AU2015335599B2 - Preparations of meta-iodobenzylguanidine and precursors thereof - Google Patents
Preparations of meta-iodobenzylguanidine and precursors thereof Download PDFInfo
- Publication number
- AU2015335599B2 AU2015335599B2 AU2015335599A AU2015335599A AU2015335599B2 AU 2015335599 B2 AU2015335599 B2 AU 2015335599B2 AU 2015335599 A AU2015335599 A AU 2015335599A AU 2015335599 A AU2015335599 A AU 2015335599A AU 2015335599 B2 AU2015335599 B2 AU 2015335599B2
- Authority
- AU
- Australia
- Prior art keywords
- preparation
- ppm
- polymer
- inert gas
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 CCCC[Sn](CCCC)(CCCc1ccc(C(C*C)*C)cc1)c1cc(CNC(N)=N)ccc1 Chemical compound CCCC[Sn](CCCC)(CCCc1ccc(C(C*C)*C)cc1)c1cc(CNC(N)=N)ccc1 0.000 description 3
- PLOKKQPWVHLXKD-UHFFFAOYSA-N CCC(CC)C1[Si+](C)(C)N(Cc2cc(Br)ccc2)[Si+](C)(C)C1 Chemical compound CCC(CC)C1[Si+](C)(C)N(Cc2cc(Br)ccc2)[Si+](C)(C)C1 PLOKKQPWVHLXKD-UHFFFAOYSA-N 0.000 description 1
- AGIQGXPHGJAUDA-UHFFFAOYSA-N C[Sn]c1cc(CNC(N)=N)ccc1 Chemical compound C[Sn]c1cc(CNC(N)=N)ccc1 AGIQGXPHGJAUDA-UHFFFAOYSA-N 0.000 description 1
- KFUJWDJOCIAHRS-UHFFFAOYSA-N N=NNCC1=C[I]=CC=C1 Chemical compound N=NNCC1=C[I]=CC=C1 KFUJWDJOCIAHRS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
- C08F230/04—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/06—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2020204062A AU2020204062B9 (en) | 2014-10-24 | 2020-06-18 | Preparations of meta-iodobenzylguanidine and precursors thereof |
| AU2022204262A AU2022204262A1 (en) | 2014-10-24 | 2022-06-17 | Preparations of meta-iodobenzylguanidine and precursors thereof |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462068598P | 2014-10-24 | 2014-10-24 | |
| US62/068,598 | 2014-10-24 | ||
| US201462069029P | 2014-10-27 | 2014-10-27 | |
| US62/069,029 | 2014-10-27 | ||
| PCT/US2015/057222 WO2016065322A1 (en) | 2014-10-24 | 2015-10-23 | Preparations of meta-iodobenzylguanidine and precursors thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020204062A Division AU2020204062B9 (en) | 2014-10-24 | 2020-06-18 | Preparations of meta-iodobenzylguanidine and precursors thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015335599A1 AU2015335599A1 (en) | 2017-05-11 |
| AU2015335599B2 true AU2015335599B2 (en) | 2020-03-19 |
Family
ID=55174697
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015335599A Active AU2015335599B2 (en) | 2014-10-24 | 2015-10-23 | Preparations of meta-iodobenzylguanidine and precursors thereof |
| AU2020204062A Active AU2020204062B9 (en) | 2014-10-24 | 2020-06-18 | Preparations of meta-iodobenzylguanidine and precursors thereof |
| AU2022204262A Abandoned AU2022204262A1 (en) | 2014-10-24 | 2022-06-17 | Preparations of meta-iodobenzylguanidine and precursors thereof |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020204062A Active AU2020204062B9 (en) | 2014-10-24 | 2020-06-18 | Preparations of meta-iodobenzylguanidine and precursors thereof |
| AU2022204262A Abandoned AU2022204262A1 (en) | 2014-10-24 | 2022-06-17 | Preparations of meta-iodobenzylguanidine and precursors thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20160115267A1 (enExample) |
| EP (2) | EP3268052B1 (enExample) |
| JP (3) | JP7078396B2 (enExample) |
| CN (1) | CN107106710A (enExample) |
| AU (3) | AU2015335599B2 (enExample) |
| CA (1) | CA2965196C (enExample) |
| ES (1) | ES2916550T3 (enExample) |
| WO (1) | WO2016065322A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7078396B2 (ja) | 2014-10-24 | 2022-05-31 | モレキュラー インサイト ファーマシューティカルズ， インコーポレイテッド | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
| CN109666039B (zh) * | 2018-12-13 | 2020-12-25 | 山西大学 | 一种五核锡（ii）化合物及其制备方法和应用 |
