JP2017536119A - キラルホスホロチオエート連結を含むｌｎａギャップマーオリゴヌクレオチド - Google Patents

キラルホスホロチオエート連結を含むｌｎａギャップマーオリゴヌクレオチド Download PDF

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JP2017536119A
JP2017536119A JP2017526918A JP2017526918A JP2017536119A JP 2017536119 A JP2017536119 A JP 2017536119A JP 2017526918 A JP2017526918 A JP 2017526918A JP 2017526918 A JP2017526918 A JP 2017526918A JP 2017536119 A JP2017536119 A JP 2017536119A
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lna
phosphorothioate
nucleoside
oligonucleotide
region
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JP2017536119A5 (enExample
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ナンナ アルベク
ナンナ アルベク
ヘンリック フリデンランド ハンセン
ヘンリック フリデンランド ハンセン
コッホ　トロールス
トロールス コッホ
ジェイコブ ラバン
ジェイコブ ラバン
クリストフ ローゼンバーム
クリストフ ローゼンバーム
ピーター ヘッジドーン
ピーター ヘッジドーン
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ロシュ イノベーション センター コペンハーゲン エーエス
ロシュ イノベーション センター コペンハーゲン エーエス
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Publication of JP2017536119A publication Critical patent/JP2017536119A/ja
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2017526918A 2014-11-19 2015-11-18 キラルホスホロチオエート連結を含むｌｎａギャップマーオリゴヌクレオチド Pending JP2017536119A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
EP14193887.8 2014-11-19
EP14193887 2014-11-19
EP14198167 2014-12-16
EP14198167.0 2014-12-16
EP15182401 2015-08-25
EP15182401.8 2015-08-25
EP15191075 2015-10-22
EP15191076.7 2015-10-22
EP15191075.9 2015-10-22
EP15191076 2015-10-22
EP15191074 2015-10-22
EP15191074.2 2015-10-22
PCT/EP2015/076967 WO2016079181A1 (en) 2014-11-19 2015-11-18 Lna gapmer oligonucleotides comprising chiral phosphorothioate linkages

Publications (2)

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JP2017536119A true JP2017536119A (ja) 2017-12-07
JP2017536119A5 JP2017536119A5 (enExample) 2018-11-15

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JP2017526905A Pending JP2017536366A (ja) 2014-11-19 2015-11-18 Ｌｎａキラルホスホロチオエート

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EP (2) EP3220921A1 (enExample)
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WO (2) WO2016079181A1 (enExample)

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JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022521510A (ja) * 2019-02-20 2022-04-08 ロシュ イノベーション センター コペンハーゲン エーエス ホスホノアセテートギャップマー型オリゴヌクレオチド

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US20180112217A1 (en) 2018-04-26
JP2017536366A (ja) 2017-12-07
EP3221329A1 (en) 2017-09-27
WO2016079183A1 (en) 2016-05-26
EP3220921A1 (en) 2017-09-27
US20180016575A1 (en) 2018-01-18
WO2016079181A1 (en) 2016-05-26

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