2
(ja)
|
2006-05-11 |
2014-03-12 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
５’修飾二環式核酸類似体
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
|
NZ574034A
(en)
|
2006-06-08 |
2011-09-30 |
Amino Up Chemical Co Ltd |
SENSE OLIGONUCLEOTIDE CAPABLE OF CONTROLLING THE EXPRESSION OF iNOS AND COMPOSITION COMPRISING THE SAME
|
|
JPWO2008001778A1
(ja)
*
|
2006-06-27 |
2009-11-26 |
武田薬品工業株式会社 |
遺伝子改変動物およびその用途
|
|
US8771946B2
(en)
|
2006-07-24 |
2014-07-08 |
Athena Diagnostics, Inc. |
PKD mutations and evaluation of same
|
|
DK2092065T4
(da)
|
2006-10-18 |
2019-10-21 |
Ionis Pharmaceuticals Inc |
Antisense-forbindelser
|
|
US20090264353A1
(en)
|
2007-10-19 |
2009-10-22 |
Santaris Pharma A/S |
Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease
|
|
EP2099461B1
(en)
|
2006-11-13 |
2012-03-28 |
Santaris Pharma A/S |
Lna nucleoside phosphoramidates
|
|
US8293684B2
(en)
|
2006-11-29 |
2012-10-23 |
Exiqon |
Locked nucleic acid reagents for labelling nucleic acids
|
|
WO2008086807A2
(en)
|
2007-01-19 |
2008-07-24 |
Exiqon A/S |
Mediated cellular delivery of lna oligonucleotides
|
|
WO2008094945A2
(en)
|
2007-01-29 |
2008-08-07 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
|
CL2008000696A1
(es)
|
2007-03-09 |
2008-09-12 |
Pioneer Hi Bred Int |
Polinucleotido aislado que codifica un modificador de un transportador de amonio (amt); casete de expresion y celula huesped que comprende la celula huesped; metodo para modular el amt en plantas.
|
|
EP2130835B1
(en)
|
2007-03-09 |
2012-05-23 |
Riken |
Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid
|
|
WO2008111908A1
(en)
|
2007-03-15 |
2008-09-18 |
Jyoti Chattopadhyaya |
Five- and six-membered conformationally locked 2',4'- carbocyclic ribo-thymidines for the treatment of infections and cancer
|
|
EP2149605B1
(en)
|
2007-03-22 |
2013-07-03 |
Santaris Pharma A/S |
Short RNA antagonist compounds for the modulation of target mRNA
|
|
EP2170917B1
(en)
|
2007-05-30 |
2012-06-27 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
ES2386492T3
(es)
|
2007-06-08 |
2012-08-21 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos carbocíclicos
|
|
CN101796062B
(zh)
|
2007-07-05 |
2014-07-30 |
Isis制药公司 |
6-双取代双环核酸类似物
|
|
JP5572090B2
(ja)
|
2007-08-15 |
2014-08-13 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
テトラヒドロピラン核酸類似体
|
|
DK2203173T3
(en)
|
2007-10-26 |
2016-02-29 |
Academisch Ziekenhuis Leiden |
Materials and methods for prevention of muscle diseases
|
|
US8637478B2
(en)
*
|
2007-11-13 |
2014-01-28 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
|
CA2910760C
(en)
|
2007-12-04 |
2019-07-09 |
Muthiah Manoharan |
Targeting lipids
|
|
US8846386B2
(en)
|
2007-12-18 |
2014-09-30 |
University Of Kentucky Research Foundation |
sVEGFR-2 and its role in lymphangiogenesis modulation
|
|
WO2009084472A1
(ja)
|
2007-12-28 |
2009-07-09 |
Public University Corporation Yokohama City University |
新生児期～乳児期発症の難治性てんかんの検出方法
|
|
EP2265627A2
(en)
|
2008-02-07 |
2010-12-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
JP5409658B2
(ja)
|
2008-03-13 |
2014-02-05 |
セレラ コーポレーション |
静脈血栓症に関連した遺伝子多型、その検出方法および使用
|
|
WO2009124238A1
(en)
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
|
EP2274423A2
(en)
|
2008-04-04 |
2011-01-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
|
CA2727285A1
(en)
|
2008-06-11 |
2009-12-17 |
Bionucleon S.R.L. |
Inhibition of hrp-3 using modified oligonucleotides
|
|
EP2151248A1
(en)
|
2008-07-30 |
2010-02-10 |
Johann Bauer |
Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
DK2356129T3
(da)
