JP7078396B2 - メタ－ヨードベンジルグアニジン及びその前駆体の調製物 - Google Patents

メタ－ヨードベンジルグアニジン及びその前駆体の調製物 Download PDF

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JP7078396B2
JP7078396B2 JP2017540977A JP2017540977A JP7078396B2 JP 7078396 B2 JP7078396 B2 JP 7078396B2 JP 2017540977 A JP2017540977 A JP 2017540977A JP 2017540977 A JP2017540977 A JP 2017540977A JP 7078396 B2 JP7078396 B2 JP 7078396B2
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JP2017534742A (ja
JP2017534742A5 (enExample
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ジェイソン モス，
マキナニ ラオ，
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モレキュラー インサイト ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
    • C08F230/04—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/06—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2017540977A 2014-10-24 2015-10-23 メタ－ヨードベンジルグアニジン及びその前駆体の調製物 Active JP7078396B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022045482A JP7399996B2 (ja) 2014-10-24 2022-03-22 メタ－ヨードベンジルグアニジン及びその前駆体の調製物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462068598P 2014-10-24 2014-10-24
US62/068,598 2014-10-24
US201462069029P 2014-10-27 2014-10-27
US62/069,029 2014-10-27
PCT/US2015/057222 WO2016065322A1 (en) 2014-10-24 2015-10-23 Preparations of meta-iodobenzylguanidine and precursors thereof

Related Child Applications (2)

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JP2020093440A Division JP7186744B2 (ja) 2014-10-24 2020-05-28 メタ－ヨードベンジルグアニジン及びその前駆体の調製物
JP2022045482A Division JP7399996B2 (ja) 2014-10-24 2022-03-22 メタ－ヨードベンジルグアニジン及びその前駆体の調製物

Publications (3)

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JP2017534742A JP2017534742A (ja) 2017-11-24
JP2017534742A5 JP2017534742A5 (enExample) 2018-12-06
JP7078396B2 true JP7078396B2 (ja) 2022-05-31

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JP2017540977A Active JP7078396B2 (ja) 2014-10-24 2015-10-23 メタ－ヨードベンジルグアニジン及びその前駆体の調製物
JP2020093440A Active JP7186744B2 (ja) 2014-10-24 2020-05-28 メタ－ヨードベンジルグアニジン及びその前駆体の調製物
JP2022045482A Active JP7399996B2 (ja) 2014-10-24 2022-03-22 メタ－ヨードベンジルグアニジン及びその前駆体の調製物

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JP2020093440A Active JP7186744B2 (ja) 2014-10-24 2020-05-28 メタ－ヨードベンジルグアニジン及びその前駆体の調製物
JP2022045482A Active JP7399996B2 (ja) 2014-10-24 2022-03-22 メタ－ヨードベンジルグアニジン及びその前駆体の調製物

Country Status (8)

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US (4) US20160115267A1 (enExample)
EP (2) EP3268052B1 (enExample)
JP (3) JP7078396B2 (enExample)
CN (1) CN107106710A (enExample)
AU (3) AU2015335599B2 (enExample)
CA (1) CA2965196C (enExample)
ES (1) ES2916550T3 (enExample)
WO (1) WO2016065322A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015335599B2 (en) 2014-10-24 2020-03-19 Molecular Insight Pharmaceuticals, Inc. Preparations of meta-iodobenzylguanidine and precursors thereof
CN109666039B (zh) * 2018-12-13 2020-12-25 山西大学 一种五核锡（ii）化合物及其制备方法和应用
TWI898889B (zh) * 2024-10-22 2025-09-21 國家原子能科技研究院 不含保護基之間三正丁基錫苯甲胍的製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030012730A1 (en) 2000-07-18 2003-01-16 Hunter Duncan H. Preparation of radiolabelled haloaromatics via polymer-bound intermediates
JP2013528161A (ja) 2010-05-11 2013-07-08 ランセウス メディカル イメージング， インコーポレイテッド 造影剤の合成および使用のための組成物、方法およびシステム

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591630A (en) * 1981-07-30 1986-05-27 Ethicon, Inc. Annealed polydioxanone surgical device and method for producing the same
US5565185A (en) 1994-07-20 1996-10-15 Merck Frosst Canada, Inc. Process for the preparation of radiolabeled meta-halobenzylguanidine
US6461585B1 (en) * 1998-10-02 2002-10-08 The University Of Western Ontario Preparation of radiolabelled haloaromatics via polymer-bound intermediates
US7335347B2 (en) * 2002-10-18 2008-02-26 Mcmaster University Methods for purifying radiolabelled compounds
GB0514087D0 (en) 2005-07-11 2005-08-17 Ge Healthcare Ltd Stabilised radiopharmaceutical compositions
AU2015335599B2 (en) 2014-10-24 2020-03-19 Molecular Insight Pharmaceuticals, Inc. Preparations of meta-iodobenzylguanidine and precursors thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030012730A1 (en) 2000-07-18 2003-01-16 Hunter Duncan H. Preparation of radiolabelled haloaromatics via polymer-bound intermediates
JP2013528161A (ja) 2010-05-11 2013-07-08 ランセウス メディカル イメージング， インコーポレイテッド 造影剤の合成および使用のための組成物、方法およびシステム

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Publication number Publication date
US20160115267A1 (en) 2016-04-28
US20190367653A1 (en) 2019-12-05
AU2020204062A1 (en) 2020-07-09
JP2020143300A (ja) 2020-09-10
US11279784B2 (en) 2022-03-22
JP2022084797A (ja) 2022-06-07
JP2017534742A (ja) 2017-11-24
AU2015335599B2 (en) 2020-03-19
US20240174782A1 (en) 2024-05-30
AU2020204062B9 (en) 2022-07-21
HK1249425A1 (zh) 2018-11-02
WO2016065322A1 (en) 2016-04-28
EP3268052B1 (en) 2021-06-23
ES2916550T3 (es) 2022-07-01
AU2022204262A1 (en) 2022-07-21
CA2965196A1 (en) 2016-04-28
CN107106710A (zh) 2017-08-29
EP3268052A1 (en) 2018-01-17
US20230008878A1 (en) 2023-01-12
JP7399996B2 (ja) 2023-12-18
US11840592B2 (en) 2023-12-12
AU2020204062B2 (en) 2022-07-07
EP3888694A1 (en) 2021-10-06
AU2015335599A1 (en) 2017-05-11
CA2965196C (en) 2024-01-23
JP7186744B2 (ja) 2022-12-09

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