JP2023512758A5 - - Google Patents
Info
- Publication number
- JP2023512758A5 JP2023512758A5 JP2022547680A JP2022547680A JP2023512758A5 JP 2023512758 A5 JP2023512758 A5 JP 2023512758A5 JP 2022547680 A JP2022547680 A JP 2022547680A JP 2022547680 A JP2022547680 A JP 2022547680A JP 2023512758 A5 JP2023512758 A5 JP 2023512758A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- guide rna
- guide
- composition according
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062971906P | 2020-02-07 | 2020-02-07 | |
| US62/971,906 | 2020-02-07 | ||
| US202062981965P | 2020-02-26 | 2020-02-26 | |
| US62/981,965 | 2020-02-26 | ||
| US202063019076P | 2020-05-01 | 2020-05-01 | |
| US63/019,076 | 2020-05-01 | ||
| PCT/US2021/016730 WO2021158858A1 (en) | 2020-02-07 | 2021-02-05 | Compositions and methods for kallikrein ( klkb1) gene editing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023512758A JP2023512758A (ja) | 2023-03-29 |
| JP2023512758A5 true JP2023512758A5 (enExample) | 2024-02-14 |
| JP7883437B2 JP7883437B2 (ja) | 2026-07-01 |
Family
ID=74873798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022547680A Active JP7883437B2 (ja) | 2020-02-07 | 2021-02-05 | カリクレイン（ｋｌｋｂ１）遺伝子編集のための組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20230295587A1 (enExample) |
| EP (1) | EP4100528A1 (enExample) |
| JP (1) | JP7883437B2 (enExample) |
| KR (1) | KR20220139352A (enExample) |
| CN (1) | CN115362256A (enExample) |
| AU (1) | AU2021216451A1 (enExample) |
| BR (1) | BR112022015380A2 (enExample) |
| CA (1) | CA3169813A1 (enExample) |
| CL (1) | CL2022002095A1 (enExample) |
| CO (1) | CO2022012196A2 (enExample) |
| IL (1) | IL295280A (enExample) |
| MX (1) | MX2022009658A (enExample) |
| PH (1) | PH12022552009A1 (enExample) |
| SA (1) | SA522440054B1 (enExample) |
| TW (1) | TWI921322B (enExample) |
| WO (1) | WO2021158858A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115362256A (zh) | 2020-02-07 | 2022-11-18 | 因特利亚治疗公司 | 用于激肽释放酶（klkb1）基因编辑的组合物和方法 |
| AU2022357561A1 (en) | 2021-10-01 | 2024-04-18 | Adarx Pharmaceuticals, Inc. | Prekallikrein-modulating compositions and methods of use thereof |
| WO2023086953A1 (en) * | 2021-11-11 | 2023-05-19 | Beam Therapeutics Inc. | Compositions and methods for the treatment of hereditary angioedema (hae) |
| TW202346586A (zh) * | 2022-01-28 | 2023-12-01 | 大陸商上海舶望製藥有限公司 | 用於抑制前激肽釋放酶（pkk）蛋白表達的組合物和方法 |
| AU2023304427A1 (en) * | 2022-07-08 | 2025-01-30 | Intellia Therapeutics, Inc. | Methods for in vivo editing of klkb1 |
| WO2024012435A1 (en) * | 2022-07-11 | 2024-01-18 | CorrectSequence Therapeutics Co., Ltd | Gene editing systems and methods for treating hereditary angioedema |
| CN122095094A (zh) * | 2023-11-02 | 2026-05-26 | 波西达治疗公司 | 靶向klkb1的组合物及其使用方法 |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| CN118303422B (zh) * | 2024-04-17 | 2024-11-12 | 华南师范大学 | Ppk基因在控制德国小蠊繁殖行为中的应用 |
| WO2026008078A1 (en) * | 2024-07-05 | 2026-01-08 | Shanghai Vitalgen Biopharma Co., Ltd. | Methods for kallikrein (klkb1) gene editing |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| ATE515510T1 (de) | 1991-12-24 | 2011-07-15 | Isis Pharmaceuticals Inc | Durch dna-abschnitte unterbrochene modifizierte oligonukleotide |
| EP0760008A1 (en) | 1994-05-19 | 1997-03-05 | Dako A/S | Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis |
| PL2578685T3 (pl) | 2005-08-23 | 2020-01-31 | The Trustees Of The University Of Pennsylvania | Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania |
| WO2012170945A2 (en) * | 2011-06-10 | 2012-12-13 | Isis Pharmaceuticals, Inc. | Methods for modulating kallikrein (klkb1) expression |
| AU2012275096B2 (en) | 2011-06-29 | 2016-02-04 | Ionis Pharmaceuticals, Inc. | Methods for modulating kallikrein (KLKB1) expression |
| US20150141497A1 (en) | 2012-06-15 | 2015-05-21 | Joslin Diabetes Center, Inc. | Methods for modulating kallikrein (klkb1) expression |
| PT2931898E (pt) | 2012-12-12 | 2016-06-16 | Harvard College | Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| IL308158A (en) | 2012-12-17 | 2023-12-01 | Harvard College | Rna-guided human genome engineering |