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituerede alpha-L-bicykliske nukleosider
|
|
CA2735129C
(en)
|
2008-11-07 |
2012-06-26 |
Centre Hospitalier Universitaire Sainte-Justine |
Syngap1 dysfunctions and uses thereof in diagnostic and therapeutic applications for mental retardation
|
|
RU2569182C2
(ru)
|
2008-12-04 |
2015-11-20 |
КьюРНА,Инк.,US |
Лечение заболеваний, связанных с фактором роста эндотелия сосудов (vegf), посредством ингибирования природного антисмыслового транскрипта к vegf
|
|
WO2010080509A1
(en)
|
2008-12-19 |
2010-07-15 |
Philadelphia Health And Education Corporation |
Compositions and methods for diminishing viral infection and inflammation associated with viral infection
|
|
US20100166784A1
(en)
|
2008-12-30 |
2010-07-01 |
The Washington University |
Method and compositions for modulating th17 cell development
|
|
CA2750379A1
(en)
|
2009-01-14 |
2010-07-22 |
Gordon J. Lutz |
Modulation of pre-mrna using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
|
|
CN102625840A
(zh)
*
|
2009-04-10 |
2012-08-01 |
肌肉学研究协会 |
用于治疗疾病的三环dna反义寡核苷酸、组合物和方法
|
|
CA2761248C
(en)
|
2009-05-08 |
2023-03-14 |
Joseph Collard |
Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
|
|
PT3449926T
(pt)
|
2009-06-17 |
2019-11-12 |
Cold Spring Harbor Laboratory |
Composições e métodos de modulação de excisões de smn2 em um sujeito
|
|
EP2275545A1
(en)
|
2009-07-16 |
2011-01-19 |
Julius-Maximilians-Universität Würzburg |
Use of microRNA-24 and/or its targets for the treatment and prevention of ischemia and induction of angiogenesis
|
|
WO2011017521A2
(en)
|
2009-08-06 |
2011-02-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US20120252877A1
(en)
|
2009-08-14 |
2012-10-04 |
Theramind Research, Llc |
Methods and compositions for treatment of tuberous sclerosis complex
|
|
WO2011031786A2
(en)
|
2009-09-08 |
2011-03-17 |
Laboratory Corporation Of America Holdings |
Compositions and methods for diagnosing autism spectrum disorders
|
|
WO2011032034A2
(en)
|
2009-09-10 |
2011-03-17 |
University Of Idaho |
Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
|
|
EP2495248B1
(en)
|
2009-10-29 |
2017-01-11 |
Osaka University |
Bridged artificial nucleoside and nucleotide
|
|
SMT201800579T1
(it)
|
2009-11-12 |
2019-01-11 |
Univ Western Australia |
Molecole antisenso e metodi per trattare patologie
|
|
ES2574625T3
(es)
|
2009-11-25 |
2016-06-21 |
Elitechgroup B.V. |
Antagonistas de miARN de oligonucleótido conjugado con aglutinante del surco menor (MGB)
|
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP3561060A1
(en)
|
2010-02-08 |
2019-10-30 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
JP2013529181A
(ja)
|
2010-03-25 |
2013-07-18 |
ザ ジェイ． デヴィッド グラッドストーン インスティテューツ |
神経障害を治療するための組成物および方法
|
|
US9006415B2
(en)
|
2010-04-06 |
2015-04-14 |
Massachusetts Institute Of Technology |
Targeted delivery of nucleic acids
|
|
KR20130103662A
(ko)
|
2010-04-19 |
2013-09-24 |
엔라이프 떼라퓨틱스, 에스.엘. |
올리고뉴클레오티드 분자들의 특정 뉴런 유형들로의 선택적인 전달을 위한 조성물들 및 방법
|
|
US20110269735A1
(en)
|
2010-04-19 |
2011-11-03 |
Celera Corporation |
Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
|
|
US9156873B2
(en)
|
2010-04-28 |
2015-10-13 |
Isis Pharmaceuticals, Inc. |
Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom
|
|
US8802642B2
(en)
|
2010-04-28 |
2014-08-12 |
Iowa State University Research Foundation, Inc. |
Spinal muscular atrophy treatment via targeting SMN2 catalytic core
|
|
EP2571530A4
(en)
|
2010-05-20 |
2014-03-05 |
Univ Rochester |
METHOD AND COMPOSITIONS FOR AUTOPHAGIA MODULATION
|
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2580228B1
(en)
|
2010-06-08 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2582397A4
(en)
|
2010-06-15 |
2014-10-29 |
Isis Pharmaceuticals Inc |
COMPOUNDS AND METHOD FOR MODULATING INTERACTION BETWEEN PROTEINS AND TARGET NUCLEIC ACIDS
|
|
KR102008708B1
(ko)
|
2010-06-23 |
2019-08-08 |
큐알엔에이, 인크. |
전압 작동 나트륨 통로, 알파 소단위(scna)에 대한 자연 안티센스 전사체의 저해에 의한 전압 작동 나트륨 통로, 알파 소단위(scna) 관련된 질환의 치료
|
|
US9222088B2
(en)
|
2010-10-22 |
2015-12-29 |
Curna, Inc. |
Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
|
|
US8853377B2
(en)
|
2010-11-30 |
2014-10-07 |
Shire Human Genetic Therapies, Inc. |
mRNA for use in treatment of human genetic diseases
|
|
US20130309246A1
(en)
|
2011-02-02 |
2013-11-21 |
The Trustees Of Princeton University |
Jagged1 as a marker and therapeutic target for breast cancer bone metastasis
|
|
WO2012138487A2
(en)
*
|
2011-04-07 |
2012-10-11 |
The Board Of Regents Of The University Of Texas System |
Oligonucleotide modulation of splicing
|
|
US9644035B2
(en)
|
2011-04-08 |
2017-05-09 |
Omeros Corporation |
Methods for treating conditions associated with MASP-2 dependent complement activation
|
|
EP2702170B1
(en)
|
2011-04-28 |
2015-12-16 |
Life Technologies Corporation |
Methods and compositions for multiplex pcr
|
|
US20140357558A1
(en)
|
2011-06-24 |
2014-12-04 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of spinal muscular atrophy
|
|
US9605019B2
(en)
|
2011-07-19 |
2017-03-28 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
US8592156B2
(en)
|
2011-08-08 |
2013-11-26 |
Roche Molecular Systems, Inc. |
Predicting response to anti-CD20 therapy in DLBCL patients
|
|
US10023861B2
(en)
|
2011-08-29 |
2018-07-17 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
BR112014005234A2
(pt)
|
2011-09-06 |
2017-04-11 |
Curna Inc |
tratamento de doenças relacionadas com subunididades alfa dos canais de sódio dependentes de voltagem (scnxa) com pequenas moléculas
|
|
US9453261B2
(en)
|
2011-09-20 |
2016-09-27 |
The George Washington University |
Alternative splicing variants of genes associated with prostate cancer risk and survival
|
|
US20140343127A1
(en)
|
2011-11-11 |
2014-11-20 |
Santaris Pharma A/S a corporation |
Compounds for the modulation of smn2 splicing
|
|
US9534222B2
(en)
|
2011-11-15 |
2017-01-03 |
University Of Utah Research Foundation |
Morpholinos, morpholino upregulating, and associated methods
|
|
EP2966180B1
(en)
|
2011-11-29 |
2017-08-16 |
Life Technologies Corporation |
Methods and compositions for multiplex pcr
|
|
IL321422A
(en)
*
|
2012-01-11 |
2025-08-01 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulation of ikbkap splicing
|
|
EP2812342B1
(en)
|
2012-02-08 |
2017-11-15 |
Ionis Pharmaceuticals, Inc. |
Modulation of rna by repeat targeting
|
|
JP6092897B2
(ja)
|
2012-02-10 |
2017-03-08 |
ピーティーシー セラピューティクス， インコーポレイテッド |
脊髄性筋萎縮症を治療するための化合物
|
|
US8846885B2
(en)
|
2012-02-17 |
2014-09-30 |
Ajinomoto Co., Inc. |
Oligonucleotide with protected base
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
US20140378526A1
(en)
|
2012-05-11 |
2014-12-25 |
City Of Hope |
Design of nucleic acid binding molecules with non-watson crick and non-canonical pairing based on artificial mutation consensus sequences to counter escape mutations
|
|
WO2013177195A1
(en)
|
2012-05-22 |
2013-11-28 |
Idenix Pharmaceuticals, Inc. |
3',5'-cyclic phosphate prodrugs for hcv infection
|
|
US9109001B2
(en)
|
2012-05-22 |
2015-08-18 |
Idenix Pharmaceuticals, Inc. |
3′,5′-cyclic phosphoramidate prodrugs for HCV infection
|
|
US20150267192A1
(en)
|
2012-06-08 |
2015-09-24 |
Shire Human Genetic Therapies, Inc. |
Nuclease resistant polynucleotides and uses thereof
|
|
KR20240148947A
(ko)
|
2012-07-13 |
2024-10-11 |
웨이브 라이프 사이언시스 리미티드 |
키랄 제어
|
|
US8729263B2
(en)
|
2012-08-13 |
2014-05-20 |
Novartis Ag |
1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
|
|
IN2015DN01765A
(enExample)
|
2012-08-20 |
2015-05-29 |
Univ California |
|
|
WO2014045283A1
(en)
|
2012-09-24 |
2014-03-27 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Restoration of the cftr function by splicing modulation
|
|
WO2014049536A2
(en)
|
2012-09-25 |
2014-04-03 |
Universidade De Lisboa |
Drug targets for cystic fibrosis and other conditions
|
|
EP2900682A1
(en)
|
2012-09-27 |
2015-08-05 |
IDENIX Pharmaceuticals, Inc. |
Esters and malonates of sate prodrugs
|
|
UA116639C2
(uk)
|
2012-10-09 |
2018-04-25 |
Рег'Юлес Терап'Ютікс Інк. |
Способи лікування синдрому альпорта
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2014066915A2
(en)
|
2012-10-26 |
2014-05-01 |
Smith Larry J |
Methods and compositions to produce ss-rnai activity with enhanced potency
|
|
US9909128B2
(en)
|
2012-11-15 |
2018-03-06 |
The Regents Of The University Of California |
Splice modulating oligonucleotides that inhibit cancer
|
|
US9211300B2
(en)
|
2012-12-19 |
2015-12-15 |
Idenix Pharmaceuticals Llc |
4′-fluoro nucleosides for the treatment of HCV
|
|
CN104004826B
(zh)
|
2013-01-07 |
2016-03-02 |
赵晨 |
突变的基因prpf4在制备遗传性视网膜疾病诊断试剂中的应用
|
|
CA2897522A1
(en)
|
2013-01-18 |
2014-07-24 |
Anna Mary Rose |
Therapeutics and diagnostics based on minisatellite repeat element 1 (msr1)
|
|
WO2014121287A2
(en)
|
2013-02-04 |
2014-08-07 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
US9315535B2
(en)
|
2013-02-18 |
2016-04-19 |
Shionogi & Co., Ltd. |
Nucleoside and nucleotide having nitrogen-containing heterocycle structure
|
|
US9339541B2
(en)
|
2013-03-04 |
2016-05-17 |
Merck Sharp & Dohme Corp. |
Thiophosphate nucleosides for the treatment of HCV
|
|
EP2970358B1
(en)
|
2013-03-04 |
2021-06-30 |
Idenix Pharmaceuticals LLC |
3'-deoxy nucleosides for the treatment of hcv
|
|
US9187515B2
(en)
|
2013-04-01 |
2015-11-17 |
Idenix Pharmaceuticals Llc |
2′,4′-fluoro nucleosides for the treatment of HCV
|
|
WO2014172698A1
(en)
|
2013-04-19 |
2014-10-23 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
|
PE20152002A1
(es)
|
2013-05-01 |
2016-01-21 |
Isis Pharmaceuticals Inc |
Composiciones y metodos para modular la expresion de ttr y vhb
|
|
WO2014198890A1
(en)
|
2013-06-13 |
2014-12-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of erythropoietic protoporphyria
|
|
WO2014201413A1
(en)
|
2013-06-14 |
2014-12-18 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating non-coding rna
|
|
RU2673542C2
(ru)
|
2013-06-25 |
2018-11-28 |
Ф. Хоффманн-Ля Рош Аг |
Соединения для лечения спинальной мышечной атрофии
|
|
JP2016531570A
(ja)
|
2013-08-16 |
2016-10-13 |
ラナ セラピューティクス インコーポレイテッド |
ユークロマチン領域を標的とするオリゴヌクレオチド
|
|
US20150050738A1
(en)
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating rna
|
|
WO2015023938A1
(en)
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Epigenetic regulators of frataxin
|
|
EP3033425A4
(en)
|
2013-08-16 |
2017-07-26 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin
|
|
CN105392790B
(zh)
|
2013-08-19 |
2019-04-19 |
豪夫迈·罗氏有限公司 |
4H-吡啶并[1,2-a]嘧啶-4-酮化合物制备用于预防或治疗癌症的药物的用途
|
|
DK3041958T3
(da)
|
2013-09-04 |
2020-03-09 |
Cold Spring Harbor Laboratory |
Reducering af nonsense-medieret mrna-degradering
|
|
IL282239B2
(en)
|
2013-09-05 |
2023-10-01 |
Sarepta Therapeutics Inc |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