| TWI898889B (zh) * | 2024-10-22 | 2025-09-21 | 國家原子能科技研究院 | 不含保護基之間三正丁基錫苯甲胍的製造方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030012730A1 (en) * | 2000-07-18 | 2003-01-16 | Hunter Duncan H. | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4591630A (en) * | 1981-07-30 | 1986-05-27 | Ethicon, Inc. | Annealed polydioxanone surgical device and method for producing the same |
| US5565185A (en) * | 1994-07-20 | 1996-10-15 | Merck Frosst Canada, Inc. | Process for the preparation of radiolabeled meta-halobenzylguanidine |
| US6461585B1 (en) * | 1998-10-02 | 2002-10-08 | The University Of Western Ontario | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
| JP4846238B2 (ja) * | 2002-10-18 | 2011-12-28 | マクマスター ユニバーシティー | 放射線標識した化合物の精製方法 |
| GB0514087D0 (en) * | 2005-07-11 | 2005-08-17 | Ge Healthcare Ltd | Stabilised radiopharmaceutical compositions |
| KR20170042373A (ko) | 2010-05-11 | 2017-04-18 | 랜티우스 메디컬 이메징, 인크. | 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 |
| JP7078396B2 (ja) | 2014-10-24 | 2022-05-31 | モレキュラー インサイト ファーマシューティカルズ， インコーポレイテッド | メタ－ヨードベンジルグアニジン及びその前駆体の調製物 |
-
2015
- 2015-10-23 JP JP2017540977A patent/JP7078396B2/ja active Active
- 2015-10-23 US US14/921,898 patent/US20160115267A1/en not_active Abandoned
- 2015-10-23 ES ES15825978T patent/ES2916550T3/es active Active
- 2015-10-23 CN CN201580064695.2A patent/CN107106710A/zh active Pending
- 2015-10-23 EP EP15825978.8A patent/EP3268052B1/en active Active
- 2015-10-23 EP EP21173328.2A patent/EP3888694A1/en not_active Withdrawn
- 2015-10-23 CA CA2965196A patent/CA2965196C/en active Active
- 2015-10-23 WO PCT/US2015/057222 patent/WO2016065322A1/en not_active Ceased
- 2015-10-23 AU AU2015335599A patent/AU2015335599B2/en active Active
-
2019
- 2019-06-11 US US16/437,061 patent/US11279784B2/en active Active
-
2020
- 2020-05-28 JP JP2020093440A patent/JP7186744B2/ja active Active
- 2020-06-18 AU AU2020204062A patent/AU2020204062B9/en active Active
-
2022
- 2022-02-14 US US17/671,128 patent/US11840592B2/en active Active
- 2022-03-22 JP JP2022045482A patent/JP7399996B2/ja active Active
- 2022-06-17 AU AU2022204262A patent/AU2022204262A1/en not_active Abandoned
-
2023
- 2023-11-07 US US18/503,465 patent/US20240174782A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030012730A1 (en) * | 2000-07-18 | 2003-01-16 | Hunter Duncan H. | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
Non-Patent Citations (1)
| Title |
|---|
| Paulekuhn et al. "Trends in Active Pharmaceutical Ingredient Salt Selection based on Analysis of the Orange Book Database", J. Med. Chem. 2007, 50, 6665-6672. * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016065322A1 (en) | 2016-04-28 |
| JP7078396B2 (ja) | 2022-05-31 |
| JP2017534742A (ja) | 2017-11-24 |
| US20230008878A1 (en) | 2023-01-12 |
| CA2965196C (en) | 2024-01-23 |
| EP3888694A1 (en) | 2021-10-06 |
| AU2020204062B2 (en) | 2022-07-07 |
| US20240174782A1 (en) | 2024-05-30 |
| AU2020204062A1 (en) | 2020-07-09 |
| AU2015335599A1 (en) | 2017-05-11 |
| JP7186744B2 (ja) | 2022-12-09 |
| JP2022084797A (ja) | 2022-06-07 |
| HK1249425A1 (zh) | 2018-11-02 |
| US20190367653A1 (en) | 2019-12-05 |
| CA2965196A1 (en) | 2016-04-28 |
| JP7399996B2 (ja) | 2023-12-18 |
| JP2020143300A (ja) | 2020-09-10 |
| AU2020204062B9 (en) | 2022-07-21 |
| CN107106710A (zh) | 2017-08-29 |
| AU2022204262A1 (en) | 2022-07-21 |
| US11840592B2 (en) | 2023-12-12 |
| ES2916550T3 (es) | 2022-07-01 |
| EP3268052A1 (en) | 2018-01-17 |
| US11279784B2 (en) | 2022-03-22 |
| EP3268052B1 (en) | 2021-06-23 |
| US20160115267A1 (en) | 2016-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |