JP2017534742A5 - - Google Patents
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- Publication number
- JP2017534742A5 JP2017534742A5 JP2017540977A JP2017540977A JP2017534742A5 JP 2017534742 A5 JP2017534742 A5 JP 2017534742A5 JP 2017540977 A JP2017540977 A JP 2017540977A JP 2017540977 A JP2017540977 A JP 2017540977A JP 2017534742 A5 JP2017534742 A5 JP 2017534742A5
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- weight
- less
- ppm
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 claims description 69
- 150000003839 salts Chemical class 0.000 claims description 36
- 229920000642 polymer Polymers 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 26
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 23
- 239000012633 leachable Substances 0.000 claims description 23
- 239000002904 solvent Substances 0.000 claims description 21
- 239000000178 monomer Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000011261 inert gas Substances 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 16
- PDWUPXJEEYOOTR-UHFFFAOYSA-N 2-[(3-iodophenyl)methyl]guanidine Chemical compound NC(=N)NCC1=CC=CC(I)=C1 PDWUPXJEEYOOTR-UHFFFAOYSA-N 0.000 description 12
- 239000002671 adjuvant Substances 0.000 description 5
- 239000003937 drug carrier Substances 0.000 description 5
- 239000003981 vehicle Substances 0.000 description 5
- LQLOGZQVKUNBRX-UHFFFAOYSA-N (3-iodophenyl)methanamine Chemical compound NCC1=CC=CC(I)=C1 LQLOGZQVKUNBRX-UHFFFAOYSA-N 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- -1 halogen ion Chemical class 0.000 description 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 4
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 229910052789 astatine Inorganic materials 0.000 description 1
- RYXHOMYVWAEKHL-UHFFFAOYSA-N astatine atom Chemical compound [At] RYXHOMYVWAEKHL-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022045482A JP7399996B2 (ja) | 2014-10-24 | 2022-03-22 | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462068598P | 2014-10-24 | 2014-10-24 | |
| US62/068,598 | 2014-10-24 | ||
| US201462069029P | 2014-10-27 | 2014-10-27 | |
| US62/069,029 | 2014-10-27 | ||
| PCT/US2015/057222 WO2016065322A1 (en) | 2014-10-24 | 2015-10-23 | Preparations of meta-iodobenzylguanidine and precursors thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020093440A Division JP7186744B2 (ja) | 2014-10-24 | 2020-05-28 | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
| JP2022045482A Division JP7399996B2 (ja) | 2014-10-24 | 2022-03-22 | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534742A JP2017534742A (ja) | 2017-11-24 |
| JP2017534742A5 true JP2017534742A5 (enExample) | 2018-12-06 |
| JP7078396B2 JP7078396B2 (ja) | 2022-05-31 |
Family
ID=55174697
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540977A Active JP7078396B2 (ja) | 2014-10-24 | 2015-10-23 | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
| JP2020093440A Active JP7186744B2 (ja) | 2014-10-24 | 2020-05-28 | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
| JP2022045482A Active JP7399996B2 (ja) | 2014-10-24 | 2022-03-22 | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020093440A Active JP7186744B2 (ja) | 2014-10-24 | 2020-05-28 | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
| JP2022045482A Active JP7399996B2 (ja) | 2014-10-24 | 2022-03-22 | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20160115267A1 (enExample) |
| EP (2) | EP3268052B1 (enExample) |
| JP (3) | JP7078396B2 (enExample) |
| CN (1) | CN107106710A (enExample) |
| AU (3) | AU2015335599B2 (enExample) |
| CA (1) | CA2965196C (enExample) |
| ES (1) | ES2916550T3 (enExample) |
| WO (1) | WO2016065322A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015335599B2 (en) | 2014-10-24 | 2020-03-19 | Molecular Insight Pharmaceuticals, Inc. | Preparations of meta-iodobenzylguanidine and precursors thereof |
| CN109666039B (zh) * | 2018-12-13 | 2020-12-25 | 山西大学 | 一种五核锡（ii）化合物及其制备方法和应用 |
| TWI898889B (zh) * | 2024-10-22 | 2025-09-21 | 國家原子能科技研究院 | 不含保護基之間三正丁基錫苯甲胍的製造方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4591630A (en) * | 1981-07-30 | 1986-05-27 | Ethicon, Inc. | Annealed polydioxanone surgical device and method for producing the same |
| US5565185A (en) | 1994-07-20 | 1996-10-15 | Merck Frosst Canada, Inc. | Process for the preparation of radiolabeled meta-halobenzylguanidine |
| US7273601B2 (en) * | 2000-07-18 | 2007-09-25 | The University Of Western Ontario | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
| US6461585B1 (en) * | 1998-10-02 | 2002-10-08 | The University Of Western Ontario | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
| US7335347B2 (en) * | 2002-10-18 | 2008-02-26 | Mcmaster University | Methods for purifying radiolabelled compounds |
| GB0514087D0 (en) | 2005-07-11 | 2005-08-17 | Ge Healthcare Ltd | Stabilised radiopharmaceutical compositions |
| TWI606842B (zh) | 2010-05-11 | 2017-12-01 | 藍瑟斯醫學影像公司 | 用於合成及使用造影劑之組合物、方法及系統 |
| AU2015335599B2 (en) | 2014-10-24 | 2020-03-19 | Molecular Insight Pharmaceuticals, Inc. | Preparations of meta-iodobenzylguanidine and precursors thereof |
-
2015
- 2015-10-23 AU AU2015335599A patent/AU2015335599B2/en active Active
- 2015-10-23 US US14/921,898 patent/US20160115267A1/en not_active Abandoned
- 2015-10-23 CN CN201580064695.2A patent/CN107106710A/zh active Pending
- 2015-10-23 ES ES15825978T patent/ES2916550T3/es active Active
- 2015-10-23 EP EP15825978.8A patent/EP3268052B1/en active Active
- 2015-10-23 WO PCT/US2015/057222 patent/WO2016065322A1/en not_active Ceased
- 2015-10-23 EP EP21173328.2A patent/EP3888694A1/en not_active Withdrawn
- 2015-10-23 JP JP2017540977A patent/JP7078396B2/ja active Active
- 2015-10-23 CA CA2965196A patent/CA2965196C/en active Active
-
2019
- 2019-06-11 US US16/437,061 patent/US11279784B2/en active Active
-
2020
- 2020-05-28 JP JP2020093440A patent/JP7186744B2/ja active Active
- 2020-06-18 AU AU2020204062A patent/AU2020204062B9/en active Active
-
2022
- 2022-02-14 US US17/671,128 patent/US11840592B2/en active Active
- 2022-03-22 JP JP2022045482A patent/JP7399996B2/ja active Active
- 2022-06-17 AU AU2022204262A patent/AU2022204262A1/en not_active Abandoned
-
2023
- 2023-11-07 US US18/503,465 patent/US20240174782A1/en not_active Abandoned
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