|
ES2739850T3
(es)
|
2013-09-11 |
2020-02-04 |
Synthena Ag |
Acidos nucleicos y procedimientos para el tratamiento de la enfermedad de Pompe
|
|
CN106661580B
(zh)
|
2014-06-10 |
2022-02-15 |
鹿特丹伊拉斯谟大学医疗中心 |
用于治疗庞帕病的反义寡核苷酸
|
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
|
GB201411468D0
(en)
|
2014-06-27 |
2014-08-13 |
Univ Edinburgh |
Novel treatment for endometriosis
|
|
GB2547586A
(en)
|
2014-08-20 |
2017-08-23 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof(In the PCT request)
|
|
WO2016027168A2
(en)
|
2014-08-20 |
2016-02-25 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof
|
|
AU2015327836B2
(en)
|
2014-10-03 |
2021-07-01 |
Cold Spring Harbor Laboratory |
Targeted augmentation of nuclear gene output
|
|
EP3207048A4
(en)
|
2014-10-17 |
2018-05-30 |
The Broad Institute, Inc. |
Compositions and methods of treating muscular dystrophy
|
|
CA2964979A1
(en)
|
2014-11-14 |
2016-05-19 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of proteins
|
|
GB201421379D0
(en)
|
2014-12-02 |
2015-01-14 |
Isis Innovation Ltd And Medical Res Council |
Molecule
|
|
JP2018509387A
(ja)
|
2015-01-21 |
2018-04-05 |
フェーズアールエックス インコーポレイテッド |
細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム
|
|
WO2016128343A1
(en)
|
2015-02-09 |
2016-08-18 |
F. Hoffmann-La Roche Ag |
Compounds for the treatment of cancer
|
|
US9840709B2
(en)
|
2015-02-20 |
2017-12-12 |
Rosalind Franklin University Of Medicine And Science |
Antisense compounds targeting genes associated with cystic fibrosis
|
|
US20180216111A1
(en)
|
2015-02-27 |
2018-08-02 |
Sarepta Therapeutics, Inc. |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
|
WO2016161429A1
(en)
|
2015-04-03 |
2016-10-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating tmprss6 expression
|
|
EP4249472A3
(en)
|
2015-05-30 |
2023-12-13 |
PTC Therapeutics, Inc. |
Methods for modulating rna splicing
|
|
CA3000660A1
(en)
|
2015-09-24 |
2017-03-30 |
The Trustees Of The University Of Pennsylvania |
Triptycene derivatives for nucleic acid junction stabilization
|
|
CN108603230A
(zh)
|
2015-10-09 |
2018-09-28 |
南安普敦大学 |
基因表达的调节与蛋白质表达失调的筛选
|
|
GB2546719B
(en)
|
2015-10-09 |
2021-07-14 |
Univ Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
|
EP3390636B1
(en)
|
2015-12-14 |
2021-05-19 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of dravet syndrome
|
|
WO2017106211A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of polycystic kidney disease
|
|
ES2903394T3
(es)
|
2015-12-14 |
2022-04-01 |
Cold Spring Harbor Laboratory |
Composiciones para el tratamiento de la retinitis pigmentosa 13
|
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
|
EP3390666A4
(en)
|
2015-12-14 |
2019-08-07 |
Cold Spring Harbor Laboratory |
COMPOSITIONS AND METHODS OF TREATING NURSE DISEASES
|
|
JP7051683B2
(ja)
|
2015-12-14 |
2022-04-11 |
コールド スプリング ハーバー ラボラトリー |
結節性硬化症の処置のためのアンチセンスオリゴマー
|
|
CA3005245A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of alagille syndrome
|
|
CA3005246A1
(en)
|
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|
|
JP2019500345A
(ja)
|
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2019-01-10 |
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|
|
JP7036723B2
(ja)
|
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|
|
CA3058189A1
(en)
|
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|
|
EP3673080B1
(en)
|
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|
|
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(sr)
|
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|