CN107106710A - 间‑碘苄基胍及其前体的制剂 - Google Patents

间‑碘苄基胍及其前体的制剂 Download PDF

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Publication number
CN107106710A
CN107106710A CN201580064695.2A CN201580064695A CN107106710A CN 107106710 A CN107106710 A CN 107106710A CN 201580064695 A CN201580064695 A CN 201580064695A CN 107106710 A CN107106710 A CN 107106710A
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CN
China
Prior art keywords
preparation
polymer
pharmaceutically acceptable
formula
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580064695.2A
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English (en)
Chinese (zh)
Inventor
J·摩斯
M·饶
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Insight Pharmaceuticals Inc
Original Assignee
Molecular Insight Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Insight Pharmaceuticals Inc filed Critical Molecular Insight Pharmaceuticals Inc
Publication of CN107106710A publication Critical patent/CN107106710A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
    • C08F230/04—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/06—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CN201580064695.2A 2014-10-24 2015-10-23 间‑碘苄基胍及其前体的制剂 Pending CN107106710A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462068598P 2014-10-24 2014-10-24
US62/068,598 2014-10-24
US201462069029P 2014-10-27 2014-10-27
US62/069,029 2014-10-27
PCT/US2015/057222 WO2016065322A1 (en) 2014-10-24 2015-10-23 Preparations of meta-iodobenzylguanidine and precursors thereof

Publications (1)

Publication Number Publication Date
CN107106710A true CN107106710A (zh) 2017-08-29

Family

ID=55174697

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580064695.2A Pending CN107106710A (zh) 2014-10-24 2015-10-23 间‑碘苄基胍及其前体的制剂

Country Status (8)

Country Link
US (4) US20160115267A1 (enExample)
EP (2) EP3268052B1 (enExample)
JP (3) JP7078396B2 (enExample)
CN (1) CN107106710A (enExample)
AU (3) AU2015335599B2 (enExample)
CA (1) CA2965196C (enExample)
ES (1) ES2916550T3 (enExample)
WO (1) WO2016065322A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI898889B (zh) * 2024-10-22 2025-09-21 國家原子能科技研究院 不含保護基之間三正丁基錫苯甲胍的製造方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7078396B2 (ja) 2014-10-24 2022-05-31 モレキュラー インサイト ファーマシューティカルズ， インコーポレイテッド メタ－ヨードベンジルグアニジン及びその前駆体の調製物
CN109666039B (zh) * 2018-12-13 2020-12-25 山西大学 一种五核锡（ii）化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693467A1 (en) * 1994-07-20 1996-01-24 Merck Frosst Canada Inc. Process for the preparation of radiolabeled meta-halobenzylguanidine
US20030012730A1 (en) * 2000-07-18 2003-01-16 Hunter Duncan H. Preparation of radiolabelled haloaromatics via polymer-bound intermediates
WO2004035744A2 (en) * 2002-10-18 2004-04-29 Biostream, Inc. Methods for purifying radiolabelled compounds

Family Cites Families (5)

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US4591630A (en) * 1981-07-30 1986-05-27 Ethicon, Inc. Annealed polydioxanone surgical device and method for producing the same
US6461585B1 (en) * 1998-10-02 2002-10-08 The University Of Western Ontario Preparation of radiolabelled haloaromatics via polymer-bound intermediates
GB0514087D0 (en) * 2005-07-11 2005-08-17 Ge Healthcare Ltd Stabilised radiopharmaceutical compositions
KR20170042373A (ko) 2010-05-11 2017-04-18 랜티우스 메디컬 이메징, 인크. 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
JP7078396B2 (ja) 2014-10-24 2022-05-31 モレキュラー インサイト ファーマシューティカルズ， インコーポレイテッド メタ－ヨードベンジルグアニジン及びその前駆体の調製物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693467A1 (en) * 1994-07-20 1996-01-24 Merck Frosst Canada Inc. Process for the preparation of radiolabeled meta-halobenzylguanidine
US20030012730A1 (en) * 2000-07-18 2003-01-16 Hunter Duncan H. Preparation of radiolabelled haloaromatics via polymer-bound intermediates
WO2004035744A2 (en) * 2002-10-18 2004-04-29 Biostream, Inc. Methods for purifying radiolabelled compounds

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
G. STEFFEN PAULEKUHN ET AL: "Trends in active pharmaceutical ingredient salt selection based on analysis of the orange book database", 《J. MED. CHEM.》 *
GANESAN VAIDYANATHAN ET AL: "A kit method for the high level synthesis of [211At]MABG", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
GANESAN VAIDYANATHAN ET AL: "No-carrier-added synthesis of meta-[131I] iodobenzylguanidine", 《APPLIED RADIATION AND ISOTOPES》 *
JEAN-MATHIEU CHRETIEN ET AL: "《Tin Chemistry Fundamentals, Frontiers, and Applications》", 26 July 2008, JOHN WILEY&SONS, LTD.PUBLICATION *
PAUL A. CULBERT ET AL: "Polymer-supported radiopharmaceuticals:1231- and 131I-labelled N-isopropyl-4-iodoamphetamine", 《REACTIVE POLYMERS》 *
WAFELMAN A R ET AL: "Synthesis, radiolabelling and stability of radioiodinated m-iodobenzylguanidine, a review", 《APPLIED RADIATION AND ISOTOPES》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI898889B (zh) * 2024-10-22 2025-09-21 國家原子能科技研究院 不含保護基之間三正丁基錫苯甲胍的製造方法

Also Published As

Publication number Publication date
WO2016065322A1 (en) 2016-04-28
JP7078396B2 (ja) 2022-05-31
JP2017534742A (ja) 2017-11-24
US20230008878A1 (en) 2023-01-12
CA2965196C (en) 2024-01-23
AU2015335599B2 (en) 2020-03-19
EP3888694A1 (en) 2021-10-06
AU2020204062B2 (en) 2022-07-07
US20240174782A1 (en) 2024-05-30
AU2020204062A1 (en) 2020-07-09
AU2015335599A1 (en) 2017-05-11
JP7186744B2 (ja) 2022-12-09
JP2022084797A (ja) 2022-06-07
HK1249425A1 (zh) 2018-11-02
US20190367653A1 (en) 2019-12-05
CA2965196A1 (en) 2016-04-28
JP7399996B2 (ja) 2023-12-18
JP2020143300A (ja) 2020-09-10
AU2020204062B9 (en) 2022-07-21
AU2022204262A1 (en) 2022-07-21
US11840592B2 (en) 2023-12-12
ES2916550T3 (es) 2022-07-01
EP3268052A1 (en) 2018-01-17
US11279784B2 (en) 2022-03-22
EP3268052B1 (en) 2021-06-23
US20160115267A1 (en) 2016-04-28

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Application publication date: 20170829