| US9670492B2 (en) * | 2013-08-28 | 2017-06-06 | Ionis Pharmaceuticals, Inc. | Modulation of prekallikrein (PKK) expression |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| US10059655B2 (en) * | 2013-12-19 | 2018-08-28 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| HUE052709T2 (hu) | 2014-05-01 | 2021-05-28 | Ionis Pharmaceuticals Inc | Módosított antiszensz oligonukleotidok konjugátumai és azok alkalmazása PKK expressziójának módosítására |
| WO2015200555A2 (en) | 2014-06-25 | 2015-12-30 | Caribou Biosciences, Inc. | Rna modification to engineer cas9 activity |
| CN106794141B (zh) | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| AU2016226077B2 (en) | 2015-03-03 | 2021-12-23 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases with altered PAM specificity |
| CA2984636A1 (en) * | 2015-05-06 | 2016-11-10 | Alnylam Pharmaceuticals, Inc. | Factor xii (hageman factor) (f12), kallikrein b, plasma (fletcher factor) 1 (klkb1), and kininogen 1 (kng1) irna compositions and methods of use thereof |
| FI4019022T3 (fi) | 2015-10-01 | 2024-04-19 | Biocryst Pharm Inc | Ihmisen plasman kallikreiinin estäjiä |
| AU2017212713B2 (en) | 2016-01-27 | 2023-01-19 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| WO2017136794A1 (en) | 2016-02-03 | 2017-08-10 | Massachusetts Institute Of Technology | Structure-guided chemical modification of guide rna and its applications |
| WO2017153936A1 (en) | 2016-03-10 | 2017-09-14 | Novartis Ag | Chemically modified messenger rna's |
| US20180112234A9 (en) * | 2016-03-14 | 2018-04-26 | Intellia Therapeutics, Inc. | Methods and compositions for gene editing |
| ES3030658T3 (en) | 2016-03-30 | 2025-07-01 | Intellia Therapeutics Inc | Lipid nanoparticle formulations for crispr/cas components |
| JP7256739B2 (ja) * | 2016-09-07 | 2023-04-12 | サンガモ セラピューティクス， インコーポレイテッド | 肝臓遺伝子のモジュレーション |
| EP3551757A1 (en) | 2016-12-08 | 2019-10-16 | Intellia Therapeutics, Inc. | Modified guide rnas |
| EP3649243A1 (en) * | 2017-07-07 | 2020-05-13 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing contact-activation pathway-associated diseases using irna compositions targeting factor xii (hageman factor) (f12) |
| MX2020000993A (es) | 2017-07-26 | 2020-07-22 | Oncorus Inc | Vectores virales oncolíticos y usos de estos. |
| EP3688162B1 (en) | 2017-09-29 | 2024-03-06 | Intellia Therapeutics, Inc. | Formulations |
| IL311278B2 (en) | 2017-09-29 | 2026-05-01 | Intellia Therapeutics Inc | Polynucleotides, compositions, and methods for genome editing |
| KR102327512B1 (ko) | 2018-01-12 | 2021-11-17 | 주식회사 큐로셀 | 이원 shrna를 이용한 향상된 면역 세포 및 이를 포함하는 조성물 |
| JP7832761B2 (ja) * | 2018-06-08 | 2026-03-18 | インテリア セラピューティクス，インコーポレイテッド | 遺伝子編集のための修飾されたガイドｒｎａ |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| US12521451B2 (en) * | 2019-11-08 | 2026-01-13 | Regeneron Pharmaceuticals, Inc. | CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy |
| CN115362256A (zh) | 2020-02-07 | 2022-11-18 | 因特利亚治疗公司 | 用于激肽释放酶（klkb1）基因编辑的组合物和方法 |
-
2021
- 2021-02-05 CN CN202180026687.4A patent/CN115362256A/zh active Pending
- 2021-02-05 CA CA3169813A patent/CA3169813A1/en active Pending
- 2021-02-05 MX MX2022009658A patent/MX2022009658A/es unknown
- 2021-02-05 IL IL295280A patent/IL295280A/en unknown
- 2021-02-05 AU AU2021216451A patent/AU2021216451A1/en active Pending
- 2021-02-05 KR KR1020227030659A patent/KR20220139352A/ko active Pending
- 2021-02-05 PH PH1/2022/552009A patent/PH12022552009A1/en unknown
- 2021-02-05 BR BR112022015380A patent/BR112022015380A2/pt unknown
- 2021-02-05 JP JP2022547680A patent/JP7883437B2/ja active Active
- 2021-02-05 TW TW110104494A patent/TWI921322B/zh active
- 2021-02-05 WO PCT/US2021/016730 patent/WO2021158858A1/en not_active Ceased
- 2021-02-05 EP EP21711973.4A patent/EP4100528A1/en active Pending
-
2022
- 2022-08-03 CL CL2022002095A patent/CL2022002095A1/es unknown
- 2022-08-04 SA SA522440054A patent/SA522440054B1/ar unknown
- 2022-08-05 US US17/882,099 patent/US20230295587A1/en not_active Abandoned
- 2022-08-26 CO CONC2022/0012196A patent/CO2022012196A2/es unknown
-
2023
- 2023-07-31 US US18/362,675 patent/US20240018496A1/en not_active Abandoned
-
2025
- 2025-01-17 US US19/028,692 patent/US12480109B2/en active Active
- 2025-09-12 US US19/327,529 patent/US20260125661A1/en active Pending
- 2025-09-17 US US19/331,096 patent/US12674151B2/en active Active
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